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| Effect of different doses of Dexmedetomidine on brain protection and early prognosis in elderly patients with traumatic brain injury#br# |
| LIU Yufang HUA Jun LIAO Xingzhi▲ |
| Department of Anesthesiology, the 904th Hospital of the Joint logistics Support Force of the Chinese People’s Liberation Army, Jiangsu Province, Wuxi 214000, China |
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Abstract Objective To investigate the effect of different doses of Dexmedetomidine on brain protection and early prognosis of elderly patients with traumatic brain injury. Methods A total of 124 elderly patients with traumatic brain injury who were admitted to the 904th Hospital of the Joint logistics Support Force of the Chinese People’s Liberation Army from May 2018 to March 2021 were selected as the research objects. They were divided into low-dose group (31 cases), middle-dose group (31 cases), high-dose group (31 cases), and blank control group (31 cases) according to the random number table method. Low-dose group, middle-dose group, and high-dose group were given intravenous maintenance of 0.3, 0.5, 0.7 μg/(kg·h) Dexmedetomidine, blank control group received saline solution during operation. The mean arterial pressure (MAP) and cerebral extraction of oxygen (CEO2) were compared before administration (T0), 30 min after administration (T1), 60 min after administration (T2) and 120 min after administration (T3); and the early prognosis of four groups was observed after three months follow-up. Results At T1-T3, MAP of four groups was lower than that at T0, and the difference was statistically significant (P < 0.05); at T2-T3, MAP of four groups was higher than that that at T1, and the difference was statistically significant (P < 0.05); at T3, MAP of four groups were higher than that at T2, and the difference was statistically significant (P < 0.05). Pairwise comparison of MAP among four groups at different time points showed no statistical significance (P > 0.05). At T1, CEO2 of four groups was lower than those at T0, and the differences were statistically significant (P < 0.05). At T2-T3, CEO2 of four groups was lower than that at T1, and the difference was statistically significant (P < 0.05). At T1, CEO2 in medium-dose and high-dose groups was lower than that in low-dose group and blank control group, and the difference was statistically significant (P < 0.05). There were no significant differences in early prognosis among four groups (P > 0.05). Conclusion Middle and high doses of Dexmedetomidine in operation of elderly patients with traumatic brain injury have certain brain protection effect and early prognosis is good.
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