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| Research progress of Chinese medicine in the prevention and treatment of atherosclerotic vulnerable plaque by the regulation of macrophage polarization |
| LI Xiaocui1 MENG Zhonghua1 WANG He2 SHANG Shasha2 WANG Jianru2 GUAN Huaimin2 CHEN Yushan2 |
1.The First Clinical Medical College, He′nan University of Chinese Medicine, He′nan Province, Zhengzhou 450000, China;
2.Ward Three, Department of Cardiovascular Medicine, the First Affiliated Hospital of He′nan University of Chinese Medicine, He′nan Province, Zhengzhou 450000, China |
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Abstract Atherosclerosis is the basic pathological change of coronary heart disease. The formation of vulnerable plaque leads to decreased plaque stability and plaque rupture, which is an important etiology of acute cardiovascular events. Macrophages are important inflammatory cells during the initial and development of atherosclerosis. The stability of plaque is closely related to the polarization of macrophage subtypes. Chinese medicine have been revealed to improve the stability of atherosclerosis plaques by regulating the polarization of macrophages, and has a good application prospect in the prevention and treatment of atherosclerotic vulnerable plaques. This article takes macrophage polarization as the entry point, and discusses about Chinese medicine to affect atherosclerosis by regulating macrophage polarization.
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