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2022 Vol. 19, No. 7 Published: 2022-03-05

	7	Analysis of research hotspots of clinical nursing post management#br#
		MAO Yazhan1 PI Hongying2▲ XU Yue3 SONG Mi1 SU Qingqing1 LI Zhuorong4
		Objective To understand the research status and existing problems of nursing post management in China in the past ten years, and provide reference for related research. Methods Literatures related to nursing position management in China published by data bases of CBM, CNKI, and Wanfang from January 2010 to August 2020 were searched, and descriptive statistical analysis and high-frequency keyword clustering analysis were performed by bibliometrics analysis. Results A total of 511 related articles were included, and the number of articles published was consistent with national policy advocacy. A total of 143 journals were published, involving 1274 authors, and the core author group was not yet established. The cities with a large number of publications were Beijing, Wuhan, Chongqing, Shanghai, Xi’an, and other places. The research hotspots have been formed but scattered, mainly focusing on the new post management model of laid-off competency, hierarchical training, quantitative assessment, post setting, and performance management in different departments, post hierarchical management, and post performance management. Conclusion Nursing post management is an inevitable trend of hospital management in China. The management methods are diverse but have not yet formed a standardized system. In the future, it is necessary to further standardize scientific research and design, and comprehensively implement nursing post management.
		2022 Vol. 19 (7): 7-10,59 [Abstract] ( 190 ) HTML (1 KB) PDF (1207 KB) ( 108 )

	11	Effects of dietary fiber on PTEN / PI3K / Akt / NF-κB signaling pathway after cerebral ischemia in rats#br#
		YANG Shida1 QU Huiling2
		Objective To investigate the effects of dietary fiber supplementation on PTEN / PI3K / AKT / NF-κB signaling pathway after cerebral ischemia in rats. Methods Twenty-four rats were randomly selected to make cerebral ischemia model by intracranial injection of endothelin. Four rats died after the model was made. The remaining 20 rats were divided into ischemia group and ischemia + dietary fiber group according to random number table method, with ten rats in each group. In addition, ten rats were randomly selected as sham operation group and intracranial injection of equal amount of normal saline was used as control. Ischemia group and sham operation group were given normal diet, ischemia + dietary fiber group was given dietary fiber. The volume of cerebral infarction in ischemic group and ischemic + dietary fiber group was detected, and the protein expression levels of p-PI3K, p-Akt, PTEN and NF-κB/P65 in the peripheral cortex of rats in each group were detected by Western blot. Results There was no significant difference in cerebral infarction volume between ischemic group and ischemic + dietary fiber group (P ＞ 0.05). The protein expression levels of p-PI3K and p-Akt in the ischemic group were lower than those in the sham group, and the differences were statistically significant (P ＜ 0.05); the protein expression levels of p-PI3K and p-Akt in the ischemic + dietary fiber group were higher than those in the ischemic group, and the differences were statistically significant (P ＜ 0.05). The protein expression levels of PTEN and NF-κB/ P65 in the ischemic group were higher than those in the sham group (P ＜ 0.05), and the protein expression levels of PTEN and NF-κB/P65 in the ischemic + dietary fiber group were lower than those in the ischemic group, the differences were statistically significant (P ＜ 0.05). Conclusion After cerebral infarction, dietary fiber can up-regulate PI3K / Akt signal and inhibit NF-κB pathway activation.
		2022 Vol. 19 (7): 11-14 [Abstract] ( 164 ) HTML (1 KB) PDF (734 KB) ( 61 )

	15	Study on cytotoxicity of Gemtuzumab Ozogamicin in acute myeloid leukemia and its relationship with expression level of CD33 #br#
		WANG Zhenzhen1 LI Weijing2
		Objective To explore the relationship between the cytotoxicity of Gemtuzumab Ozogamicin (GO) on acute myeloid leukemia (AML) cells and the expression level of CD33 and the mechanism of action. Methods Human myeloid OCI-AML3 and KG-1a cells were transfected with lentivirus containing CD33 plasmid, then the cells were divided into CD33 high expression group and CD33 low expression group according to CD33 expression level. Both groups were treated with 15 μg/L GO, and then the survival rate of cells in the two groups was determined by MTT assay. OCI-AML3 cells were treated with different concentrations of GO (0, 5, 10, 15 μg/L), and then the expression levels of apoptosis-related proteins Bcl-2, cleaved caspase 3, and caspase 3 were detected by Western blot. Results After transfection, the expression levels of CD33 on OCI-AML3 and KG-1a cells were higher than that before transfection, and the differences were statistically significant (P ＜ 0.05). After the same concentration of GO treatment, the survival rates of OCI-AML3 and KG-1a cells in CD33 high expression group were lower than those in CD33 low expression group, the differences were statistically significant (P ＜ 0.05). When GO concentration was 5, 10, 15 μg/L, the Bcl-2 level of OCI-AML3 cells was lower than those when GO concentration was 0, and cleaved-caspase 3 and caspase 3 levels were higher than those when GO concentration was 0. When GO concentration was 10, 15 μg/L, the Bcl-2 level of OCI-AML3 cells was lower than that when GO concentration was 5 μg/L, and cleaved-caspase 3 and caspase 3 levels were higher than those when GO concentration was 5 μg/L. When GO concentration was 15 μg/L, the Bcl-2 level of OCI-AML3 cells was lower than those when GO concentration was 10 μg/L, and cleaved-caspase 3 and caspase 3 levels were higher than those when GO concentration was 10 μg/L, the differences were statistically significant (P ＜ 0.05). Conclusion GO has enhanced inhibitory effect on proliferation of human myeloid cells with high CD33 expression, and can promote apoptosis of AML cells by regulating the expression of apoptotic proteins.
		2022 Vol. 19 (7): 15-18 [Abstract] ( 132 ) HTML (1 KB) PDF (549 KB) ( 66 )

	19	Diagnostic value of conventional ultrasound combined with elastography in idiopathic granulomatous mastitis and ductal carcinoma in situ#br#
		XING Boyuan1 ZHANG Bingyi1 LIU Jie1 YAN Ziwei1 DONG Meng1 LI Xingzi2
		Objective To investigate the conventional ultrasonographic features and elastic characteristics of idiopathic granulomatous mastitis (IGM) and ductal carcinoma in situ (DCIS), in order to improve the differential diagnosis level of IGM and DCIS by ultrasonography. Methods IGM patients who underwent conventional ultrasound and elastography examination and were confirmed by hollow needle biopsy or surgical pathology in the Department of Ultrasound, the First People’s Hospital of Yichang, Hubei Province from January 2018 to July 2021 were selected as IGM group (45 cases), and DCIS patients as DCIS group (56 cases). The clinical characteristics, ultrasonic imaging characteristics, and ultrasonic elastic parameters of two groups were compared; receiver operating characteristic curve was drawn to calculate the sensitivity, specificity and optimal cut-off value of elastic ratio in diagnosis of IGM. Results There were statistically significant differences in age and maximum diameter of lesions between two groups (P < 0.05). There were statistically significant differences in internal echo, posterior echo characteristics, microcalcification, surrounding tissue edema, ipsilateral axillary lymph node enlargement, and elastic score between two groups (P < 0.05). The elastic ratio in IGM group was lower than that in DCIS group, and the difference was statistically significant (P < 0.05). The optimal cut-off value of elastic ratio for IGM diagnosis was 2.27, the sensitivity and specificity were 86.70% and 94.60%, respectively, and the area under the curve was 0.818 (95%CI: 0.706-0.929, P < 0.05). Conclusion Conventional ultrasound combined with elastography is helpful for the differential diagnosis of IGM and DCIS.
		2022 Vol. 19 (7): 19-22 [Abstract] ( 71 ) HTML (1 KB) PDF (918 KB) ( 48 )

	23	Predictive value of red blood cell distribution width to albumin ratio in prognosis of acute respiratory distress syndrome#br#
		XU Luyang LI Jing ZHANG Guojun
		Objective To investigate the predictive value of red blood cell distribution width to albumin ratio (RAR) in the prognosis of acute respiratory distress syndrome (ARDS). Methods A retrospective study was performed on ARDS patients admitted to the ICU of the First Affiliated Hospital of Zhengzhou University from October 2019 to October 2020. The patients were divided into survival group and death group according to the 28-day outcome, general data, laboratory examinations, and other indicators were collected, the risk factors of 28-day death were analyzed by Cox regression, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value. Results A total of 105 ARDS patients were included, including 59 cases in the death group and 46 cases in the survival group, with a 28-day mortality rate of 56.19%. Age, acute physiology, and chronic health status scores, lactate, red blood cell distribution width, blood urea nitrogen, procalcitonin, neutrophil to lymphocyte count ratio, RAR, and procalcitonin to albumin ratio were higher in death group than survival group, while albumin was lower than that in the survival group, and the differences were statistically significant (P ＜ 0.05). Multivariate Cox regression analysis showed that RAR was an independent risk factor for 28-day death in ARDS patients (HR = 3.06, P ＜ 0.05). ROC analysis showed that the area under the curve of RAR was 0.829 (95%CI: 0.752-0.907, P ＜ 0.001), and the optimal cutoff value was 0.50. ARDS patients had higher mortality when RAR＞0.50. Conclusion RAR has a good predictive value for the 28-day prognosis of ARDS patients and is an independent risk factor for 28-day death.
		2022 Vol. 19 (7): 23-26 [Abstract] ( 119 ) HTML (1 KB) PDF (647 KB) ( 213 )

