中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2020 Vol. 17, No. 35
Published: 2020-12-15
 
 
4 Research on innovative path of traditional Chinese medicine healthy development from the perspective of sports and health integration
OUYANG Jing1 CHEN Xiaodong2 YE Ziyi3 MENG Yingting1
This paper discusses the innovative transformation from the combination of sports and medical treatment to the integration of sports and health in detail, and analyzes the coupling characteristics of Chinese medicine health industry and sports industry from three aspects of industry competitiveness, endurance and spread in depth. The new model of “Chinese medicine health + sports industry” with the goal of national health is built with the breakthrough of cultural ecology, national fitness, multiple coordination, educational function and artificial intelligence. And for the development of the new model of “Chinese medicine health + sports industry”, an extension path, an embedding path and a fusion path are designed, in order to further promote the prosperity and development of the large health industry through the deep integration of the Chinese medicine industry and the sports industry.
2020 Vol. 17 (35): 4-7 [Abstract] ( 98 ) HTML (1 KB)  PDF (564 KB)  ( 243 )
8 Exploration on the innovation of “new master-apprentice” practical teaching mode under the background of omnimedia
ZHU Shu1 WANG Chunyan2 WANG Shijun1 REN Jian1 WANG Lin3 LYU Yingyu1 WANG Jin1
Master-apprentice is the main way of inheriting education of ancient Chinese medicine, but the large-scale cultivation and standardized development of higher education of traditional Chinese medicine have affected master-apprentice education to a certain extent. Many colleges and universities of traditional Chinese medicine try to realize teacher training again through various ways. Although some progress has been made, there are still some problems. Under the background of omnimedia, Shandong University of Traditional Chinese Medicine tries to create the innovative teaching mode of “new master-apprentice”. So-called “new”, the first is to innovate the form of inheritance, change the previous “one-to-one” single form of teacher-student inheritance, create the project of inheriting students, build the inheritance team of teachers and students, realize various forms of “one to many, many to one, many to many”, and promote the large-scale development of teacher apprenticeship training. The second is to innovate the content of inheritance, change the previous inheritance of “academic view of one’s own”, summarize the excellent medical ethics, academic ideas and characteristic skills of famous doctors in the past, organically integrate them into the inheritance and training, and highlight the local characteristics while realizing the standardized inheritance. The third is to innovate the inheritance media. Under the background of omnimedia, we should promote the full integration of the new and old inheritance media, and thus start the innovative exploration of the “new master-apprentice” teaching mode.
2020 Vol. 17 (35): 8-11 [Abstract] ( 100 ) HTML (1 KB)  PDF (575 KB)  ( 111 )
12 Study on implementation strategy of the integrated development of Chinese medicine health service and nationwide fitness campaign
LYU Shaojun
This paper takes the integrated development of Chinese medicine health service and national fitness as the research object, takes taijiquan, baduanjin and other traditional forms of martial arts as the breakthrough point, and conducts in-depth research on the goal positioning and implementation path of the integration development of Chinese medicine health service and national fitness, so as to provide new concepts and new methods for comprehensively promoting the high-quality development of “healthy China action” and “sports and medicine integration”. At the same time, it is suggested that we should make full use of the international influence of traditional Chinese medicine and martial arts, create a healthy culture brand with “Chinese characteristics”, actively promote the “going out” of Chinese taiji health culture, contribute “Chinese wisdom” to the world health industry, and provide “Chinese solution”, so that people all over the world can share the healthy life concept of “nature and harmony”.
2020 Vol. 17 (35): 12-15,18 [Abstract] ( 99 ) HTML (1 KB)  PDF (655 KB)  ( 151 )
16 Experience in promoting high-quality development of childcare services during the new period
Department of Population Surveillance and Family Development, National Health Commission
To do a good job in providing care services for infants and children under three years of age and promote the early development of infants and children has a bearing on the well-being of millions of families and the future of the country and nation. This article reviewed the childcare services in China since the founding of new China’s development and comprehensive two children policy implementation with difficulty, the contradiction between supply and demand of China’s infant and child care after introduced the country to swallow the public service, perfect the system of family support policy has taken important measures, as well as the National Health Committee takes office responsible earnestly, to play a lead role, actively promote nursery has achieved initial success, service development, and accumulated valuable experience.
