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2020 Vol. 17, No. 13 Published: 2020-05-05

	4	Effect of salidroside/chitosan hydrogel on oxidative stress injury in rat adipose tissue derived mesenchymal stem cells
		CHENG Yu ZHENG Jie CHEN Hao LI Jianlan HUANG Ling YAO Yaocong CHEN Can
		Objective To investigate the effect of salidroside/chitosan hydrogel on oxidative stress injury in rat adipose tissue derived mesenchymal stem cells. Methods The cell lines were divided into Control group, H2O2 group (model group), low, medium and high concentration experimental group, while oxidative stress modeling was performed on the model group and each experimental group. The temperature sensitivity of the hydrogel was observed at different temperatures, the cell morphology was observed by a light microscope, the cell viability was detected by the CCK-8 method, while the cells were labeled with CM-Dil Dye for counting and 3D morphological observation. Results The hydrogel was in a sol state at 4℃ and in a gel state at 37℃. The cells in the medium concentration experimental group formed obvious colonies under the light microscope. There was no statistically significant difference in cell viability between the groups on days 0 and 1 (P ＞ 0.05). On days 3 and 7, the cell viability of the model group was lower than that of the Control group, while the cell viability of each experimental group was higher than that of the model group, and the differences were statistically significant (P ＜ 0.05). On days 0 and 1, there was no statistically significant difference in the number of cells in each group (P ＞ 0.05). On days 3 and 7, the number of cells in the model group was lower than that in the control group, while the number of cells in each experimental group was higher than that in the model group, and the differences were statistically significant (P ＜ 0.05). The 3D images observed that the cells in the medium concentration experimental group grew from spherical to dendritic with time. Conclusion Salidroside-modified hydrogel promotes survival of rat adipose stem cells injured by oxidative stress.
		2020 Vol. 17 (13): 4-7 [Abstract] ( 156 ) HTML (1 KB) PDF (991 KB) ( 132 )

	8	Effect of Dexmedetomidine on glycocalyx in mice with cerebral ischemia-reperfusion injury
		MA Haibo1 YANG Yingchun2 LIU Jingjing3 MU Dongliang4 XIA Rui5▲
		Objective To investigate the effect of Dexmedetomidine on glycocalyx in mice with cerebral ischemia-reperfusion injury. Methods Forty-five C57BL6/J male adult mice were randomly divided into sham operation group, normal saline group and Dexmedetomidine group, with 15 mice in each group. In sham operation group, only the skin of the right neck was cut and the right common carotid artery was exposed. In Dexmedetomidine group, 40 μg/kg Dexmedetomidine was injected intraperitoneally 30 minutes before the establishment of the model. The mice in normal saline group were injected with equal volume of normal saline 30 minutes before modeling, and then acute cerebral ischemia-reperfusion injury model was established 24 hours after 60 minutes of ischemia-reperfusion. The percentage of infarct volume was calculated by TTC staining, the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay (ELISA), and the expression of oxidative stress-related proteins (malondialdehyde [MDA], superoxide dismutase [SOD]) were detected by ELISA. Results Compared with normal saline group, the infarct volume and neurological deficit score of Dexmedetomidine group were significantly reduced, the differences were statistically significant (P < 0.05). Compared with normal saline group, the activity time and distance of Dexmedetomidine group were significantly lengthened, the differences were statistically significant (P < 0.05 or P < 0.01). Compared with normal saline group, the levels of HPSE/β-actin, TNF-α/β-actin and NF-κB/β-actin in Dexmedetomidine group were significantly decreased, and the levels of SDC-1/β-actin and Tie-2/β-actin in Dexmedetomidine group were significantly increased, the differences were highly statistically significant (P < 0.01). Compared with normal saline group, the levels of TNF-α and IL-6 in Dexmedetomidine group were significantly reduced, the differences were highly statistically significant (P < 0.01). Compared with normal saline group, MDA level of Dexmedetomidine group was significantly decreased, and SOD level of Dexmedetomidine group was significantly increased, the differences were highly statistically significant (P < 0.01). Conclusion Dexmedetomidine can protect glycocalyx from cerebral ischemia-reperfusion injury, reduce inflammation and stress response.
		2020 Vol. 17 (13): 8-12,26 [Abstract] ( 254 ) HTML (1 KB) PDF (1104 KB) ( 126 )

	13	Study on the effect of apoptosis and autophagy of pine pollen on human hepatocellular carcinoma SK-Hep-1 cells
		LI Beilin DENG Yibin LUO Yanhong
		Objective To observe the effect of pine pollen on apoptosis and autophagy of human hepatocellular carcinoma SK-Hep-1 cells, and to explore the anti-tumor effect and mechanism of pine pollen, so as to provide experimental basis for the clinical application of pine pollen. Methods SK-Hep-1 cells were cultured in vitro and randomly divided into 4 groups: the control group, the pine pollen low-dose group (30 mg/mL), the pine pollen medium-dose group (45 mg/mL), and the pine pollen high-dose group (60 mg/mL). The inhibition rate of SK-Hep-1 cells was determined by CCK-8 method after pine pollen intervention at different concentrations at different time (12, 24, 48 and 72 h). After pollen treatment for 48 h, cell morphology was observed by phase contrast microscopy and Hoechst33258 fluorescence staining. The apoptosis rate was observed by flow cytometry and mRNA expression levels of autophagy were detected by RT-PCR. Results CCK-8 assay showed that pine pollen could significantly inhibit SK-Hep-1 cell proliferation in time and dose dependence. Phase contrast microscopy showed that pine pollen could inhibit cell proliferation. Hoechst33258 fluorescence staining showed that, compared with the control group, the pine pollen low-dose, medium-dose and high-dose groups showed obvious apoptotic changes in cell morphology. Annexin V-FITC/PI double staining results showed that the apoptosis rates in the pine pollen low-dose, medium-dose and high-dose groups were significantly increased compared with the control group, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). RT-PCR analysis showed that, compared with the control group, intervention of pine pollen intervention after 48 h, the expression of Beclin-1, LC3-Ⅱwas up-regulated obviously in the pine pollen low-dose, medium-dose and high-dose groups, but P62 expression was down-regulated, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). Conclusion Pine pollen can effectively inhibit the proliferation of human hepatocellular carcinoma SK-Hep-1 cells, promote their apoptosis, and induce their autophagy. Pine pollen may promote apoptosis of hepatocellular carcinoma cells by inducing autophagy.
		2020 Vol. 17 (13): 13-17 [Abstract] ( 139 ) HTML (1 KB) PDF (1113 KB) ( 114 )

	18	Study on the therapeutic effect and mechanism of Bairesi Pills on vitiligo model induced by hydroquinone in C57BL/6 mice
		Reshalati·Yizize1 MA Li2 MA Fuchang2 HUO Shixia2 Silafu·Aibai2 LI Zhijian2
		Objective To investigate the therapeutic effect of Bairesi Pills on the skin coated with hydroquinone to establish a decolorized model of vitiligo in C57BL/6 mice, so as to provide experimental support for the preclinical study of Bairesi Pill. Methods The model of vitiligo in C57BL/6 mice was established by applying hydroquinone ointment on the skin: C57BL/6 mice, SPF level, 32 mice, male and female half. After passing quarantine, 2.5% hydroquinone ointment was applied on the skin for 20 days. All the model animals had vitiligo on their skin. According to the random number table of the size of vitiligo, the model animals were divided into the blank control group, the model control group, the Vitiligo Capsules group, and the Bairesi Pills treatment group, with 8 patients in each group, half male and half female. The blank control group and the model control group were given equal volume solvent according to 20 mL/kg, and the other groups were given corresponding solution once a day for 30 consecutive days. On the next day, the decolorization and decolorization area of the hair were observed and photographed. After the treatment, the eyeballs were collected and the blood was collected. The serum was isolated and the tyrosinase content was determined by enzyme-linked immunosorbent assay (ELISA). The hair follicles containing melanin were counted by hematoxylin-eosin (HE) staining in skin. Results There were statistically significant differences in the proportion of hair follicles, hair decolorization score and serum tyrosinase content in the four groups (all P ＜ 0.05). Compared with the blank control group, the proportion of melanin hair follicles and the serum tyrosinase content in the model control group decreased, and the hair decolorization score increased, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). Compared with the blank control group, the proportion of melanin hair follicles in the Vitiligo Capsules group and the Bairesi Pills treatment group decreased, and the hair decoloration score increased, the differences were highly statistically significant (all P ＜ 0.01), but there was no statistically significant difference in the serum tyrosinase content between the two groups compared with the blank control group (P ＞ 0.05). Compared with the model control group, the proportion of melanin hair follicle number, the serum tyrosinase content and the hair decolorization score in the Vitiligo Capsules group and the Bairesi Pills treatment group increased, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The proportion of melanin hair follicles, hair decolorization score and serum tyrosinase content in the Bairesi Pills treatment group were not statistically significant compared with the Vitiligo Capsules group (P ＞ 0.05). Conclusion Bairesi Pills can promote the increase of tyrosinase content, promote the proliferation of active melanocytes, so as to promote the generation of melanin, hair decolorization score is also significantly reduced, on the C57BL/6 mice model of vitiligo has a good therapeutic effect, and may have the same therapeutic effect as Vitiligo Capsules.
		2020 Vol. 17 (13): 18-21 [Abstract] ( 200 ) HTML (1 KB) PDF (779 KB) ( 109 )

