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| Systematic evaluation and meta-analysis on the efficacy and safety of Biqi Capsules in the treatment of knee osteoarthritis |
| WANG Huanrui1 WU Jiaqi2 CAI Xiao2 HUANG Runyue2,3 CHEN Xiumin2,3 HUANG Qingchun2 |
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Rheumatology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Province, Guangzhou 510006, China;
3.Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Province, Guangzhou 510006, China |
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Abstract Objective To assess clinical effect and safety of Biqi Capsules combined with Western medicine in the treatment of knee osteoarthritis (KOA). Methods Cochrane Library, PubMed, Embase, CNKI, VIP and Wanfang databases were searched by computer, with the search time from the establishment to August 2019. Chinese key words include “Biqi Capsules, Biqi, knee osteoarthritis, knee arthritis”, etc. A randomized controlled trial on the treatment of KOA with Biqi Capsules combined with Western medicine compared with Western medicine was included. Cochrane Handbook 5.2.0 was used to analyze the quality of literature. Review Manager 5.3 was used to evaluate the overall efficiency, WOMAC score, VAS score, SF-36, adverse reactions and meta-analysis. Results Six RCTs that contained 841 patients were included. Meta analysis results: the overall effective rate of Biqi Capsules combined with Western medicine in the treatment of KOA was higher than that of Western medicine group (RR = 1.22, 95%CI [1.15, 1.29], P < 0.000 01). WOMAC score of Biqi Capsules combined with Western medicine in the treatment of KOA was lower than that of Western medicine group (MD = -10.57, 95%CI [-12.17, -8.97], P ＜ 0.000 01). Systematic evaluation results: Biqi Capsules combined with Western medicine was better than Western medicine group in reducing VAS score of KOA and improving SF-36, and there was no serious adverse event. Conclusion The result of this systematic review shows that Biqi Capsules combined with Western medicine has good clinical efficacy in KOA treatment with acceptable tolerability. However, due to the low quality and limitations of the included researches, more large-scale RCTs are needed to evaluate the long-term efficacy and safety of Biqi Capsules in the treatment of KOA.
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