2D-B/W、CDFI联合血浆Fib、D-D检测对DVT的诊断价值

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Abstract Objective To explore the diagnostic value of two dimensional black-and-white ultrasound (2D-B/W), color doppler flow imaging (CDFI) combined with plasma fibrinogen (Fib) and D-Dimer (D-D) detection in deep venous thrombosis (DVT) of lower limbs. Methods A total of 90 patients with lower limb swelling and pain admitted to Anqing First People’s Hospital of Anhui Medical University from July 2019 to March 2021 were selected as the research subjects, among them, 41 patients with DVT. All patients underwent 2D-B/W and CDFI examinations, and plasma D-D and fibrinogen (Fib) levels were determined. The receiver operator characteristic curves for DVT were drawn and the area under the curve (AUC) was calculated. The diagnostic efficacy of 2D-B/W, CDFI, plasma Fib, and plasma D-D for DVT alone and in combination was compared. Results The levels of Fib and D-D in DVT patients were significantly higher than those in non-DVT patients (P ＜ 0.05). The AUC of the combination of four tests for DVT was 0.938 (95%CI: 0.888-0.989), which was significantly higher than that of 2D-B/W (0.739 [95%CI: 0.631-0.847]), CDFI (0.891 [95%CI: 0.823-0.959]), plasma Fib (0.758 [95%CI: 0.653-0.864]), and plasma D-D (0.826 [95%CI: 0.742-0.909]) were diagnosed separately (P ＜ 0.05). The sensitivity, specificity and accuracy of the four tests were 97.56%, 93.88% and 95.56%, respectively. Conclusion 2D-B/W, CDFI combined with plasma Fib and D-D detection can significantly improve the diagnostic accuracy of early diagnosis of DVT, and reduce the risk of missed diagnosis and misdiagnosis.

Key words： Two dimensional black-and-white ultrasound Color doppler flow imaging Fibrinogen D-Dimer Deep vein thrombosis

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	HAO Junxia HU Jinhua XIA Qun YU Yi

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HAO Junxia HU Jinhua XIA Qun YU Yi. Diagnostic value of 2D-B/W, CDFI combined with plasma Fib and D-D detection for DVT#br#[J]. 中国医药导报, 2022, 19(7): 104-107.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I7/104

