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2021 Vol. 18, No. 31 Published: 2021-11-05

	4	Study of the in vitro stress culture of New Zealand rabbit carotid artery
		FU Haiyang1 LI Min1,2 YU Hao1,2 FU Bufang1 WANG Zhaoxu1
		Objective To study the changes of vascular structure in vitro stress culture of carotid artery in New Zealand rabbits by adjusting the parameters of fluid flow, flow rate and periodic pulsation. Methods Carotid arteries of SPF New Zealand rabbits were put in a bioreactor to establish the vessel culture model in vitro. There were four groups, the static group was static culture, and the dynamic groups (group 80, group 50 and group 25) were maintained under the same operating displacement and frequency of pulse pump, and the flow rates of culture medium were 80, 50 and 25 ml/min, respectively, to maintain the stress state culture. After the culture, the changes of vascular structure were evaluated by HE, Masson and EVG staining. Results In static group, vascular endothelial cells remained intact, smooth muscle cells were arranged in disorder, elastic fibers contracted sharply, and collagen fibers remained basically unchanged at 15 days. In group 80, elastic fibers did not change significantly, and endothelial cells could not be seen，and the smooth muscle in the 8th day was more orderly than that in the 4th day, and collagen fibers decreased significantly in the 8th day. In group 50, endothelial cells were not visible, smooth muscle cells were arranged in order, elastic fibers became loose and flat at the 15th days, and vascular collagen fibers decreased significantly. In group 25, the changes of elastic fibers and collagen fibers were milder than those in group 50. Conclusion Under the condition of simulating various parameters in vivo, the dynamic culture of blood vessels in vitro is helpful to maintain the physiological structure of blood vessels. The difficulty of culture is to prevent pollution and supplement collagen. Under the condition of high stress, vascular endothelial cells will be damaged, resulting in the proliferation of smooth muscle cells and the more serious loss of collagen fibers.
		2021 Vol. 18 (31): 4-6,16 [Abstract] ( 73 ) HTML (1 KB) PDF (699 KB) ( 13 )

	7	Effect of Tasosartan on human renal tubular epithelial cells induced by glucose and oxygen deprivation and its mechanism
		LIU Xiujuan1▲ WU Yu2 ZOU Xin1 YU Yanyan1 GENG Yanqiu3▲ SHUANG Feng4
		Objective To investigate the effect of Tasosartan on human renal tubular epithelial cells (HK-2) induced by glucose and oxygen deprivation and its mechanism. Methods HK-2 cells were divided into control group (normal culture), glucose and oxygen deprivation group (glucose and oxygen deprivation culture) and Tasosartan group (glucose and oxygen deprivation cells were cultured with Tasosartan). MTT assay was used to detect cell proliferation, flow cytometry was used to detect cell apoptosis, Western blot analysis of α-smooth muscle actin (α-SMA), type Ⅰ collagen (Col Ⅰ), fibronectin (Fibronectin), E-cadherin (E-cadherin), glucose-regulated protein 78 (GRP78), C/EBP-homologous protein (CHOP), and toll-like receptor 4 (TLR4); meanwhile, the effect of TLR4 overexpression on HK-2 cells was detected. Results The cell proliferation rate in 15 μmol/L Tasosartan group was lower than that in glucose and oxygen deprivation group (P < 0.05). 10 μmol/L Tasosartan was selected as the concentration of glucose and oxygen deprivation HK-2 cells. The apoptosis rate of Tasosartan group was lower than that of glucose and oxygen deprivation group, the protein expression of α-SMA, Col Ⅰ and Fibronectin was lower than that of glucose and oxygen deprivation group, the protein expression of E-cadherin was higher than that of glucose and oxygen deprivation group, and the protein expression of GRP78 and CHOP were lower than those of glucose and oxygen deprivation group (P < 0.05). The expression of TLR4 in Tasosartan+ PCDNA3.1-TLR4 group was higher than that in Tasosartan group, and the apoptosis rate was higher than that in Tasosartan group, the protein expression of α-SMA, Col Ⅰ, Fibronectin, GRP78, and CHOP was higher than those in Tasosartan group, while the protein expression of E-cadherin was lower than that in Tasosartan group (P < 0.05). Conclusion Tasosartan can reduce endoplasmic reticulum stress in HK-2 cells cultured with glucose and oxygen deprivation, thereby attenuating the cell damage induced by glucose and oxygen deprivation, and its effect is produced by inhibiting TLR4.
		2021 Vol. 18 (31): 7-11 [Abstract] ( 91 ) HTML (1 KB) PDF (1339 KB) ( 10 )

	12	Visual analysis of research hotspots and trends of drug-food homology based on CiteSpace
		DENG Siqi PAN Xiaoyan XIAO Ziwei LI Fang
		Objective To understand the research hotspots and trends in the field of drug-food homology, and to provide reference for deeper and broader research in the future. Methods Literatures on drug-food homology were searched from CNKI database from base-building to November 2020, and CiteSpace 5.7.R1 software was used for visual analysis of authors, institutions and keywords. Results A total of 1282 articles were included, and the total number of articles was on the rise. The largest articles number of institution was Heilongjiang University of Chinese Medicine, but lack of cooperation between the author teams and research institutions. The research focuses mainly on the drug-food homology, antioxidation, safety, health food and related diseases, etc. Conclusion The research teams and institutions should carry out interdisciplinary and cross regional cooperation and exchanges; the research direction is to increase high-level mechanism research, explore more dominant diseases of drug-food homology, and strengthen the discussion of traditional Chinese medicine classics and the theory of drug-food homology.
		2021 Vol. 18 (31): 12-16 [Abstract] ( 107 ) HTML (1 KB) PDF (1592 KB) ( 19 )

	17	Knowledge graph analysis of clinical research progress of traditional Chinese medicine prevention of deep vein thrombosis based on CiteSpace#br#
		WANG Yingrui1 LIU Zheng2 LIU Guoyan1 WANG Hongjie1
		Objective To analyze the knowledge graph of the clinical research progress of traditional Chinese medicine prevention of deep vein thrombosis based on CiteSpace software. Methods Literatures related to the prevention of deep vein thrombosis by traditional Chinese medicine from inception to December 2020 of China National Knowledge Infrastructure database were searched, and CiteSpace software was used for measurement and visualization analysis. Results A total of 810 articles were included, and the number of articles published showed a trend of steady growth year by year. Ten high-yielding authors formed four stable teams. Luoyang Orthopedic-Traumatological Hospital of Henan Province was the institution with the most articles published, with key words Shuxuetong Injection, Xuefu Zhuyu Decoction and so on. Conclusion The prevention of deep vein thrombosis by traditional Chinese medicine has attracted more and more attention, and research forms are diverse. In the future, it is still necessary to strengthen cooperation and conduct multi-disciplinary and multi-center research.
		2021 Vol. 18 (31): 17-21,33 [Abstract] ( 165 ) HTML (1 KB) PDF (1514 KB) ( 24 )

	22	Study on the mechanism of Chaihu Guizhi Decoction in the treatment of depression based on network pharmacology and molecular docking technology#br#
		LAN Shaohang1 LUO Jun1,2 LI Nana1 LUO Yehao1 CHEN Qiuxia1 CHEN Jingqin1 LI Hongyi1 FANG Gang1,3
		Objective To study the mechanism of Chaihu Guizhi Decoction in the treatment of depression by network pharmacology and molecular docking technology. Methods Traditional Chinese medicine systems pharmacology database and analysis platform was used to collect the main chemical components and targets of nine traditional Chinese medicines in Chaihu Guizhi Decoction. Depression related targets were obtained from GeneCards, pharmacogenomics knowledgebase, online Mendelian inheritance in man, DrugBank, TTD, and other databases. Proteinprotein interaction network of potential targets was constructed by using STRING online platform, and GO functional enrichment analysis and KEGG pathway analysis were obtained by R language. The “active component-disease target” network was constructed and topologically analyzed by Cytoscape3.7.2. Finally, AutoDock vina and other software were used to verify the molecular docking between the active ingredients with high network intermediate value and the core target. Results A total of 154 chemical constituents including quercetin and kaempferol were screened and 250 related targets were identified, among which the key targets were JUN, Akt1, and ESR1. A total of 2900 enrichment results were obtained by GO functional enrichment analysis, which mainly involved the regulation of biological processes such as lipopolysaccharide response and oxidative stress response. A total of 170 pathways were enriched by KEGG pathway analysis, mainly involving MAPK signaling pathway, PI3K-Akt signaling pathway, etc. The molecular docking results showed that the main active ingredients had strong binding ability with the core target. Conclusion This study preliminarily shows that Chaihu Guizhi Decoction plays a synergistic role in the treatment of depression through multiple components, multiple targets and multiple pathways.
		2021 Vol. 18 (31): 22-27 [Abstract] ( 106 ) HTML (1 KB) PDF (1533 KB) ( 89 )

