磁共振T2-mapping与DTI序列对膝关节软骨慢性损伤的应用研究

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Abstract To investigate the application value of different magnetic resonance sequences in the assessment of chronic injury severity of articular cartilage in knee osteoarthritis (KOA). Methods A total of 35 patients with osteoarthritis (OA) who underwent knee magnetic resonance imaging (MRI) in the Second Affiliated Hospital of Inner Mongolia Medical University from December 2017 to December 2018 were selected as the pathological group and another 35 healthy adult volunteers were selected as the normal group. The two groups were simultaneously scanned with the conventional and functional MRI sequences of the knee joint (T2 relaxation time diagram [T2-mapping], diffusion tensor imaging [DTI]). T2-mapping values, apparent diffusion coefficient (ADC) value and fractional anisotropic (FA) value of the five areas of interest of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, and patellar cartilage in the two groups were measured respectively. By two physicians (associate chief physician) according to the Recht MRI classification standard of the lesion group of knee joint cartilage in various areas of interest (divided intoⅠ, Ⅱ, Ⅲ and Ⅳ level). At the same time, the measured values were compared between the groups of the pathological group and were statistically analyzed between the pathological group and the normal group. Results The T2-mapping values of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage, the ADC values of the articular surface of the patella cartilage in the pathological group were all higher than those of the normal group, and the FA values of the articular surface of the patella cartilage were lower than those of the normal group, with highly statistically significant differences (all P ＜ 0.01). The T2-mapping values of knee joint of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage and the ADC values of of knee joint of the articular surface of the patella cartilage in theⅠ, Ⅱ, Ⅲ, Ⅳ level groups were significantly higher than those in the normal group, and Ⅳ level group was higher than Ⅲ, Ⅱ, Ⅰ level groups, Ⅲ level group was higher than Ⅱ, Ⅰ level group, Ⅱ level group was higher than Ⅰ level group, the differences were highly statistically significant (all P ＜ 0.01). There was no statistically significant difference between the FA value of articular surface of patellar cartilage of the knee in theⅠ level group and that in the normal group (P ＞ 0.05). The FA value of articular surface of patellar cartilage in the Ⅱ, Ⅲ, Ⅳ level groups was lower than that in the normal group, and Ⅳ level group was lower than Ⅲ, Ⅱ, Ⅰ level groups, Ⅲ level group was lower than Ⅱ, Ⅰlevel group, Ⅱ level group was lower than Ⅰ level group, the differences were highly statistically significant (all P ＜ 0.01). The T2-mapping values of the medial and lateral condylar cartilage of the femur, the medial and lateral tibial plateau cartilage, the articular surface of the patella cartilage, the ADC values of the articular surface of the patella cartilage were significantly positively correlated with the Recht classification (r ＞ 0, all P ＜ 0.01), and the FA values of the articular surface of the patella cartilage were negatively correlated with the Recht classification (r ＜ 0, P ＜ 0.01). The ADC value of the pathological group under the curve of the patellar cartilage area was larger than the T2-mapping value and the FA value of the same site. Conclusion T2-mapping and DTI imaging techniques can quantitatively assess the degree of articular cartilage injury in KOA patients.

Key words： Magnetic resonance imaging T2 relaxation time diagram Diffusion tensor imaging Knee cartilage

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	ZHANG Xinhui1 YU Jinghong2▲

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ZHANG Xinhui1 YU Jinghong2▲. Study on the application of magnetic resonance T2-mapping and DTI sequence in chronic injury of knee articularcartilage[J]. 中国医药导报, 2020, 17(13): 93-97.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I13/93

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