FAM83A在恶性肿瘤中的研究进展

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Abstract FAM83A, namely the family with sequence similarity 83 member A gene, is a protein-coding gene containing domain 1669 whose function remains to be defined. Initially identified as a potential tumor gene, it is up-regulated in lung cancer, liver cancer, breast cancer, and other malignant tumors, promoting cancer cell proliferation, migration, invasion, epithelial-mesenchymal transformation, and other functions. Current studies suggest that a variety of microRNAs can act as tumor suppressor genes, and circRNA or long non-coding RNA is its upstream, directly or indirectly targeting FAM83A to form an axis to act on signaling pathways and inhibit the occurrence and development of cancer. However, the specific molecular mechanism remains to be further studied. This article reviews the expression and role of FAM83A in malignant tumors.

Key words： FAM83A Malignant tumor Signaling pathway Biomarker

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	ZHU Qiumin XU Min

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ZHU Qiumin XU Min. Research progress of FAM83A in malignant tumors#br#[J]. 中国医药导报, 2021, 18(31): 50-53.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I31/50

[1] Li Y，Dong X，Yin Y，et al. BJ-TSA-9，a novel human tumor-specific gene，has potential as a biomarker of lung cancer [J]. Neoplasia，2005，7：1073-1080.
[2] Fulcher LJ，Bozatzi P，Tachie-Menson T，et al. The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms [J]. Sci Signal，2018，11（531）：eaao2341.
[3] Cai L，Luo D，Yao B，et al. Systematic analysis of gene expression in lung adenocarcinoma and squamous cell carcinoma with a case study of FAM83A and FAM83B [J]. Cancers（Basel），2019，11（6）：886.
[4] Yu WS，Wang ZG，Guo RP，et al. Hepatocellular carcinoma progression is protected by miRNA-34c-5p by regulating FAM83A [J]. Eur Rev Med Pharmacol Sci，2020，24（11）：6046-6054.
[5] Parameswaran N，Bartel CA，Hernandez-Sanchez W，et al. A FAM83A positive feed-back loop drives survival and tumorigenicity of pancreatic ductal adenocarcinomas [J]. Sci Rep，2019，9（1）：13396.
[6] Liu L，Ma C，Xu Q，et al. A rapid nested polymerase chain reaction method to detect circulating cancer cells in breast cancer patients using multiple marker genes [J]. Oncol Lett，2014，7（6）：2192-2198.
[7] Hu H，Wang F，Wang M，et al. FAM83A is amplified and promotes tumorigenicity in non-small cell lung cancer via ERK and PI3K/Akt/mTOR pathways [J]. Int J Med Sci，2020，17（6）：807-814.
[8] Shi R，Jiao Z，Yu A，et al. Long noncoding antisense RNA FAM83A-AS1 promotes lung cancer cell progression by increasing FAM83A [J]. J Cell Biochem，2019，120（6）：10505-10512.
[9] Lee SY，Meier R，Furuta S，et al. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice [J]. J Clin Invest，2012，122（9）：3211-3220.
[10] Zheng YW，Li ZH，Lei L，et al. FAM83A promotes lung cancer progression by regulating the Wnt and hippo signaling pathways and indicates poor prognosis [J]. Front Oncol，2020，10：180.
[11] Liu C，Jiang Y，Han B. miR-613 Suppresses Chemoresistance and Stemness in Triple-Negative Breast Cancer by Targeting FAM83A [J]. Cancer Manag Res，2020，12：12623-12633.
[12] Yao X，Zhang H，Tang S，et al. Bioinformatics Analysis to Reveal Potential Differentially Expressed Long Non-Coding RNAs and Genes Associated with Tumour Metastasis in Lung Adenocarcinoma [J]. Onco Targets Ther，2020，13：3197-3207.
[13] Richtmann S，Wilkens D，Warth A，et al. FAM83A and FAM83B as prognostic biomarkers and potential new therapeutic targets in NSCLC [J]. Cancers（Basel），2019， 11（5）：652.
[14] Zhou F，Wang X，Liu F，et al. FAM83A drives PD-L1 expression via ERK signaling and FAM83A/PD-L1 co-expression correlates with poor prognosis in lung adenocarcinoma [J]. Int J Clin Oncol，2020，25（9）：1612-1623.
[15] Wang Y，Xu R，Zhang D，et al. Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression [J]. Transl Lung Cancer Res，2019，8（6）：862-875.
[16] Liu PJ，Chen YH，Tsai KW，et al. Involvement of MicroRNA-1-FAM83A Axis Dysfunction in the Growth and Motility of Lung Cancer Cells [J]. Int J Mol Sci，2020，21（22）：8833.
[17] Wang G，Li X，Yao Y，et al. FAM83A and FAM83A AS1 both play oncogenic roles in lung adenocarcinoma [J]. Oncol Lett，2021，21（4）：297.
[18] Zhang M，Huo C，Jiang Y，et al. AURKA and FAM83A are prognostic biomarkers and correlated with Tumor-infiltrating Lymphocytes in smoking related Lung Adenocarcinoma [J]. J Cancer，2021，12（6）：1742-1754.
[19] Li Y，Xiao X，Ji X，et al. RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients [J]. Tumour Biol，2015，36（11）：8993-9003.
[20] He J，Yu J. Long noncoding RNA FAM83A-AS1 facilitates hepatocellular carcinoma progression by binding with NOP58 to enhance the mRNA stability of FAM83A [J]. Biosci Rep，2019，39（11）：BSR20192550.
[21] Liu C，Peng X，Li Y，et al. Positive feedback loop of FAM83A/PI3K/AKT/c-Jun induces migration，invasion and metastasis in hepatocellular carcinoma [J]. Biomed Pharmacother，2020，123：109780.
[22] Ma Z，Zhou Z，Zhuang H，et al. Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma [J]. Dis Markers，2021，2021：6682697.
[23] 倪猛，殷涛，王旸，等.FAM83A对胰腺癌细胞PANC-1干细胞样表型和放射敏感性的影响[J].中华放射医学与防护杂志，2018，38（9）：647-653.
[24] Chen S，Huang J，Liu Z，et al. FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer [J]. Oncogenesis，2017，6（3）：e300.
[25] Zhou C，Liang Y，Zhou L，et al. TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer [J]. Autophagy，2020，22：1-21.
[26] Bartel CA，Jackson MW. HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss [J]. PLoS One，2017，12（5）：e0176778.
[27] Boyer AP，Collier TS，Vidavsky I，et al. Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers [J]. Mol Cell Proteomics，2013，12（1）：180-193.
[28] Rong L，Li H，Li Z，et al. FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway [J]. Front Med (Lausanne)，2020，7：608441.
[29] Xu J，Liu H，Yang Y，et al. Genome-wide profiling of cervical RNA-binding proteins identifies human papillomavirus regulation of RNASEH2A expression by viral E7 and E2F1 [J]. mBio，2019，10（1）：e02687-e02718.
[30] Xu J，Lu W. FAM83A exerts tumorsuppressive roles in cervical cancer by regulating integrins [J]. Int J Oncol，2020，57（2）：509-521.
[31] Tomar T，Alkema NG，Schreuder L，et al. Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer [J]. BMC Med，2017，15（1）：116.