	28	Research hotspots and trend analysis of health industry development of traditional Chinese medicine in the field of “Healthy China” from 2006 to 2020#br#
		JIANG Yijiao ZHANG Siwen JIANG Qingdan MA Yuedan LIANG Xu
		Objective To explore the research hotspots and trend of health industry of traditional Chinese medicine under the background of “Healthy China”. Methods With the help of CiteSpace and bibliometric methods, taking CNKI as the literature database, “traditional Chinese medicine health” or “traditional Chinese medicine industry” as keywords, the literatures related to traditional Chinese medicine health industry from January 2006 to December 2020 were searched and screened. Results A total of 1239 valid literatures were obtained. The researches were divided into steady stage and rapid development stage by the annual number of published papers; the distribution of authors co-occurrence atlas was mainly scattered, a stable core author cluster had not been formed. There was a certain cooperative relationship between institutions, but the overall research power was relatively weak; and there were 11 categories in the related clustering sets, the industry and culture of traditional Chinese medicine, health tourism of traditional Chinese medicine, combination of medical treatment and endowment, and health management were the focus of this research field. Conclusion The health industry of traditional Chinese medicine in China is booming, which is in the early stage, but it has broad prospects. Based on keywords’s cluster analysis, health tourism of traditional Chinese medicine, multi-industry synergetic development paths, cultural output of traditional Chinese medicine and technological intelligent products may become the future research hotspots in the field.
		2021 Vol. 18 (31): 28-33 [Abstract] ( 60 ) HTML (1 KB) PDF (2133 KB) ( 100 )

	34	Expression of miR-21-5p in oral submucosal fibrotic cancerous cells and bioinformatics analysis#br#
		HU Zhaoyong1 TAN Jin2 CHEN Ming2 YANG Qingze3 LIU Yanli3
		Objective To observe the expression of miR-21-5p in oral submucosal fibrotic cancerous cells and its bioinformatics analysis. Methods The primary oral mucosal epithelial cells of rats were divided into experimental group and normal control group. The experimental group was induced with areca nut extract of 50 μg/ml, and the model of oral submucosal fibrotic cancerous cells was established. RT-qPCR was used to detect the expression of miR-21-5p in the two groups, and 30 databases including miRDB and TargetScan were used to predict the target genes of hsa-miR-21-5p, and functional enrichment analysis and signal pathway enrichment analysis were performed. Results RT-qPCR results showed that the expression of miR-21-5p in the experimental group was higher than that in the control group, and the difference was highly statistically significant (P ＜ 0.01). The results of bioinformatics analysis showed that Smad7, PLAG1, and TGF-β1 ranked the top three in the comprehensive score of miR-21-5p target gene prediction. MiR-21-5p target genes were mainly enriched in cellular macromolecular metabolism, intracellular organelles, and other components and protein enzyme aggregation, while the signaling pathways were significantly enriched in MAPK and other signaling pathways. Conclusion MiR-21-5p is highly expressed in oral submucosal fibrotic cancerous cells. Smad7 may influence oral submucosal fibrotic carcinogenesis by mediating the cross-dialogue between miR-21-5p and TGF-β.
		2021 Vol. 18 (31): 34-37,41 [Abstract] ( 80 ) HTML (1 KB) PDF (486 KB) ( 25 )

	37	Effect of Shenxiong Glucose Injection on permeability of blood-cerebrospinal fluid barrier in hypoperfusion rats#br#
		FENG Peipei ZHANG Qianying HUANG Yan LI Yongjie LIU Kun LI Min
		Objective To study the effect of Shenxiong Glucose Injection on the permeability of blood-cerebrospinal fluid barrier in hypoperfusion rats. Methods Sixty SPF male SD rats were divided into sham operation group, hypoperfusion group and Shenxiong group by random number table method, with 20 rats in each group. In the hypoperfusion group and Shenxiong group, the common carotid artery was ligation to make an animal model of cerebral ischemia, while in the sham operation group, only the common carotid artery was exposed without ligation. Shenxiong group was intraperitoneally injected with Shenxiong Glucose Injection 24 mg/kg, sham operation group and hypoperfusion group were intraperitoneally injected with normal saline. Serum albumin (SAlb) and cerebrospinal fluid albumin (CAlb) were determined by enzyme linked immunosorbent assay. The mRNA of ZO-1 and Occludin in choroid plexus was detected by real-time fluorescence quantitative PCR. The fluorescence intensity of ZO-1 and Occludin in choroid plexus was detected by laser confocal method. Results CAlb and serum albumin and cerebrospinal fluid quotient (QAlb) in the hypoperfusion group were higher than those in the sham operation group, and CAlb and QAlb in the Shenxiong group were lower than those in the hypoperfusion group, with statistical significance (P ＜ 0.05). There was no significant difference in SAlb between the hypoperfusion group and sham operation group (P ＞ 0.05). There was no significant difference in SAlb between the Shenxiong group and hypoperfusion group (P ＞ 0.05). The mRNA and fluorescence intensity of ZO-1 and Occludin in the hypoperfusion group were lower than those in the sham operation group, and the mRNA and fluorescence intensity of ZO-1 and Occludin in the Shenxiong group were higher than those in the hypoperfusion group, with statistical significance (P ＜ 0.05). Conclusion The permeability of blood-cerebrospinal fluid barrier increased in rats under hypoperfusion state, and Shenxiong Glucose Injection had protective effect on blood-cerebrospinal fluid barrier to some extent.
		2021 Vol. 18 (31): 37-41 [Abstract] ( 84 ) HTML (1 KB) PDF (543 KB) ( 11 )

	42	Research progress on the mechanism of mitochondrial structural and functional homeostasis imbalance after cerebral ischemia / reperfusion injury#br#
		WU Dan1 QI Zhongwen1 ZHANG Wei1 MA Yan2
		[Abstract] Ischemic stroke is a disease characterized by high mortality, high disability rate and low cure rate. Ischemia/reperfusion injury caused by blood flow recanalization after stroke will cause more serious damage to brain tissue, the destruction of mitochondrial structure and function homeostasis is one of the main pathological links. The changes of mitochondrial structure and function after cerebral ischemia / reperfusion injury have great significance to promote the neuronal protection of ischemic brain injury. In recent years, the research on mitochondrial homeostasis imbalance such as mitochondrial oxidative stress, permeability transition pore, calcium overload and mitochondrial autophagy has become more theoretical and systematic, and the interaction mechanism with cerebral ischemia / reperfusion injury has become more clear. This paper summarizes and discusses the specific mechanism of mitochondrial structural and functional homeostasis imbalance after cerebral ischemia / reperfusion injury, in order to provide new ideas and methods for the clinical application of ischemic stroke.
		2021 Vol. 18 (31): 42-45，66 [Abstract] ( 133 ) HTML (1 KB) PDF (593 KB) ( 74 )

	46	Research progress on pyroptosis and its role in atherosclerosis#br#
		XU Lu1 WANG He2 YUE Ke1 WEI Ke1 XIE Jinhong2 GUAN Huaimin2
		Pyroptosis is a new type of programmed cell death, which is significantly different in form from traditional cell death such as apoptosis and necrosis. Atherosclerotic cardiovascular disease seriously affects the physical and mental health of residents. Recent studies have found that vascular endothelial cells, macrophages and smooth muscle cells all experience pyroptosis, which affects the development process of atherosclerosis. This article intends to review the relationship between pyroptosis and atherosclerosis, in order to provide new ideas and find new directions for the treatment of cardiovascular diseases.
		2021 Vol. 18 (31): 46-49 [Abstract] ( 190 ) HTML (1 KB) PDF (572 KB) ( 29 )

	50	Research progress of FAM83A in malignant tumors#br#
		ZHU Qiumin XU Min
		FAM83A, namely the family with sequence similarity 83 member A gene, is a protein-coding gene containing domain 1669 whose function remains to be defined. Initially identified as a potential tumor gene, it is up-regulated in lung cancer, liver cancer, breast cancer, and other malignant tumors, promoting cancer cell proliferation, migration, invasion, epithelial-mesenchymal transformation, and other functions. Current studies suggest that a variety of microRNAs can act as tumor suppressor genes, and circRNA or long non-coding RNA is its upstream, directly or indirectly targeting FAM83A to form an axis to act on signaling pathways and inhibit the occurrence and development of cancer. However, the specific molecular mechanism remains to be further studied. This article reviews the expression and role of FAM83A in malignant tumors.
		2021 Vol. 18 (31): 50-53 [Abstract] ( 154 ) HTML (1 KB) PDF (571 KB) ( 45 )