	27	Analysis of differential genes and functions of macrophages in ulcerative colitis #br#
		CHEN Mengxue WANG Honggang XIE Rui▲
		Objective To study the difference in gene expression and biological functions of intestinal macrophages in ulcerative colitis (UC). Methods Seven UC patients and seven healthy controls who visited the VA San Diego Healthcare facility from January to December 2019 were selected as the study subjects. The colonic mucosal single cell sequencing data were analyzed, and the differentially expressed genes in macrophages were compared, then gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were performed. Results The cells were filtered and the cluster of macrophage was determined. A total of 31 differentially expressed genes were selected in intestinal mucosa of UC group and control group, including TIMP1, IFITM3, IGHG1, etc. GO and KEGG enrichment analysis of differentially expressed genes showed mainly enriched in the biological process of oxidative stress and IL-17 signaling pathway. Conclusion The oxidative stress and IL-17 signaling pathway of intestinal macrophages may be involved in the process of UC disease.
		2022 Vol. 19 (7): 27-30 [Abstract] ( 60 ) HTML (1 KB) PDF (1077 KB) ( 60 )

	31	Effect of different de-enzyme techniques on main functional components of Callicarpa nudiflora Hook.et Arn. #br#
		SONG Xiao ZUO Meiling YANG Zhongbao
		Objective To analyze the effects of different pre-treatment techniques on quality of Callicarpa nudiflora Hook.et Arn.. Methods A high performance liquid chromatography method simultaneous determination of one flavonoid and one phenylethanol glycoside in the leaves of Callicarpa nudiflora Hook.et Arn. was established, and the content of the sample was determined by this method. The leaves of Callicarpa nudiflora Hook.et Arn. were dried at different temperatures after different steam cleaning time, and the leaves of Callicarpa nudiflora Hook.et Arn. were directly dried without cleaning, and the optimum steam degreening conditions were optimized. Results The contents of luteolin and calycoside were the highest in the leaves of Callicarpa nudiflora Hook.et Arn. which were dried at 60℃ after one min of steam treatment. The content of luteolin was 2.36 mg/g, and that of mulin was 50.94 mg/g. Conclusion The processing technology of steam dewatering and then drying can reduce the loss of active component content of Callicarpa nudiflora Hook.et Arn., which provides experimental basis for the processing and production of Callicarpa nudiflora Hook.et Arn.
		2022 Vol. 19 (7): 31-34 [Abstract] ( 63 ) HTML (1 KB) PDF (699 KB) ( 38 )

	35	Application status of digital information technology in traditional Chinese medicine clinical diagnosis of coronary heart disease#br#
		OU Ying XIA Shuaishuai LI Jing CHEN Shanda WANG Shunwei JING Xiaoshuo XIE Mengzhou LI Liang
		With the continuous development of digital information technology, its clinical efficacy and scope are also expanding. Coronary heart disease is a serious threat to human health, and the use of digital information technology plays a good auxiliary role in traditional Chinese medicine diagnosis and treatment of coronary heart disease. This paper collects digital information technology application in the clinical diagnosis of coronary heart disease of traditional Chinese medicine in recent years, which mainly includes the technology of digital image processing and data mining technology two categories, the above techniques for traditional Chinese medicine of coronary heart disease diagnosis and treatment process, mainly on the inspection, and palpation and pulse feeling, provides the important reference data, and can make effective judgment on its traditional Chinese medicine syndrome differentiation. The application of digital information technology in clinical practice is beneficial to accelerate the digitalization process of traditional Chinese medicine diagnosis.
		2022 Vol. 19 (7): 35-38，64 [Abstract] ( 119 ) HTML (1 KB) PDF (721 KB) ( 183 )

	39	Research progress on factors related to pregnancy outcome after fertility preservation therapy for endometrial atypical hyperplasia and early endometrial cancer#br#
		XING Yan HE Yue WU Yumei
		With the change of life style and the delay of average childbearing age, many women were diagnosed with endometrial atypical hyperplasia and early endometrial cancer during their childbearing years. At present, the clinical effect of fertility preservation therapy is confirmed, but only about 50% of patients successfully get pregnant and deliver after complete remission of the disease. Clinical studies have found that age, obesity and overweight, insulin resistance, and diabetes mellitus, endometrial damage and conception mode are important factors affecting pregnancy outcome. This article summarizes the latest research results at home and abroad, discuss, and review the above factors, and provides evidence for patients with endometrial atypical hyperplasia and early endometrial cancer to obtain better pregnancy outcome after fertility preservation therapy.
		2022 Vol. 19 (7): 39-42 [Abstract] ( 82 ) HTML (1 KB) PDF (447 KB) ( 183 )

	43	Research progress in diagnosis of molecular components of airborne pollen allergens in children
		SONG Huifang1 WANG Yumin2
		Allergen molecular component diagnosis plays an important role in the diagnosis of allergic diseases. Airborne plant pollen is one of the main causes of seasonal allergic diseases, and the seasonal distribution characteristics vary in different regions, resulting in the regional specificity of different pollen sensitization to humans. This paper reviews the research status of component diagnosis of airborne pollen allergens in children at home and abroad, regional differences in sensitization, component detection technology differences, component cross reaction, and other aspects. It provides a reference for the diagnosis, immunotherapy, and further prevention of allergic diseases in children’s respiratory tract, and provides a new idea for the study of component diagnosis in airborne pollen sensitization.
		2022 Vol. 19 (7): 43-46 [Abstract] ( 92 ) HTML (1 KB) PDF (523 KB) ( 201 )

	47	Research progress of Chinese and Western medicine treatment for promoting recovery of perianal necrotizing fasciitis after operation#br#
		SHEN Ruihong1 WANG Jiaxin1 GE Dongxu2 XING Wenyu1 SUN Lida1 CHEN Xueqing1
		Perianal necrotizing fasciitis has the characteristics of dangerous progression and high mortality, there are many problems such as wound infection and long-term non healing after surgical treatment, so it is of great significance to promote wound healing. At present, in terms of controlling infection and promoting wound healing, Western medicine mostly focuses on cleaning and protecting wounds, such as local wound dressing, negative pressure wound therapy, hyperbaric oxygen therapy and honey therapy, but there are certain limitations in clinical application. Traditional Chinese medicine has unique advantages in promoting healing. Traditional Chinese medicine has a unique advantage in the treatment of wound healing. Traditional Chinese medicine believes that wound infection is more difficult to be associated with heat, dampness, deficiency and other factors, and the treatment is mostly based on heat toxicity, damp-heat and Yin deficiency. Traditional Chinese and Western medicine have their own merits in promoting postoperative wound healing. Integrated Chinese and Western medicine can complement each other. Now mainly from the aspects of Western medicine, Chinese medicine and integrated Chinese and Western medicine treatment, the treatment of postoperative healing of perianal necrotizing fasciitis is discussed, in order to provide reference for future research.
		2022 Vol. 19 (7): 47-50 [Abstract] ( 106 ) HTML (1 KB) PDF (617 KB) ( 104 )

	51	Research progress of LncRNA in esophageal cancer#br#
		WANG Ping1 HU Xin1 LIU Kang2 BIE Jun1
		Esophageal cancer is a common malignant tumor all over the world. Due to the lack of specific tumor markers for esophageal cancer, it is difficult to timely and effectively monitor the occurrence and development of tumor, the occurrence of drug resistance and the effective evaluation of prognosis, resulting in poor clinical treatment effect. Many studies have shown that long non-coding RNA (lncRNA) is a functional genomic element, which can play roles at multiple levels. In recent years, a variety of lncRNA have been found to be abnormally expressed in esophageal cancer. These abnormally expressed lncRNA can promote or inhibit cancer in the occurrence and development of esophageal cancer, and are closely related to drug resistance and prognosis of esophageal cancer. lncRNA is expected to become new biological targets for diagnosis or treatment.
		2022 Vol. 19 (7): 51-54 [Abstract] ( 168 ) HTML (1 KB) PDF (850 KB) ( 51 )