	22	The protective effect of Itaconic Acid on acute renal injury in sepsis mice
		JIAO Zhihua BU Li′na CHEN Jun ZOU Feng OUYANG Yuanming
		Objective To observe the changes of inflammatory factors in renal tissue of sepsis mice with acute kidney injury and to investigate the effect of Itaconic Acid on inflammatory factors in sepsis mice and the protective effect on lipopolysaccharide (LPS) induced acute kidney injury in mice. Methods A total of 24 male C57BL/6 mice were divided into three groups: blank control group, LPS group, and Ttaconic Acid + LPS group, with 8 mice in each group. A total of 50 mg/kg of Itaconic Acid was given to the abdominal cavity of the Itaconic Acid + LPS group, and the same amount of normal saline was given to the abdominal cavity of the blank control group and the LPS group. After 2 h of administration, the mice in the blank control group were injected with the same amount of normal saline, and the mice in the other two groups were intraperitoneally injected with LPS (10 mg/kg). After 24 h, the mice were anesthetized and kidney tissue was taken for reserve. Renal tissue sections were stained with hematoxylin-eosin to observe the degree of renal injury. Serum levels of interleukin (IL) -1, IL-6 and tumor necrosis factor-α (TNF-α) were determined by enzyme linked immunosorbent assay. Phosphorylation levels of extracellular regulatory protein kinase (ERK), c-Jun amino-terminal kinase (JNK), P38 and P65 proteins in renal tissues were detected by Western blot. Results The renal injury score, MPO activity, the levels of IL-1β, IL-6 and TNF-α in the plasma, the levels of ERK, JNK, P38 and P65 protein phosphorylated in the renal tissue of LPS group were higher than those of the control group, the differences were statistically significant (P ＜ 0.05). While those of Itaconic Acid + LPS group were lower than LPS group, the differences were statistically significant (P ＜ 0.05). Conclusion Itaconic Acid has a protective effect on LPS-induced acute kidney injury, possibly by inhibiting the inflammatory response mediated by the mitogen-activated protein kinase signal pathway.
		2020 Vol. 17 (13): 22-27 [Abstract] ( 126 ) HTML (1 KB) PDF (1270 KB) ( 90 )

	27	Study on apigenin improvement of oxidative stress injury in diabetic rats based on Nrf2/HO-1 pathway
		YANG Li1 ZHAO Gang2 FAN Xiumei2 WU Lingling3 TIAN Shuqing1
		Objective To study the effect of apigenin on oxidative stress injury in gestational diabetic rats based on Nrf2/HO-1 pathway. Methods Thirty-six pregnant SD rats of high-fat feeding were selected, the gestational diabetes rat model was established by intraperitoneal injection of chain urea with cephalosporins method, according to the random number table method they were divided into model group, apigenin group (50 mg/kg), ML385 group (Nrf2/HO-1 pathway inhibitor, dose of 20 mg/kg), apigenin + ML385 group (apigenin dose of 50 mg/kg, ML385 dose of 20 mg/kg), with 9 mice in each group. Another 9 mice were set as the control group. After grouping, the levels of fasting serum blood glucose (FSG), triglyceride (TG), total cholesterol (TC) and pathological changes of liver tissue were measured; the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured, and the levels of superoxide dismutase (SOD), malonic dialdehyde (MDA) and Nrf2/HO-1 pathway protein expression of rats in each group were detected. Results Compared with the control group, the liver tissue of the model group showed structural disorder, accompanied by inflammatory cell infiltration, hepatocyte degeneration, necrosis, cytoplasm contraction, deep staining and other pathological damage, the levels of FSG, TG, TC, serum TNF-α and IL-6, and MDA in liver tissue increased significantly (P ＜ 0.05), and SOD level, Nrf2, HO-1 protein expressions in liver tissue were significantly decreased (P ＜ 0.05). Compared with the model group, the pathological damage of liver tissue in ML385 group was aggravated, the levels of FSG, TG, TC, serum TNF-α and IL-6, and MDA in liver tissue increased significantly (P ＜ 0.05), and SOD level, Nrf2, HO-1 protein expressions in liver tissue were significantly decreased (P ＜ 0.05). Compared with the model group, the pathological damage of liver tissue in the apigenin group was alleviated, the levels of FSG, TG, TC, serum TNF-α and IL-6, and MDA in liver tissue decreased significantly (P ＜ 0.05), and SOD level, Nrf2 and HO-1 protein expressions in liver tissue were significantly increased (P ＜ 0.05). Compared with ML385 group, the pathological damage of liver tissue in apigenin+ML385 group was alleviated, the levels of FSG, TG, TC, serum TNF-α and IL-6, and MDA in liver tissue decreased significantly (P ＜ 0.05), and SOD level, Nrf2 and HO-1 protein expressions in liver tissue were significantly increased (P ＜ 0.05). Conclusion Apigenin can improve oxidative stress injury in gestational diabetic rats by activating Nrf2/HO-1 pathway.
		2020 Vol. 17 (13): 27-31 [Abstract] ( 168 ) HTML (1 KB) PDF (837 KB) ( 154 )

	32	Study on endoplasmic reticulum stress mechanism of treating heart failure with Yiqi Huoxue Recipe
		ZHANG Ting1 WANG Jie2 WU Aiming1 MA Zhe1 ZHAO Yizhou1 ZHANG Dongmei1 JIN Qiushuo1 LOU Lixia1
		Objective To explore the molecular mechanism of improvement effect of Yiqi Huoxue Recipe in heart failure treatment by regulating endoplasmic reticulum stress signaling (ERS) pathway. Methods Thirty SPF male SD rats were divided into sham operation group (10 rats) by the random number table method, and the remaining 20 rats model of acute myocardial infarction was prepared by ligating the anterior descending branch of the left coronary artery. Rats with successful modeling were randomly divided into model group and Yiqi Huoxue group, with 10 rats in each group. The rats in model group and sham operation group were gavaged with deionized water 5 mL/(kg·d), 1 time/d. Rats in Yiqi Huoxue group were gavaged with Yiqi Huoxue Recipe 5 mL/(kg·d). The drug was administered continuously for 4 weeks. Hemodynamic index including left ventricular end-diastolic pressure (LVEDP), left ventricular internal pressure maximal rate of increase (+dp/dt max), left heart maximum drop rate of indoor pressure (-dp/dt max), left ventricular systolic pressure (LVSP) and heart rate (HR) were detected by left ventricular intubation method. The expressions of brain natriuretic peptide (BNP) and calcineurin A (CaNA) mRNA were detected by Rt-PCR and the protein levels of caspase-12, protein kinase R-like endoplasmic reticulum kinase (PERK), inositol requiring enzymes 1(IRE1) and glucose-regulated protein 78 (GRP78) were detected by Western blot. Results LVEDP, -dp/dt max and HR in model group were higher than those in sham group, +dp/dt max and LVSP were significantly lower than those in sham operation group, and the differences were highly statistically significant (P < 0.01). LVEDP, -dp/dt max and HR of rats in Yiqi Huoxue group were lower than those in model group, LVSP and +dp/dt max were higher than those in model group, and the differences were highly statistically significant (P < 0.01). The expressions of BNP and CaNA mRNA in model group were higher than those in sham operation group, with statistically significant differences (P < 0.05 or P < 0.01). The expressions of BNP and CaNA mRNA in Yiqi Huoxue group were lower than those in model group, with statistically significant differences (P < 0.05). The expression levels of caspase-12, PERK, IRE1 and GRP78 in model group were higher than those in sham operation group, with statistically significant differences (P < 0.05). The expression levels of caspase-12, PERK and IRE1 in Yiqi Huoxue group were lower than those in model group, with statistically significant differences (P < 0.05). Conclusion Yiqi Huoxue Recipe can improve the cardiac function of rats with heart failure induced by myocardial infarction, and the mechanism included may be related to the endoplasmic reticulum stress signaling pathway regulation.
		2020 Vol. 17 (13): 32-36,40 [Abstract] ( 136 ) HTML (1 KB) PDF (870 KB) ( 100 )

	37	Effect of Tangluoning on expression of TRL2 /4 in dorsal root ganglion of rats with diabetic peripheral neuropathy
		LI Yixiao1 WANG Liying1 GUO Yuxin1 LIU Qin1 CHEN Feng1 ZHANG Taojing2
		Objective To investigate the regulating effect of Tangluoning on Toll-like receptors 2/4 (TLR2/4) in dorsal root ganglion (DRG) of rats with diabetic peripheral neuropathy (DPN). Methods Eighty of eight-week-old male SD rats were selected. Fourteen rats were randomly selected as normal group, the rest of 66 rats were intraperitoneally injected with 60 mg/kg streptozotocin to induce DPN rat model, among which 61 rats were succeeded. They were divided into the model group (21 rats), the Western medicine group (19 rats) and the Chinese medicine group (21 rats) by random number table method. Chinese medicine group was gavaged Tangluoning with 5 g/(kg·d), the Western medicine group was gavaged α-lipoic acid with 20 mg/(kg·d), the model group and normal group were gavaged equal amount of distilled water. The drug was administered continuously for 8 weeks. After 8 weeks, the expression of TLR2 and TLR4 proteins in DRG was detected by Western blot. Results The expression levels of TLR2 and TLR4 proteins in normal group were weak, while the expression levels of TLR2 and TLR4 proteins in the model group were higher than those in normal group (P < 0.01). The expression levels of TLR2 and TLR4 proteins in the Chinese medicine group and the Western medicine group were lower than those in the model group (P < 0.05). There were no statistically significant differences in the expression levels of TLR2 and TLR4 proteins between the Chinese medicine group and the Western medicine group (P > 0.05). Conclusion Tangluoning may have impact on the signaling pathways such as the mediated NF-κB by inhibiting the expression of TLR2 and TLR4, thereby reducing inflammation and oxidative stress and reducing nerve damage.
		2020 Vol. 17 (13): 37-40 [Abstract] ( 167 ) HTML (1 KB) PDF (503 KB) ( 77 )