	54	Research status of long non-coding RNA in the occurrence and development of colorectal cancer#br#
		WANG Tong1* WANG Jinge2,3* JIA Chen1 HUANG Jingjing1 HUO Xiaoyan4 MENG Qinghui1 LIANG Desen1 PAN Huayang1
		Colorectal cancer is one of the most common malignant tumors of the digestive tract. Its incidence and mortality are increasing year by year. Because its early symptoms are not obvious, it is mostly in the advanced stage when it is discovered, leading to poor prognosis and survival. Long non-coding RNA is an RNA molecule, which consists of more than 200 nucleotides in length and lacks protein-coding functions, but it has a crucial regulatory role at the level of epigenetic, transcription, post-transcriptional. Studies find that long non-coding RNA is closely related to the occurrence and development of colorectal cancer, the underlying mechanism mainly includes direct binding with RNA, DNA, and protein to play a biological role. Therefore, this article describes the research progress of long non-coding RNA in colorectal cancer, which can provide a theoretical basis and practical direction for a specific diagnosis, targeted therapy and prognostic evaluation of colorectal cancer.
		2021 Vol. 18 (31): 54-57 [Abstract] ( 129 ) HTML (1 KB) PDF (572 KB) ( 40 )

	58	Research progress in animal models of bronchiectasis#br#
		TIAN Li ZHANG Shaoyan WU Xianwei QIU Lie LIU Xifang WU Dingzhong ZHANG Huiyong LU Zhenhui
		Bronchiectasis is a chronic inflammatory bronchial disease caused by infection and bronchial obstruction. It is characterized by repeated attacks and long treatment course. Due to the increased incidence and mortality of the disease, it has gradually attracted worldwide attention. Previous studies in China mostly adopte endotracheal infusion of Pseudomonas aeruginosa to establish the model of bronchiectasis in rats. Foreign studies mostly use the mouse model of bronchiectasis. In recent years, organoid models have been added to provide more alternative models for basic research on bronchiectasis. In this review, we reviewed the progress of the mouse model of new bronchiectasis, including alginate, agar or agarose globules, endotracheal intubation with Pseudomonas aeruginosa, Mycobacterium abscess, and Stomatococcus mucilaginosus. The model of bronchiectasis is established in IFT88, Cby, Pkd2, and other ciliated gene knockout mice, and the model of respiratory tract organ such as human lung organ and gas-liquid interface tissue culture was established for reference in the study of this disease.
		2021 Vol. 18 (31): 58-62 [Abstract] ( 36 ) HTML (1 KB) PDF (579 KB) ( 478 )

	63	Research progress on the synergistic effect of polysaccharides and bioactive small molecules in pharmacokinetics and pharmacodynamics#br#
		QIN Zhiwei DONG Wenting REN Xiaolei LIU Xiaodong HUO Jinhai
		Polysaccharides is a kind of macromolecular substances widely existed in organic organisms, which have been paid increasingly attention on the field of medicine at home and abroad, because of their pharmacological effects, such as immunomodulatory, antitumor, antioxidant, depressing blood glucose, and so on. In this paper, two forms of binding of polysaccharides to active components of small molecules are summarized. In terms of pharmacokinetics, polysaccharides promote absorption and distribution of active components of small molecules in vivo, and its synergistic mechanism in pharmacodynamics with immunomodulatory, anticancer and hypoglycemic drugs provides theoretical basis for the research and development of polysaccharide related drugs.
		2021 Vol. 18 (31): 63-66 [Abstract] ( 44 ) HTML (1 KB) PDF (570 KB) ( 188 )

	67	Teaching innovation of research and development of new Chinese medicine course in our university#br#
		WANG Lisheng WU Ying ZHANG Yingfeng CAO Hongying YUAN Jie
		With the increasing recognition of traditional Chinese medicine in society, more and more people believe that traditional Chinese medicine is irreplaceable. For the development of traditional Chinese medicine, traditional Chinese medicine colleges and universities play an important role in traditional Chinese medicine teaching and product innovation research and development. According to the characteristics of research and development of new Chinese medicine course and the present situation of teachers’ teaching style and students’ study style in Guangzhou University of Chinese Medicine, this paper puts forward several measures to improve the teaching quality and students’ learning level: At the level of teachers, establishing teaching teams, improving teaching methods and advocating the use of network resources; in terms of students, adjusting their learning attitude, cultivating their thoughts and promoting traditional Chinese medicine culture; school level, advocating school policy intervention and so on. Finally, the effect and significance of the teaching reform are reviewed. The teaching innouation is based on the cultivating innovative talents and the ultimate goal is to promote the continuous development and progress of traditional Chinese medicine.
		2021 Vol. 18 (31): 67-70 [Abstract] ( 85 ) HTML (1 KB) PDF (747 KB) ( 52 )

	71	Research on the integration of “moving to the west spirit” into medical ethics education of medical students#br#
		CAO Zhuolin1,2 LIU Renjing2 LIU Ning3
		With the continuous development of China’s medical and health undertakings, medical talents with noble medical ethics are of vital importance to the development of the country, universities and society. Combining with the social cognition theory, this paper summarizes the theoretical basis and practical value of integrating the “moving to the west spirit” into medical ethics education of medical students, and puts forward the methods to change individual cognition, such as increasing individual self-efficacy and improving outcome expectation; building a strong campus cultural environment and other ways to improve medical students’ medical ethics education level lay a foundation for effectively improving medical students ideological and political education.
		2021 Vol. 18 (31): 71-74 [Abstract] ( 46 ) HTML (1 KB) PDF (687 KB) ( 10 )

	75	Teaching ward round based on multi-angle traditional Chinese medicine classic dialectical thinking#br#
		HOU Jiarui1 YAO Meiyu2
		In the teaching of traditional Chinese medicine, the mode of thinking is the core and soul of clinical curative effect. Clinical thinking of traditional Chinese medicine should be cultivated in practice. Teaching ward round is a good way to study and strengthen clinical thinking of traditional Chinese medicine. The teaching should take the clinical case as the breakthrough point, combine the system of disease differentiation and syndrome differentiation, and use the form of question and answer to narrate the clinical thinking method of traditional Chinese medicine, in the standardized and orderly mode of thinking guidance, teaching students identification, legislation, using side, at the same time, uhder the traditional Chinese medicine classic background, the multi-angle thinking mode is put forward characteristics, for the future teaching of Chinese medicine to open up new ideas.
		2021 Vol. 18 (31): 75-78 [Abstract] ( 50 ) HTML (1 KB) PDF (689 KB) ( 163 )

	79	Application of health education salon for doctors, nurses and patients in medical nutrition support for patients with type 2 diabetes mellitus#br#
		ZHUANG Lei XU Yajuan LI Mengde YUAN Cuiping▲
		Objective To explore the application effect of health education salon for doctors, nurses and patients with type 2 diabetes mellitus in medical nutrition support. Methods A total of 130 patients with type 2 diabetes mellitus who were admitted to Jiangsu Provincial People’s Hospital from July 2018 to June 2019 were selected and divided into 65 cases in the experimental group and 65 cases in the control group by random number table method. The control group was given regular health education, and the experimental group was combined with health education based on the salon model of doctors, nurses and patients. The two groups were followed up for six months and the dietary control behavior, glucose and lipid metabolism level and quality of life were compared between the two groups. Results The follow-up was six months, 62 cases and 56 cases were actually completed in the experimental group and control group respectively. The experimental group dietary self-control, glycolipid self-control, oil-salt self-control, fruit and vegetable self-control, and the overall compliance rate of diet control were higher than those of the control group (P ＜ 0.05); fasting plasma glucose, 2 h blood glucose after meal, glycosylated hemoglobin, triacylglycerol, and total cholesterol were all lower than those of the control group (P ＜ 0.05); the scores of physiological function, psychological function, treatment, and overall quality of life of the test group were lower than those of the control group (P ＜ 0.05). Conclusion The health education salon for doctors, nurses and patoents can help promote the development of diet control behaviors, control the level of glucose and lipid metabolism, and improve the quality of life in medical nutrition support for patients with type 2 diabetes millitus.
		2021 Vol. 18 (31): 79-82,95 [Abstract] ( 128 ) HTML (1 KB) PDF (714 KB) ( 11 )

	83	Thoughts and suggestions on postgraduate training of orthopedics and traumatology of traditional Chinese medicine under the mode of medical teaching research cooperation#br#
		SONG Xin1 ZHANG Chao2
		With the promotion of healthy China and the strategy of strengthening the country with talents, as well as the implementation of Outline of Strategic Planning for the Development of Traditional Chinese Medicine and Development Plan for Health Services of Traditional Chinese Medicine, the postgraduate education of orthopedics and traumatology of traditional Chinese medicine has ushered in a new opportunity of inheritance and innovation. The author in the actual postgraduates teaching management, the author thinks about the problems existing in the current education of postgraduates majoring in orthopedics and traumatology of traditional Chinese medicine. In view of the new needs of the society for the cultivation of talents majoring in orthopedics and traumatology of traditional Chinese medicine in the new era, the author proposes to construct students’ thinking of traditional Chinese medicine under the cooperation mode of medical teaching and research, shape the humanistic spirit, strengthen the education of teachers, innovate the teaching mode, and enhance the output of academic research achievements. The corresponding suggestions are expected to have new ideas and inspiration for the cultivation of postgraduates majoring in orthopedics and traumatology of traditional Chinese medicine in the new era.
		2021 Vol. 18 (31): 83-86,107 [Abstract] ( 74 ) HTML (1 KB) PDF (1105 KB) ( 230 )