	55	Research progress in opioid addiction related conditions#br#
		LIU Peng LI Ping DU Hongxia WEI Ming
		Drug addiction is a kind of recurrent and chronic brain disease, and the recognition of the biological mechanism of drug addiction has become an urgent requirement to develop targeted and effective treatment methods. One of the major limitations of opioids is that opioids are inevitably addictive in their application. This article provides an overview of opioid addiction and summarizes the new findings of existing researches from five aspects: opioid classification, opioid receptors，current status and treatment of drug abuse, genetic susceptibility to addiction, important brain regions and neural circuits related to Morphine addiction, in order to help researchers to form a preliminary, overall understanding of opioid addiction.
		2022 Vol. 19 (7): 55-59 [Abstract] ( 35 ) HTML (1 KB) PDF (664 KB) ( 54 )

	60	Application of game-education interactive mode to traditional Chinese medicine teaching#br#
		WEN Qiao1 ZHANG Yanze2 XIAO Yi3 ZHAO Fanying4 YAN Yongyi5 CHEN Qiutong6 LI Feng7
		On the basis of discussing the research background on combination of games and education, this paper discusses the connotation of the interactive model of games-education. It also, based on the social role theory, flow theory, and narrative medical education, analyzes the interaction and theoretical basis between Chinese medicine subject learners, subject knowledge, medical cases and game characters, levels and stories. That demonstrates the adaptability of the game-education interaction model applied to traditional Chinese medicine education. Meanwhile, an role-playing game (RPG) “The Road to Famous traditional Chinese medicine” is taken as an example to show the construction path of the game-education interactive mode. The mode includes selecting the game form with RPG as the framework, identifying the positioning of the game with traditional Chinese medicine education as the core, and clarifying the design principles based on game-education-participant with the three-way interaction between game. With the further development and application of information technology, game-education interactive mode may become more operable and extensible, and become a new mode of traditional Chinese medicine teaching, which can effectively supplement the traditional Chinese teaching mode.
		2022 Vol. 19 (7): 60-64 [Abstract] ( 187 ) HTML (1 KB) PDF (1314 KB) ( 251 )

	65	Exploration and practice of teaching mode of modern Lingnan dermatology school #br#
		YANG Xianping ZHEN Qingyu HAN Shanshan LIN Ying LIANG Jiafen LI Hongyi
		Lingnan dermatology school adheres to integrity and innovation in inheritance, development and talent training, and advocates the academic concept of “learning from the ancient rather than the ancient”. This has formed a new diversified teaching model for undergraduates, postgraduates of dermatology specialty, and different groups of advanced studies and apprentices. For undergraduates, online and offline teaching will be combined, mainly to cultivate students’ interest and deepen clinical understanding; for postgraduates of dermatology specialty, the team focuses on the cultivation of their specialized knowledge and skills, outside the classroom, postgraduates are required to follow famous teachers, and integrate modern science and technology into teaching; for advanced studies and apprentices, they mainly follow up with teachers, learn laser and surgical operation, and improve their clinical ability.
		2022 Vol. 19 (7): 65-67,80 [Abstract] ( 66 ) HTML (1 KB) PDF (607 KB) ( 39 )

	68	The exploration of interdisciplinary postgraduate training model of traditional Chinese and Western medicine under the background of first-class discipline#br#
		XU Zihan1 XIE Mingzheng2 XIA Shilin2 LI Jia2 ZHOU Bo1 Yi Yujuan1 SUN Zheng1
		Interdisciplinary postgraduate training model of traditional Chinese and Western medicine education is an important part of training high-level medical talents. Because of the students diversity, single training mode, and lack of training experience, traditional Chinese and Western medicine postgraduate training mode has been unable to meet the current needs. This paper discusses from three aspects of student training, tutor system and school interdisciplinary mode, aiming at exploring diversified, personalized, and internationalized training model for interdisciplinary postgraduate students of traditional Chinese and Western medicine.
		2022 Vol. 19 (7): 68-71,84 [Abstract] ( 112 ) HTML (1 KB) PDF (771 KB) ( 79 )

	72	Discussion on the integration design of ideological and political teaching idears in drug analysis experiment course#br#
		WANG Lei LI Xinxia
		In view of the problems existing in pharmaceutical analysis experiment teaching, such as students’ fuzzy learning objectives, teachers’ neglect of education, and the incomplete integration of ideological and politics courses with professional courses, it is necessary to pay attention to the organic combination of professional education and curriculum ideological and political education. In the pharmaceutical analysis experiment teaching, combing and mining the ideological and political elements, “moistening things silently”, the ideological and political education such as legal awareness, development concept, overall concept, environmental protection awareness, and safety is reasonably integrated into the pharmaceutical analysis experiment teaching process, and the curriculum ideological and politics is reflected in the experimental curriculum evaluation system, so as to realize the same direction of professional course education and curriculum ideological and political education. In order to achieve the goal of moral education in an all-round way, we should improve the quality of professional teachers, cultivate the teaching concept of ideological and political education, strengthen the cooperation between professional teachers and ideological and political teachers, develop online teaching resources, realize the interaction between teachers and students, and constantly explore, practice and innovate in all aspects.
		2022 Vol. 19 (7): 72-75 [Abstract] ( 38 ) HTML (1 KB) PDF (636 KB) ( 220 )

	76	Application of “seven-step learning method” in the ultrasonic medicine practice teaching for foreign students
		KONG Yanpeng CHEN Kun
		Objective To explore the application and effect of “seven-step learning method” in the practice teaching of ultrasound medicine for foreign students. Methods A total of 62 foreign students who entered the ultrasonic internship from September 2016 to June 2019 in the Second Affiliated Hospital of Kunming Medical University were divided into two groups according to the random number table method. The 31 students in the experimental group adopted the “seven-step learning method” through case-based learning, problem-based learning, flipped classrooms, block-based step-by-step learning, combined with WeChat, and limited internships time to teach ultrasound and operate on the machine. The 31 students in the control group adopted traditional teaching methods. The two groups were compared for performance and teaching feedback. Results The operational skills, theoretical examinations and total scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the evaluation of teacher’s communication ability, satisfaction with teaching methods, interest in learning, promotion of autonomous learning and understanding of ultrasonic image and knowledge of the experimenta group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); there was no statistical difference in homework scores between the two groups (P ＞ 0.05). Conclusion The “seven-step learning method” can teach students in accordance with their aptitude, stimulate interest in learning, and improve teaching quality. It is worthy of widespread promotion.
		2022 Vol. 19 (7): 76-80 [Abstract] ( 95 ) HTML (1 KB) PDF (739 KB) ( 65 )

	81	Value and realization path of humanistic literacy in talents training of traditional Chinese medicine colleges#br#
		ZOU Xiangni1 WANG Shurong2 ZHANG Min3 CHI Wencheng1
		At present, the form of national doctor-patient ethics has changed from the traditional mode of biological Chinese medicine to the current mode of “biology-psychology-society” Chinese medicine, so the humanistic ethics requirements for doctors are also gradually improved. As a traditional medical mode in China, traditional Chinese medicine has its unique humanistic quality for thousands of years. Therefore, traditional Chinese medicine teaching should not be stripped of the humanistic quality education of tradition Chinese medicine students. Strengthening the cultivation of humanistic quality of medical college students can help students adapt to the future working environment, improve their professional quality, and play an important role in the transportation of high-level inter-disciplinary talents for the country. So, this article focus on the value of the humanities in Chinese medicine colleges and universities personnel training and implementation path, expounds the connotation of the humanities, briefly describes the value of the humanities in Chinese medicine colleges and universities personnel training, and discusses the realization of humanistic quality in colleges and universities of traditional Chinese medicine personnel training path, and the corresponding discussion, humanistic quality in colleges and universities of traditional Chinese medicine personnel training will provide theoretical basis and reference significance.
		2022 Vol. 19 (7): 81-84 [Abstract] ( 93 ) HTML (1 KB) PDF (605 KB) ( 51 )

	85	On the teaching reform of Chinese traditional rehabilitation skills from the perspective of “cultural education”#br#
		LIN Guoqing1 CHEN Longfang1 ZHANG Huizhen1 ZHANG Li1 LIN Tao2 WANG Mingjun3
		It is one of the important directions of the teaching reform of colleges and universities in China to infiltrate the idea of “cultural education” into the teaching of specialized courses and strengthen the teaching effect of specialized courses. Aimed at the present situation of Chinese traditional rehabilitation skill course focus on skill development, ignoring the present situation of the students’ cultural quality education, this paper expounds the teaching reform measures such as optimizing teaching content, reforming teaching evaluation system, innovating teaching mode and turning teaching difficulties into highlights in order to enhance ideological and political education’s explanatory power and action of Chinese traditional culture in Chinese traditional rehabilitation skill course, it will play a useful guiding role in strengthening students’ confidence in traditional culture and consciously integrating the spirit of “benevolence and sincerity” into their future rehabilitation treatment career.
		2022 Vol. 19 (7): 85-87,99 [Abstract] ( 44 ) HTML (1 KB) PDF (659 KB) ( 169 )

