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| Evaluation of the vascular endothelium flow-mediated dilation of cavernosal artery in T2DM patients by ultrasound |
| LI Jinbing1 LIU Qiang2 SHU Shengchun1 CHEN Sinan1 TANG Xianyu3 |
1.Department of Ultrasonography, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China; 2.Department of Imaging, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China;
3.Department of Endocrinology, the Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China |
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Abstract Objective To investigate the changes in vascular endothelium flow-mediated dilation (FMD) of cavernosal artery (CA) in patients with type 2 diabetes mellitus (T2DM). Methods From March to November 2019, 54 cases with T2DM who were outpatient or in-patient in the Guangdong Provincial Hospital of Traditional Chinese Medicine were selected. According to the questionnaire score of the intemational index of erectile function 5, they were divided into T2DM with erectile dysfunction（T2DMED）group (≤21 points) 29 cases and T2DM with normal erectile function（T2DMNEF）group (22-25 points) 25 cases. Meanwhile, 25 volunteers with normal penile erection function were selected as control group. The diameter (D), peak systolic velocity (PSV) and mean flow velocity (Vmean) of CA in three groups were measured by color doppler ultrasound before and after the reactive hyperemia, and FMD, the change rate of peak systolic velocity (CRPSV) and the change rate of blood flow volume (CRVol) were calculated after the reactive hyperemia. Results Endothelial FMD of CA in T2DMNEF group and T2DMED group were lower than those in control group, and FMD in T2DMED group was lower than that in T2DMNEF group, and the differences were highly statistically significant (all P < 0.01). There were no statistically significant differences in CRPSV and CRVol of CA between T2DMNEF group and control group (P > 0.05), while CRPSV and CRVol of CA in T2DMED group were lower than those in T2DMNEF group and control group, and the differences were highly statistically significant (all P < 0.01). Conclusion Endothelial FMD of CA is impaired in T2DM patients. With the occurrence of ED in patients with T2DM, the damage to CA vascular endothelial function is also aggravated.
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