	87	Practice and thinking on graduation internship work of undergraduates majoring in Chinese medicine#br#
		WANG Liang1,2 MIN Wen1,2 WEI Wenxia3▲
		Graduation internship is an important link in the training process of Chinese medicine professionals, the effect of graduation internship work is directly related to the quality of Chinese medicine talent training. Nanjing University of Chinese Medicine has been exploring and practicing in its graduation internship work for many years. Through optimizing the management system of graduation internship, fixing the admittance standard of graduation internship, strengthening the construction of internship bases, establishing the whole period examination and evaluation system for internship and other teaching reform measures, the graduation internship work is meticulous, exquisite, solid, and skillful and the internship management system of Chinese medicine has been further improved, which effectively improves the training quality of students majoring in Chinese medicine, and provides certain reference and guidance for the graduation internship of undergraduates majoring in Chinese medicine in colleges and universities.
		2021 Vol. 18 (31): 87-90 [Abstract] ( 37 ) HTML (1 KB) PDF (748 KB) ( 115 )

	91	Application effect of formative evaluation in clinical practice teaching of nursing students in traditional Chinese medicine colleges and universities#br#
		ZHENG Yaojie1 ZHANG Peiling2▲ DENG Hao3 NI Meiqin4
		Objective To explore the influence of formative evaluation on self-learning ability and critical thinking ability of nursing students in traditional Chinese medicine colleges and universities. Methods A total of 73 nursing students majoring in nursing from July to December 2019 in Changzhou Hospital of Traditional Chinese Medicine in Jiangsu Province were selected and divided into control group (37 students) and experimental group (36 students) by random number table method. The two groups carried out the same practice of traditional Chinese medicine nursing theory and nursing skills according to the practice teaching syllabus. The control group adopted the summative evaluation method, and the experimental group carried out formative evaluation on a weekly basis. The internship rotation duration was six months. At the end of the practice, the two groups were compared in theoretical and operational assessment results, independent learning ability, and critical thinking ability. Results The theoretical and operational assessment average results of experimental group was higher than that of control group (P ＜ 0.05). At the end of the internship, the scores of learning motivation, self-management ability, learning cooperation ability, information literacy, and the total score of independent learning ability of the two groups were higher than before, and the experimental group was higher than the control group, the differences were statistically significant (P ＜ 0.05). At the end of the practice, the scores of the truth seeking, open mind, analytical ability, systematic ability, self-confidence, desire for knowledge, cognitive maturity and the total scores of critical thinking of the two groups were higher than before the practice; the scores of truth seeking, analytical ability, self-confidence, desire for knowledge, cognitive maturity and the total scores of critical thinking in the experimental group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Formative evaluation can promote the cultivation of independent learning ability and critical thinking ability of nursing students and improve the effect of practice.
		2021 Vol. 18 (31): 91-95 [Abstract] ( 75 ) HTML (1 KB) PDF (700 KB) ( 17 )

	96	Short-term clinical observation of Belimumab in the treatment of systemic lupus erythematosus#br#
		XU Lei1 ZHU Yun2 ZHANG Hao1
		Objective To evaluate the efficacy and safety of Belimumab in the treatment of systemic lupus erythematosus（SLE）. Methods A total of 42 patients who were diagnosed with SLE from the Department of Rheumatology and Immunology, Weifang People’s Hospital from September 2019 to August 2020 were selected. According to the treatment regimen, patients were divided into SoC (stand of care) group (21 cases) and Belimumab group (21 cases) (standard treatment + Belimumab). The clinical efficacy, complement, immunoglobulin G (IgG) levels were compared between the two groups, hormone dose, disease activity index (SLEDAI), and, adverse events were compared between the two groups. Results After treatment, the total effective rate of Belimumab group was higher than that of SoC group, and the difference was statistically significant (P ＜ 0.05). C3 and C4 in the two groups were higher than before treatment, and IgG was lower than before treatment. Complement C3 and C4 in Belimumab group were higher than SoC group, and IgG was lower than SoC group, with statistical significance (P ＜ 0.05); there was no significant difference in hormone dose between the two groups (P ＞ 0.05), SLEDAI score of the two groups was lower than before treatment, and Belimumab group was lower than SoC group, the differences were statistically significant (P ＜ 0.05); there was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Belizumab can improve the therapeutic effect in patients with systemic lupus erythematosus and is safe.
		2021 Vol. 18 (31): 96-99 [Abstract] ( 74 ) HTML (1 KB) PDF (551 KB) ( 7 )

	100	Comparison of Ticagrelor and Clopidogrel in patients with upper gastrointestinal bleeding within 12 months after drug-eluting stent implantation#br#
		HE Xiaoquan ZHOU Li GAO Xiangyu QIU Hui ZHAO Shumei SHEN Aidong CHEN Hui ZHAO Huiqiang▲
		Objective To compare the safety and effectiveness of Ticagrelor and Clopidogrel in patients with upper gastrointestinal bleeding within 12 months after drug-eluting stent implantation. Methods A total of 108 patients with upper gastrointestinal bleeding after dual antiplatelet therapy for less than 12 months after second-generation drug-eluting stent implantation in Beijing Friendship Hospital from January 2016 to August 2019 were selected. According to the P2Y12 inhibitor received before upper gastrointestinal bleeding, they were divided into Ticagrelor group (45 cases) and Clopidogrel group (63 cases). The clinical characteristics were summarized and the cumulative incidence of ischemic and bleeding events was compared between the two groups. Results The proportion of percutaneous coronary intervention treatment for ST-segment elevation myocardial infarction and acute coronary syndrome in Ticagrelor group was significantly higher than that in Clopidogrel group(P ＜ 0.05). The incidence of non-target vessel revascularization in Ticagrelor group was lower than that in Clopidogrel group, the difference was statistically significant (P ＜ 0.05), there were no significant differences in the characteristics of complications, coronary artery lesions, target vessel reconstruction, incidence of major adverse cardiovascular events, and serious bleeding events between the two groups (P ＞ 0.05). Kaplan-Meier survival analysis showed that the cumulative incidence of non-target vessel revascularization in the Ticagrelor group was lower than that in the Clopidogrel group (P ＜ 0.05). Conclusion Ticagrelor versus Clopidogrel reduces the risk of coronary ischemic events and does not increase the risk of bleeding in patients with upper gastrointestinal bleeding within 12 months after second-generation drug-eluting stenting.
		2021 Vol. 18 (31): 100-103 [Abstract] ( 80 ) HTML (1 KB) PDF (621 KB) ( 81 )

	104	Investigation of learning curve for the three-port laparoscopic appendectomy #br#
		WU Yadong ZHU Chunlin XI Weiwei
		Objective To investigate the related learning curve and of the three-port laparoscopic appendectomy （LA）. Methods A retrospective analysis was performed on the clinical data of 72 patients with acute appendicitis who underwent LA independently for the first time and continuously by the same attending physician in the Department of General Surgery of Chuzhou First People’s Hospital of Anhui Province from August 2018 to July 2020. According to the median operation time, 72 patients were divided into longer operation time group (37 cases) and shorter operation time group (35 cases). Univariate analysis was used to compare the factors influencing the operation time, and the factors with P ＜ 0.05 in univariate analysis were included in logistic regression analysis to calculate the factors influencing the operation time. The truncation value of LA learning curve was calculated by means of moving average line and analysis of variance test. Results Logistic regression analysis confirmed that surgical proficiency and body mass index were the final risk factors affecting the duration of surgery. The results showed that the learning curve of three-hole LA was about 48 cases. Conclusion For the surgeon who firstly perform LA independently, patients chosen with a small body wass index and short course can help reduce the difficulty of surgery and quickly cross the learning curve.
		2021 Vol. 18 (31): 104-107 [Abstract] ( 151 ) HTML (1 KB) PDF (576 KB) ( 13 )