	88	Application effect of target learning method combined with case-based learning teaching in the teaching of nurse interns in respiratory intensive care unit#br#
		MA Baojing ZHANG Yinping ZHOU Lijie LI Yu ZHANG Yuping▲
		Objective To explore the effect of target learning method combined with case-based learning (CBL) in the teaching of nurse interns in respiratory intensive care unit (RICU). Methods A total of 100 nurse interns in RICU of Jiangsu Provincial People’s Hospital from March 2018 to March 2021 were selected, according to the random number table method, they were divided into two groups, with 50 cases in each group. The control group was given CBL teaching, and the observation group was given target learning method combined with CBL teaching, and both were practiced for four weeks. The graduation scores, recognition of teaching methods, and teaching satisfaction of the two groups were compared. Results The scores of case-based learning, operation performance, subjective question, and objective question of the observation group were higher than those of the control group, with a statistical significant differences (P ＜ 0.05); the scores of improving critical thinking ability, broadening knowledge, improving self-study ability, clarifying learning objectives, and comprehensively mastering knowledge in the observation group were higher than those in the control group, with statistical significant differences (P ＜ 0.05); the satisfaction degree of teaching of the observation group was higher than that of the control group, with a statistical significant difference (P ＜ 0.05). Conclusion Target learning method combined with CBL teaching can improve the graduation performance and recognition of teaching methods of nurse interns in RICU, and improve teaching satisfaction.
		2022 Vol. 19 (7): 88-91 [Abstract] ( 37 ) HTML (1 KB) PDF (541 KB) ( 43 )

	92	Effect of Alanyl Glutamine-assisted Ulinastatin in the treatment of severe acute pancreatitis lung injury and the influence on lung function, inflammation, and immune function#br#
		LI Xia1 ZHUANG Wei1 MA Chong1 CHEN Xianhai2 ZHANG Zheng1 WANG Jian1▲
		Objective To explore and analyze the effect of Alanyl Glutamine-assisted Ulinastatin in the treatment of severe acute pancreatitis lung injury and the influence on lung function, inflammation, and immune function. Methods A total of 96 patients with severe acute pancreatitis lung injury treated in the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected from August 2017 to August 2020, they were divided into control group and observation group by random number table method, 48 cases in each group. Ulinastatin was given to the control group, and Alanyl Glutamine was added to the observation group on the basis of the control group. After one week of continuous treatment, lung CT morphological grade, disease severity, blood gas indexes, and serum levels of interferon -γ (IFN-γ), interleukin-4 (IL-4), IFN-γ/IL-4, IL-6, and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment. Results After treatment, lung CT morphological grades of two groups were better than those before treatment, acute physiology and chronic health evaluationⅡ (APACHEⅡ) score, Balthazar CT score, Murray lung injury score, serum IFN-γ, IL-6, IFN-γ/IL-4, and TNF-α of two groups were all lower than those before treatment, arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), oxygenation index, and IL-4 of two groups were all higher than those before treatment, while the lung CT morphological grades of observation group were better than those of control group, APACHEⅡ score, Balthazar CT score, Murray lung injury score, serum IFN-γ, IL-6, IFN-γ/IL-4, and TNF-α of observation group were all lower than those of the control group, PaO2, SaO2, oxygenation index, and IL-4 in observation group were all higher than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion Alanyl Glutamine-assisted Ulinastatin treatment of severe acute pancreatitis lung injury can promote the improvement of blood gas analysis indicators, reduce lung injury, improve the body’s inflammatory response and immune function, reduce the severity of the disease, promote the improvement of prognosis.
		2022 Vol. 19 (7): 92-95 [Abstract] ( 155 ) HTML (1 KB) PDF (584 KB) ( 48 )

	96	Effect of extracorporeal shock wave combined with draft training on plantar fasciitis#br#
		ZHANG Tingting REN Yingmei▲ YANG Xiaolin
		Objective To observe the effects of extracorporeal shock wave combined with draft training on plantar fasciitis. Methods Ninety patients with plantar fasciitis admitted to Rugao People’s Hospital of Jiangsu Province from March 2019 to December 2020 were randomly divided into control group (drafting training) and experimental group (drafting training + extracorporeal shock wave therapy) according to the random number table method, with 45 patients in each group. The patients were treated for 12 weeks continuously. After treatment, the two groups were evaluated for clinical efficacy. Visual analog scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) ankle function scoring system, and Berg balance scale were used to score the two groups before treatment (T0), 4 weeks after treatment (T4), 8 weeks after treatment (T8), and 12 weeks after treatment (T12). The levels of serum nerve growth factor (NGF) and prostaglandin E2 (PGE2) were compared between the two groups at each time point, and the incidence of adverse reactions between the two groups was recorded. Results The clinical efficacy of experimental group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). The AOFAS and Breg scores in both groups at T4, T8, and T12 in both groups were higher than those at T0, and VAS score and NGF and PGE2 levels were lower than those at T0. The AOFAS and Breg scores in experimental groups at T4, T8, and T12 were higher than those in control group at the same time points, and VAS score, NGF, and PGE2 levels were lower than those in control group at the same time points, the differences were statistically significant (P ＜ 0.05). There were no adverse reactions in two groups during treatment. Conclusion Extracorporeal shock wave combined with draft training can improve the effect of plantar fasciitis, and it is safe and reliable.
		2022 Vol. 19 (7): 96-99 [Abstract] ( 89 ) HTML (1 KB) PDF (609 KB) ( 57 )

	100	Clinical observation of implanting catgut in acupoint combined with continuous positive airway pressure in the treatment of patients with obstructive sleep apnea hypopnea syndrome and obesity#br#
		PENG Licheng YANG Xiaoming
		Objective To observe the clinical effect of implanting catgut in acupoint combined with continuous positive airway pressure in the treatment of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and obesity. Methods A total of 60 patients with OSAHS and obesity admitted to Department of Pulmonary Diseases, Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Chinese Medicine from April 2019 to September 2020 were selected and divided into control group and treatment group according to random number table method, with 30 patients in each group. Both groups were treated with diet control and moderate aerobic exercise, while the control group was treated with continuous positive airway pressure ventilation at night. The treatment group was treated with implanting catgut in acupoint on the basis of the control group. The treatment course of both groups was 60 d. The clinical efficacy of the two groups and the changes of sleep apnea hypopnea index (AHI), lowest arterial oxygen saturation (LSaO2), Epworth sleepiness scale score (ESS), body weight, and body mass index (BMI) were compared between the two groups before and after treatment. Results The therapeutic effect of the treatment group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, AHI, ESS score, body weight, and BMI of two groups were lower than those before the treatment, LSaO2 was higher than that before the treatment, while AHI, ESS score, body weight, and BMI in the treatment group were lower than those in the control group, LSaO2 was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Implanting catgut in acupoint combined with continuous positive airway pressure in the treatment of patients with OSAHS with obesity has significant effect, which is worthy of clinical recommendation.
		2022 Vol. 19 (7): 100-103 [Abstract] ( 64 ) HTML (1 KB) PDF (596 KB) ( 39 )

	104	Diagnostic value of 2D-B/W, CDFI combined with plasma Fib and D-D detection for DVT#br#
		HAO Junxia HU Jinhua XIA Qun YU Yi
		Objective To explore the diagnostic value of two dimensional black-and-white ultrasound (2D-B/W), color doppler flow imaging (CDFI) combined with plasma fibrinogen (Fib) and D-Dimer (D-D) detection in deep venous thrombosis (DVT) of lower limbs. Methods A total of 90 patients with lower limb swelling and pain admitted to Anqing First People’s Hospital of Anhui Medical University from July 2019 to March 2021 were selected as the research subjects, among them, 41 patients with DVT. All patients underwent 2D-B/W and CDFI examinations, and plasma D-D and fibrinogen (Fib) levels were determined. The receiver operator characteristic curves for DVT were drawn and the area under the curve (AUC) was calculated. The diagnostic efficacy of 2D-B/W, CDFI, plasma Fib, and plasma D-D for DVT alone and in combination was compared. Results The levels of Fib and D-D in DVT patients were significantly higher than those in non-DVT patients (P ＜ 0.05). The AUC of the combination of four tests for DVT was 0.938 (95%CI: 0.888-0.989), which was significantly higher than that of 2D-B/W (0.739 [95%CI: 0.631-0.847]), CDFI (0.891 [95%CI: 0.823-0.959]), plasma Fib (0.758 [95%CI: 0.653-0.864]), and plasma D-D (0.826 [95%CI: 0.742-0.909]) were diagnosed separately (P ＜ 0.05). The sensitivity, specificity and accuracy of the four tests were 97.56%, 93.88% and 95.56%, respectively. Conclusion 2D-B/W, CDFI combined with plasma Fib and D-D detection can significantly improve the diagnostic accuracy of early diagnosis of DVT, and reduce the risk of missed diagnosis and misdiagnosis.
		2022 Vol. 19 (7): 104-107 [Abstract] ( 86 ) HTML (1 KB) PDF (609 KB) ( 54 )