2020 Vol. 17 (35): 16-18 [Abstract] ( 101 ) HTML (1 KB)  PDF (530 KB)  ( 23 )
19 Regulating effect of Fuzheng Qudu Decoction on cellular immunity of mice carrying chronic hepatitis B virus
WANG Bingran1,2 ZHANG Liping1,2 GUO Zining2 PENG Long1,2
Objective To observe the regulation of Fuzheng Qudu Decoction on cellular immunity of mice carrying chronic hepatitis B virus (HBV). Methods Thirty male HBV transgenic C57BL/6J mice were selected, and they were randomly divided into the model group, the Western medicine group, and the traditional Chinese medicine group according to the random number table method, with 10 mice in each group, and 10 normal male (non-transgenic) mice of the same line as the blank group. The traditional Chinese medicine group was given Fuzheng Qudu Decoction 0.10 mL/ (10 g·d) by gavage, the Western medicine group was given Adefovir Dipivoxil 0.08 mL/ (10 g·d) by gavage, the model group and the blank group were given physiological saline 0.10 mL/(10 g·d) by gavage, and all groups were administered once every day. After 24 weeks, the mice were sacrificed and taken, and the proportions of CD8+T lymphocytes and CD4+T lymphocytes in the peripheral blood of the mice were detected by flow cytometry, and the CD4+T/CD8+T was calculated. Enzyme-linked immunosorbent assay was used to measure the levels of interleukin (IL)-2 and IL-4 in liver tissue, which indirectly reflected the ratio of Th1 to Th2 in helper T cells (Th). Results The proportion of CD8+T lymphocytes in the traditional Chinese medicine group was higher than that in the model group (P ＜ 0.05). CD4+T/CD8+T in the model group was higher than that in the blank group (P ＜ 0.05). CD4+T/CD8+T in the Western medicine group and the traditional Chinese medicine group were lower than that in the model group (P ＜ 0.05). The level of IL-2 in the model group was higher than that in the blank group (P ＜ 0.05), and the level of IL-2 in the traditional Chinese medicine group was higher than that in the Western medicine group and the model group (P ＜ 0.05). The level of IL-4 in the model group was higher than that in the blank group (P ＜ 0.05), and the level of IL-4 in the the Western medicine group and the traditional Chinese medicine group were lower than that in the model group (P ＜ 0.05). Conclusion Fuzheng Qudu Decoction can improve the cellular immune level of chronic HBV carrying mice, its mechanism may be related to the regulation of the proportion of Th1/Th2.
2020 Vol. 17 (35): 19-22 [Abstract] ( 135 ) HTML (1 KB)  PDF (636 KB)  ( 72 )
23 Effect of miR-221/222 targeted inhibition on Cisplatin sensitivity of triple-negative breast cancer MDA-MB-231 cells
YE Huirong YUAN Huiling CAO Yin WANG Xiyue WU Lihua CHEN Guilin CHEN Lijuan ZHANG Yujuan▲
Objective To investigate the Cisplatin (DDP) sensitivity of microRNA (miR)-221/222 targeted inhibition on triple-negative breast cancer (TNBC) MDA-MB-231 cells. Methods MDA-MB-231 cells were randomly divided into control group, miR-221 inhibition group, miR-222 inhibition group and miR-221/222 inhibition group, transfected with blank reagent, miR-221 inhibitor, miR-222 inhibitor and miR-221/222 inhibitor respectively, and after transfection, DDP 5 μg/mL was given for culture. Relative expression of miR-221/222 mRNA was detected by fluorescence quantitative polymerase chain reaction, inhibition rate of cell proliferation was detected by MTT method, apoptosis rate was detected by Annexin V-FTTC/PI double staining method, and the expression levels of apoptosis related proteins were detected by Western blot. Results Comparing the expression level of miR-221 mRNA, the miR-221 inhibition group was lower than the control group, the miR-222 inhibition group was higher than the miR-221 inhibition group, and the miR-221/222 inhibition group was lower than the miR-222 inhibition group, and the differences were statistical significance (all P ＜ 0.05). The expression level of miR-222 mRNA in the miR-222 inhibition group and miR-221/222 inhibition group were lower than that of the miR-221 inhibition group and the control group, and the differences were statistically significant (all P ＜ 0.05). The inhibition rate of cell proliferation and apoptosis of the miR-221/222 inhibition group was higher than that of the other three groups at 24 and 48 h after transfection, and the differences were statistically significant (all P ＜ 0.05). The levels of Caspase-9 and Bax in the miR-221/222 inhibition group were higher than those of the other three groups at 48 h after transfection, and the Bcl-2 level was lower than that of the other three groups, and the differences were statistically significant (all P ＜ 0.05). Conclusion Co-inhibition of miR-221/222 can increase DDP sensitivity of MDA-MB-231 cells.