	41	Effect of 1,25-dihydroxyvitamin D3 delaying renal interstitial fibrosis by T regulatory cell
		GAO Feng1 GUO Hui2
		Objective To study the effect of 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO). Methods According to random number table method, 54 wistar rats were divided into sham operation group (group A), UUO group (group B) and 1,25 (OH)2D3 treatment group (group C), with 18 rats in each group. Group C was gavaged 3 ng/(d·100 g) of 1,25（OH）2D3 every day. Group A and group B were gavaged the same amount of peanut oil. The left ureter ligation was performed in group B and group C. Group A was treated with ureteral free, but not ligated. On the 1st, 3rd and 7th day after operation, 6 rats were killed in batches, and the left kidney was retained. Serum creatinine were measured in each group. Renal pathological changes were observed by hematoxylin-eosin (HE) staining. The expression of a-smooth muscle actin (a-SMA) and forkhead P3 protein (FOXP3) in the kidney was detected by immunohistochemistry. Western blot was used to detect the protein expression of phosphorylated adenosine monophosphate activated protein kinase (p-AMPK). Results On the 1st, 3rd and 7th day after operation, the serum creatinine，a-SMA levels of group B was higher than those of group A, and the serum creatinine，a-SMA levels of group C was lower than those of group B (all P < 0.05). The renal tissue morphology of group A was normal, while the renal tissue of group B was prolonged with the obstruction time, showing renal tubules dilatation and interstitial edema, while the tubular degeneration of group C was reduced compared with that of group B. On the 1st, 3rd and 7th day after operation, p-AMPK and FOXP3 levels in group B were lower than those in group A, p-AMPK and FOXP3 levels in group C were higher than those in group B (all P < 0.05). Conclusion 1,25(OH)2D3 can delay renal interstitial fibrosis, and its mechanism may be related to the activation of AMPK to promote the activation of regulatory T cells.
		2020 Vol. 17 (13): 41-44 [Abstract] ( 114 ) HTML (1 KB) PDF (719 KB) ( 81 )

	45	Screening of antioxidant active components and the GC-MS analysis of the low polar components from Philydrum lanuginosum Banks et Sol. ex Gaertner
		SUN Xueping1 LIU Zhengjie1 TAN Xiaoming1 CHAI Ling2 LIU Buming2
		Objective To screen out the antioxidant components of Guangxi Zhuang medicine Philydrum lanuginosum Banks et Sol. ex Gaertner, and to analyze the chemical composition of the low polar components. Methods The ethanol crude extraction of Philydrum lanuginosum Banks et Sol. ex Gaertner was dispersed in water and extracted by petroleum ether，ethyl acetate and n-butanol to obtain the relative components，respectively. The antioxidant activities of the crude extraction and the organic phase extractions including ABTS，DPPH，superoxide and hydroxyl free radical scavenging ability were investigated by microplate reader. And the gas chromatography-mass spectrometry (GC-MS) was used to analyze the low polar components. The relative percentage of each component was calculated by peak area normalization. Results All the extracted phases of Philydrum lanuginosum Banks et Sol. ex Gaertner had certain antioxidant activity, among which the ethyl acetate phase had better antioxidant activity, and the IC50 values of ABTS, DPPH and superoxide radical were 697.7, 742.2 μg/mL and 705.8 μg/mL respectively, which were similar to the IC50 values of positive control vitamin E. Forty-one compounds were identified by GC-MS from the petroleum ether phase of the field onion, with the highest organic acid content (53.59%). Conclusion The main components of the low-polarity parts of Philydrum lanuginosum Banks et Sol. ex Gaertner are unsaturated fatty acids, terpenes and steroids. All compounds are first discovered from scallions. The components with better antioxidant activity in vitro are mainly concentrated in the ethyl acetate phase, which provides a research basis for the application of Philydrum lanuginosum Banks et Sol. ex Gaertner as a natural antioxidant.
		2020 Vol. 17 (13): 45-49,53 [Abstract] ( 140 ) HTML (1 KB) PDF (739 KB) ( 124 )

	50	Determination of 13 kinds of metal elements in different materials of plastic drug packaging by microwave digestion ICP-MS
		RAO Yanchun ZHU Bijun XIONG Wei
		Objective To establish a method of simultaneously determine the element content of aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), arsenic (As), cadmium (Cd), tin (Sn), antimony (Sb), barium (Ba), mercury (Hg), lead (Pb) in polypropylene (PP), polyethylene (PE), polyester (PET) pharmaceutical packaging. Methods After microwave digestion of samples, with scandium (Sc), germanium (Ge), indium (In) and bismuth (Bi) as internal standard, the content of the above elements were determined by inductively coupled plasma mass spectrometry (ICP-MS) method at the same time, the ICP-MS power was 1550 W, sampling depth was 7.6 mm, plasma gas, carrier gas and auxiliary gas flow were 15.0, 0.86, 1.0 L/min respectively, the pump speed was 0.10 r/s, the atomizing chamber temperature was 2℃, reaction mode was helium, data was collected for three times. Results The linear relationship between the determined elements was good, r = 0.9986-0.9999, the sample recovery rate of each element in PP, PE and PET is between 85.8% and 99.1%, and the RSD was 1.5%-4.7% (n = 9). Conclusion The method is fast, simple, sensitive, and accurate. It can be used for the determination of various metal elements in plastic medicine packaging made of different materials.
		2020 Vol. 17 (13): 50-53 [Abstract] ( 134 ) HTML (1 KB) PDF (499 KB) ( 50 )

	54	Application progress of data mining in modern Chinese medicine research
		FENG Jihong1 ZHANG Pengyu2
		Data mining is an emerging discipline. Its advantage lies in extracting and analyzing potential laws from huge databases and reflecting the essence of things from different aspects. The application of data mining technology can make traditional Chinese medicine information more intuitive, help to quickly obtain traditional Chinese medicine knowledge resources from a large number of literatures, discover new problems, and broaden research ideas. This paper analyzes the research results of data mining technology used in the field of traditional Chinese medicine in recent years by many scholars, and summarizes the application of data mining technology in traditional Chinese medicine, prescriptions, syndromes, treatment methods, famous experts′ experience, classic medical records and disease prevention, in order to provide reference for its further application.
		2020 Vol. 17 (13): 54-57 [Abstract] ( 170 ) HTML (1 KB) PDF (565 KB) ( 101 )

	58	Research progress of Chinese medicine in the prevention and treatment of atherosclerotic vulnerable plaque by the regulation of macrophage polarization
		LI Xiaocui1 MENG Zhonghua1 WANG He2 SHANG Shasha2 WANG Jianru2 GUAN Huaimin2 CHEN Yushan2
		Atherosclerosis is the basic pathological change of coronary heart disease. The formation of vulnerable plaque leads to decreased plaque stability and plaque rupture, which is an important etiology of acute cardiovascular events. Macrophages are important inflammatory cells during the initial and development of atherosclerosis. The stability of plaque is closely related to the polarization of macrophage subtypes. Chinese medicine have been revealed to improve the stability of atherosclerosis plaques by regulating the polarization of macrophages, and has a good application prospect in the prevention and treatment of atherosclerotic vulnerable plaques. This article takes macrophage polarization as the entry point, and discusses about Chinese medicine to affect atherosclerosis by regulating macrophage polarization.
		2020 Vol. 17 (13): 58-61 [Abstract] ( 139 ) HTML (1 KB) PDF (570 KB) ( 243 )

	62	Development and evaluation of detection methods for adenoidhypertrophy
		CUI Jiawen1 GU Fei2 WANG Yichao2 LIU Kunpeng2 WANG Shuxia2 HU Lijun2
		Adenoid hypertrophy is a common clinical disease, especially in children. In the past, the diagnosis was mainly based on nasal endoscopy, electronic nasopharyngoscope and X-ray. However, because of the problems of trauma and radiation, it is rejected by the families of children, the diagnosis, treatment and scientific research of the disease are limited. In recent years, with the continuous update and development of inspection methods, the means of diagnosis and detection of adenoid hypertrophy have shown a trend of diversification, providing more choices for clinical and scientific research. This paper reviews the literature in recent years, focusing on the current clinical and scientific research commonly used adenoid examination methods, including images, endoscopy, polysomnography, blood test, etc, and according to the conclusions of relevant literature, the advantages and disadvantages of these examination methods are evaluates, hoping to provide reference for otolaryngologists to diagnose and detect these diseases.
		2020 Vol. 17 (13): 62-65 [Abstract] ( 195 ) HTML (1 KB) PDF (568 KB) ( 77 )

	66	Research progress on basic and adjuvant therapy of diabetic foot ulcer
		SONG Aibo1 SUN Jin2
		Diabetic foot ulcer (DFU) is one of the the most disabling late complications in diabetic patients, which has many problems during treatment such as time-consuming, slow effect, easy to relapse, etc. Currently, there are various treatment methods for DFU, which can be divided into basic treatment and adjuvant treatment except the treatment of primary disease. The basic treatment includes thorough debridement, unloading of wound pressure and infection control. The adjuvant therapy includes oxygen therapy, negative pressure therapy, recombinant human growth factor, energy therapy, etc. In recent years, there have been more and more clinical reports on the use of combination regimens for DFU treatment, which may provide a new direction for the development of DFU treatment. This paper briefly reviews the research progress of DFU in terms of its foundation and adjuvant therapy, so as to provide clinicians with ideas and help in choosing DFU combined therapy.
		2020 Vol. 17 (13): 66-68,72 [Abstract] ( 193 ) HTML (1 KB) PDF (586 KB) ( 132 )

	69	Application of carbon quantum dots in tumor therapy
		ZHANG Ya′nan WEN Haixia▲
		Carbon quantum dots is a kind of new fluorescent nano material, has excellent electrical conductivity, excellent biological compatibility, environment friendly and stable performance advantages, it has made tremendous progress in the fields of biology, medicine, optics, nanoelectronics, sensors, etc., tumor targeting imaging in the diagnosis and treatment of drug targeting. This paper mainly reviews the preparation, biological characteristics, biological applications of carbon quantum dots, in vivo and in vitro imaging, new fluorescence markers of organisms, drug delivery, targeted therapy, mitigation drugs, prolonging drug action time to improve the efficacy of treatment, and the future application prospect in the treatment of breast cancer.
		2020 Vol. 17 (13): 69-72 [Abstract] ( 194 ) HTML (1 KB) PDF (610 KB) ( 160 )