	108	Feasibility of double-hole total thoracoscopic approach for mitral valve replacement #br#
		CHEN Yingqi1 LIU Yan2 GU Song2 SU Pixiong2 GAO Jie2▲
		Objective To investigate the safety and feasibility of double-hole total thoracoscopic mitral valve replacement with double orifice. Methods The clinical data of 90 patients with mitral stenosis admitted to Department of Cardiac Surgery, Beijing Chaoyang Hospital Capital Medical University from January 2015 to December 2016 were retrospectively analyzed. A total of 36 (40%) patients underwent complete thoracoscopic mitral valve replacement by double-hole total thoracoscopic approach. Fifty-four patients underwent conventional thoracotomy for mitral valve replacement. Perioperative variables and one year postoperative follow-up data were analyzed. Results Twenty-three patients (25.5%) underwent tricuspid valvuloplasty at the same time. There were no significant differences in total operation time, cardiopulmonary bypass time and myocardial blood supply blockade time between the two groups (P ＞ 0.05). The mean mechanical ventilation time of the total thoracoscopy group was shorter than that of the conventional thoracotomy group (P ＜ 0.05). The drainage volume of thoracoscopic thoracoscopy was less than that of conventional thoracotomy group (P ＜ 0.05). In the conventional thoracotomy group, one patient had secondary thoracotomy (1.8%). There were no deaths, perivalvular leakage, infective endocarditis, or pulmonary complications in one year of follow-up in both groups. Conclusion The double-hole total thoracoscopic approach for mitral value replacement is safe and feasible.
		2021 Vol. 18 (31): 108-110,114 [Abstract] ( 43 ) HTML (1 KB) PDF (564 KB) ( 68 )

	111	Effect of PASE in the treatment of simple grade Ⅲ and Ⅳ traumatic splenic rupture with hemorrhagic shock and its influence on immune function #br#
		ZHANG Yuxin YAN Jinliang TIAN Jingzhong
		Objective To investigate the effect of partial splenic artery embolization (PASE) in the treatment of simple grade Ⅲ and Ⅳ traumatic splenic rupture with hemorrhagic shock and its influence on immune function. Methods The clinical data of 86 patients with simple grade Ⅲ and Ⅳ traumatic splenic rupture complicated with hemorrhagic shock admitted to Bozhou People’s Hospital of Anhui Province from June 2017 to December 2020 were retrospectively analyzed, according to the operation method, they were divided into observation group and control group, with 43 cases in each group. The control group was treated with traditional surgery, and the observation group was treated with PASE. The perioperative situation, the changes of T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+), and the incidence of complications were compared between the two groups. Results The operation time, systolic blood pressure recovery time, ambulation time, and hospitalization time in the observation group were shorter than those in the control group, and the intraoperative blood loss of the observation group was less than those in the control group, and the differences were statistically significant (P ＜ 0.05); the differences of CD3+, CD4+, CD4+/CD8+ between the two groups, time point and interaction compared were statistically significant (P ＜ 0.05); the total incidence of complications the obseruation group was lower than that of the control group (P ＜ 0.05). Conclusion PASE in treatment of simple grade Ⅲ and Ⅳ traumatic splenic rupture with hemorrhagic shock have obvious effect, which is worth promoting.
		2021 Vol. 18 (31): 111-114 [Abstract] ( 47 ) HTML (1 KB) PDF (551 KB) ( 21 )

	115	Analysis of the efficacy of ultrasound guided brachial plexus anesthesia manipulation release combined with internal heat needles skeletal muscle attachment point release for frozen shoulder #br#
		LI Jing1 HUANG Ying1 ZHOU Jianbin2 ZHU Tong1 LIN Jian1 TAO Gaojian1
		Objective To investigate the clinical effect of ultrasound guided brachial plexus anesthesia manipulation release combined with internal heat needles skeletal muscle attachment point release for frozen shoulder. Methods A total of 62 patients diagnosed with frozen shoulder from January 2019 to June 2020 in the Department of Pain Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical College were selected as the research subjects. They were divided into group A and group B, according to the random number table method. Group A (30 cases) received ultrasound guided brachial plexus anesthesia manipulation release supplemented by oral non-steroidal drugs, and ordered shoulder joint exercise; on the basis of group A, group B (32 cases) underwent internal heat needles skeletal muscle attachment point release. Visual analogue scale (VAS) score and Constant-Murley shoulder function score were compared between two groups before and 7, 30, and 90 d after treatment; the clinical efficacy of two groups were compared, and the occurrence of adverse reactions during treatment was recorded. Results After treatment, VAS scores of both groups at each time point were significantly different from those before treatment, with statistical significance (P < 0.05); VAS scores in group B at each time point were lower than those in group A, with statistical significance (P < 0.05). After treatment, Constant-Murley shoulder function scores at each time point in both groups were significantly different from those before treatment, with statistical significance (P < 0.05); Constant-Murley shoulder function scores at each time point in group B were lower than those in group A, with statistical significance (P < 0.05). At 7, 30, and 90 days after treatment, there were statistical significance in good improment rate between two groups (P < 0.05). There were no complications such as nerve injury, local anesthetic poisoning, and injury of muscles and tendons around shoulder in both groups. Conclusion Ultrasound guided brachial plexus anesthesia manipulation release combined with internal heat needles skeletal muscle attachment point release is reliable and has the advantages of high safety, quick effect, lasting effect and few adverse reactions.
		2021 Vol. 18 (31): 115-118,127 [Abstract] ( 79 ) HTML (1 KB) PDF (1032 KB) ( 45 )

	119	Minimum local analgesic concentration of Ropivacaine combined with Hydromorphone for epidural labor analgesia during incubation period using sequential allocation method#br#
		WANG Kegong WANG Haijin ZHANG Zhen LUO Huiyu
		Objective To determine the minimum local analgesic concentration (MLAC) and 90% effective concentration (EC90) of Ropivacaine combined with Hydromorphone for epidural labor analgesia during latent period. Methods Thirty cases of singleton primiparous admitted to Xiangyang NO.1 People’s Hospital, Affiliated Hospital of Hubei University of Medicine from June 2019 to January 2020 were selected as study objects. All parturients entered the incubation period of the first stage of labor, L2-3 was selected for epidural labor analgesia, and 10 ml of Ropivacaine mixed with 15 μg/ml Hydromorphone was given. According to the modified sequential allocation method to increase or decrease the concentration of Ropivacaine, the initial concentration was 0.07%, the concentration gradient was 0.01%. Visual analogue scale (VAS) was used to evaluate the analgesia effect. If VAS score ≤3 points, the next patient was reduced a concentration gradient; if VAS score >3 points, after giving 6 ml of dose 0.1% Ropivacaine mixed with 0.5 μg/ml Sufentanil to remedy and VAS score≤3 points, the following one patient was increased a concentration gradient; if after giving remedy drugs and VAS score >3 points, this case was eliminated, and the next patient was repeated this concentration. VAS score during contractions were recorded before injection, 5, 15, and 30 min after injection. MLAC and EC90 of Ropivacaine were calculated by probability unit regression analysis. Results MLAC of Ropivacaine combined with Hydromorphone for epidural labor analgesia in incubation period was 0.035%, and EC90 was 0.049%. Conclusion MLAC of Ropivacaine combined with Hydromorphone for epidural labor analgesia in incubation period is 0.035%, and EC90 is 0.049%, it can be safely used for epidural labor analgesia with fast analgesic effect and few adverse reactions.
		2021 Vol. 18 (31): 119-122 [Abstract] ( 26 ) HTML (1 KB) PDF (510 KB) ( 95 )

	123	Research on application rule of traditional Chinese medicine in erosive oral lichen planus based on data mining#br#
		WANG Xueting1 LIN Lin2 GUO Ruitong1 XU Jiagen1 WU Mengmeng1 WANG Xiang2
		Objective To explore the laws of composition and medication of traditional Chinese medicine in the treatment of erosive oral lichen planus (EOLP) based on data mining technology. Methods CNKI, Wanfang and VIP database were retrieved. The relevant literatures on traditional Chinese medicine in the treatment of EOLP were searched with “erosive oral lichen planus” “EOLP” “oral erosion” “Chinese medicine” as retrieval words. The retrieval time limit was from the establishment of each database to June 2020. The nature and taste, meridian and category of traditional Chinese medicine were statistically analyzed, and the association rules and cluster analysis were carried out. Results A total of 83 prescriptions were collected, involving 141 kinds of Chinese medicine. There were 37 kinds of Chinese medicines with medication frequency more than eight times, most of which were Radix Angelicae Sinensis, Radix Rehmanniae Recens, Radix Glycyrrhizae, Cortex Moutan Radicis, Radix Scutellariae. The liver meridian was the main meridian; the main medicinal properties were cold and sweet; most of the drugs were clearing heat and cooling blood drugs, tonifying deficiency and tonifying qi drugs, clearing heat and dispelling dampness drugs. Thirty-eight Chinese medicine combinations with high support were obtained by association analysis, and six cluster groups were obtained by systematic cluster analysis. Conclusion The treatment of EOLP with traditional Chinese medicine mainly focuses on clearing heat and removing toxicity, tonifying deficiency and qi, promoting blood circulation and removing blood stasis, supplemented by soothing liver and invigorating spleen, nourishing yin and reducing fire. Its medication law can provide reference for clinical treatment and new drugs research and development.
		2021 Vol. 18 (31): 123-127 [Abstract] ( 124 ) HTML (1 KB) PDF (1090 KB) ( 9 )