	108	Efficacy of Treitz muscle preservation with small V-incision combined with PPH in the treatment of mixed hemorrhoids #br# #br#
		ZHAO Shiming CHEN Yin HE Jianlin
		Objective To study the effect of Treitz muscle preservation with small V-incision combined with procedure for prolapse and hemorrhoids (PPH) in the treatment of mixed hemorrhoids. Methods A total of 80 patients with mixed hemorrhoids admitted to the People’s Hospital of Xuancheng City of Anhui Province from June 2017 to January 2021 were selected as the research subjects, and they were divided into study group and control group according to random number table method, with 40 patients in each group. The control group was treated with PPH, and the research group was treated with Treitz muscle preservation with small V-incision on the basis of PPH. The clinical effective rate, anal distention, anal pain, urination status, incidence of complications and safety were analyzed and compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Twenty-four h after surgery, the degree of anal distension, pain, and urination status score of both groups were significantly lower than those of 6 h after surgery, the differences were statistically significant (P ＜ 0.05). At 6 and 24 h after surgery, the degree of anal distension, pain and urination status score in the study group were significantly lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of complications in the study group was significantly lower than that in the control group, the differences were statistically significant (P ＜ 0.05). There were no adverse reactions such as nausea and vomiting, dizziness and obstructive breathing, abnormal liver and kidney function, and the safety was good in the two groups. Conclusion Treitz muscle preservation with small V-incision combined with PPH has good clinical efficacy in the treatment of mixed hemorrhoids and can effectively reduce postoperative anal distension and pain, which is a safe and effective treatment.
		2022 Vol. 19 (7): 108-111 [Abstract] ( 187 ) HTML (1 KB) PDF (543 KB) ( 45 )

	112	Effect of transnasal high-flow nasal cannula oxygen therapy and nasal catheter oxygen therapy on patients with acute exacerbation of chronic obstructive pulmonary disease complicated with type Ⅱ respiratory failure#br#
		ZHANG Yanxi SHANG Longmei RUI Xiaoyan▲
		Objective To explore the therapeutic effect of transnasal high-flow nasal cannula oxygen therapy (HFNC) and nasal catheter oxygen therapy (NCO) on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with type Ⅱ respiratory failure. Methods A total of 80 patients with AECOPD complicated with type Ⅱ respiratory failure admitted to Department of Respiratory, the First People’s Hospital of Chuzhou of Anhui Province from March 2018 to March 2021 were selected as the research objects. The patients were divided into observation group and control group by random number table method, with 40 cases in each group. HFNC was added to the basic treatment in the observation group, and NCO was added to basic treatment in the control group. The total treatment time of two groups was more than or equal to three days. The heart rate, respiratory rate and mean arterial pressure of the two groups before and after treatment were compared. Arterial partial pressure of oxygen (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), and partial pressure of oxygen in arterial blood / fractional concentration of inspiratory oxygen (PaO2/FiO2) of the two groups before and after treatment were compared. The comfort level of treatment was investigated at discharge. Results After three days of treatment, heart rate, respiratory rate and mean arterial pressure in two groups were significantly decreased compared with before treatment, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05). After three days of treatment, the levels of PaO2 and PaO2/FiO2 in two groups were significantly increased compared with before treatment, and PaCO2 was significantly decreased compared with before treatment, the differences were statistically significant (P ＜ 0.05). There were no significant differences in PaO2, PaCO2, and PaO2/FiO2 levels between two groups before and after three days of treatment (P ＞ 0.05). Comparison of treatment comfort between the two groups showed highly statistically significant difference (P ＜ 0.01). Conclusion HFNC and NCO both have relatively stable efficacy for patients with AECOPD combined with type Ⅱ respiratory failure, but HFNC has a better remission rate and treatment comfort compared with NCO. HFNC can be widely used for patients requiring oxygen therapy in clinical practice.
		2022 Vol. 19 (7): 112-115 [Abstract] ( 93 ) HTML (1 KB) PDF (538 KB) ( 68 )

	116	Effect of different doses of Dexmedetomidine on brain protection and early prognosis in elderly patients with traumatic brain injury#br#
		LIU Yufang HUA Jun LIAO Xingzhi▲
		Objective To investigate the effect of different doses of Dexmedetomidine on brain protection and early prognosis of elderly patients with traumatic brain injury. Methods A total of 124 elderly patients with traumatic brain injury who were admitted to the 904th Hospital of the Joint logistics Support Force of the Chinese People’s Liberation Army from May 2018 to March 2021 were selected as the research objects. They were divided into low-dose group (31 cases), middle-dose group (31 cases), high-dose group (31 cases), and blank control group (31 cases) according to the random number table method. Low-dose group, middle-dose group, and high-dose group were given intravenous maintenance of 0.3, 0.5, 0.7 μg/(kg·h) Dexmedetomidine, blank control group received saline solution during operation. The mean arterial pressure (MAP) and cerebral extraction of oxygen (CEO2) were compared before administration (T0), 30 min after administration (T1), 60 min after administration (T2) and 120 min after administration (T3); and the early prognosis of four groups was observed after three months follow-up. Results At T1-T3, MAP of four groups was lower than that at T0, and the difference was statistically significant (P < 0.05); at T2-T3, MAP of four groups was higher than that that at T1, and the difference was statistically significant (P < 0.05); at T3, MAP of four groups were higher than that at T2, and the difference was statistically significant (P < 0.05). Pairwise comparison of MAP among four groups at different time points showed no statistical significance (P > 0.05). At T1, CEO2 of four groups was lower than those at T0, and the differences were statistically significant (P < 0.05). At T2-T3, CEO2 of four groups was lower than that at T1, and the difference was statistically significant (P < 0.05). At T1, CEO2 in medium-dose and high-dose groups was lower than that in low-dose group and blank control group, and the difference was statistically significant (P < 0.05). There were no significant differences in early prognosis among four groups (P > 0.05). Conclusion Middle and high doses of Dexmedetomidine in operation of elderly patients with traumatic brain injury have certain brain protection effect and early prognosis is good.
		2022 Vol. 19 (7): 116-119 [Abstract] ( 167 ) HTML (1 KB) PDF (583 KB) ( 47 )

	120	Professor Lu Wenping’s experience in the classification and treatment of climacteric like syndrome of breast cancer#br#
		ZUO Xi1 JIANG Cuihong2 LU Wenping2
		Breast cancer is the most common malignant tumor in women. After receiving various treatment methods, especially endocrine therapy, breast cancer patients may develop climacteric like syndrome, thus reducing compliance with standard treatment and quality of life. Traditional Chinese medicine has certain advantages in the prevention and treatment of climacteric like syndrome. Professor Lu Wenping has profound atrements and rich experience in this aspect, and has his own unique views on the etiology and pathogenesis of the disease and clinical medication. Professor Lu Wenping believes that the etiology, pathogenesis and prognosis of non-hormone-dependent and hormone-dependent patients are not the same. And according to the age and different endocrine environment, the medication for zang-fu organs will be different, with increased or decreased medication according to symptoms, clinical effect is significant.
		2022 Vol. 19 (7): 120-123,131 [Abstract] ( 70 ) HTML (1 KB) PDF (807 KB) ( 100 )

	124	Discussion on the law of acupoint selection of acupuncture in the treatment of epilepsy based on traditional Chinese medicine inheritance auxiliary platform#br#
		REN Runxue FAN Wentao
		Objective To explore the law of acupoint selection of acupuncture in the treatment of epilepsy based on traditional Chinese medicine inheritance auxiliary platform. Methods The literatures of China national knowledge internet, Wanfang data knowledge service platform and VIP databases from inception to April 2021 were retrieved. Acupoint frequency, core combination and new prescription were analyzed through the use of traditional Chinese medicine inheritance auxiliary platform. Results A total of 80 literatures were included in the study, high frequency acupoints were bǎihuì, shuǐgōu and tàichōng. High frequency meridians were du meridian, foot yangming stomach meridian. Total 11 pairs of acupoint combinations, 14 core combinations, 3 new party were obtained. Conclusion Bǎihuì is the main single point for acupuncture in the treatment of epilepsy, and shénmén-bǎihuì combination is preferred. Calm heart for tranquilization while calming mind for resuscitation, at the same time, the acupoints of du meridian and foot yangming stomach meridian may have better curative effect.
		2022 Vol. 19 (7): 124-127,136 [Abstract] ( 202 ) HTML (1 KB) PDF (851 KB) ( 90 )

