缺血修饰白蛋白对急性冠脉综合征心肌缺血早期诊断价值的荟萃分析

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Abstract Objective To systematically review the diagnostic value of ischemic modified albumin (IMA) for early myocardial ischemia in acute coronary syndrome (ACS). Methods PubMed, Embase, Web of Science, CNKI, VIP and CBM Data databases for studies about IMA in the diagnosis of ACS were searched by computers from the establishment of the database to September 2019. Two researchers screened the literature according to the inclusion and exclusion criteria, extracted data and used the QUADAS-2 tool to evaluate the risk of bias in the included studies. Based on the bivariate mixed-effects model, meta-analysis was performed using Stata 12.0 software. Results A total of 12 articles, while a total of 14 studies were included, including 1247 patients with ACS and 1377 patients with non-ischemic chest pain. The summary sensitivity of IMA diagnosis ACS was 0.77 (0.68, 0.84), specificity was 0.68 (0.57, 0.77), positive likelihood ratio was 2.4 (1.7, 3.3), negative likelihood ratio was 0.34 (0.24, 0.49), diagnostic odds ratio was 7 (4, 13) and the area under the summary receiver operator characteristic curve was 0.79 (0.75, 0.82). Conclusion IMA has certain value in the early diagnosis of ACS myocardial ischemia, combined with clinical symptoms and other diagnostic indicators can further improve the accuracy of diagnosis.

Key words： Ischemic modified albumin Acute coronary syndrome Myocardial ischemia Diagnostic value Meta-analysis

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	HUANG Qianyi1 GUAN Zhongying2 HAN Huajing1 YANG Fangyu1 SHI Ting1 DIAO Qizhi1

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HUANG Qianyi1 GUAN Zhongying2 HAN Huajing1 YANG Fangyu1 SHI Ting1 DIAO Qizhi1. Meta-analysis of the value of ischemia-modified albumin for early diagnosis of myocardial ischemia in acute coronary syndrome[J]. 中国医药导报, 2020, 17(13): 164-168,176.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I13/164

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