2020 Vol. 17 (35): 23-26,41 [Abstract] ( 170 ) HTML (1 KB)  PDF (709 KB)  ( 28 )
27 Based on estrogen receptor-mediated neurotrophic factor pathway to explore the protective effect of Zuogui Pills on cerebral ischemia-reperfusion injury
LIU Hong1,2 YI Yajing3 YU Ying3 DAI Qiaomei1 ZHANG Yuwei1 YANG Jing1 ZHANG Bo4 ZHONG Lili5
Objective To explore whether Zuogui Pills can play a neuroprotective role by regulating estrogen receptor pathway. Methods A total of 108 female SD rats were eight-ten weeks old and SPF grade level. They were randomly divided into six groups: sham operation group (incision without thread insertion), I/R group (middle cerebral artery occlusion [MCAO] operation by longa thread bolt method), OVX+I/R group (ovariectomy+MCAO operation), OVX+I/R+Zuogui Pills group (ovariectomy+MCAO operation+Zuogui Pills 1.62 g/kg gavage), OVX+I/R+Zuogui Pills+ICI182780 group (ovariectomy+MCAO operation+Zuogui pills gavage+ICI182780 3 mg/kg intraperitoneal injection), OVX+I/R +17β-estradiol group (ovariectomy+MCAO+17β-estradiol 100 μg/kg intraperitoneal injection), 18 rats in each group. The neurological deficit score was used to evaluated the sensory motor function of rats of each group, the novel object recognition experiment was used to observe the memory of rats, and the protein and mRNA expressions of estrogen receptor (ER) α, ERβ, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), tyrosine kinase (Trk) A, TrkB, phosphorylated cAMP response element binding (p-CREB) and CREB were observed. Results The motor function and memory of the rats in the I/R group were lower than those in the sham operation group (P ＜ 0.05); the motor function and memory of the rats in the OVX+I/R group were lower than those in the I/R group (P ＜ 0.05); the motor function and memory of rats in the OVX+I/R+Zuogui Pills group were higher than those of the OVX+I/R group (P ＜ 0.05); the motor function and memory of the OVX+I/R+Zuogui Pills+ICI182780 group were lower than that of OVX+I/R+ Zuogui Pills group (P ＜ 0.05); OVX+I/R+Zuogui Pills group motor function and memory compared with OVX+I/R+17β-estradiol group, and the differences were not statistically significant (P ＞ 0.05). The protein and mRNA (except BDNF) expressions of ERα, ERβ, BDNF, NGF, TrkA, TrkB, and P-CREB in the I/R group were higher than those in the sham operation group (P ＜ 0.05 or P ＜ 0.01); the expression of above indexes in the OVX+I/R group were lower than that in the I/R group (P ＜ 0.05 or P ＜ 0.01); the expression of above indexes in the OVX+I/R+Zuogui Pills group were higher than that in the OVX+I/R group; the expression of above indexes in the OVX+I/R+Zuogui Pills+ICI182780 group were lower than that in the OVX+I/R+Zuogui Pills group (P ＜ 0.05 or P ＜ 0.01). Compared with the OVX+I/R+17β-estradiol group, the expression of each indexes in the OVX+I/R+Zuogui Pills group were not statistically differences (P ＞ 0.05). Conclusion Zuogui Pills may improve the brain I/R damage of OVX rats through ER-mediated BDNF-TrkB and NGF-TrkA signal transduction.
