碳量子点在肿瘤治疗中的应用

Abstract
Figure/Table
References (40)
Related Citation (15)

Download: PDF (610 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Carbon quantum dots is a kind of new fluorescent nano material, has excellent electrical conductivity, excellent biological compatibility, environment friendly and stable performance advantages, it has made tremendous progress in the fields of biology, medicine, optics, nanoelectronics, sensors, etc., tumor targeting imaging in the diagnosis and treatment of drug targeting. This paper mainly reviews the preparation, biological characteristics, biological applications of carbon quantum dots, in vivo and in vitro imaging, new fluorescence markers of organisms, drug delivery, targeted therapy, mitigation drugs, prolonging drug action time to improve the efficacy of treatment, and the future application prospect in the treatment of breast cancer.

Key words： Carbon quantum dots Fluorescent probe Biological imaging Breast cancer

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Ya′nan WEN Haixia▲

Cite this article:

ZHANG Ya′nan WEN Haixia▲. Application of carbon quantum dots in tumor therapy[J]. 中国医药导报, 2020, 17(13): 69-72.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I13/69

[1] 闫鹏，艾凡荣，严喜鸾，等.碳量子点的生物应用：成像、载药与毒性[J].材料导报，2017，31（19）：35-42.
[2] Baker S，Baker GA. Luminescent Carbon Nanodots：Emergent Nanolights [J]. Angew Chem Int Ed，2010，49（1）：6726-6744.
[3] Xu X，Ray R，Gu Y，et al. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments [J]. JASC，2015，126（40）：12736-12737.
[4] Sun YP，Zhou B，Lin Y，et al. Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence [J]. J Am Chem Soc，2006，128（24）：7756-7757.
[5] Shen J，Zhu Y，Yang X，et al. Graphene quantum dots：emergent nanolights for bioimaging，sensors，catalysis and photovoltaic devices [J]. Chem Commun，2012，43（1）：3686-3699.
[6] Fang Y，Guo S，Li D，et al. Easy synthesis and imaging applications of cross-linked green fluorescent hollow carbon nanoparticles [J]. Acs Nano ，2012，6（1）：400-409.
[7] Guo YG，Zhang LF，Zhang SS，et al. Fluorescent carbon nanoparticles for the fluorescent detection of metal ions [J]. Biosens Bioelectron，2015，63（3）：61-71.
[8] Li H，Zhang Y，Wang L，et al. Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform [J]. Chem Commun，2011，47（4）：961-963.
[9] Zhao HX，Liu LQ，Liu ZD，et al. Highly selective detection of phosphate in very complicated matrixes with an off-on fluorescent probe of europium-adjusted carbon dots [J]. Chem Commun，2011，47（5）：2604-2606.
[10] Yang ST，Cao L，Luo PG，et al. Carbon dots for optical imaging in vivo [J]. JASC，2009，131（6）：11308-11309.
[11] Kong B，Zhu A，Ding C，et al. Carbon dot-based inorganic-organic nanosystem for two-photon imaging and biosensing of pH variation in living cells and tissues [J]. Adv Mater，2012，24（7）：5844-5848.
[12] 董小绮，菅晓婷，柴双双，等.荧光碳量子点的特性及检测巯基化合物的研究进展[J].化学研究，2018，29（5）：529-534.
[13] Wang Y，Hu A. Carbon quantum dots：synthesis，properties and applications [J]. J Mater Chem，2015，2（34）：6921-6939.
[14] Lai CW，Hsiao YH，Peng YK，et al. Facile synthesis of highly emissive carbon dots from pyrolysis of glycerol; gram scale production of carbon dots/mSiO2 for cell imaging and drug release [J]. J Mater Chem，2012，22（29）：14403-14409.
[15] Anilkumar P，Wang X，Cao L，et al. Toward quantitatively fluorescent earbon-based “quantum” dots [J]. Nanoscale，2011，3（5）：2023-2027.
