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| Analysis of medication rule of traditional Chinese medicine in the treatment of children with cough variant asthma based on data mining#br# |
| LYU Xianwei CHENG Shuang FANG Shunshun ZHANG Ziwei SUN Taoyu |
| Department of Pediatrics , Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China |
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Abstract Objective To analyze the medication rule of traditional Chinese medicine in the treatment of children with cough variant asthma (CVA) based on data mining, in order to provide theoretical basis for the guidance of clinical rational prescription of children with CVA. Methods Literature related to traditional Chinese medicine treatment of CVA in children was retrieved from CNKI, VIP, and Wanfang databases from the establishment of the database to December 2020, frequency statistics, association rule analysis, and systematic cluster analysis were conducted. Results A total of 284 prescriptions were included, involving 222 drugs, and 18 high-frequency drugs were screened out; Semen Armeniacae Amarum, Herba Ephedrae, and Radix Glycyrrhizae were used more frequently; the main types of drugs were dissipating phlegm and relieving cough and asthma, tonifying deficiency, calming liver and extinguishing wind; the property of drugs were mainly cold, warm, and flat; the tastes of drugs were mainly bitter, pungent, and sweet; the main meridians were lung, spleen, and stomach meridians; there were nine binomial association rules through analyzing the association rules; six core drug groups were obtained by systematic cluster analysis. Conclusion Traditional Chinese medicine prescriptions for children with CVA mainly include dispelling wind and relieving spasmolysis, descending qi and relieving asthma, nourishing yin and clearing heat, besides, insect drugs can be used to extinguish wind of lung meridian.
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