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| Research progress on basic and adjuvant therapy of diabetic foot ulcer |
| SONG Aibo1 SUN Jin2 |
1.Medical College, China Three Gorges University, Hubei Province, Yichang 443002, China;
2.Department of Orthopedics, the Third Clinical Medical College of China Three Gorges University Gezhouba Central Hospital of Sinopharm, Hubei Province, Yichang 443002， China |
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Abstract Diabetic foot ulcer (DFU) is one of the the most disabling late complications in diabetic patients, which has many problems during treatment such as time-consuming, slow effect, easy to relapse, etc. Currently, there are various treatment methods for DFU, which can be divided into basic treatment and adjuvant treatment except the treatment of primary disease. The basic treatment includes thorough debridement, unloading of wound pressure and infection control. The adjuvant therapy includes oxygen therapy, negative pressure therapy, recombinant human growth factor, energy therapy, etc. In recent years, there have been more and more clinical reports on the use of combination regimens for DFU treatment, which may provide a new direction for the development of DFU treatment. This paper briefly reviews the research progress of DFU in terms of its foundation and adjuvant therapy, so as to provide clinicians with ideas and help in choosing DFU combined therapy.
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[1] Leila Y，Hajieh S，Iraj N，et al. Incidence and Risk Factors of Diabetic Foot Ulcer：A Population-Based Diabetic Foot Cohort（ADFC Study）-Two-Year Follow-Up Study [J]. Int J Endocrinol，2018，2018：7631659.
[2] Hicks CW，Selvarajah S，Mathioudakis N，et al. Burden of Infected Diabetic Foot Ulcers on Hospital Admissions and Costs [J]. Ann Vasc Surg，2016，33：149-158.
[3] Xu Z，Ran X. Diabetic foot care in China：challenges and strategy [J]. Lancet Diabetes Endocrinol，2016，4（4）：297-298.
[4] Lavery LA，Davis KE，Berriman SJ，et al. WHS guidelines update：Diabetic foot ulcer treatment guidelines [J]. Wound Repair Regen，2016，24（1）：112-126.
[5] Everett E，Mathioudakis N. Update on management of diabetic foot ulcers [J]. Ann N Y Acad Sci，2018，1411（1）：153-165.
[6] Hingorani A，LaMuraglia GM，Henke P，et al. The management of diabetic foot：A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine [J]. J Vasc Surg，2016，63（2 Suppl）：3S-21S.
[7] Michailidis L，Bergin SM，Haines TP，et al. A Systematic Review to Compare the Effect of Low-frequency Ultrasonic Versus Nonsurgical Sharp Debridement on the Healing Rate of Chronic Diabetes-related Foot Ulcers [J]. Ostomy Wound Manage，2018，64（9）：39-46.
[8] Yavuz M，Ersen A，Hartos J，et al. Plantar shear stress in individuals with a history of diabetic foot ulcer：An emerging predictive marker for foot ulceration [J]. Diabetes Care，2017，40（2）：e14-e15.
[9] Bus SA，Armstrong DG，Van Deursen RW，et al. IWGDF guidance on footwear and offloading interventions to prevent and heal foot ulcers in patients with diabetes [J]. Diabetes Metab Res Rev，2016 Suppl 1，32：25-36.
[10] Bus SA. The Role of Pressure Offloading on Diabetic Foot Ulcer Healing and Prevention of Recurrence [J]. Plast Reconstr Surg，2016，138（3 Suppl）：179S-187S.
[11] Bus SA，Van Netten JJ，Lavery LA，et al. IWGDF guidance on the prevention of foot ulcers in at-risk patients with diabetes [J]. Diabetes Metab Res Rev，2016，32 Suppl 1：16-24.
[12] Acar E，Kacιra BK. Predictors of Lower Extremity Amputation and Reamputation in the Diabetic Foot [J]. J Foot Ankle Surg，2017，56（6）：1218-1222.
[13] Abbas M，Uckay I，Lipsky BA. In diabetic foot infections antibiotics are to treat infection，not to heal wounds [J]. Expert Opin Pharmacother，2015，16（6）：821-832.
[14] Tae KT，Armstrong DG. Microbiology and Antimicrobial Therapy for Diabetic Foot Infections [J]. Infect Chemother，2018，50（1）：11-20.
[15] Markakis K，Faris AR，Sharaf H，et al. Local Antibiotic Delivery Systems：Current and Future Applications for Diabetic Foot Infections [J]. Int J Low Extrem Wounds，2018，17（1）：14-21.
[16] De Smet GHJ，Kroese LF，Menon AG，et al. Oxygen therapies and their effects on wound healing [J]. Wound Repair Regen，2017，25（4）：591-608.
[17] Driver VR，Reyzelman A，Kawalec J，et al. A Prospective，Randomized，Blinded，Controlled Trial Comparing Transdermal Continuous Oxygen Delivery to Moist Wound Therapy for the Treatment of Diabetic Foot Ulcers [J]. Ostomy wound Manag，2017，63（4）：12-28.
[18] Perren S，Gatt A，Papanas N，et al. Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes：A Clinical Trial [J]. Open Cardiovasc Med J，2018，12：80-85.
[19] Chen W，Liang X，Nong Z，et al. The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy [J]. Med Chem，2019，15（5）：459-471.
[20] Jaffe L，Wu SC. Dressings，Topical Therapy，and Negative Pressure Wound Therapy [J]. Clin Podiatr Med Surg，2019，36（3）：397-411.
[21] 常宇，韩睿.负压封闭引流术治疗糖尿病足的研究进展[J].中国医药导报，2018，15（36）：32-35，43.
[22] 李军，张莉莉，张凤新，等.重组人酸性成纤维细胞生长因子促进慢性溃疡性创面愈合的临床研究[J].中国医药导报，2014，11（31）：49-51，60.
[23] Jhamb S，Vangaveti VN，Malabu UH. Genetic and molecular basis of diabetic foot ulcers：Clinical review [J]. J Tissue Viability，2016，25（4）：229-236.
[24] Ojalvo AG，Acosta JB，Marí YM，et al. Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction [J]. Int Wound J，2017，14（1）：214-225.
[25] Sridharan K，Sivaramakrishnan G. Growth factors for diabetic foot ulcers：Mixed treatment comparison analysis of randomized clinical trials：Growth factors for diabetic foot ulcers [J]. Br J Clin Pharmacol，2018，84（3）：434-444.
[26] Piaggesi A，Sambataro M，Nicoletti C，et al. Safety and effectiveness of therapeutic magnetic resonance in diabetic foot ulcers：a prospective randomised controlled trial [J]. J Wound Care，2016，25（12）：704-711.
[27] 王军辉，王利君，卞学平，等.不同物理因子治疗糖尿病足研究进展[J].中国医药导报，2010，7（2）：13-14.
[28] Brocco E，Ninkovic S，Marin M，et al. Diabetic foot management：multidisciplinary approach for advanced lesion rescue [J]. J Cardiovasc Surg（Torino），2018，59（5）：670-684.
[29] Kasiya MM，Mang′anda GD，Heyes S，et al. The challenge of diabetic foot care：Review of the literature and experience at Queen Elizabeth Central Hospital in Blantyre，Malawi [J]. Malawi Med J，2017，29（2）：218-223. |
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