|
|
|
| Hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level #br# |
| Ainur Khaiti XING Jinling |
| Department of Gynecology, Urumqi Hospital of Traditional Chinese Medicine, Xinjiang Uygur Autonomous Region, Urumqi 830000, China |
|
|
|
Abstract Objective To study the hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction on adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level. Methods A total of 96 adolescent patients with metrorrhagia and metrostaxis admitted to Urumqi Hospital of Traditional Chinese Medicine from February 2019 to March 2021 were selected as research subjects, and they were divided into single group and combined group by random number table method, with 48 cases in each group. The single group was treated with Ethinylestradiol and Cyproterone Acetate Tablets alone, while the combined group was treated with Ethinylestradiol and Cyproterone Acetate Tablets and Guben Zhibeng Decoction. Both groups were treated for three menstrual cycles. The hemostatic effect, blood coagulation function indexes (thrombin time [TT], prothrombin time [PT], activated partial thrombin time [APTT]), sex hormones (estradiol [E2], progesterone [P], follicle-stimulating hormone [FSH], luteinizing hormone [LH]) before and after treatment were compared between the two groups. Results After treatment, the bleeding control time and hemostasis time of combined group were shorter than those of single group, the differences were statistically significant (P ＜ 0.05). After treatment, TT, PT, and APTT of the two groups were longer than before treatment, and TT, PT, and APTT of the combined group were longer than those of single group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of E2, P, FSH, and LH in the two groups were lower than before treatment, and the levels of E2, P, FSH, and LH in combined group were lower than those in single group, the differences were statistically significant (P ＜ 0.05). Conclusion Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis can effectively improve hemostatic effect, blood coagulation function and sex hormone level.
|
|
|
|
|
|
| Cite this article: |
|
Ainur Khaiti XING Jinling. Hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level #br#[J]. 中国医药导报, 2021, 18(31): 139-142.
|
|
|
|
| URL: |
| https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I31/139 |
[1] 李燕，张爱英，臧学利，等.雌激素联合醋酸甲羟孕酮治疗功能失调性子宫出血患者的临床研究[J].中国临床药理学杂志，2020，36（20）：3208-3211.
[2] 翟红卫.阿胶黄芪口服液联合复方炔诺酮对功能失调性子宫出血患者的临床疗效[J].中成药，2019，41（7）：1745-1747.
[3] Papapanagiotou IK，Charamanta M，Roidi S，et al. The use of norethisterone for the treatment of severe uterine bleeding in adolescents：an audit of our experience [J]. J Pediatr Adolesc Gynecol，2019，32（6）：121-126.
[4] 汪旭虹，胡甜甜.二甲双胍联合达英-35菊粉治疗肥胖型多囊卵巢综合征的效果及对患者血清相关指标的影响[J].中国妇幼保健，2020，35（22）：165-168.
[5] 赵永新，周英.桂枝茯苓丸联合GnRH-a治疗围绝经期子宫肌瘤并发异常子宫出血临床效果及机制[J].山东医药，2019，59（26）：45-47.
[6] 张美微，侯丽辉，李妍，等.侯丽辉教授治疗多囊卵巢综合征合并崩漏的临证经验[J].吉林中医药，2019，39（8）：997-1000.
[7] 陈宝莹，卢肖霞，张纯，等.固本止崩汤结合针灸治疗气虚型崩漏的效果观察[J].中国当代医药，2017，24（15）：123-125.
[8] 乐杰.妇产科学[M].7版.北京：人民卫生出版社，2008：301-306.
[9] 中华中医药学会.中医妇科常见病诊疗指南[M].北京：中国中医药出版社，2012：96-100.
[10] 马金平.左炔诺孕酮宫内节育系统联合米非司酮对围绝经期功能性子宫出血诊断性刮宫术后患者月经量改善的影响[J].现代医用影像学，2019，28（5）：1140-1141.
[11] Hussein E. The use of levonorgestrel-releasing system （metraplant-e） in the treatment of abnormal uterine bleeding [J]. The Egyptian Journal of Hospital Medicine，2018，72（2）：3979-3985.
[12] 冯丽，阳纯平，李禺，等.抵当汤加减治疗瘀血内阻型崩漏出血期的临床应用[J].广州中医药大学学报，2019， 36（1）：128-131.
[13] 刘源瀛.中西医结合分期论治无排卵性功能失调性子宫出血[J].中国中医基础医学杂志，2019，25（2）：268-270.
[14] 汪沛，朱玲.岭南罗氏妇科二稔汤治疗脾肾不足型崩漏塞流理论探讨[J].中医学报，2020，35（9）：85-88.
[15] 刘伟平，滕秀香，刘慧兰.补肾调周法治疗青春期功能失调性子宫出血肾阴虚证的临床观察[J].中国临床医生杂志，2017，45（6）：114-116.
[16] 欧莉，苗彦霞，高峰，等.二色补血草总黄酮治疗功能性子宫出血的止血作用及机制研究[J].吉林中医药，2019， 39（5）：638-641.
[17] 李萍，姚玉华，李芳.加味固本止崩汤联合米非司酮片治疗围绝经期功能失调性子宫出血临床研究[J].新中医，2019，51（4）：100-102.
[18] 李砚，王运萍，姚念玲，等.达英-35联合二甲双胍治疗多囊卵巢综合征对患者性激素，胰岛素抵抗的影响[J].海南医学，2019，30（17）：33-35.
[19] 温钱杏，曾国禄，叶文亭，等.益气活血经验方联合达英-35治疗青春期崩漏的止血效果及对激素水平、凝血功能的影响[J].环球中医药，2018，11（1）：120-123.
[20] 吴媛媛，罗志娟，李芳艳，等.桂罗氏参补汤治疗出血期气虚血瘀型崩漏的临床疗效[J].广西医学，2018，40（24）：2884-2886.
[21] 郭东艳，范宇，程江雪，等.生地黄汤不同配伍比例干预“肾虚血瘀”型崩漏的实验研究[J].中南药学，2020，18（2）：182-188.
[22] 陈珉，尹东辉.左炔诺孕酮宫内节育系统联合米非司酮对围绝经期功能性子宫出血患者月经量改善及不良反应的影响[J].中国地方病防治杂志，2018，33（2）：223， 225.
[23] 黄金燕，陈林兴，刘平，等.运气学说结合辨证论治在崩漏治疗中的运用[J].成都中医药大学学报，2020，43（1）：31-34.
[24] 张丽丹，张鑫，庾珊，等.针刺结合刺络放血治疗血瘀型崩漏的临床研究[J].针灸临床杂志，2017，33（1）：7-10.
[25] 李全，赵小萱，曹雯雯，等.《竹林寺女科证治》崩漏论治特色及用药规律数据挖掘[J].中国医药导报，2020，17（28）：121-124. |
|
|
|