	128	Combination of couplet medicines of the “same strain”#br#
		YANG Shengjie WU Min
		The couplet medicines are the basic unit of drug formulation in prescriptions of Chinese materia medica, and it is the summary of clinical practice experience of doctors in past dynasties. In the development of the theory of couplet medicines, there are many Chinese medicines from the same origin with different effects. The couplet medicines of the “same strain” are special type of medicine compatibility. The homologous traditional Chinese medicines have common function, and the combination of the two can play a synergistic role. Both of them are good at their own advantages and can be used together to expand the therapeutic scope of traditional Chinese medicines and reduce the adverse reactions while exerting their efficacy. The application of couplet medicines is the extension of holism of traditional Chinese medicine in pharmacology. This paper analyzes some of couplet medicines of the “same strain”, in order to provide reference for clinical application and improvement of efficacy.
		2021 Vol. 18 (31): 128-130,154 [Abstract] ( 103 ) HTML (1 KB) PDF (762 KB) ( 12 )

	131	Analysis on the medicine law of traditional Chinese medicine compound prescriptions in the treatment of diabetic nephropathy based on national patent database#br#
		ZHOU Chunmei1 XIAO Yang2 LU Bo2 YUAN Qiuzhen1 QI Haiyan2 HANG Cheng2 CHENG Luping2 WANG Gaolei2
		Objective To study the medicine law of patent traditional Chinese medicine compound prescriptions in the treatment of diabetic nephropathy in China in the past 20 years through data mining techniques. Methods Traditional Chinese medicine compound prescriptions in the treatment of diabetic nephropathy in CNKI patent database from January 1, 2000 to December 31, 2020 were searched, and traditional Chinese medicine compound prescriptions met the research requirements were recorded into traditional Chinese medicine inheritance support system V2.5. The frequency of drug usage, flavour, meridian tropism and prescription laws were analyzed by using the methods of frequency statistics, association rule analysis, and so on. Results A total of 214 patent prescriptions were selected, involving 374 kinds of traditional Chinese medicine, and the top five medicines in the rank of use frequency were Radix Astragali seu Hedysari, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae, Radix et Rhizoma Rhei, Fructus Corni; the top three of drugs classifies were tonifying deficiency drugs (tonifying qi drugs were mainly used), promoting blood circulation for removing blood stasis drugs, promoting diuresis and permeating dampness drugs; the top three of four nature of drugs were warm, cold and flat; the top three of five flavours were sweet, bitter and pungent; and the top three of channel tropism were liver meridian, spleen meridian and kidney meridian. According to association rules, seven pairs of commonly used couplet medicines were analyzed, and four new prescriptions were analyzed by entropy clustering method. Conclusion Traditonal Chinese medicine patent compound prescriptions for treating diabetic nephropathy are mainly tonifying deficiency and eliminating pathogen, tonifying deficiency mainly involves tonifying qi, tonifying liver and kidney, eliminating pathogen mainly involves promoting blood circulation, promoting dampness and clearing heat, which can be used as a clinical reference.
		2021 Vol. 18 (31): 131-134 [Abstract] ( 170 ) HTML (1 KB) PDF (873 KB) ( 51 )

	135	Clinical effect of modified Xiaochaihu Granules in the treatment of posterior circulation ischemic vertigo with syndrome of inhibited flow of meridian qi#br#
		TONG Xiaoling1 FENG Xuegong1 ZHANG Lianwen2
		Objective To observe the clinical efficacy of modified Xiaochaihu Granules in the treatment of posterior circulation ischemic vertigo with syndrome of inhibited flow of meridian qi. Methods A total of 72 posterior circulation ischemic vertigo patients with syndrome of inhibited flow of meridian qi admitted to Beijing Hospital of Integrated Traditional Chinese and Western Medicine from April 2019 to December 2020 were selected as the research subjects. According to random number table method, they were divided into observation group and control group, with 36 cases in each group. Both groups were given conventional treatment, on basis of which, observation group was treated with modified Xiaochaihu Granules, the total course of treatment was two weeks. The differences of clinical efficacy, traditional Chinese medicine (TCM) syndrome score, vertigo degree score and serum superoxide dismutase (SOD) of the two groups were observed. Results After treatment, the total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). There was no significant difference of TCM syndrome score and vertigo degree score between the two groups before treatment (P ＞ 0.05). After treatment, the TCM syndrome score and vertigo degree score in the two groups were significantly lower than those before treatment, which in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in SOD level between the two groups before treatment (P ＞ 0.05). After treatment, the SOD levels in the two groups were higher than those before treatment, and the SOD level in the observation group was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Modified Xiaochaihu Granules have a definite curative effect in the treatment of posterior circulation ischemic vertigo with syndrome of inhibited flow of meridian qi, which can obviously improve the TCM symptoms of patients with posterior circulation ischemic vertigo, alleviate the recurrence of vertigo, and raise the serum SOD, enhance the body’s antioxidant capacity and protect brain tissue.
		2021 Vol. 18 (31): 135-138 [Abstract] ( 48 ) HTML (1 KB) PDF (751 KB) ( 10 )

	139	Hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level #br#
		Ainur Khaiti XING Jinling
		Objective To study the hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction on adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level. Methods A total of 96 adolescent patients with metrorrhagia and metrostaxis admitted to Urumqi Hospital of Traditional Chinese Medicine from February 2019 to March 2021 were selected as research subjects, and they were divided into single group and combined group by random number table method, with 48 cases in each group. The single group was treated with Ethinylestradiol and Cyproterone Acetate Tablets alone, while the combined group was treated with Ethinylestradiol and Cyproterone Acetate Tablets and Guben Zhibeng Decoction. Both groups were treated for three menstrual cycles. The hemostatic effect, blood coagulation function indexes (thrombin time [TT], prothrombin time [PT], activated partial thrombin time [APTT]), sex hormones (estradiol [E2], progesterone [P], follicle-stimulating hormone [FSH], luteinizing hormone [LH]) before and after treatment were compared between the two groups. Results After treatment, the bleeding control time and hemostasis time of combined group were shorter than those of single group, the differences were statistically significant (P ＜ 0.05). After treatment, TT, PT, and APTT of the two groups were longer than before treatment, and TT, PT, and APTT of the combined group were longer than those of single group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of E2, P, FSH, and LH in the two groups were lower than before treatment, and the levels of E2, P, FSH, and LH in combined group were lower than those in single group, the differences were statistically significant (P ＜ 0.05). Conclusion Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis can effectively improve hemostatic effect, blood coagulation function and sex hormone level.
		2021 Vol. 18 (31): 139-142 [Abstract] ( 77 ) HTML (1 KB) PDF (748 KB) ( 33 )

	143	Exploration on the importance of traditional Chinese medicine classical thinking for the training of traditional Chinese medicine talents in the future from the perspective of “inheriting the essence of classical learning”#br#
		TANG Xintian1 LI Xunyi2 ZHU Moli3 JIAN Guangfeng4
		From the perspective of “inheriting the essence of classical learning”, this paper explains the important fundamental role of traditional Chinese medicine classical thinking in the system of traditional Chinese medicine syndrome differentiation, makes a rational analysis of the existing problems in the training process of traditional Chinese medicine classical thinking, and further discusses the influence of modern clinical teaching mode in the training of traditional Chinese medicine classical thinking. This paper emphasizes the importance of traditional Chinese medicine classical thinking in the training process of traditional Chinese medicine talents, and puts forward development path and development strategy in the training of clinical traditional Chinese medicine classical thinking in traditional Chinese medicine universities in the future, which has certain significance in the training of future talents of traditional Chinese medicine.
		2021 Vol. 18 (31): 143-146,163 [Abstract] ( 115 ) HTML (1 KB) PDF (1010 KB) ( 28 )

	147	Experience summary on diagnosis and treatment of chronic gastritis by famous veteran traditional Chinese medicine doctor Cui Minlu#br#
		WANG Xiongli1 LIN Mingyu1 LI Chunxiang2 CHEN Lifen3
		Cui Minlu’s treatment of chronic gastritis is due to deficiency of qi and yang, stagnation of dampness and heat, and the combination of cold and heat, resulting in the disorder of ascending and descending, stomach disharmony and descending. Therefore, the treatment principle is to take care of the middle yang, transport spleen for eliminating dampness, relieve oppression and eliminate distension, and recover its rise and fall. Chronic gastritis is associated with psychological factors, from the point of view of five viscera storing spirit and spleen as pivot and ascending and descending pivot of spleen and stomach, traditional Chinese medicine should focus on regulating spleen and stomach, restoring its ascending and descending, supplemented with tranquilizing products. The recognition of chronic gastritis caused by Helicobacter pylori infection is more in line with the theory of dampness toxin in traditional Chinese medicine. In terms of treatment, the three factors should be taken into consideration in combination with the regional characteristics of Southern Fujian, in the first half of the year, the growth is more than enough, but in the second half of the year, the collection is insufficient. Spring and summer are long, autumn and winter are short, damp and hot are common, yang in constitution is insufficient, and spleen and kidney are deficient in the later period. Therefore, on the basis of clearing heat and removing dampness, we should pay attention to the care of zhongyang, it is advocated to warm and transport spleen yang to help clear away dampness and heat, combined with the progress of modern medicine, the micro syndrome differentiation, combined with endoscopic lesions, pay attention to the addition and subtraction of special drugs, pay attention to nourishing the kidney and latent yang in the later stage, pay attention to its root, recover its rise and fall, which is worthy of popularization and application.
		2021 Vol. 18 (31): 147-150 [Abstract] ( 118 ) HTML (1 KB) PDF (752 KB) ( 18 )