	73	Study on the training method of clinical thinking in emergency for interns based on case training
		DENG Xiaoyan XIAN Li′na LIN Zhixing ZHENG Yanling
		Objective To explore the effect of the training method of clinical thinking in emergency for interns based on case training. Methods A total of 160 emergency interns in Emergency Trauma College of Hainan Medical College from January 2014 to June 2019 were selected, they were divided into observation group (from January 2017 to June 2019，80 cases) and control group (from January 2014 to December 2016, 80 cases) by chronological order. The control group was given the traditional demonstration teaching method, while the observation group was given the clinical thinking training method based on case training. The results of theory, skill assessment, teacher evaluation and questionnaire feedback were compared between the two groups. Results The scores of theoretical knowledge, clinical thinking and total scores in the observation group were significantly higher than those in the control group (P ＜ 0.05). The results of defibrillation, tracheal intubation, thoracic puncture, abdominal puncture and cardiopulmonary resuscitation in the observation group were significantly higher than those in the control group (P ＜ 0.05). Teachers′ satisfaction with interns′ autonomous learning ability, analytical problem-solving ability, emergency clinical thinking, emergency theoretical knowledge, emergency first aid skills and teaching learning atmosphere in the observation group were significantly higher than those in the control group (P ＜ 0.05). The results of questionnaire feedback from interns in the observation group were significantly better than those in the control group (P ＜ 0.05). Conclusion The training method of clinical thinking based on case training has good effect. It can guide interns to explore and find problems on their own initiative, cultivate their ability to solve problems independently, combine theoretical knowledge with clinical practice, improve practical ability and thinking ability of emergency department, and it can be widely used in clinical work of emergency department.
		2020 Vol. 17 (13): 73-76 [Abstract] ( 117 ) HTML (1 KB) PDF (631 KB) ( 104 )

	77	The role and significance of the Youth Forum in the standardized training of general practitioners
		ZHANG Mingxin LU Ning CUI Manli WANG Jia DU Zhaozhao ZHU Lin▲
		The generalized resident standardization training plays an important role in the training and re-education of general practitioners, but it also has certain deficiencies. In the long-term practice of general practitioners, the Department of Gastroenterology in the First Affiliated Hospital of Xi′an Medical University (“our hospital” for short) has gradually explores a characteristic training mode in the long-term standardized training practice of general practice residents, among which the most significant one is “youth forum”. The specific practice method is to take 1 month as a cycle and the time is every Monday. In the first week, a general practitioner and a young doctor in the Department of Gastroenterology report and discuss the current hot spots and difficulties in diagnosis and treatment. In the second week, young doctors from other departments in our hospital are invited to give lectures. The multidisciplinary communication is more conducive to the cultivation of clinical thinking of general practitioners. In the third week, young doctors from key departments of other hospitals in Shaanxi Province are invited to the department of gastroenterology for exchange and study, so that the rotation of specialties and general practice learning can be interchanged, so that the general practitioners can see their own shortcomings and receive better teaching resources, so as to improve their interest in learning and communication. In the fourth week, domestic experts and professors are invited to give academic lectures, so that general practitioners can broaden their vision, understand and learn the latest medical knowledge and improve medical literacy during the training period. The review is conducted every 3 months and is reported by the general practitioner. Through the development of the youth forum, not only has the general practitioners′ medical skills been improved, but the most important thing is to enhance their sense of belonging in our hospital, facilitate centralized management, stimulate their independent learning, and comprehensively improve the quality of teaching.
		2020 Vol. 17 (13): 77-80 [Abstract] ( 152 ) HTML (1 KB) PDF (631 KB) ( 123 )

	81	Study on the extensibility of cultivation of pharmaceutical talents in higher vocational colleges under the background of hospital pharmacy reform
		LIU Yuanfen
		In recent years, hospital pharmacies have tried many reforms, from self-management of pharmacies to the implementation of pharmacy trusteeship and then to the support of provinces for the separation of pharmacies. These reforms have brought opportunities and challenges to the development of pharmacy specialty in higher vocational colleges, which may promote the rational allocation of human resources for pharmacy practitioners, promote the employment of a large number of pharmacy students in higher vocational schools, and improve the precise positioning of professional training. In order to seize the opportunity of pharmacy reform and development, higher vocational colleges should strengthen the publicity of medical reform policy, change the concept, accurately locate pharmaceutical technicians, adjust the setting of curriculum system, attach importance to the cultivation of professional skills and comprehensive quality of talents, improve the quality of talent training, and make the trained talents more suitable for the needs of society.
		2020 Vol. 17 (13): 81-84 [Abstract] ( 131 ) HTML (1 KB) PDF (593 KB) ( 37 )

	85	The teaching design and practice of Huangtu Decoction in blood regulating agent of Formulas of Chinese medicine
		LI Qingwei HUANG Jingwen AN Lifeng
		Teaching is also an academic. In the process of teaching, a reasonable teaching design can guide the teaching, strengthen the students′ grasp of the course content, optimize the knowledge vein system, and improve the students′ independent learning ability and comprehensive quality. For teachers, they can improve their professional level, sublimate their knowledge and improve their teaching quality. Teaching design plays an important role in classroom teaching, so it requires teachers to carefully optimize the structure of the course, and temper the classroom design of each class. This paper mainly shows the author′s teaching design of Huangtu Decoction, a famous prescription of traditional Chinese medicine, from the two aspects of pre-class system and teaching activity process, in order to fill a corner for the teaching of formulas of Chinese medicine.
		2020 Vol. 17 (13): 85-88 [Abstract] ( 135 ) HTML (1 KB) PDF (729 KB) ( 55 )

	89	Exploration of electrocardiogram teaching reform by combining various teaching methods
		WANG Yue ZHANG Hongshan YIN Lin LI Yilin ZHOU Meng
		Electrocardiogram diagnostics is an important and practical subject in clinical practice, but the traditional teaching methods are relatively simple and the teaching effect needs to be improved. In order to improve the teaching quality of electrocardiogram, the author′s team explores the effective teaching mode and optimizes the teaching design. In the process of electrocardiogram teaching, this study carries out the reform of multiple teaching methods, including flipped classroom, problem-based learning (PBL), case-based learning (CBL), rain classroom, mini-clinical evaluation exercise (Mini-CEX) and other teaching methods, and improves the way of student assessment and teacher training. Through the teaching reform, students′ interest in learning has been increased and their comprehensive ability to solve practical problems has been improved. Combining a variety of teaching methods in electrocardiogram teaching can effectively improve the teaching efficiency and teaching quality, which is conducive to the training of medical college talents with solid basic skills.
		2020 Vol. 17 (13): 89-92 [Abstract] ( 159 ) HTML (1 KB) PDF (598 KB) ( 181 )

	93	Study on the application of magnetic resonance T2-mapping and DTI sequence in chronic injury of knee articularcartilage
		ZHANG Xinhui1 YU Jinghong2▲
		To investigate the application value of different magnetic resonance sequences in the assessment of chronic injury severity of articular cartilage in knee osteoarthritis (KOA). Methods A total of 35 patients with osteoarthritis (OA) who underwent knee magnetic resonance imaging (MRI) in the Second Affiliated Hospital of Inner Mongolia Medical University from December 2017 to December 2018 were selected as the pathological group and another 35 healthy adult volunteers were selected as the normal group. The two groups were simultaneously scanned with the conventional and functional MRI sequences of the knee joint (T2 relaxation time diagram [T2-mapping], diffusion tensor imaging [DTI]). T2-mapping values, apparent diffusion coefficient (ADC) value and fractional anisotropic (FA) value of the five areas of interest of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, and patellar cartilage in the two groups were measured respectively. By two physicians (associate chief physician) according to the Recht MRI classification standard of the lesion group of knee joint cartilage in various areas of interest (divided intoⅠ, Ⅱ, Ⅲ and Ⅳ level). At the same time, the measured values were compared between the groups of the pathological group and were statistically analyzed between the pathological group and the normal group. Results The T2-mapping values of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage, the ADC values of the articular surface of the patella cartilage in the pathological group were all higher than those of the normal group, and the FA values of the articular surface of the patella cartilage were lower than those of the normal group, with highly statistically significant differences (all P ＜ 0.01). The T2-mapping values of knee joint of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage and the ADC values of of knee joint of the articular surface of the patella cartilage in theⅠ, Ⅱ, Ⅲ, Ⅳ level groups were significantly higher than those in the normal group, and Ⅳ level group was higher than Ⅲ, Ⅱ, Ⅰ level groups, Ⅲ level group was higher than Ⅱ, Ⅰ level group, Ⅱ level group was higher than Ⅰ level group, the differences were highly statistically significant (all P ＜ 0.01). There was no statistically significant difference between the FA value of articular surface of patellar cartilage of the knee in theⅠ level group and that in the normal group (P ＞ 0.05). The FA value of articular surface of patellar cartilage in the Ⅱ, Ⅲ, Ⅳ level groups was lower than that in the normal group, and Ⅳ level group was lower than Ⅲ, Ⅱ, Ⅰ level groups, Ⅲ level group was lower than Ⅱ, Ⅰlevel group, Ⅱ level group was lower than Ⅰ level group, the differences were highly statistically significant (all P ＜ 0.01). The T2-mapping values of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage, the ADC values of the articular surface of the patella cartilage were significantly positively correlated with the Recht classification (r ＞ 0, all P ＜ 0.01), and the FA values of the articular surface of the patella cartilage were negatively correlated with the Recht classification (r ＜ 0, P ＜ 0.01). The ADC value of the pathological group under the curve of the patellar cartilage area was larger than the T2-mapping value and the FA value of the same site. Conclusion T2-mapping and DTI imaging techniques can quantitatively assess the degree of articular cartilage injury in KOA patients.
		2020 Vol. 17 (13): 93-97 [Abstract] ( 139 ) HTML (1 KB) PDF (694 KB) ( 78 )