2020 Vol. 17 (35): 27-33 [Abstract] ( 173 ) HTML (1 KB)  PDF (1734 KB)  ( 69 )
34 Evaluation value of red blood cell distribution width combined with neutrophil/lymphocyte ratio in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease
WANG Lifang HAN Han SHI Bin
Objective To investigate the evaluation value of red blood cell distribution width (RDW) combined with neutrophil/lymphocyte ratio (NLR) in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods One hundred and sixty patients with AECOPD admitted to Suqian Hospital Affiliated to Xuzhou Medical University from January 2017 to December 2019 were selected and divided into survival group (120 cases) and death group (40 cases) according to their prognosis and survival. The treatment methods, complications, RDW and NLR levels of two groups were compared. The effects of RDW and NLR on the prognosis of AECOPD were analyzed by multivariate logistic regression. The diagnostic value of serum RDW and NLR in the prognosis of AECOPD were evaluated by the area under ROC curve. Results The proportion of mechanical ventilation in survival group was significantly lower than that in death group (P < 0.05). There were no significant differences in the proportion of β2 receptor agonist and inhaled hormone between two groups (P > 0.05). The incidence rate of pulmonary heart disease in survival group was significantly lower than that in death group (P < 0.05). There were no significant differences in the incidence of hypertension, hyperlipidemia, diabetes and atrial fibrillation between two groups (P > 0.05). The levels of RDW and NLR in survival group were significantly lower than those in death group (P < 0.05). Multivariate logistic regression analysis showed that mechanical ventilation (OR = 23.050, 95%CI: 1.688-314.701, P < 0.05), pulmonary heart disease (OR = 15.223, 95%CI: 1.248-185.706, P < 0.05), RDW (OR = 171.288, 95%CI: 6.075-4829.307, P < 0.05) and NLR (OR = 8.410, 95%CI: 1.414-50.022, P < 0.05) were independent risk factors for the prognosis of AECOPD (P < 0.05). The area under the curve of combined detection was significantly higher than that of RDW and NLR (P < 0.05). Conclusion The elevated levels of RDW and NLR are risk factors for the prognosis of AECOPD patients, early combined detection can be used as an important biochemical marker to diagnose the prognosis of patients.
2020 Vol. 17 (35): 34-37 [Abstract] ( 136 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
38 Risk factors of cerebral microbleeds in patients with ischemic stroke and the relationship between serum CysC， NLR and cerebral microbleeds
ZHANG Duobin CHEN Houqin CAI Hongxing ZUO Jian
Objective To study the risk factors of cerebral microbleeds (CMBs) in patients with ischemic stroke and to analyze the relationship between serum cystatin C (CysC), neutrophil/lymphocyte ratio (NLR) and CMBs. Methods A total of 80 patients with ischemic stroke admitted to Wuhu NO.1 People’s Hospital, Anhui Province from January 2017 to February 2020 were selected and divided into CMBs group (33 cases) and non-CMBs group (47 cases) according to the occurrence of CMBs. The differences of baseline data and biochemical indexes were compared between the two groups. The risk factors of CMBs and predictive value of CysC and NLR for CMBs were analyzed. Results The age and hypertension history rate in CMBs group were significantly higher than non-CMBs group (all P ＜ 0.05). The fasting blood-glucose (FBG), NLR and CysC levels of the CMBs group were higher than those of the non-CMBs group (all P ＜ 0.05). High age, with history of hypertension, high NLR, and high CysC levels were all independent risk factors for CMBs (all P ＜ 0.05). The receiver operating characteristic (ROC) curve analysis for the prediction and diagnosis of CMBs showed that the theoretical threshold of NLR was 2.60, the sensitivity was 80.2%, the specificity was 73.9%, and the area under curve (AUC) was 0.727 (P ＜ 0.05). The theoretical threshold of serum CysC level was 1.19 mg/L, the sensitivity was 82.6%, the specificity was 71.8%, and the AUC was 0.758 (P ＜ 0.05). The combined application of the two indexes had higher diagnostic efficiency: the sensitivity was 84.2%, the specificity was 85.0%, and the AUC was 0.845 (P ＜ 0.05). Conclusion Elderly patients with ischemic stroke who have a history of hypertension, high serum CysC level, and high NLR may be at higher risk of CMBs. Serum CysC level and NLR can be used as sensitive indicators for CMBs occurrence.