	151	Study on the reality and guarantee strategies of culture security of traditional Chinese medicine#br#
		YAN Li1 LI Xiaoying2 WANG Shanshan1
		The culture security of traditional Chinese medicine is related to the survival and prosperity of the brilliant Chinese traditional culture. Though it is an important component of Chinese non-traditional culture security, it is seldom discussed and studied academically ever before. The paper expounds the reality of culture security of traditional Chinese medicine, and puts forward some guarantee strategies of culture security of traditional Chinese medicine in China. At present, there are weaknesses in the culture consciousness of traditional Chinese medicine, the development of culture industry is relatively unsatisfactory, and the culture management mechanism needs to be improved. It argues that multi-subjects such as individuals, society, profession and government should improve cognitive awareness of culture security of traditional Chinese medicine, develop clinical efficacy of traditional Chinese medicine, focus on the development of traditional Chinese medicine culture industry, and build institutional system of culture security of traditional Chinese medicine. They are united to jointly promote the sustainable development of traditional Chinese medicine culture ecology and help ensure the security of Chinese national culture resources.
		2021 Vol. 18 (31): 151-154 [Abstract] ( 145 ) HTML (1 KB) PDF (817 KB) ( 58 )

	155	Comparative analysis of HIV screening test and confirmation test results#br#
		GUO Huijuan1 CHEN Xun1 ZHANG Yinqiang2 GONG Yaoyao3 ZHENG Ying1 WANG Fengmei1 LI Qi1
		Objective To analyze the results of the human immunodeficiency virus (HIV) antibody screening test and confirmation test, and to explore the reasons for false positives in the screening test. Methods From January 2017 to December 2019, a total of 184 HIV antibody screening-positive patients in Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine were sent to the confirmation laboratory for confirmation test, the test results were analyzed and statistics, and the characteristics and causes of false positive patients were explored. Results The false positive rate of HIV antibody screening increased year by year from 2017 to 2019, and the difference was statistically significant (P ＜ 0.05). The screening test values of false-positive patients were concentrated in a relatively low interval, and the specimens with a screening value of 1≤S/CO＜10 confirm that the verification was indeed all false positives; the false-positive rate decreased with the increase of S/CO value, and the specimens with S/CO≥100 were confirmed to be all positive. False positive patients have different basic medical histories. Among them, infection, cardiovascular and cerebrovascular diseases, autoimmune diseases, etc. interfered with the screening experiment to a certain extent, leading to the appearance of false positives. Conclusion For HIV antibody screening positive patients with relatively low S/CO, attention should be paid to the patient’s basic medical history and personal condition, whether there is interference in the test, and reasonable communication and explanation to the patient to reduce the patient’s psychological burden.
		2021 Vol. 18 (31): 155-158 [Abstract] ( 39 ) HTML (1 KB) PDF (352 KB) ( 200 )

	159	Research on optimization strategy of internet hospital construction based on 4C management theory framework#br#
		LI Minyan YANG Feng ZHU Junmin
		Internet hospitals in China are developing rapidly, but there are some problems at present, such as lack of high-quality doctor resources, difficult cost control for both hospital and patient, small medical service caliber and low recognition of online medical treatment. Based on the 4C management theory framework, this paper proposes four strategies to optimize the construction of internet hospitals from the perspectives of customer, cost, convenience and communication. By improving the construction of internet hospitals, improve the quality of online medical services, improve the competitiveness of internet hospitals, and maximize the internet through measures such as improving customer satisfaction with medical treatment, two-way control of medical expenditures, improving medical service construction, and emphasizing doctor-patient communication. The social and economic benefits of the hospital.
		2021 Vol. 18 (31): 159-163 [Abstract] ( 37 ) HTML (1 KB) PDF (451 KB) ( 37 )

	164	Influence of group sand table game on mood state and coping style of patients after gastric cancer surgery#br#
		LI Miao KANG Yunmei YU Xuexia LI Meng YAO Xiaojun
		Objective To explore the influence of group sand table games on the mood state and coping styles of patients after gastric cancer surgery. Methods A total of 120 postoperative gastric cancer patients admitted to the Sixth People’s Hospital of Fuyang City, Anhui Province from August 2017 to December 2020 were selected and divided into observation group and control group according to the random number table method, with 60 cases in each group. The control group was given routine nursing intervention, and the observation group was combined with group sand table games. After three weeks of intervention, the mood states, coping styles, and patient satisfaction of the two groups were compared. Results Finally, a total of 52 cases were included in the observation group and a total of 58 cases were included in the control group. After three weeks of intervention, the profile of mood states (POMS) scores of the two groups were significantly lower than those of the same group before the intervention, and the differences were statistically significant (P ＜ 0.05). The scores of stress-anxiety, depression-frustration, and confusion-confusion in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the face scores of the two groups were higher than those before the intervention, while the avoidance and depression scores were lower than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The face score of the observation group was higher than that of the control group, while the scores of avoidance, depression, yielding, and fantasy were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Group sand table games can help improve the mood of patients, avoid negative coping behaviors, and promote the development of positive coping styles.
		2021 Vol. 18 (31): 164-167 [Abstract] ( 99 ) HTML (1 KB) PDF (634 KB) ( 52 )

	168	Meta analysis of the application of bird nest nursing in the nursing of full-term newborns#br#
		HUANG Yongmei YIN Juan▲
		Objective To systematically evaluate the application value of bird nest nursing in the nursing of full-term newborns. Methods The China biomedical database, CNKI, Wanfang Data, and VIP database, etc. were searched fully by computer system to search the relevant literature about the application value of bird nest nursing in the nursing of full-term newborns, the retrieval time period of research was set as from January 2011 to January 2021. The articles which did not meet the inclusion criteria were excluded, according to the improved Jadad scoring standard, the quality of the eligible included literatures was evaluated. The main outcome indicators in the selected literature were entered, meta analysis was performed with Review Manager 5.0 software. Results A total of eight eligible randomized controlled trials were included finally, a total of 729 full-term newborns were included, there were six articles on the observation and analysis of neonatal weight gain, blood oxygen saturation, sleep time and other growth and development, which could extract effective data; after all the main outcome data were entered, through meta analysis the results showed that compared with routine nursing measures, bird nest nursing was more conducive to improving neonatal weight gain （MD[95%CI]=8.74[6.52，10.96], P ＜ 0.000 01), blood oxygen saturation (MD[95%CI]=4.63[3.81，5.46], P ＜ 0.000 01), sleep time (MD[95%CI]=4.72[3.72，5.73], P ＜ 0.000 01) in the nursing of full-term newborns. Conclusion Compared with routine nursing, bird nest nursing has more advantages in improving growth and development indicators such as weight gain, blood oxygen saturation and sleep time in the nursing of full-term newborns.
		2021 Vol. 18 (31): 168-171，184 [Abstract] ( 56 ) HTML (1 KB) PDF (1322 KB) ( 301 )

	172	Application and effect evaluation of traditional Chinese medicine nursing program in the acute stage of stroke#br#
		WANG Xiaoxiao KONG Tingting▲
		Objective To discuss the application and effect evaluation analysis of traditional Chinese medicine nursing program in the acute stage of stroke. Methods A total of 102 patients with acute stroke admitted to the Eye Hospital of the Chinese Academy of Chinese Medical Sciences from January 2019 to January 2021 were selected. They were divided into control group and study group by random number table method, with 51 cases in each group. The control group used conventional nursing, and the study group used traditional Chinese medicine nursing program on this basis. The neurological deficit, daily living ability and traditional Chinese medicine syndrome score of the two groups were evaluated, and the nursing effects, anxiety and depression of the two groups were compared. Results There was no statistically significant difference between the two groups before the intervention on the scores of the National Institutes of Health stroke scale (NIHSS), clinical symptom, and activities of daily living (ADL) (P ＞ 0.05). After the intervention, the scores of NIHSS, traditional Chinese medicine symptom, and ADL of the two groups were lower than those before the intervention, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The effective rate of nursing care in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). In the pre-intervention hospital anxiety and depression scale (HADS) between the two groups, the difference between HADS-A and HADS-D scores were not statistically significant (P ＞ 0.05). After the intervention, HADS-A and HADS-D in the two groups were lower than before the intervention, and the study group was lower than the control group (P ＜ 0.05). Conclusion The nursing effect of traditional Chinese medicine nursing program for patients with acute stroke is better, which can effectively improve the anxiety and depression of the patient, improve the nursing effect, and reduce the patient’s neurological deficit, traditional Chinese medicine symptom score and ability of daily living.
		2021 Vol. 18 (31): 172-175 [Abstract] ( 130 ) HTML (1 KB) PDF (636 KB) ( 26 )