[16] Hsu PC，Chang HT. Synthesis of high-quality carbon nanodots from hydrophilie compounds：Role of funetional Rroups [J]. Chem Commun，2012，48（33）：3984-3986.
[17] Jaiswal A，Ghosh SS，Chattopadhyay A. One step synthesis of Cdots by microwave mediated caramelization of poly （ethylene glycol） [J]. Chem Commun，2012，48（3）：407-409.
[18] 王晓磊.基于水热合成和梯度分离法探究碳量子点的发光机理[D].北京：北京化工大学，2015.
[19] Zhu S，Song Y，Zhao X，et al. The photoluminescence mechanism in carbon dots（graphene quantum dots. carbon nanodots. and polymer dots）：Current state and future perspective [J]. Nano Res，2015，8（2）：355-381.
[20] Sun YP，Zhou B，Lin Y，et al. Quantunm-sized carbon dots for bright and colorful Photoluminescence [J]. J Am Chem Soc，2006，128（24）：7756-7757.
[21] Liu H，Ye T，Mao C. Fluorescent carbon nanoparticles derived from candle soot [J]. Angew Chem Int Ed，2007，46（34）：6473.
[22] Zhang YN，Zhang XW，Shi YP，et al. The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging [J]. Molecules，2020， 25（306）：2-11.
[23] Yang ST，Wang X，Wang H，et al. Carbon dots as nontoxic and high-performance fluorescence imaging agents [J]. J Phys Chem C Nanomater Interfaces，2009，113（42）：18110-18114.
[24] Zhang J，Yu SH. Carbon dots：large-scale synthesis，sensing and bioimaging [J]. Materials Today，2016，19（7）：382-393.
[25] 李黎波，李文敏，项蕾红，等.光动力疗法在中国的应用与临床研究[J].中国激光医学杂志，2012，21（5）：278-280.
[26] Wang QL，Huang XX，Long YJ，et al. Hollow luminescent carbondots for drug delivery [J]. Carbon，2013，59（4）：192-199.
[27] Liu C，Zhang P，Zhai X，et al. Nano-carrier for gene delievery and bioimaging based on carbon dots with PEI-passivation enchanced fluorescence [J]. Biomaterials，2012，33（13）：3604-3613.
[28] Song Y，Feng D，Shi W，et al. Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanopartides, and carbon nanodots on live cells as well as green gram sprouts [J]. Talanta，2013，116：237-244.
[29] Huang X，Zhang F，Zhu L，et al. Effect of injection routes on the biodistribution clearance，and tumor uptake of carbon dot [J]. ACS Nano，2013，7（7）：5684-5693.
[30] 盛英卓.水热法制备水溶性碳点及其荧光性能与应用研究[D].兰州：兰州大学，2015.
[31] 高娜.新型碳量子点—透明质酸/阿霉素复合体系在肿瘤细胞成像及药物传输中的应用[D].延安：延安大学，2017.
[32] Fang M，Peng CW，Pang DW，et al. Quantum Dots for Cancer Research：Current Status，Remaining Issues，and Future Perspectives [J]. Cancer Biol Med，2012，9（3）：151-163.
[33] Zeng Q，Shao D，He X，et al. Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo [J]. J Mater Chuem B，2016，4（30）：5119-5126.
[34] Tang J，Kong B，Wu H，et al. Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging [J]. Adv Mater，2013，25（45）：6569-6574.
[35] Li WQ，Wang Z，Hao S，et al. Mitochondria -based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug [J]. Nanoscale，2018， 10（8）：3744-3752.
[36] 梁君伟，方志华，李青山.二甲双胍联合紫杉醇对人乳腺癌细胞凋亡及AMPK信号通路的影响[J/OL].中国病理生理杂志，2018，34（12）：2186-2192.
[37] Chen W，Zheng R，Baade PD，et al. Cancer statistics in China，2015 [J]. CA Cancer J Clin，2016，66（2）：115-132.
[38] 张丽.新型钆掺杂碳量子点用于肿瘤靶向性成像及其放疗增敏研究[D].镇江：江苏大学，2016.
[39] Hardman R. A toxicologic review of quantum dots：toxicity depends on physicochemical and environmental factors [J]. Environ Health Perspect，2006，114（2）：165-172.
[40] Rzigalinski BA，Strobl JS. Cadmium-containing nanoparticles：perspectives on pharmacology and toxicology of quantum dots [J]. Toxicol Appl Pharmacol，2009，238（3）：280-288.