	98	Meta analysis of acupuncture combined with swallowing function training in the treatment of dysphagia after stroke
		TAN Shiyun1 LIAO Jun2 ZHANG Li3 LIU Yanmei4 BAI Weiwei1
		Objective To evaluate the efficacy and safety of acupuncture combined with functional training in the treatment of dysphagia after stroke. Methods CNKI, VIP, Wanfang database, PubMed, Cochrance Library and Embase were retrieved from September 2019. Randomized controlled test (RCT) were selected, the included studies were analyzed with RevMan 5.3 software, and the publication bias was evaluated with Cochrane systematic evaluation tools. Results A total of 12 RCT were included. Clinical effect of experimental group was better than that of control group (RR = 1.22, 95%CI [1.15, 1.29], Z = 6.68, P < 0.000 01). The effect of drinking water test between the two groups had no significant difference (SMD = -0.47, 95%CI [-2.23, 1.39], Z = 0.50, P = 0.62). The effect of drinking water test (after elimination) in experimental group was better than that in control group (SMD = -0.76, 95%CI [-1.09, -0.43], Z = 4.54, P ＜ 0.000 01). The video fluoroscopy swallowing study (VFSS) in experimental group was better than that in control group (MD = 1.54, 95%CI [0.96, 2.13], Z = 5.19, P < 0.000 01). VFSS (after elimination) in experimental group was better than that in control group (MD = 1.82, 95%CI [1.37, 2.28], Z = 7.83, P < 0.000 01). Conclusion Acupuncture combined with swallowing function training is a good clinical effect in treating dysphagia after stroke. However, the included literatures have a certain publication bias, high inter-study heterogeneity, and the trial design is not rigorous enough. Therefore, more well-designed large sample clinical trials are still needed to be verified.
		2020 Vol. 17 (13): 98-102 [Abstract] ( 179 ) HTML (1 KB) PDF (1667 KB) ( 87 )

	103	Statistics of inpatients with malignant tumors from 2013 to 2017 in a hospital in Xinjiang
		SUN Yajing LI Chunyang
		Objective To discusse the first page of the electronic medical record of inpatients with malignant tumors, analyze the incidence of malignant tumors, and to provide reference for clinical prevention and treatment. Methods From 2013 to 2017, the first page of medical records of inpatients with malignant tumors in a grade A hospital in Xinjiang was collected. Based mainly on the discharged diagnosis, the disease constitution, gender, operation situation and age were analyzed. Results The number of malignant tumor patients increased year by year, accounting for 3.13% of the total discharged patients, among which the top 10 malignant tumor cases accounted for 82.41% of all total malignancy. 5 years′ statistics showed that lung cancer and thyroid cancer always rank the top 2 in each year. The number of patients with malignant tumor in the hospital in males was slightly higher than that in females, with a male-female ratio of 1.03 to 1.00. Among all malignant tumors, thyroid cancer, breast cancer and skin cancer had the highest surgical rate, reaching 96.61%, 77.64% and 77.19%, respectively. Conclusion The establishment of early screening mechanism for some specific groups can effectively avoid and prevent the occurrence and development of malignant tumors, or reduce the burden on patients and medical institutions.
		2020 Vol. 17 (13): 103-105,113 [Abstract] ( 116 ) HTML (1 KB) PDF (619 KB) ( 71 )

	106	Effects of depression on relapse rate and quality of life in chronic alcohol dependent patients
		ZHAO Zhiqiang1 XIA Yeling2▲ JI Xiangping3 XU Qiong1 FU Hui1
		Objective To investigate the effect of depression on the relapse rate and quality of life in chronic alcohol dependent patients. Methods From January to December 2016, a total of 275 patients diagnosed as “chronic alcohol dependence” by the Department of Addiction Medicine of Xinjiang Mental Health Center (the Fourth People′s Hospital of Urumqi) were selected. According to whether they drank again or not, they were divided into the relapse group (165 cases) and the non-relapse group (110 cases). The general situation questionnaire and Hamilton depression rating scale (HAMD) and 36-item short form health survey (SF-36) were used to measure the patients. Results The HAMD score of depression scale and the final score of SF-36 in the quality of life scale was significantly lower than that in the non-relapse group (P ＜ 0.05). There was no statistically significant difference in the final score of relapse rate and quality of life between the HAMD score < 7 and > 24 (P ＞ 0.05). The final scores of the two groups with HAMD score < 7 and 7-24 showed statistically significant differences in the rate of relapse and quality of life (P ＜ 0.05). The final scores of relapse rate and quality of life in the HAMD scores of 7-24 and ＞ 24 showed statistically significant differences (P ＜ 0.05). Conclusion Depression can lead to increased relapse rates and decreased quality of life in patients with chronic alcohol dependence. However, mild to moderate depression may have a more serious impact on the relapse rate and quality of life of patients with chronic alcohol dependence. Therefore, more attention should be paid in chronic alcohol dependent patients accompanied by mild to moderate depression in future work.
		2020 Vol. 17 (13): 106-109 [Abstract] ( 134 ) HTML (1 KB) PDF (657 KB) ( 53 )

	110	Effect of deep hyperthermic therapy combined with routine treatment on pulmonary ventilation function and inflammatory response level in patients with inflammatory pleural effusions
		ZHAO Fang1 JIANG Guorong2 WANG Ziting3 YAN Shanshan1 XIAO Jian1 DONG Weiwei1 LI Danhua1 LI Runpu1
		Objective To explore the effects of deep hyperthermia combined with conventional methods on the treatment of inflammatory pleural effusion inflammatory response, lung function and clinical effect. Methods Eighty patients with inflammatory pleural effusion diagnosed in Baoding Second Central Hospital from July 2016 to July 2018 were selected and divided into treatment group and control group by random number table method, 40 cases in each group. The treatment group was treated with antibiotics, symptomatic treatment and deep hyperthermia, while the control group was only given antibiotic treatment and symptomatic treatment. The inflammatory indexes, lung function and clinical effects of the two groups were compared after treatment. Results Serum procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-8 and IL-10 of the two groups after treatment were significantly lower than those before treatment, while the treatment group were lower than those of control group, and the differences were statistically significant (P ＜ 0.05). Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and maximum ventilation per minute (MVV) after treatment were significantly higher than those before treatment, while the treatment group were higher than those of control group, and the differences were statistically significant (P ＜ 0.05). The clinical effect of the patients in the treatment group was significantly better than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Deep hyperthermia combined with conventional methods for treating inflammatory pleural effusions can more effectively promote the absorption of effusions, improve the anti-infective effect, and improve the patients′ lung function than conventional treatments.
		2020 Vol. 17 (13): 110-113 [Abstract] ( 118 ) HTML (1 KB) PDF (610 KB) ( 63 )

	114	Statistical analysis of white matter changes in patients with chronic obstructive pulmonary disease and subclinical cognitive impairment based on voxel analysis
		WANG Chunrong1 LIU Yong2 ZHAN Yafeng3 GAO Dehong1 ZOU Liqiu1 PENG Kewen1 CHEN Jiming4 QIU Shijun5
		Objective To investigate the changes of white matter structure in patients with stable subclinical cognitive impairment chronic obstructive pulmonary disease (COPD). Methods From July 2012 to March 2015, 60 patients with COPD treated in Huazhong University of Science and Technology Union Shenzhen Hospital (hereinafter referred to as “our hospital”) were selected as the COPD group, while a total of 62 healthy people who underwent a physical examination in our hospital during the same period were selected as the control group. The general data, physiological and neuropsychological data of the two groups were collected, while the changes in the whole brain white matter microstructure of the two groups were analyzed by the voxel level analysis (VBA). Results The smoking time of the COPD group was longer than that of the control group, and the difference was statistically significant (P ＜ 0.05). The total scores of mini mental state examination, Montreal cognitive assess ment and the visual space and executive function, naming and delayed memory scores were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). In the COPD group, the white matter FA values in the left middle occipital gyrus, right auxiliary motor area, left superior temporal gyrus, and right posterior cerebellar area were significantly lower than those in the control group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion FA value of the white matter in patients with COPD in the stable phase is abnormal, and the microstructural integrity of the fibers is destroyed, which should be paid attention to clinically.
		2020 Vol. 17 (13): 114-117 [Abstract] ( 153 ) HTML (1 KB) PDF (730 KB) ( 84 )

	118	Effect of inverse ratio ventilation on pulmonary function in infants with pulmonry lobectomy during one lung ventilation
		WANG Yun LI Yongle FANG Qin HAN Baoyi LIU Jing HU Zurong
		Objective To investigate the effect of inverse ratio ventilation （IRV） on pulmonary ventilation and exchange function in infants with pulmonary lobectomy during one lung ventilation（OLV）. Methods A total of 66 infants of Guangdong Women and Children′s Hospital with thoracoscopic lobectomy were selected from October 2017 to October 2018, while they were divided into the inverse ventilation group and the conventional ventilation group by random number table method, with 33 infants in each group. The respiratory mechanics indexes of the infants′ threshold limit ventilation (TLV) 15 min (T1), OLV 30 min (T2), OLV 60 min (T3), and recovery TLV 15 min (T4) were recorded, and blood gas analysis was performed. Results Peak airway pressure (Ppeak), mean airway pressure (Pmean), arterial carbon dioxide partial pressure (PaCO2), pulmonary alveolar arterial oxygen partial pressure difference (PA-aO2), respiratory index (RI), void rate (VD/VT) at T2 and T3 were higher than those at T1, while the dynamic lung compliance (Cdyn), pH, arterial blood oxygen partial pressure (PaO2), oxygenation index (OI) were lower than those at T1, and the differences were statistically significant (P ＜ 0.05). Pmean, Cdyn, PaO2, OI in the inverse ventilation group at T2 and T3 were higher than those in the conventional ventilation group, while Ppeak, PaCO2, PA-aO2, and RI were lower than those in the conventional ventilation group, and the differences were statistically significant (P ＜ 0.05). In addition to Ppeak and pH, there were interaction between other indicators of the two groups. There were no statistically significant difference in postoperative hypoxemia between the two groups (P ＞ 0.05). In addition, there was no complications such as delayed recovery, atelectasis and pneumothorax in the two groups. Conclusion IRV applied to infants with single lung ventilation under thoracoscope lobectomy can increase lung compliance, reduce Ppeak, improve lung diffusion function, and promote oxygenation to a certain extent.
		2020 Vol. 17 (13): 118-121 [Abstract] ( 118 ) HTML (1 KB) PDF (351 KB) ( 163 )