	176	Impact of multimedia-led health education on the level of knowledge, belief, behavior and self-care ability of patients with liver cancer interventional therapy with contrast-enhanced ultrasound#br#
		QIU Sha WANG Jianhong LU Wei▲
		Objective To explore the application of multimedia-led health education in patients with interventional treatment of liver cancer by contrast-enhanced ultrasound. Methods A total of 400 patients with liver cancer who underwent contrast-enhanced ultrasound interventional therapy from Xijing Hospital were selected from January to December 2020, and they were divided into control group and observation group by random number table method, each group with 200 cases. The control group was used conventional health education, and the observation group was used multimedia-led health education. The level of knowledge, belief, behavior, self-care ability, and compliance were compared between the two groups. Results Before the intervention, there was no statistically significant difference in the knowledge, belief, and behavior scores between the two groups (P ＞ 0.05); after the intervention, the knowledge, belief, and behavior scores of the two groups were higher than before the intervention, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Before the intervention, there was no statistically significant difference in the scores of health knowledge, self-concept, self-care responsibility, and self-care skills between the two groups (P ＞ 0.05); after the intervention, the health knowledge level, self-concept, self-care responsibility, and self-care skills of the two groups were higher than those before the intervention, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The nursing compliance of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Based on the multimedia-led health education model, applied to patients with liver cancer undergoing interventional therapy with contrast-enhanced ultrasound, it can improve knowledge, belief and behavior, enhance self-care ability, and enhance nursing compliance.
		2021 Vol. 18 (31): 176-179 [Abstract] ( 147 ) HTML (1 KB) PDF (634 KB) ( 26 )

	180	Application effect of timeliness incentive mode in pulmonary rehabilitation nursing of patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure#br#
		ZHANG Siyuan ZHANG Qin CAI Zongyu
		Objective To explore the application effect of timeliness incentive mode in pulmonary rehabilitation nursing of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and respiratory failure. Methods A total of 91 AECOPD patients with respiratory failure admitted to the Department of Respiratory and Critical Care Medicine, the Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology, from January 2016 to January 2021 were prospectively selected as the research subjects, they were divided by a random number table method into control group with 45 cases and observation group with 46 cases. Both groups received routine treatment, the control group was given routine pulmonary rehabilitation nursing, and the observation group was given timeliness incentive mode on the basis of the control group. The compliance of pulmonary rehabilitation training of patients was evaluated before and one month after nursing, St. George’s respiratory questionnaire (SGRQ) was used to assess the respiratory status of the patients, Herth hope inventory scale (HHI) was used to evaluate the hope level of patients, pulmonary function indexes were detected, such as peak expiratory flow (PEF) and forced vital capacity (FVC). Results The pulmonary rehabilitation compliance of the observation group was better than that of the control group, with statistical significant difference (P ＜ 0.05); the SGRQ scores of both groups one month after nursing were decreased than those before nursing, the HHI scores were increased than those before nursing, and the SGRQ score of the observation group was lower than that of the control group, the HHI score was higher than that of the control group, with statistical significant differences (P ＜ 0.05); PEF and FVC of both groups one month after nursing were increased than those before nursing, and the observation group was higher than the control group, with statistical significant differences (P ＜ 0.05). Conclusion Timeliness incentive mode can improve the compliance of pulmonary rehabilitation of AECOPD patients with respiratory failure, improve the hope level and respiratory status of patients, and promote the improvement of pulmonary function.
		2021 Vol. 18 (31): 180-184 [Abstract] ( 88 ) HTML (1 KB) PDF (685 KB) ( 19 )

	185	Application effect of health education based on feedforward control in patients with schizophrenia and its influence on violence#br#
		ZHU Lu
		Objective To explore the application effect of health education based on feedforward control in patients with schizophrenia and its impact on violence. Methods A total of 120 patients with schizophrenia in Huzhou Third People’s Hospital from February 2018 to May 2020 were selected as the research objects. According to the random number table method, they were divided into control group 60 cases and observation group 60 cases. Two groups of patients were given Aripiprazole twice a day, 10 mg each time. The control group was given routine health education, and the observation group was given health education based on feedforward control. The inpatient observation scale (NOSIE) score and positive and negative symptom scale (PANSS) score of the two groups after eight weeks of treatment were compared and analyzed, and the influence of related treatment on the violent behavior of the two groups was evaluated. Results After treatment, the scores of social ability, social interest, personal neatness, irritability, slowness and depression in NOSIE score factors of the two groups were lower than those before treatment, and the scores of NOSIE factors in the observation group were significantly lower than those in the control group, with statistical significance (P ＜ 0.05); after treatment, the PANSS scores of lack of response, thinking disorder, paranoia, activation, depression and aggression in both groups were lower than before treatment, and the scores of PANSS factors in the observation group were lower than those in the control group, with statistical significance (P ＜ 0.05); the total effective rate of observation group was higher than control group, the difference was statistically significant (P ＜ 0.05); the incidence of violent behavior in observation group was significantly lower than that in control group, the difference was statistically significant (P ＜ 0.05). Conclusion The application of health education based on feedforward control in hospitalized patients with schizophrenia can effectively prevent the occurrence of violence, which is worthy of clinical promotion and application.
		2021 Vol. 18 (31): 185-188 [Abstract] ( 80 ) HTML (1 KB) PDF (635 KB) ( 10 )

	189	Effects of structured psychological intervention combined with health education on social function coping style and quality of life of elderly parturient patients with postpartum depression#br#
		LU Guoxiang LI Yueqin ZHAO Chunlian
		Objective To explore the effects of structured psychological intervention combined with health education on social function coping style and quality of life of elderly parturient patients with postpartum depression. Methods A total of 200 elderly women with postpartum depression admitted to Qinghai Red Cross Hospital from January 2019 to December 2020 were selected, by random number table method, they were divided into control group (routine nursing intervention) and observation group (combined structural psychological intervention and health education on the basis of control group), with 100 cases in each group. Self-rating anxiety score (SAS), self-rating depression score (SDS), social support rating scale (SSRS), simplified coping style questionnaire (SCSQ), generic quality of life inventory (GQOLI-74) and health knowledge mastery were compared between the two groups. Results SAS and SDS scores of the two groups after intervention were lower than before, and the observation group was lower than the control group (P ＜ 0.05). SSRS, SCSQ, and GQOLI-74 scores in two groups after intervention were higher than before, and observation group was higher than control group (P ＜ 0.05). The total rate of health knowledge mastery in observation group was higher than control group (P ＜ 0.05). Conclusion Structural psychological intervention combined with health education can alleviate depression, improve social function and coping style, and improve the quality of life in elderly women with postpartum depression.
		2021 Vol. 18 (31): 189-192 [Abstract] ( 161 ) HTML (1 KB) PDF (633 KB) ( 171 )

	193	Influence of perioperative evidence-based nursing on complications and pain degree of patients with kidney stones treated by ureteroscopic holmium laser lithotripsy#br#
		ZHAO Xueli YU Xiaoping LI Zhen CHENG Rui▲
		Objective To explore the influence of perioperative evidence-based nursing on complications and pain degree of patients with kidney stones treated by ureteroscopic holmium laser lithotripsy. Methods A total of 105 patients undergoing ureteroscopic holmium laser lithotripsy in Xijing Hospital, Air Force Military Medical University from December 2019 to December 2020 were selected and divided into control group 53 cases (routine perioperative intervention) and observation group 52 cases (evidence-based nursing intervention). The nursing indicators, visual analogue scale score (VAS), 36-item short form health survey (SF-36) score, and complication rate were compared between the two groups before intervention and one month after intervention. Results The recovery time of gastrointestinal function and hospitalization time in observation group were shorter than those in control group (P ＜ 0.05). After one month of intervention, VAS score of both groups was lower than before intervention, SF-36 score was higher than before intervention, VAS score of observation group was lower than that of control group, SF-36 score was higher than that of control group (P ＜ 0.05). The complication rate of observation group was lower than that of control group (P ＜ 0.05). Conclusion The application of perioperative evidence-based nursing intervention can improve the therapeutic effect of ureteroscopic holmium laser lithotripsy, reduce the pain suffered by patients, improve the quality of life and reduce the complication rate.
		2021 Vol. 18 (31): 193-196 [Abstract] ( 91 ) HTML (1 KB) PDF (667 KB) ( 24 )

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