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| Application of contrast enhanced transrectal ultrasound and its guided prostate biopsy in new Gleason grading groups of prostate cancer |
| HE Jieling1 CHEN Shaomin2 YU Qian3 LIU Dawei4 LI Wenhui3 HE Jinhua5 LIANG Zhanpeng1▲ YANG Ruilin6▲ |
1.Department of Ultrasound, Guangzhou Panyu Central Hospital, Guangdong Province, Guangzhou 511400, China;
2.Department of Finance, the Third People′s Hospital of Panyu District, Guangdong Province, Guangzhou 511403, China;
3.Department of Pathology, Guangdong Panyu Central Hospital, Guangdong Province, Guangzhou 511400, China;
4.Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong Province, Guangzhou 510150, China;
5.Department of Laboratory, Guangzhou Panyu Central Hospital, Guangdong Province, Guangzhou 511400, China;
6.Department of Urology, Guangzhou Panyu Central Hospital, Guangdong Province, Guangzhou 511400, China |
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Abstract Objective To investigate the application value of contrast enhanced transrectal ultrasound (CETRUS) and its guided prostate biopsy in the new Gleason grading groups of prostate cancer (PCa). Methods From January 2016 to January 2020, 118 cases with suspected PCa who underwent prostate biopsy in Guangzhou Panyu Central Hospital were selected. The patients were divided into the PCa group (46 cases) and the benign group (72 cases), according to the pathological result. According to Gleason Grading groups, PCa patients were divided into Gleason ≤ 3+4 group (13 cases) and Gleason ≥ 4+3 group (33 cases). The sensitivity, specificity and diagnosis rate of CETRUS in diagnosis of PCa were analyzed. The contrast parameters were obtained and compared by time-intensity curve, and the parameters of benign and malignant tissues and the gleason grading groups of PCa were analyzed according to the pathological results. Results Forty-six cases were diagnosed with PCa. The sensitivity, specificity and diagnostic rate of CETRUS in diagnosis of PCa were 74%, 83% and 80%, respectively. The PCa classification grouping result showed that 5 cases (11%) in Group 1, 8 cases (17%) in Group 2, 9 cases (20%) in Group 3, 12 cases (26%) in Group 4 and 12 cases (26%) in Group 5, respectively. There were no significant differences in base intensity (B) and area under curve (AUC) between the PCa group and the benign group (P > 0.05). Time to peak (TIP) and peak in half time (IHT) of the PCa Group were shorter than those of the benign group, peak intensity (PI) of the PCa Group was higher than that of the benign Group, and the differences were statistically significant (all P < 0.05). B, PI and AUC of cancer tissues in PCa patients were higher than those of surrounding tissues, TIP and IHT of cancer tissues were shorter than those of surrounding tissues, and the differences were statistically significant (all P < 0.05). B, PI and AUC in Gleason ≥ 4+3 group (Group 3-5) were higher than Gleason ≤ 3+4 group (Group 1-2), and the differences were statistically significant (all P < 0.05); there were no significant differences in TIP, IHT between two Groups (P > 0.05). Conclusion CETRUS with its guided prostate biopsy has a high diagnostic rate, and can reflect the difference of new Gleason grading groups of PCa. The combination of both can evaluate the prognosis of PCa and also help to targeted biopsy for PCa.
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