	122	Application and experience in Yanjing famous acupuncturist Yu Shuzhuang′s theory of “five definite answer in clinical practice”
		YOU Wei1，2 ZHAO Jiping3 WANG Linpeng2 WANG Yizhan2 LI Bin2
		The theory of “five definite answer in clinical practice” proposed by professor Yu Shuzhuang, it′s emphasized that acupuncturist should clarify diagnosis, syndrome differentiation, meridians and acupoints, treating methods. This paper summarizes professor Yu Shuzhuang′s experience in the application of his thoery, and preliminarily analyzes his academic thoughts about diagnosis and treatment. Combined with clinical practice, the author briefly talks about the personal experience of applying the theory of “five definite answer in clinical practice”.
		2020 Vol. 17 (13): 122-126 [Abstract] ( 228 ) HTML (1 KB) PDF (694 KB) ( 69 )

	127	Systematic evaluation and meta-analysis on the efficacy and safety of Biqi Capsules in the treatment of knee osteoarthritis
		WANG Huanrui1 WU Jiaqi2 CAI Xiao2 HUANG Runyue2,3 CHEN Xiumin2,3 HUANG Qingchun2
		Objective To assess clinical effect and safety of Biqi Capsules combined with Western medicine in the treatment of knee osteoarthritis (KOA). Methods Cochrane Library, PubMed, Embase, CNKI, VIP and Wanfang databases were searched by computer, with the search time from the establishment to August 2019. Chinese key words include “Biqi Capsules, Biqi, knee osteoarthritis, knee arthritis”, etc. A randomized controlled trial on the treatment of KOA with Biqi Capsules combined with Western medicine compared with Western medicine was included. Cochrane Handbook 5.2.0 was used to analyze the quality of literature. Review Manager 5.3 was used to evaluate the overall efficiency, WOMAC score, VAS score, SF-36, adverse reactions and meta-analysis. Results Six RCTs that contained 841 patients were included. Meta analysis results: the overall effective rate of Biqi Capsules combined with Western medicine in the treatment of KOA was higher than that of Western medicine group (RR = 1.22, 95%CI [1.15, 1.29], P < 0.000 01). WOMAC score of Biqi Capsules combined with Western medicine in the treatment of KOA was lower than that of Western medicine group (MD = -10.57, 95%CI [-12.17, -8.97], P ＜ 0.000 01). Systematic evaluation results: Biqi Capsules combined with Western medicine was better than Western medicine group in reducing VAS score of KOA and improving SF-36, and there was no serious adverse event. Conclusion The result of this systematic review shows that Biqi Capsules combined with Western medicine has good clinical efficacy in KOA treatment with acceptable tolerability. However, due to the low quality and limitations of the included researches, more large-scale RCTs are needed to evaluate the long-term efficacy and safety of Biqi Capsules in the treatment of KOA.
		2020 Vol. 17 (13): 127-131 [Abstract] ( 178 ) HTML (1 KB) PDF (1136 KB) ( 87 )

	132	Differentiation and analysis of the differences between acupuncture and internal medicine of traditional Chinese medicine
		JIN Yiting1 XU Xinyin1，2 WANG Xuefeng1 YANG Tingting1
		Acupuncture and internal medicine of traditional Chinese medicine are both important parts of traditional Chinese medicine. Based on the theory of meridians and collaterals, acupuncture and moxibustion is characterized by differentiation and treatment of meridians. It can dredge meridians and regulate qi and blood by selecting appropriate shu points, operating measures and techniques, stimulating amount, etc. The theory of internal medicine of traditional Chinese medicine includes five elements of yin and yang, five movements and six qi, qi, blood and body fluid, etc. It has the characteristics of syndrome differentiation and treatment. Based on traditional Chinese medicine, it can play the role of strengthening the body and removing pathogenic factors and harmonizing yin and yang by applying appropriate prescription, processing and decoction. At present, the system of acupuncture and moxibustion is gradually converged in the internal medicine of traditional Chinese medicine, which mistakenly confuses syndrome differentiation with syndrome differentiation, and rigidly selects the prescription of acupuncture and moxibustion. Making clear the difference between acupuncture and internal medicine of traditional Chinese medicine, it is convenient to give full play to the thinking of acupuncture diagnosis and treatment, show the characteristics and advantages of acupuncture, and better serve the clinical diagnosis and treatment.
		2020 Vol. 17 (13): 132-135 [Abstract] ( 143 ) HTML (1 KB) PDF (689 KB) ( 141 )

	136	Study on the drug use rules of Song Bochuan′s Complete Book of Obstetrics based on data mining
		SONG Linyi1，2 YU Jing2 WANG Jun2 YU Chaoqin3▲
		Objective To analyze medication rules and discuss the characteristics of Song Bochuan′s drug use in the treatment of postpartum diseases and his academic thoughts on postpartum diseases. Methods From December 2018 to March 2019, the prescriptions that met the inclusion criteria in Song Bochuan′s Complete Book of Obstetrics were selected. The database was established according to the specification. The data in the database by frequency analysis, cluster analysis and association rule analysis were analyzed with excel and SPSS statistics. Results In postpartum formula, 28 drugs were used more than 4 times. The frequency of thermophilic drugs of tonifying deficiency and guipi meridian was the first. The top two drug frequencies were Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxiong, which were also the first combination of drug pairs. The top four drug use frequencies were Radix Angelicae Sinensis, Rhizoma Ligustici Chuanxiong, Radix Glycyrrhizae and Ginseng, which were also the highest among the four drug related combinations. Cluster analysis results were divided into five categories according to professional knowledge. Conclusion It reflects Song Bochuan′s academic thoughts on the treatment of postpartum diseases, such as invigorating blood, taking care of the spleen, using warm-based medicine and paying attention to the alternative.
		2020 Vol. 17 (13): 136-139 [Abstract] ( 234 ) HTML (1 KB) PDF (889 KB) ( 85 )

	140	Effect of comprehensive therapy based on blood pricking therapy on Bell′s facial paralysis
		WANG Ping1 DONG Can2 TAO Wei2 ZHANG Cairong2 CHENG Changcheng2 LIN Wanqi2
		Objective To study the effect of comprehensive therapy based on blood pricking therapy on Bell′s facial paralysis. Methods From January 2016 to December 2018, 60 patients with Bell′s facial paralysis were collected from Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Nanjing University of Chinese Medicine. According to the random number table method, they were divided into two groups, each group of 30 cases. One case was lost or removed, 59 cases were completed, 30 cases in control group and 29 cases in treatment group. Control group was treated with acupuncture, while treatment group was treated with blood pricking therapy and acupuncture. Control group was treated 5 times a week, 10 times a course, a total of 4 courses. In treatment group, acupuncture plus bloodletting was performed 5 times a week in the acute period, 3 times a week in the recovery period and linkage period, 10 times as a course of treatment, a total of 4 courses of treatment. The physical function, social function, H-B facial nerve function score and recovery time of two groups were observed. Results The overall analysis showed that there were no significant differences in the scores of body function, social function and H-B facial nerve function between two groups (P > 0.05). Intra group comparison: the body function score of FDI in control group on the 15th day of treatment was higher than that on the 0th day of treatment, and H-B facial nerve function score was lower than that on the 0th day of treatment; the score of FDI body function in control group on the 30th day was higher than that on the 15th day, and the scores of FDI social function and H-B facial nerve function were lower than those on the 15th day, the differences were statistically significant (P < 0.05). The score of FDI body function in treatment group on the 30th day was higher than that on the 15th day, and the scores of FDI social function and H-B facial nerve function were lower than those on the 15th day, the differences were statistically significant (P < 0.05). Among groups comparison: there were no significant differences between two groups in the scores of body function, social function and H-B facial nerve function (P > 0.05). The recovery time of treatment group was shorter than that of control group, the difference was statistically significant (P < 0.05). Conclusion Acupuncture combined with bleeding therapy and acupuncture alone are both effective in the treatment of Bell′s facial paralysis. By contrast, acupuncture combined with bleeding therapy shortened the period of treatment and had a higher cure rate.
		2020 Vol. 17 (13): 140-143,147 [Abstract] ( 128 ) HTML (1 KB) PDF (754 KB) ( 175 )

	144	Analysis on supporting manipulation sequential treatment of perianal abscess
		GAO Yuan1 HE Jinling1 LIANG Jianguo1 ZHANG Fushun1 LIU Yantong2 GE Bin2
		The pathogenesis of perianal abscess has a period of constant change between the struggle of immunity and disease. According to the different situations of the immunity and disease, it can be divided into three stages: early disease, disease progression and later disease. Supporting manipulation of traditional Chinese medicine can be used throughout the disease. In the early stage of the dispelling, Xianfang Huoming Decoction is used to anti-inflammatory and make blood circulation. In the middle of the disease, Tou Nong Powder is used to help the wound cleanse and remove carrion. In the later stages of the disease, Tuoli Xiaodu Powder is used to promote wound healing and improve immunity. It can be believe that in clinical application, supporting manipulation sequential treatment is used to treated the whole of perianal abscess, have the characteristics of comprehensive, flexible and fast. And supporting manipulation sequential treatment has a good effect on relieving symptoms, reducing secretions, and promoting wound healing. It is safe and has the obvious characteristics of traditional Chinese medicine. So it is worthy of promotion and application.
		2020 Vol. 17 (13): 144-147 [Abstract] ( 179 ) HTML (1 KB) PDF (690 KB) ( 78 )