	128	Professor Yao Shukun’s clinical experience in the diagnosis and treatment of primary biliary cholangitis#br#
		NIU Zuohu1 YUN Zhangjun1 PENG Hongye1 YAO Shukun2
		Primary biliary cholangitis is an autoimmune liver disease, and its incidence has been increasing in recent years. Many patients only use Western medicine, and the treatment effect is not well. Professor Yao Shukun is good at diagnosing and treating primary biliary cholangitis from the perspective of integrated traditional Chinese and Western medicine, with excellent curative effect and quite experience. Professor Yao Shukun believes that most patients nowadays are damp-heat syndrome with the change of lifestyle, especially diet habits. He pays special attention to healthy diet during treatment, and instructs patients to eat whole grains and vegetables as the main diet, which embodies the idea of “seeking the basis for curing diseases, herbal medicine and food being of the same source”. Professor Yao Shukun advocates that treatment must be based on the principle of clearing damp-heat, supplemented by regulating qi and removing blood stasis. The prescription is concise, and the herbal medicine can be added or subtracted flexibly according to the patient’s condition and the symptom. It is worth learning and using for reference.
		2022 Vol. 19 (7): 128-131 [Abstract] ( 135 ) HTML (1 KB) PDF (646 KB) ( 69 )

	132	Clinical observation of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency#br#
		HU Xinxin SUN Yun MA Dazheng GAO Chuchu
		Objective To investigate clinical effect of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency. Methods One hundred and twenty patients with primary dysmenorrhea treated in Department of Gynecology of Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from January 2018 to June 2020 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Control group began to take Ibuprofen Sustained Release Capsules orally at the onset of menstruation for three days. Treatment group began to take Danggui Sini Decoction seven days before menstruation, it lasted until menstruation for three days, two groups were given continuous treatment of three menstrual cycl. Clinical efficacy, dysmenorrhea symptom score, visual analogue scale (VAS), the MOS item short from health survey (SF-36) score and traditional Chinese medical syndrome score were compared between two groups. Results Clinical effect of treatment group was better than that of control group, the difference was statistically significant (P < 0.05). The overall analysis showed that there were significant differences in dysmenorrhea symptom score, VAS score and SF-36 score between groups, time points and interaction (P < 0.05). Intra group comparison: dysmenorrhea symptom score and VAS score of two groups after treatment and three months after drug withdrawal were lower than those before treatment, and SF-36 score of two groups after treatment and three months after drug withdrawal was higher than that before treatment, the differences were statistically significant (P < 0.05); dysmenorrhea symptom score and VAS score of control group three months after drug withdrawal were higher than those after treatment, and SF-36 score of control group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05); VAS score of treatment group three months after drug withdrawal was higher than that after treatment, and SF-36 score of treatment group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05). Comparison between groups: dysmenorrhea symptom score and VAS score of treatment group were lower than those of control group, and SF-36 score of treatment group was higher than that of control group, the differences were statistically significant (P < 0.05). The scores of irritability, cold sweat, nausea and vomiting, anal distension in two groups after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of breast pain and limb chills in treatment group after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of irritability and limb chills in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Danggui Sini Decoction can improve clinical effect of patients with primary dysmenorrhea of syndrome of coagulation cold due to blood deficiency, reduce dysmenorrhea symptom score and VAS score, increase SF-36 score, and improve menstrual irritability, cold sweat, nausea and vomiting, anal distension, breast pain and limb chills.
		2022 Vol. 19 (7): 132-136 [Abstract] ( 60 ) HTML (1 KB) PDF (696 KB) ( 199 )

	137	Zuo Xinhe’s Experience of commonly used triplet herbs in the treatment of thyroid nodules#br#
		WANG Xiaolu1 ZUO Xinhe2,3 ZHAO Yong3 XIE Min3 FU Chang3
		Professor Zuo Xinhe has been engaged in the clinical, teaching, and scientific research of thyroid disease for many years. Professor Zuo thinks that thyroid disease results from emotional dysfunction, qi stagnation, spittoon coagulation, stasis and stagnant, wet obstruction as the standard, mainly liver and spleen lesions. Triplet herbs is a drug group between single medicine and prescription agent, composes of three traditional Chinese medicine, and compatibility of drugs has profound significance. Professor Zuo uses triplet herbs opportunely when treating thyroid nodule in clinic, and listes 11 pairs of commonly used triplet herbs, such as soothing liver and regulating qi, breaking qi and releasing stagnation, cleaning phlegm and dissipating bind, resolving phlegm and dissipating bind, breaking blood to move stasis, breaking blood and moving qi, fortifying the spleen and disinhibiting water, fortifying the spleen and resolving phlegm, softening hardness and dissipating bind, replenishing qi and enriching yin, removing toxin and dissipating bind. This paper summarizes the characteristics of triplet herbs compatibility of Professo Zuo in the treatment of thyroid nodules for reference.
		2022 Vol. 19 (7): 137-140 [Abstract] ( 116 ) HTML (1 KB) PDF (686 KB) ( 101 )

	141	Clinical study of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury#br#
		LI Wei YU Xingqun GAO Zhiling NIE Weiqun WANG Longmei
		Objective To explore the clinical effect of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury. Methods A total of 40 patients with sepsis acute gastrointestinal injury hospitalized in the Department of Critical Care Medicine of the First Affiliated Hospital of Anhui University of Chinese Medicine from April 2020 to May 2021 were selected as the research objects. They were divided into control group and intervention group according to random number table method, with 20 cases in each group, the control group was treated with conventional Western medicine, the intervention group was treated with Houpo Paiqi Mixture on the basis of the control group, 7 days for a course of treatment. The changes of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), the number of bowel sounds, enteral nutrition, sequential organ failure assessment score (SOFA), acute physiology and chronic health score Ⅱ (APACHE Ⅱ), and clinical effects were observed in the two groups. Results After treatment, hS-CRP and PCT in the two groups were lower than those before treatment, and the intervention group was lower than those in the control group (P ＜ 0.05). After treatment, the frequency of bowel sounds and enteral nutrition in the two groups were higher than those before treatment, and the intervention group was higher than those in the control group (P ＜ 0.05). After treatment, SOFA score and APACHE Ⅱ score of the two groups were lower than those before treatment, and the intervention group was lower than those in the control group (P ＜ 0.05). The clinical effect of intervention group was better than that in the control group (P ＜ 0.05). Conclusion Houpo Paiqi Mixture for patients with sepsis acute gastrointestinal injury is better than simple treatment of Western medicine, can reduce inflammatory reaction, improve gastrointestinal function, reduce the degree of critical illness, also improve the prognosis.
		2022 Vol. 19 (7): 141-144 [Abstract] ( 74 ) HTML (1 KB) PDF (579 KB) ( 130 )

	145	Analysis of medication rule of traditional Chinese medicine in the treatment of children with cough variant asthma based on data mining#br#
		LYU Xianwei CHENG Shuang FANG Shunshun ZHANG Ziwei SUN Taoyu
		Objective To analyze the medication rule of traditional Chinese medicine in the treatment of children with cough variant asthma (CVA) based on data mining, in order to provide theoretical basis for the guidance of clinical rational prescription of children with CVA. Methods Literature related to traditional Chinese medicine treatment of CVA in children was retrieved from CNKI, VIP, and Wanfang databases from the establishment of the database to December 2020, frequency statistics, association rule analysis, and systematic cluster analysis were conducted. Results A total of 284 prescriptions were included, involving 222 drugs, and 18 high-frequency drugs were screened out; Semen Armeniacae Amarum, Herba Ephedrae, and Radix Glycyrrhizae were used more frequently; the main types of drugs were dissipating phlegm and relieving cough and asthma, tonifying deficiency, calming liver and extinguishing wind; the property of drugs were mainly cold, warm, and flat; the tastes of drugs were mainly bitter, pungent, and sweet; the main meridians were lung, spleen, and stomach meridians; there were nine binomial association rules through analyzing the association rules; six core drug groups were obtained by systematic cluster analysis. Conclusion Traditional Chinese medicine prescriptions for children with CVA mainly include dispelling wind and relieving spasmolysis, descending qi and relieving asthma, nourishing yin and clearing heat, besides, insect drugs can be used to extinguish wind of lung meridian.
		2022 Vol. 19 (7): 145-148,163 [Abstract] ( 199 ) HTML (1 KB) PDF (1620 KB) ( 65 )