[1] 王文静.彩色多普勒超声对孕产妇下肢深静脉血栓的诊断价值研究[J].中国基层医药，2021，28（5）：760-763.
[2] Komatsu H，Shimada M，Osaku D，et al. Deep vein thrombosis and serum D-dimer after pelvic lymphadenectomy in gynecological cancer [J]. Int J Gynecol Cancer，2020，30（6）：860-864.
[3] 张艳，杨俊萍，张均.彩色多普勒超声联合高频超声在下肢深静脉血栓诊断中的应用[J].血栓与止血学，2020，26（2）：248-249.
[4] 肖琨.灰阶和彩色多普勒超声诊断高龄下肢深静脉血栓的价值及临床意义[J].中国数字医学，2019，14（7）：22-24.
[5] 徐亮，刘凤英，丁倩.Caprini评分、D-二聚体、纤维蛋白原水平在骨折后下肢深静脉血栓病人中的变化及其临床意义[J].临床外科杂志，2019，27（4）：328-330.
[6] 中华医学会外科学分会血管外科学组.深静脉血栓形成的诊断和治疗指南（第三版）[J].中华普通外科杂志，2017， 32（9）：807-812.
[7] 何明清，王娴，何芳，等.彩色多普勒超声联合血液凝血功能检查对孕妇产后血栓前状态诊断及血栓发生预测的价值[J].中国综合临床，2018，34（3）：272-276.
[8] Ha SH，Kim YJ，Heo SH，et al. Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke [J]. BMC Neurol，2020，20（1）：257.
[9] 解红娟，张叔军，夏群，等.彩色多普勒超声联合D-二聚体水平检测在早期下肢深静脉血栓诊断中的临床研究[J].内蒙古医科大学学报，2018，40（3）：255-258，267.
[10] 高彬，邵丽娟，王翠茹，等.D-二聚体在脊柱退行性变患者围术期变化及其对术后下肢深静脉血栓形成的预测价值[J].解放军医学杂志，2020，32（12）：72-76.
[11] Chopard R，Albertsen IE，Piazza G. Diagnosis and Treatment of Lower Extremity Venous Thromboembolism：A Review [J]. JAMA，2020，324（17）：1765-1776.
[12] 杨寿强，张丽，张渊，等.彩色多普勒超声联合外周血miR-195水平诊断下肢深静脉血栓的价值[J].检验医学与临床，2020，17（16）：2377-2380.
[13] Ren B，Yan F，Deng Z，et al. Extremely High Incidence of Lower Extremity Deep Venous Thrombosis in 48 Patients With Severe COVID-19 in Wuhan [J]. Circulation，2020，142（2）：181-183.
[14] 杭欣，王春光，张帅，等.彩色多普勒超声联合D-二聚体对周围型下肢深静脉血栓筛查的价值[J].医学影像学杂志，2020，30（3）：475-478.
[15] Koleilat I，Galen B，Choinski K，et al. Clinical characteristics of acute lower extremity deep venous thrombosis diagnosed by duplex in patients hospitalized for coronavirus disease 2019 [J]. J Vasc Surg Venous Lymphat Disord，2021，9（1）：36-46.
[16] Cheng J，Fu Z，Zhu J，et al. The predictive value of plasminogen activator inhibitor-1，fibrinogen，and D-dimer for deep venous thrombosis following surgery for traumatic lower limb fracture [J]. Ann Palliat Med，2020，9（5）：3385-3392.
[17] 高军，肖际东.彩色多普勒血流显像联合X射线在下腔静脉滤器置入治疗骨折后下肢深静脉血栓中的临床应用[J].临床与病理杂志，2018，38（7）：1519-1522.
[18] 梁政巧，奚嘉婧，陈香洁.彩色多普勒超声检查在下肢深静脉血栓诊断中的应用价值[J].中国当代医药，2020， 27（10）：148-150，154.
[19] 陈昌礼，银保，徐德兴，等.D-D、FIB及PAI-1在创伤性脊柱骨折表达及术后静脉血栓的预测[J].分子诊断与治疗杂志，2021，13（1）：43-46.
[20] 伍正根，徐伟，王自鸿，等.老年髋部骨折围手术期深静脉血栓形成的发生规律及血浆D-二聚体、纤维蛋白原的诊断价值[J].实用老年医学，2019，33（8）：783-787.
[21] 卞锦花，高艳，达婷，等.彩色多普勒超声联合D二聚体对周围型下肢深静脉血栓形成的筛查价值[J].血栓与止血学，2020，26（6）：939-940.
[22] 高振巢，王明鑫，陈秋，等.下肢骨折术后Fib、D-二聚体检测的意义及其在术后深静脉血栓形成中的预测价值[J].实用药物与临床，2018，21（12）：1346-1349.
[23] Kamolratanapiboon K，Tantanate C. Inappropriate use of D-dimer and impact on the test characteristics for deep vein thrombosis exclusion [J]. Scand J Clin Lab Invest，2019，79（6）：431-436.
[24] 代玲玉，赵红乐，赵广芳，等.Caprini评分联合D-二聚体诊断妇科恶性肿瘤深静脉血栓形成的价值[J].中国医药导报，2020，17（2）：85-88.
[25] 杨帆，王晓云，黄莉，等.下肢静脉彩超联合Caprini评分评估慢性精神分裂症患者深静脉血栓风险的价值[J].中国当代医药，2021，28（30）：136-139.
[26] 宋永财，卫永鲲，杨立峰，等.血栓弹力图参数联合D-二聚体对胸腰椎结核术后并发深静脉血栓形成的预测作用[J].疑难病杂志，2021，20（2）：171-175.
[27] 徐燕军，黄江山，陈智阳.常用血常规指标、血浆D-D、Fib监测对下肢创伤发生深静脉血栓的诊断价值[J].中国医药科学，2021，11（15）：142-146.
[28] 杨松杰，张清旭，吴晓滨，等.血浆纤维蛋白原、D-二聚体检测及双下肢静脉彩超诊断老年下肢骨折并发深静脉血栓的临床价值[J].中国老年学杂志，2018，38（12）：2930-2932.