	148	Clinical application value of ultrasound and MRI in rotator cuff injury
		YUAN Hongmei1 PU Jingsong2 YUE Wensheng1 CHEN Tianwu3 ZHOU Haiying3 GU Peng1 LEI Huilan1
		Objective To evaluate the clinical value of ultrasound (US) and magnetic resonance imaging (MRI) in rotator cuff injury. Methods From January 2016 to February 2018, 38 cases of rotator cuff injury who confirmed by arthroscopy were collected in Affiliated Hospital of North Sichuan Medical College. US and MRI were performed before operation. Shoulder arthroscopy was the gold standard. McNemer test was performed on US and MRI results of rotator cuff injury and Kappa test were used to evaluate the consistency of US and MRI in the diagnosis of rotator cuff injury and common complications. Results Arthroscopic examination showed that there were 26 full-thickness tears and 23 partial-thickness tears. The sensitivity，specificity，and accuracy of US in diagnosis of full-thickness tear were 92.31%, 100.00% and 98.24% respectively，while MRI was 96.15%, 100.00%, and 99.12% respectively. The sensitivity，specificity，and accuracy in US of the diagnosis of partial-thickness tear were 78.26%, 97.80% and 93.85% respectively, while 86.96%, 96.70% and 94.74% respectively in MRI. There was no statistically significant difference between the two methods in the diagnosis of rotator full-thickness tear and partial-thickness tear (P > 0.05). There was a good consistency between US and MRI in the diagnosis of rotator cuff full-thickness tears and partial-thickness tears (κ= 0.922, 0.811), but the consistency of US and MRI in the diagnosis of complications after rotator cuff tears was poor (κ = -0.068). Conclusion US can be used as the first screening diagnosis of clinical rotator cuff injury and the first choice for routine follow-up. When the diagnosis of rotator cuff injury is not clear or more detailed complications information is needed before surgery, MRI can be further performed.
		2020 Vol. 17 (13): 148-151,156 [Abstract] ( 252 ) HTML (1 KB) PDF (749 KB) ( 57 )

	152	Application of contrast enhanced transrectal ultrasound and its guided prostate biopsy in new Gleason grading groups of prostate cancer
		HE Jieling1 CHEN Shaomin2 YU Qian3 LIU Dawei4 LI Wenhui3 HE Jinhua5 LIANG Zhanpeng1▲ YANG Ruilin6▲
		Objective To investigate the application value of contrast enhanced transrectal ultrasound (CETRUS) and its guided prostate biopsy in the new Gleason grading groups of prostate cancer (PCa). Methods From January 2016 to January 2020, 118 cases with suspected PCa who underwent prostate biopsy in Guangzhou Panyu Central Hospital were selected. The patients were divided into the PCa group (46 cases) and the benign group (72 cases), according to the pathological result. According to Gleason Grading groups, PCa patients were divided into Gleason ≤ 3+4 group (13 cases) and Gleason ≥ 4+3 group (33 cases). The sensitivity, specificity and diagnosis rate of CETRUS in diagnosis of PCa were analyzed. The contrast parameters were obtained and compared by time-intensity curve, and the parameters of benign and malignant tissues and the gleason grading groups of PCa were analyzed according to the pathological results. Results Forty-six cases were diagnosed with PCa. The sensitivity, specificity and diagnostic rate of CETRUS in diagnosis of PCa were 74%, 83% and 80%, respectively. The PCa classification grouping result showed that 5 cases (11%) in Group 1, 8 cases (17%) in Group 2, 9 cases (20%) in Group 3, 12 cases (26%) in Group 4 and 12 cases (26%) in Group 5, respectively. There were no significant differences in base intensity (B) and area under curve (AUC) between the PCa group and the benign group (P > 0.05). Time to peak (TIP) and peak in half time (IHT) of the PCa Group were shorter than those of the benign group, peak intensity (PI) of the PCa Group was higher than that of the benign Group, and the differences were statistically significant (all P < 0.05). B, PI and AUC of cancer tissues in PCa patients were higher than those of surrounding tissues, TIP and IHT of cancer tissues were shorter than those of surrounding tissues, and the differences were statistically significant (all P < 0.05). B, PI and AUC in Gleason ≥ 4+3 group (Group 3-5) were higher than Gleason ≤ 3+4 group (Group 1-2), and the differences were statistically significant (all P < 0.05); there were no significant differences in TIP, IHT between two Groups (P > 0.05). Conclusion CETRUS with its guided prostate biopsy has a high diagnostic rate, and can reflect the difference of new Gleason grading groups of PCa. The combination of both can evaluate the prognosis of PCa and also help to targeted biopsy for PCa.
		2020 Vol. 17 (13): 152-156 [Abstract] ( 144 ) HTML (1 KB) PDF (492 KB) ( 28 )

	157	Evaluation of the vascular endothelium flow-mediated dilation of cavernosal artery in T2DM patients by ultrasound
		LI Jinbing1 LIU Qiang2 SHU Shengchun1 CHEN Sinan1 TANG Xianyu3
		Objective To investigate the changes in vascular endothelium flow-mediated dilation (FMD) of cavernosal artery (CA) in patients with type 2 diabetes mellitus (T2DM). Methods From March to November 2019, 54 cases with T2DM who were outpatient or in-patient in the Guangdong Provincial Hospital of Traditional Chinese Medicine were selected. According to the questionnaire score of the intemational index of erectile function 5, they were divided into T2DM with erectile dysfunction（T2DMED）group (≤21 points) 29 cases and T2DM with normal erectile function（T2DMNEF）group (22-25 points) 25 cases. Meanwhile, 25 volunteers with normal penile erection function were selected as control group. The diameter (D), peak systolic velocity (PSV) and mean flow velocity (Vmean) of CA in three groups were measured by color doppler ultrasound before and after the reactive hyperemia, and FMD, the change rate of peak systolic velocity (CRPSV) and the change rate of blood flow volume (CRVol) were calculated after the reactive hyperemia. Results Endothelial FMD of CA in T2DMNEF group and T2DMED group were lower than those in control group, and FMD in T2DMED group was lower than that in T2DMNEF group, and the differences were highly statistically significant (all P < 0.01). There were no statistically significant differences in CRPSV and CRVol of CA between T2DMNEF group and control group (P > 0.05), while CRPSV and CRVol of CA in T2DMED group were lower than those in T2DMNEF group and control group, and the differences were highly statistically significant (all P < 0.01). Conclusion Endothelial FMD of CA is impaired in T2DM patients. With the occurrence of ED in patients with T2DM, the damage to CA vascular endothelial function is also aggravated.
		2020 Vol. 17 (13): 157-159,163 [Abstract] ( 155 ) HTML (1 KB) PDF (694 KB) ( 172 )

	160	Clinical effect of retention enema with Lianshao Enema Agent in the treatment of mild and moderate ulcerative colitis
		HONG Zifu JIA Fei YUAN Liang LI E HE Yinghua QU Mouwen FENG Lipeng
		Objective To investigate the clinical efficacy of Lianshao Enema Agent retention enema in the treatment of ulcerative colitis (UC). Methods A total of 40 cases of mild and moderate UC patients from January 2013 to December 2014 in the Department of Proctology, Guang′anmen Hospital were selected and divided into the treatment group and the control group according to the random number table method, with 20 cases in each group. However, one patient in the treatment group showed obvious rectal stimulation symptoms after enema and withdrew automatically, so 19 cases were included in the treatment group. Both groups took Mesalazine Enteric-coated Tablets orally for 1 g, 3 times/d. In the treatment group, the retention enema was added with the Lianshao Enema Agent, once a night, once a day. The treatment course was 3 weeks. Clinical efficacy, traditional Chinese medicine syndrome score and traditional Chinese medicine symptom score before and after treatment were observed. Results The effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment (P ＞ 0.05). After treatment, the traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment, and the treatment group was lower than the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in traditional Chinese medicine symptom score between the two groups before treatment (P ＞ 0.05). After treatment, the traditional Chinese medicine symptom scores in the two groups were lower than those before treatment, and the scores of mucus blood stools, abdominal pain, tenesmus and anal burning symptoms in the treatment group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in diarrhea symptom scores between the two groups after treatment (P ＞ 0.05). Conclusion Lianshao Enema Agent retention enema for the treatment of mild to moderate UC is effective, especially in the improvement of clinical symptoms, the efficacy is significant, and easy to use, it is worthy of promotion and application.
		2020 Vol. 17 (13): 160-163 [Abstract] ( 160 ) HTML (1 KB) PDF (382 KB) ( 43 )

	164	Meta-analysis of the value of ischemia-modified albumin for early diagnosis of myocardial ischemia in acute coronary syndrome
		HUANG Qianyi1 GUAN Zhongying2 HAN Huajing1 YANG Fangyu1 SHI Ting1 DIAO Qizhi1
		Objective To systematically review the diagnostic value of ischemic modified albumin (IMA) for early myocardial ischemia in acute coronary syndrome (ACS). Methods PubMed, Embase, Web of Science, CNKI, VIP and CBM Data databases for studies about IMA in the diagnosis of ACS were searched by computers from the establishment of the database to September 2019. Two researchers screened the literature according to the inclusion and exclusion criteria, extracted data and used the QUADAS-2 tool to evaluate the risk of bias in the included studies. Based on the bivariate mixed-effects model, meta-analysis was performed using Stata 12.0 software. Results A total of 12 articles, while a total of 14 studies were included, including 1247 patients with ACS and 1377 patients with non-ischemic chest pain. The summary sensitivity of IMA diagnosis ACS was 0.77 (0.68, 0.84), specificity was 0.68 (0.57, 0.77), positive likelihood ratio was 2.4 (1.7, 3.3), negative likelihood ratio was 0.34 (0.24, 0.49), diagnostic odds ratio was 7 (4, 13) and the area under the summary receiver operator characteristic curve was 0.79 (0.75, 0.82). Conclusion IMA has certain value in the early diagnosis of ACS myocardial ischemia, combined with clinical symptoms and other diagnostic indicators can further improve the accuracy of diagnosis.
		2020 Vol. 17 (13): 164-168,176 [Abstract] ( 133 ) HTML (1 KB) PDF (1276 KB) ( 67 )

