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| Clinical observation of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency#br# |
| HU Xinxin SUN Yun MA Dazheng GAO Chuchu |
| Department of Gynecology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhejiang Province, Wenzhou 325000, China |
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Abstract Objective To investigate clinical effect of modified Danggui Sini Decoction in the treatment of primary dysmenorrhea with syndrome of coagulation cold due to blood deficiency. Methods One hundred and twenty patients with primary dysmenorrhea treated in Department of Gynecology of Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from January 2018 to June 2020 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Control group began to take Ibuprofen Sustained Release Capsules orally at the onset of menstruation for three days. Treatment group began to take Danggui Sini Decoction seven days before menstruation, it lasted until menstruation for three days, two groups were given continuous treatment of three menstrual cycl. Clinical efficacy, dysmenorrhea symptom score, visual analogue scale (VAS), the MOS item short from health survey (SF-36) score and traditional Chinese medical syndrome score were compared between two groups. Results Clinical effect of treatment group was better than that of control group, the difference was statistically significant (P < 0.05). The overall analysis showed that there were significant differences in dysmenorrhea symptom score, VAS score and SF-36 score between groups, time points and interaction (P < 0.05). Intra group comparison: dysmenorrhea symptom score and VAS score of two groups after treatment and three months after drug withdrawal were lower than those before treatment, and SF-36 score of two groups after treatment and three months after drug withdrawal was higher than that before treatment, the differences were statistically significant (P < 0.05); dysmenorrhea symptom score and VAS score of control group three months after drug withdrawal were higher than those after treatment, and SF-36 score of control group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05); VAS score of treatment group three months after drug withdrawal was higher than that after treatment, and SF-36 score of treatment group three months after drug withdrawal was lower than that after treatment, the differences were statistically significant (P < 0.05). Comparison between groups: dysmenorrhea symptom score and VAS score of treatment group were lower than those of control group, and SF-36 score of treatment group was higher than that of control group, the differences were statistically significant (P < 0.05). The scores of irritability, cold sweat, nausea and vomiting, anal distension in two groups after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of breast pain and limb chills in treatment group after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). The scores of irritability and limb chills in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Danggui Sini Decoction can improve clinical effect of patients with primary dysmenorrhea of syndrome of coagulation cold due to blood deficiency, reduce dysmenorrhea symptom score and VAS score, increase SF-36 score, and improve menstrual irritability, cold sweat, nausea and vomiting, anal distension, breast pain and limb chills.
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[1] 谢幸，孔北华，段涛.妇产科学[M].9版.北京：人民卫生出版社，2018：351-352.
[2] 张仲景.伤寒论[M].北京：人民卫生出版社，2014：95.
[3] 罗颂平，刘雁峰.中医妇科学[M].3版.北京：人民卫生出版社，2016：100.
[4] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：243.
[5] 谭冠先.疼痛诊疗学[M].3版.北京：人民卫生出版社，2011：12.
[6] 李鲁，王红妹，沈毅.SF-36健康调查量表中文版的研制及其性能测试[J].中华预防医学杂志，2002，36（2）：109-113.
[7] 肖承悰.中医妇科临床研究[M].北京：人民卫生出版社，2009：94.
[8] 王丹丹，王东梅，蔡平平，等.温经化瘀止痛法治疗原发性痛经的临床疗效及其对T细胞亚群的调控机制[J].中国实验方剂学杂志，2020，26（20）：94-99.
[9] 向曦.自拟温阳活血方与脐疗治疗寒凝血瘀型原发性痛经临床疗效及安全性对比观察[J].湖北中医杂志，2020， 42（6）：32-34.
[10] 刘卉，张涵，李珂.郑惠芳从”因虚、积冷、结气”辨治痛经经验[J].山东中医杂志，2021，40（8）：779-783.
[11] 刘伟平，滕秀香.温经汤加减改善原发性痛经寒凝血瘀证疼痛症状的临床研究[J].中国临床医生杂志，2021， 49（7）：872-875.
[12] 王熙月，伍涛，邱天.温经汤治疗寒凝血瘀型痛经运用探讨[J].湖北中医药大学学报，2021，23（3）：53-56.
[13] 张介宾.景岳全书·妇人规[M].北京：人民卫生出版社，2017：791.
[14] 田代华.黄帝内经素问[M].北京：人民卫生出版社，2017：77.
[15] 任晴，王昕.原发性痛经患者中医体质分布特征及其相关因素研究[J].世界中西医结合杂志，2020，15（5）：892-895.
[16] 陶弘景.名医别录[M].北京：人民卫生出版社，1986：112.
[17] 汪昂.本草备要[M].太原：山西科学技术出版社，2015：110.
[18] 黄元御.长沙药解[M].北京：中国医药科技出版社，2017：125.
[19] 王国强.全国中草药汇编[M].北京：人民卫生出版社，2014：71.
[20] 南京中医药大学.中药大辞典[M].北京：人民卫生出版社，2017：60.
[21] 李乐之，姚树桥.慢性疼痛患者生活质量影响因素的路径分析[J].中华行为医学与脑科学杂志，2010，19（4）：319-321.
[22] 孙艳明，王玲，吕仕超.痛经相关症状对女大学生经期生活质量的影响[J].天津中医药，2010，27（5）：375-377. |
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