红细胞分布宽度与白蛋白比值对急性呼吸窘迫综合征预后的预测价值

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Abstract Objective To investigate the predictive value of red blood cell distribution width to albumin ratio (RAR) in the prognosis of acute respiratory distress syndrome (ARDS). Methods A retrospective study was performed on ARDS patients admitted to the ICU of the First Affiliated Hospital of Zhengzhou University from October 2019 to October 2020. The patients were divided into survival group and death group according to the 28-day outcome, general data, laboratory examinations, and other indicators were collected, the risk factors of 28-day death were analyzed by Cox regression, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive value. Results A total of 105 ARDS patients were included, including 59 cases in the death group and 46 cases in the survival group, with a 28-day mortality rate of 56.19%. Age, acute physiology, and chronic health status scores, lactate, red blood cell distribution width, blood urea nitrogen, procalcitonin, neutrophil to lymphocyte count ratio, RAR, and procalcitonin to albumin ratio were higher in death group than survival group, while albumin was lower than that in the survival group, and the differences were statistically significant (P ＜ 0.05). Multivariate Cox regression analysis showed that RAR was an independent risk factor for 28-day death in ARDS patients (HR = 3.06, P ＜ 0.05). ROC analysis showed that the area under the curve of RAR was 0.829 (95%CI: 0.752-0.907, P ＜ 0.001), and the optimal cutoff value was 0.50. ARDS patients had higher mortality when RAR＞0.50. Conclusion RAR has a good predictive value for the 28-day prognosis of ARDS patients and is an independent risk factor for 28-day death.

Key words： Red blood cell distribution width Albumin Acute respiratory distress syndrome Prognosis

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	XU Luyang LI Jing ZHANG Guojun

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XU Luyang LI Jing ZHANG Guojun. Predictive value of red blood cell distribution width to albumin ratio in prognosis of acute respiratory distress syndrome#br#[J]. 中国医药导报, 2022, 19(7): 23-26.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I7/23

[1] Bellani G，Laffey JG，Pham T，et al. Epidemiology，Patterns of Care，and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J]. JAMA，2016，315（8）：788-800.
[2] Fanelli V，Ranieri VM. Mechanisms and clinical consequences of acute lung injury [J]. Ann Am Thorac Soc，2015， 12（Suppl 1）：S3-S8.
[3] Menk M，Estenssoro E，Sahetya SK，et al. Current and evolving standards of care for patients with ARDS [J]. Intensive Care Med，2020，46（12）：2157-2167.
[4] Ma X，Liu X，Feng J，et al. Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability [J]. Inflammation，2019，42（5）：1901-1912.
[5] Lippi G，Targher G，Montagnana M，et al. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients [J]. Arch Pathol Lab Med，2009，133（4）：628-632.
[6] Weiss G，Goodnough LT. Anemia of Chronic Disease [J]. N Engl J Med，2005，352（10）：1011-1023.
[7] Yu XS，Chen ZQ，Hu YF，et al. Red blood cell distribution width is associated with mortality risk in patients with acute respiratory distress syndrome based on the Berlin definition：A propensity score matched cohort study [J]. Heart Lung，2020，49（5）：641-645.
[8] 王丽芳，韩寒，施斌.红细胞分布宽度联合中性粒细胞/淋巴细胞比值对慢性阻塞性肺疾病急性加重期患者预后的评估价值[J].中国医药导报，2020，17（35）：34-37.
[9] 张意.血清白蛋白和前白蛋白对ARDS患者死亡预后的评估作用[J].中国临床新医学，2013（10）：965-968.
[10] 孔程，祥李莉，金萍，等.血清白蛋白、乳酸脱氢酶及乳酸脱氢酶/白蛋白比值检测在儿童急性呼吸窘迫综合征诊治中的临床意义[J].中国实用医药，2020，15（15）：19-21.
[11] 程梦蝶.红细胞分布宽度与血清白蛋白比值对冠心病PCI术后患者的长期死亡率的预测价值[D].郑州：郑州大学，2020.
[12] 王健.红细胞分布宽度与白蛋白的比值作为预测乙肝肝硬化严重程度和预后的新指标[D].郑州：郑州大学，2018.
[13] Ranieri VM，Rubenfeld GD，Thompson BT，et al. Acute respiratory distress syndrome：the Berlin Definition [J]. JAMA，2012，307（23）：2526-2533.
[14] 江浩，郑贸根，朱超男，等.APACHEII、SS、SOFA评分对创伤继发ARDS严重程度及预后的预测价值比较[J].临床肺科杂志，2018，23（11）：2074-2078.
[15] Thompson BT，Chambers RC，Liu KD. Acute Respiratory Distress Syndrome [J]. N Engl J Med，2017，377（6）：562-572.
[16] Chow CW，Herrera Abreu MT，Suzuki T，et al. Oxidative stress and acute lung injury [J]. Am J Respir Cell Mol Biol，2003，29（4）：427-431.
[17] Derwall M，Martin L，Rossaint R. The acute respiratory distress syndrome： pathophysiology，current clinical practice，and emerging therapies [J]. Expert Rev Respir Med，2018，12（12）：1021-1029.
[18] Zhan Y，Yang C，Zhang Q，et al. Silent information regulator type-1 mediates amelioration of inflammatory response and oxidative stress in lipopolysaccharide-induced acute respiratory distress syndrome [J]. J Biochem，2021，169（5）：613-620.
[19] 邵从军.红细胞分布宽度在临床疾病诊疗中的研究进展[J].临床输血与检验，2021，23（3）：400-404.
[20] Ku NS，Kim HW，Oh HJ，et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia [J]. Shock，2012， 38（2）：123-127.
[21] Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis [J]. Antioxid Redox Signal，2008，10（11）：1923-1940.
[22] 许永春，许毓灵，余涛，等.血清清蛋白及C反应蛋白对新型冠状病毒肺炎预后的评估价值[J].医学研究生学报，2021，34（3）：278-281.
[23] 叶阳，周瑞卿，胡志强.急性呼吸窘迫综合征患者血乳酸和红细胞分布宽度与病情严重程度的相关性分析[J].中国急救医学，2018，38（6）：481-484.
[24] 王玉，黄栋，梁宗安，等.降钙素原与白蛋白比值对急性呼吸窘迫综合征患者预后的预测价值[J].中国呼吸与危重监护杂志，2020，19（3）：240-245.
[25] 姬涛，高洁.早期血清乳酸清除率预测脓毒症患者预后的价值[J].解放军医学院学报，2020，41（9）：889-892.