	169	Study on antibacterial effect of 10 kinds of traditional Chinese medicine granules on carbapenem-resistant Enterobacteriaceae in vitro
		LAN Xiaoqin LIN Nan YANG Dachao SU Xiaoxiang YAN Xueping GUO Jianwei
		Objective To study the antibacterial effect of 10 kinds of traditional Chinese medicine granules such as Galla Chinensis on carbapenem-resistant Enterobacteriaceae (CRE) in vitro. Methods Twenty strains of CRE were collected from Department of Clinical Laboratory of Beijing First Hospital of Integrated Chinese and Western Medicine from May 2017 to July 2018. The broth dilution method was used to detect the minimum inhibitory concentration (MIC) of 10 traditional Chinese medicine granules against CRE. The antibacterial activity of 10 traditional Chinese medicine granules against CRE was analyzed and tested. Results Galla Chinensis and Coptis Chinensis have a certain bacteriostatic effect on CRE, with MIC values of 125 and 500 mg/mL, respectively. Rhubarb, Scutellaria baicalensis, Honeysuckle, Dandelion, Phellodendron, Atractylodes, Radix Isatidis and Houttuynia Cordata have not shown Antibacterial effect. There was no change in the MIC value of the commonly used antimicrobial drugs before and after the action of traditional Chinese medicine, and it did not show that the traditional Chinese medicine reversed drug resistance. Conclusion Galla Chinensis and Coptis Chinensis have antibacterial effect on CRE and have development prospects.
		2020 Vol. 17 (13): 169-172 [Abstract] ( 132 ) HTML (1 KB) PDF (511 KB) ( 213 )

	173	Performance evaluation of health-scientific research in public interest based on data envelopment analysis
		CUI Chunshun XU Chang LIU Yaru YU Hui GAO Dongping
		Objective To analyse the input and output general condition of the projects supported by the health-scientific research in public interest and analyse the performance of the projects supported by the health-scientific research in public interest by data envelopment analysis. Methods Performance evaluation was mainly performed on the data provided by the 145 projects in the evaluation task of the “health-scientific research in public interest” carried out by the Department of Science, Technology and Education of the National Health Commission. Data envelopment analysis was used to establish the efficient boundary of optimal decision-making units, namely the production frontier, and to assign an efficiency index according to the distance from each non-boundary unit to the efficient boundary. Results The data envelopment method was used to calculate the comprehensive technical efficiency, pure technical efficiency, and scale efficiency and the result showed that 131 projects worked well and achieved good results. Among them, 52 projects had a comprehensive technical efficiency value of 1 and 80 projects had a pure technical efficiency value of 1. Except for the mentioned 80 projects, another 24 projects were in a state of increasing returns to scale, and 3 projects were in a state of constant returns to scale and increasing input could output more output. Twenty-four projects of the remaining 38 projects had no need to increase the most of output, and the most of output of these projects had reached a good state. Conclusion In the nine years since its implementation, as the core research fund at the national level, the health-scientific research in public interest has supported a large number of scientific research needs of the health industry, produced a large number of excellent scientific research achievements, and promoted the vigorous development of China′s health science research.
		2020 Vol. 17 (13): 173-176 [Abstract] ( 143 ) HTML (1 KB) PDF (334 KB) ( 36 )

	177	Analysis on the strategy of constructing high quality scientific research team in public hospitals from the perspective of psychological contract
		ZHAO Huitong1 SHAN Zheng2▲
		Based on literature review and psychological contract theory, the framework is developed to analyze the supportive measures taken by a tertiary university-affiliated hospital in Beijing to build high-quality research teams. It is proved that some strategies are necessary for public hospital to fulfill the expectations of researchers so as to build high-performance research teams. Such strategies include simplifying process of management, selective management by objectives, supportive supervision, strengthening communication, tailored models of reward and training, and flexible performance-based evaluation. Psychological contract theory is used to guide the management practice, this paper provides strategies for public hospitals to build high-performance research teams, aiming to improve public hospitals′ research and development innovation ability and to generate original medical research breakthrough in China.
		2020 Vol. 17 (13): 177-180 [Abstract] ( 124 ) HTML (1 KB) PDF (481 KB) ( 93 )

	181	Establishment and application effect of clinical evaluation system of department nursing information management platform
		LIN Hua1 CHEN Xi2 FENG Yonghong3 WANG Xiaoxia2 LI Fuli2
		Objective To study the establishment and application effect of the information management platform evaluation system in clinical departments. Methods Based on the nursing information digital management system of Haikou People′s Hospital, the application of information construction in the clinical nursing field was studied. Building a clinical data repository (CDR) on the basis of comprehensive integration of clinical information of medical medicine, technology and finance. Combined with the clinical decision system constructed by CDR and the nine closed-loop management around clinical diagnosis and treatment, optimize nursing workflow, guarantee nursing quality and safety, develop and establish clinical nursing information system, including nursing electronic medical record management system, nurses workstation platform, intravenous drug configuration platform, nursing logistics support and other information systems, to understand the nursing management effect after the establishment of information. Results After implementation of information management, the average daily nursing service of all kinds of specimens and notification, the dispensary, collect all kinds of supplies, transper patient, check treatment, send patients out of the hospital or admitted to hospital, repaire all kinds of instruments and time were significantly shortened, while basic nursing, disease observation hours, health education hours were extended, the differences were statistically significant (P ＜ 0.05). Conclusion Application of information management model in the clinical nursing work has a good role in promoting. It can improve the quality of management, and optimize nursing quality and efficiency.
		2020 Vol. 17 (13): 181-184 [Abstract] ( 154 ) HTML (1 KB) PDF (549 KB) ( 146 )

	185	Study on the relationship between knowledge sharing ability and learning engagement of nursing students based on educational background differences
		DU Juan CAI Shaolian
		Objective To investigate the level of knowledge sharing and learning engagement among nursing students with different educational backgrounds, and to explore whether the difference of educational background has a moderating effect on students′ knowledge sharing ability and learning engagement. Methods From January 2017 to January 2018, a total of 338 full-time nursing students (“nursing student” for short) from a vocational medical college in Guangdong Province were selected, according to different educational background, they were divided into the junior college group (145 nursing student) and the technical secondary school group (193 nursing student), the knowledge sharing and learning engagement scale was used to investigate. Results The differences in knowledge sharing behavior and learning involvement between two groups were statistically significant (P ＜ 0.05); there is a significant positive correlation between knowledge sharing ability and learning engagement (r = 0.539, 0.570, 0.580, 0.600, P ＜ 0.001); the ability to extract knowledge had a significant positive predictive effect on learning engagement (P ＜ 0.05); education background played a moderating role between knowledge sharing and learning engagement of nursing students (P ＜ 0.001). Conclusion Knowledge sharing ability has an impact on learning engagement, and with the enhancement of knowledge extraction ability, the learning engagement of junior college nursing students increases more rapidly.
		2020 Vol. 17 (13): 185-188 [Abstract] ( 133 ) HTML (1 KB) PDF (585 KB) ( 238 )

	189	Effect of enteral nutrition support combined with personalized nursing mode in reducing the incidence of pressure sore in elderly bedridden patients
		WU Yongmei DENG Xia WU Peiyu
		Objective To study the effect of enteral nutrition support combined with personalized nursing mode on reducing the incidence of pressure sore in elderly bedridden patients. Methods From May 2018 to July 2019, a total of 160 elderly patients with pressure ulcer risk who were admitted to Chongqing People′s Hospital（“our hospital for short”) were selected as subjects. According to the order of treatment, patients were randomly divided into control group and experimental group, with 80 cases in each group. The control group received conventional pressure ulcer intervention mode. The experimental group received an enteral nutrition support combined with personalized nursing model based on the control group. The intervention time of both groups was 4 weeks. The indexes of serum albumin (ALB), total serum protein (TP) and serum pre-albumin (PA), mini-nutritional assessment (MNA) score, Barden score, gastrointestinal adverse reaction rate and hospitalization were observed and compared. Results There were no significant differences in serum related indicators ALB, TP, PA, MNA scores and Barden scores between the two groups before intervention (all P ＞ 0.05). After 4 weeks of intervention, the serum-related indicators ALB, TP, PA, MNA scores, and Barden scores of the two groups were all higher than those before the intervention, while ALB, TP, PA, MNA and Barden scores in the experimental group were all higher than those in the control group, with statistically significant differences (all P ＜ 0.05). The incidence of gastrointestinal adverse reactions in the experimental group was lower than that in the control group (P ＜ 0.05). The nutritional improvement rate and hospitalization satisfaction rate of the experimental group were higher than those of the control group, and the incidence of pressure ulcers and the rate of re-hospitalization within one month after discharge were lower than those of the control group, with statistically significant differences (all P ＜ 0.05). Conclusion The model of enteral nutrition support combined with personalized nursing has a positive effect on reducing the incidence of pressure ulcers and improving the quality of life in elderly bedridden patients. It is worth promoting and applying.
		2020 Vol. 17 (13): 189-192,196 [Abstract] ( 184 ) HTML (1 KB) PDF (545 KB) ( 134 )

	193	Effect analysis of emergency thrombolysis clinical intervention pathway based on time-effect analysis in emergency thrombolysis
		QIN Juanping MENG Yuzhi▲ ZHOU Junshan
		Objective To explore the effect of emergency thrombolysis clinical intervention pathway based on time-effect analysis on acute ischemic stroke patients. Methods From June 2017 to May 2018, a total of 58 patients with acute ischemic stroke admitted to Nanjing First Hospital. Nanjing Medical University (Nanjing First Hospital) (hereinafter referred to as “our hospital”) for thrombolysis in the ward were selected, as the control group. In addition, a total of 58 patients with acute ischemic stroke admitted to our hospital from June 2018 to May 2019 with emergency thrombolytic clinical intervention pathway based on aging analysis were selected, as an observation group. The aging index, nerve function and living ability of the two groups were compared. Results In terms of doctor′s advice issued-CT registration time, CT examination-thrombolytic treatment time, and door-to-needle time (DNT) time from admission to intravenous thrombolytic portal in the observation group were significantly shorter than those in the control group (P ＜ 0.05). The national institutes of health stroke scale score of the observation group was significantly lower than that of the control group 7 days after thrombolytic therapy (P ＜ 0.05). The rate of good living ability 3 months after the onset of the disease in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of the clinical intervention path of emergency thrombolysis based on the aging analysis in the emergency thrombolysis treatment can effectively shorten DNT time and improve the neurological function and living ability of patients, which is worth promoting.
		2020 Vol. 17 (13): 193-196 [Abstract] ( 100 ) HTML (1 KB) PDF (555 KB) ( 65 )

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