支气管扩张症动物模型研究进展

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Abstract Bronchiectasis is a chronic inflammatory bronchial disease caused by infection and bronchial obstruction. It is characterized by repeated attacks and long treatment course. Due to the increased incidence and mortality of the disease, it has gradually attracted worldwide attention. Previous studies in China mostly adopte endotracheal infusion of Pseudomonas aeruginosa to establish the model of bronchiectasis in rats. Foreign studies mostly use the mouse model of bronchiectasis. In recent years, organoid models have been added to provide more alternative models for basic research on bronchiectasis. In this review, we reviewed the progress of the mouse model of new bronchiectasis, including alginate, agar or agarose globules, endotracheal intubation with Pseudomonas aeruginosa, Mycobacterium abscess, and Stomatococcus mucilaginosus. The model of bronchiectasis is established in IFT88, Cby, Pkd2, and other ciliated gene knockout mice, and the model of respiratory tract organ such as human lung organ and gas-liquid interface tissue culture was established for reference in the study of this disease.

Key words： Bronchiectasis Mouse model Infection Gene deletion Organoid

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	TIAN Li ZHANG Shaoyan WU Xianwei QIU Lie LIU Xifang WU Dingzhong ZHANG Huiyong LU Zhenhui

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TIAN Li ZHANG Shaoyan WU Xianwei QIU Lie LIU Xifang WU Dingzhong ZHANG Huiyong LU Zhenhui. Research progress in animal models of bronchiectasis#br#[J]. 中国医药导报, 2021, 18(31): 58-62.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I31/58

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