	149	Analysis of medication rules of famous veteran traditional Chinese medicine doctor in the treatment of viral myocarditis#br#
		CHEN Qiuhan1 ZHOU Yabin2 FAN Zengguang1 YANG Jianfei2 WANG He2 CHI Kuo1
		Objective To make data statistics and analysis on the medical records of famous veteran traditional Chinese medicine doctor in treating viral myocarditis and the literatures of CNKI, and to explore the medication rule of famous veteran traditional Chinese medicine doctor in treating viral myocarditis. Methods Medical cases diagnosed with viral myocarditis from famous old TCM medical case books and CNKI literatures were collected and searched from the establishment of database to February 2021, and entered into the traditional Chinese medicine inheritance support platform V2.5, and the data were statistically for symptoms, syndromes, treatment rules and methods, and prescription patterns, etc, the patient’s syndromes and the medication pattern of the famous veteran traditional Chinese medicine doctor were analyzed. Results A total of 86 cases and 95 prescriptions were included. The most common syndrome was the syndrome of deficiency of both qi and yin, the main symptom was palpitations, the most frequent used in a single herb was Radix Glycyrrhizae, and the four nature of drugs were mainly cold and sweet, and the five flavours were mainly sweet and bitter, and the main channels were the heart and lung meridians, and the highest confidence level of the association rule analysis was Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis→Radix Ophiopogonis, and the new formula clustering analysis yielded had eight new prescriptions. Conclusion The main type of syndrome of viral myocarditis is the syndrome of deficiency of both qi and yin, in the treatment of this disease, famous veteran traditional Chinese medicine doctors mostly combine “tonifying” and “clearing”, the mainly treatment is supplementing qi and yin, cleaning heat and poison, and the secondary treatment is resolving blood stasis, calming mind and restoring heart pulse.
		2022 Vol. 19 (7): 149-152 [Abstract] ( 202 ) HTML (1 KB) PDF (826 KB) ( 67 )

	153	Observation of abnormal changes of brain structure in patients with alcohol dependence based on MRI#br#
		ZHANG Xiang1 CHENG Zusheng1 ZHU Shaofeng1 WANG Liang2 LING Yingchun3
		Objective To observe the abnormal changes of brain structure in patients with alcohol dependence based on magnetic resonance imaging (MRI). Methods A total of 150 patients with alcohol dependence admitted to Shaoxing Seventh People’s Hospital, Zhejiang Province (hereinafter referred to as “our hospital”) from June 2019 to December 2020 were selected as the research subjects and included in the research group. Another 150 healthy people who underwent routine physical examination in our hospital at the same period were selected as the control group. MRI examination was performed in both groups, and the ventricular temporal horn width, hippocampal volume, nucleus accumbens volume, and the occurrence of brain mass lesions (brain atrophy, white matter demyelinating spot, cerebral softening focus, and corpus callosum degeneration) were compared. Results The ventricular temporal horn width and the hippocampal volume in both sides in the research group were larger than those in the control group, and the nucleus accumbens volume on both sides were smaller than those in the control group, the incidence of brain mass lesions was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion MRI examination is helpful to observe the abnormal changes of brain structure in patients with alcohol dependence, among which the width of temporal horn of ventricle, hippocampus volume, nucleus accumbens volume, and brain mass lesions are sensitive indicators.
		2022 Vol. 19 (7): 153-155 [Abstract] ( 38 ) HTML (1 KB) PDF (480 KB) ( 103 )

	156	Research on the construction of the evaluation index system for the appointment of senior title of professional post of clinicians in a tertiary class hospital#br#
		MA Qianhui1 WU Endong2 YANG Nan1 ZHOU Xiaoping3▲ XIE Na1▲
		Objective To establish a set of relatively scientific, reasonable, and fair evaluation system for the appointment of clinicians with senior title of professional post, and serve as a reference for the talent evaluation of tertiary class hospitals. Methods From March to June 2020, a total of 15 experts were selected from four fields: the health administrative department (Beijing evaluation center), hospital management department (Beijing Chest Hospital, Beijing Ditan Hospital, Beijing Friendship Hospital), hospital clinical department (Beijing Chest Hospital, Beijing Ditan Hospital, Beijing Chaoyang Hospital) and university experts (Capital Medical University). Delphi expert consultation method was used to screen the evaluation indexes of the appointment of senior title of professional post. From July to October 2020, the analytic hierarchy process was used to determine the weight of each evaluation index. Results The authoritative coefficient Cr value of the expert letter inquiry was 0.89, the Kendall harmony coefficient of the coordination degree was 0.170, P ＜ 0.05. Four first-level evaluation indicators, 13 second-level evaluation indicators, and 49 third-level evaluation indicators were screened and determined. Conclusion The establishment of the evaluation index system is scientific and rigorous, representative and comprehensive, and its weight assignment is in line with the characteristics of title of a senior professional post, and the appointment of professional post evaluation index system is dynamically adjusted.
		2022 Vol. 19 (7): 156-159,168 [Abstract] ( 73 ) HTML (1 KB) PDF (643 KB) ( 61 )

	160	Psychological care for medical staff in hematology department in children’s hospital#br#
		WANG Xue YAO Wenying
		As the medical staff of hematology department in children’s hospital, due to their special working environment and service objects, they often need to face great psychological pressure. In the long run, the psychological pressure of medical staff is increasing, which is bound to affect their work and life. Therefore, the mental health status of hematology staff at the children’s hospital should be widely paid attention. Medical staff in the face of work pressure, in addition to learn to self-regulate, hospitals should increase psychological care for pediatric medical staff. This paper analyzes the source of pressure of medical staff in hematology department of children’s hospital, discusses the possible harm to the mental health of medical staff under long-term pressure, and puts forward how to relieve the working pressure of medical staff through psychological care in hospital management level, so as to ensure the physical and mental health of medical staff.
		2022 Vol. 19 (7): 160-163 [Abstract] ( 166 ) HTML (1 KB) PDF (648 KB) ( 78 )

	164	Mediating effect of caregiver hope level of family members of patients with heart failure on disease uncertainty and caregiver readiness#br#
		LIU Yumiao1 SUN Dandan2 WANG Yafei1 ZENG Gaofeng3 ZHANG Qing1
		Objective To explore the mediating role of caregiver hope level of family members of patients with heart failure on disease uncertainty and caregiver readiness. Methods From July to December 2020, a total of 323 family caregivers of patients with heart failure in the Department of Cardiovascular Medicine of the Second Affiliated Hospital of South China University, South China Hospital Affiliated to South China University, and Hengyang Central Hospital were selected as the research objects by convenience sampling. The survey was conducted using the general information inventory, the mishel uncertainty in illness scale for family member, the Herth hope index, and the caregiver preparedness scale. The correlation and mediating effect of disease uncertainty, hope level, and caregiver readiness were analyzed. Results The family caregivers of heart failure patients had an uncertainty score of (86.07±10.35) points, a hope level score of (35.13±4.01) points, and a caregiver readiness score of (21.45±5.09) points. Correlation analysis showed that caregiver readiness was negatively correlated with disease uncertainty (r = -0.480, P ＜ 0.01); caregiver readiness was positively correlated with hope level (r = 0.419, P ＜ 0.01); disease uncertainty was negatively correlated with hope level (r = -0.433, P ＜ 0.01). Bootstrap test verified the mediating effect of hope level between disease uncertainty and caregiver readiness (β = -0.055, P ＜ 0.01), and the mediating effect accounted for 23.31% of the total effect. Conclusion The level of caregiver hope of family members of patients with heart failure partially mediates the relationship between disease uncertainty and caregiver readiness.
		2022 Vol. 19 (7): 164-168 [Abstract] ( 43 ) HTML (1 KB) PDF (883 KB) ( 41 )

	169	Bibliometric analysis of perinatal palliative care based on Web of Science database#br#
		GUO Nafei ZHANG Lan LIU Ying ZHANG Ran JIANG Hui▲
		Objective To analyze the research status of perinatal period palliative care and provide references for follow-up research. Methods The perinatal palliative care literature published from January 1975 to December 2020 in the Web of Science core collection database was searched, and the external and internal characteristics were analyzed. Results A total of 573 papers were retrieved, which were first published in 1993. The first country with the number of papers was the United States, the journal was Advances in Neonatal Care, and the author was Charlotte Wool. Conclusion The research on perinatal palliative care is gradually becoming an academic hotspot, and the development of this field in our country still needs further exploration.
		2022 Vol. 19 (7): 169-172,185 [Abstract] ( 163 ) HTML (1 KB) PDF (1087 KB) ( 83 )

	173	Comparison of application effects of different systems in continuous invasive blood pressure monitoring in elderly patients with septic shock#br#
		LIU Guangdi1,2 TANG Li1,2 LIU Yiwen2,3▲ LI Qian2
		Objective To explore the effect of different systems in the protection of access for continuous invasive blood pressure monitoring in elderly patients with septic shock. Methods A total of 80 elderly patients with septic shock who were placed with arterial pressure monitoring catheters in West China Hospital of Sichuan University from May 2020 to May 2021 were selected and divided into experimental group and control group by random number table method, with 40 cases in each group. The experimental group was given a total closed system to monitor the arterial pressure for access protection, while the control group was given the general system. The postoperative catheter retention time, catheter complications, stability, and comfort of the arterial pressure measurement system were compared between the two groups. Results The catheter indwelling time in the experimental group was longer than that in the control group, while the time for a single collection of blood gas analysis specimens in the experimental group was shorter than that in the control group, and the difference was statistically significant (P ＜ 0.05). The bleeding rate, swelling rate, tube blocking rate, and complication rate in the experimental group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the number of abnormal numerical values and the number of abnormal waveforms between the two groups (P ＞ 0.05). The comfort level of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The fully closed system has the same effect as the general system in maintaining the stability of the arterial pressure measurement system, which can reduce the occurrence of complications and improve the patient’s comfort.
		2022 Vol. 19 (7): 173-176 [Abstract] ( 162 ) HTML (1 KB) PDF (626 KB) ( 66 )

