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| Effect of Alanyl Glutamine-assisted Ulinastatin in the treatment of severe acute pancreatitis lung injury and the influence on lung function, inflammation, and immune function#br# |
| LI Xia1 ZHUANG Wei1 MA Chong1 CHEN Xianhai2 ZHANG Zheng1 WANG Jian1▲ |
1.Department of Emergency Medicine, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250001, China;
2.Department of Pulmonology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China |
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Abstract Objective To explore and analyze the effect of Alanyl Glutamine-assisted Ulinastatin in the treatment of severe acute pancreatitis lung injury and the influence on lung function, inflammation, and immune function. Methods A total of 96 patients with severe acute pancreatitis lung injury treated in the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected from August 2017 to August 2020, they were divided into control group and observation group by random number table method, 48 cases in each group. Ulinastatin was given to the control group, and Alanyl Glutamine was added to the observation group on the basis of the control group. After one week of continuous treatment, lung CT morphological grade, disease severity, blood gas indexes, and serum levels of interferon -γ (IFN-γ), interleukin-4 (IL-4), IFN-γ/IL-4, IL-6, and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment. Results After treatment, lung CT morphological grades of two groups were better than those before treatment, acute physiology and chronic health evaluationⅡ (APACHEⅡ) score, Balthazar CT score, Murray lung injury score, serum IFN-γ, IL-6, IFN-γ/IL-4, and TNF-α of two groups were all lower than those before treatment, arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), oxygenation index, and IL-4 of two groups were all higher than those before treatment, while the lung CT morphological grades of observation group were better than those of control group, APACHEⅡ score, Balthazar CT score, Murray lung injury score, serum IFN-γ, IL-6, IFN-γ/IL-4, and TNF-α of observation group were all lower than those of the control group, PaO2, SaO2, oxygenation index, and IL-4 in observation group were all higher than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion Alanyl Glutamine-assisted Ulinastatin treatment of severe acute pancreatitis lung injury can promote the improvement of blood gas analysis indicators, reduce lung injury, improve the body’s inflammatory response and immune function, reduce the severity of the disease, promote the improvement of prognosis.
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