	177	Effect of exercise intervention based on behavior change theory in elderly diabetic patients#br#
		LI Li ZHU Xiaozhen▲
		Objective To investigate the effect of exercise based on behavioral change theory on frailty in elderly patients with diabetes. Methods A total of 120 elderly diabetic patients who were admitted to the Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine from October 2018 to December 2019 were selected and divided into experimental group and traditional group according to the random number table method, with 60 cases in each group. The experimental group received exercise instruction that matched the stage of behavioral change, and a return visit was conducted by telephone; the traditional group was received regular exercise education. Fasting blood glucose, glycosylated hemoglobin, Chinese version of Tilburg frailty scale, and other indicators were used to evaluate the intervention effect. Results After the intervention, there were no significant differences in fasting plasma glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, low-density lipoprotein cholesterol, and total cholesterol in the traditional group compared with those before the intervention (P ＞ 0.05); the above indicators in the experimental group were lower than those before the intervention, while the experimental group was lower than the traditional group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the total score of frailty, physical frailty, mental frailty, and social frailty in the two groups were lower than those before the intervention, while the experimental group was lower than the traditional group, with statistically significant differences (P ＜ 0.05). Conclusion Exercise intervention based on behavioral change theory can significantly improve the control level of blood glucose and blood lipids in elderly patients with type 2 diabetes mellitus, and improve the debilitating status of patients, which is worthy of clinical application.
		2022 Vol. 19 (7): 177-180 [Abstract] ( 118 ) HTML (1 KB) PDF (522 KB) ( 209 )

	181	Application effect of acupoint massage combined with Baduanjin exercise on knee osteoarthritis with liver and kidney deficiency, blood stasis and internal resistance#br#
		GAO Chao1 SHI Zhimin2 LI Xueqing3
		Objective To observe the application effect of acupoint massage combined with Baduanjin exercise in improving knee osteoarthritis of liver and kidney deficiency and blood stasis internal resistance. Methods A total of 82 patients with knee osteoarthritis with liver and kidney insufficiency and blood stasis and internal resistance were selected from February 2019 to January 2020 in the Department of Bone Injury and Pain, Tangshan Hospital of Traditional Chinese Medicine, Hebei Province, according to random number table method, they were divided into control group and observation group, with 41 cases in each group. The control group was given acupoint massage treatment, and the observation group was given Baduanjin exercise treatment based on the control group. After eight weeks of treatment, the clinical efficacy of the two groups were compared, and the scores of Western Ontario and McMaster University arthritis index, Chinese medicine symptom score and knee MRI score were analyzed before and after eight weeks of treatment. Results After eight weeks of treatment, the total effective rate of observation group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). Western Ontario and McMaster University arthritis index score, Chinese medicine symptom score and knee MRI score were all lower than those before treatment, and the observation group was lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Acupoint massage combined with Baduanjin exercise has a remarkable effect on the treatment of knee osteoarthritis with liver and kidney insufficiency and blood stasis. Significantly reduced Western Ontario and McMaster University arthritis index scores, Chinese medicine symptom scores, and knee MRI scores.
		2022 Vol. 19 (7): 181-185 [Abstract] ( 150 ) HTML (1 KB) PDF (727 KB) ( 162 )

	186	Application of diversified self-management health education in patients undergoing coronary artery bypass grafting#br#
		WANG Min1 HUANG Li2 QU Yan1 CHEN Guilan1▲
		Objective To explore the influence of diversified self-management health education on the self-management ability and quality of life of patients undergoing coronary artery bypass graft surgery. Methods A total of 128 cases of coronary artery bypass surgery patients admitted to Nantong Hospital of Traditional Chinese Medicine from October 2014 to December 2018 were selected, they were divided into treatment group and control group by random number table, with 64 cases in each group. The control group was given regular health education, and the treatment group was combined with diversified self-management health education. Follow up for six months, the self-management behavior and quality of life between the two groups were compared. Results After six months of follow-up, the self-management behavior scores of the two groups were significantly higher than those before the intervention, the dietary management, compliance behavior, emotional management, and bad habits control scores of the treatment group were higher than those of the control group (P ＜ 0.05). The scores of life quality of the two groups were significantly higher than those before the intervention, the scores of physical limitation, angina pectoris stability, angina pectoris frequency, and disease awareness in the treatment group were higher than those of the control group (P ＜ 0.05). Conclusion Diversified self-management health education is helpful to enhance the self-management ability of coronary artery bypass graft patients and improve the quality of life.
		2022 Vol. 19 (7): 186-189 [Abstract] ( 191 ) HTML (1 KB) PDF (550 KB) ( 38 )

	190	Nursing effect of group behavior intervention combined with aerobic exercise of patients with colorectal cancer after operation#br#
		MIAO Danping XU Wei▲
		Objective To explore the effect of group behavior intervention combined with aerobic exercise on nursing of patients with colorectal cancer after operation. Methods A total of 100 postoperative colorectal cancer patients admitted to Nanjing First Hospital of Jiangsu Province from December 2019 to July 2020 were selected as the research objects, according to the random number table method, they were divided into observation group and control group, with 50 cases in each group. All patients received routine intervention after operation, on this basis, the control group was performed group behavior intervention, the observation group was performed group behavior intervention combined with aerobic exercise, both groups were intervened for two weeks. The anal function [anal incontinence Wexner score] and negative emotion [self-rating anxiety scale (SAS), self-rating depression scale (SDS)] of the two groups were compared before and two weeks after intervention. The incidence of complications during intervention was counted and compared between the two groups. Results Two weeks after intervention, the anal incontinence Wexner score of both groups were lower than those before intervention, and the observation group were lower than those of the control group (P ＜ 0.05). The SAS and SDS scores of both groups were lower than those before intervention, and the observation group were lower than those of the control group (P ＜ 0.05). The total incidence of complications in observation group was lower than that in control group (P ＜ 0.05). Conclusion Group behavior intervention combined with aerobic exercise can improve anal function, reduce negative emotions, and reduce the incidence of complications in patients with colorectal cancer after operation.
		2022 Vol. 19 (7): 190-193 [Abstract] ( 111 ) HTML (1 KB) PDF (546 KB) ( 46 )

	194	Clinical study of family health education on postoperative nursing of microscopical varicocele#br#
		QIU Aiping1 FAN Xiaomeng1 ZHU Zhimin2 LIU Yongsheng1 HAO Jie1
		Objective To explore the application effect of family health education on postoperative nursing of microscopical varicocele. Methods A total of 100 adult male patients with severe varicocele without mental illness diagnosed in Baoding Second Hospital of Hebei Province from January 2014 to January 2018 were selected, and all patients adopted microscopic varicocele ligation. According to the random number table method, they were divided into control group and observation group, with 50 cases in each group. The control group was given routine nursing measures, and the observation group was given family health education intervention based on the control group. The results of scrotal ultrasonography and semen analysis were observed three and six months after operation, and the diameter of spermatic vein and semen recovery were compared. Negative emotions, compliance, satisfaction, postoperative complications and pregnancy of the patient’s wife were investigated. Results Three months after operation, the semen concentration, sperm survival rate, forward movement, and testosterone content in the observation group were significantly higher than those in the control group, the maximum diameter of the spermatic vein was smaller than that of the control group the differences were statistically significant (P ＜ 0.05). There was no significant difference in total sperm motility and testicular volume between the two groups (P ＞ 0.05). There were no significant differences in semen concentration, sperm survival rate, forward movement, testosterone content, total sperm motility, and testicular volume between the two groups at six months after operation (P ＞ 0.05). The negative emotion score of the observation group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05); the satisfaction score of the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05); there was no statistical significance in compliance between the two groups (P ＞ 0.05). The incidence rate of postoperative complications in the observation group was significantly lower than that in the control group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in pregnancy rate of wife between the two groups (P ＞ 0.05). Conclusion The recovery degree of patients in the observation group with family health education in the first three months after operation was better than that in the control group, and there were fewer postoperative complications. Family health education after low ligation of spermatic vein under microscope is a palliative and effective nursing method, which is of great significance to promote the recovery of patients and ensure the curative effect.
		2022 Vol. 19 (7): 194-封三 [Abstract] ( 151 ) HTML (1 KB) PDF (580 KB) ( 41 )

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