2020 Vol. 17 (35): 38-41 [Abstract] ( 85 ) HTML (1 KB)  PDF (645 KB)  ( 43 )
42 Relationship between serum bone morphogenetic protein level and prognosis of non-small cell lung cancer
LIU Qiwei1 WU Qiong2 WANG Zhiwu2
Objective To evaluate the effect of serum bone morphogenetic protein-2 (BMP-2) level on the prognosis of patients with non-small cell lung cancer (NSCLC). Methods A total of 57 NSCLC patients admitted to Tangshan People’s Hospital, Hebei Province from January to December 2017 were selected. Clinicopathological features and overall survival data of the patients were collected and the serum BMP-2 level of the patients were detected. The relationship between serum BMP-2 level and clinicopathological characteristics and the relationship between serum BMP-2 level and prognosis in patients with lung cancer were analyzed, and the influence of BMP-2 level and other clinicopathological factors on patients with NSCLC was discussed by univariate and multivariate survival analysis. Results The difference of serum BMP-2 level in patients with different pathological stages and metastatic sites was statistically significant (P ＜ 0.05). There was no significant difference in serum BMP-2 level among patients with different age, sex, histological type and degree of tumor cell differentiation (P ＞ 0.05). The median survival time of all patients was 9.8 months (95%CI: 7.3-11.5). The median survival time of NSCLC patients with high BMP-2 level was 6.8 months (95%CI: 4.5- 9.3), shorter than that of NSCLC patients with low BMP-2 level was 12.1 months (95%CI: 9.4-14.8), the difference was highly statistically significant (χ2 = 9.15, P < 0.001). Single factor survival analysis found that the pathological stage Ⅳ (HR = 1.539, 95%CI: 1.127-3.228, P = 0.013), number of metastatic sites (≥three sites) (HR = 1.738, 95%CI: 1.194-4.380, P = 0.001) and BMP-2 levels (≥75 pg/mL) (HR = 2.019, 95%CI: 1.233-6.229, P = 0.000) were the adverse factors affecting the prognosis of patients with NSCLC. Multivariate survival analysis showed that serum BMP-2 level (≥75 pg/mL) (HR = 1.837, 95%CI: 1.146-3.473, P = 0.007) and number of metastatic sites (≥three sites) (HR = 1.199, 95%CI: 1.028-2.337, P = 0.037) were independent adverse factors affecting the prognosis of NSCLC patients. Conclusion High serum BMP-2 level and more than three metastatic sites are independent adverse prognostic factors for NSCLC patients, which can predict the prognosis of NSCLC.
2020 Vol. 17 (35): 42-45 [Abstract] ( 142 ) HTML (1 KB)  PDF (640 KB)  ( 76 )
46 Research progress of immune cells in atherosclerotic inflammation response
WANG Yiru ZHANG Yifan LIU Ping
Innate immune cells and adaptive immune cells play an important role in the pathogenesis and development of atherosclerosis （AS）. Innate immune cells include mononuclear macrophages, natural killer cells, neutrophils, dendritic cells and so on. Adaptive immune cells include T lymphocytes and B lymphocytes. These cells promote or inhibit the formation of atherosclerotic plaques through different differentiation phenotypes and the secretion of various cytokines. In-depth understanding the role of immune cells in the AS pathological process is helpful to explore new therapeutic targets and methods for AS.
2020 Vol. 17 (35): 46-48,52 [Abstract] ( 120 ) HTML (1 KB)  PDF (509 KB)  ( 174 )
49 Research progress of traditional Chinese medicine in preventing and treating hypertensive renal damage
LIU Shufang LIU Xiangying ZHANG Lin
Hypertension is a widespread primary chronic disease in China. Long-term poorly controlled hypertension may cause intimal thickening of renal arteries and arterioles and lumen stenosis, glomerular sclerosis, interstitial fibrosis, and renal tubular atrophy. Kidney damage caused by high blood pressure is a multifactorial process that plays a vital role in the development of chronic kidney disease. According to the kidney database, hypertensive renal damage is the main cause of end-stage renal failure, second only to diabetic nephropathy. Hypertension and chronic kidney disease are serious public health problems related to each other. Hypertension can cause cardiovascular and cerebrovascular diseases and kidney damage. However, chronic kidney disease can also cause cardiovascular events, cerebrovascular events and all-cause death. The increase in the prevalence of hypertensive renal damage, the high cost of treatment and poor prognosis are an important health problem, which to a certain extent causes social and economic burdens and waste of medical resources. The concept of “preventive treatment of disease” in Chinese medicine has a long history. This article explains the specific measures of traditional Chinese medicine prevention and treatment of hypertensive renal damage from the two aspects of “prevention before disease” and “prevention after disease”.
2020 Vol. 17 (35): 49-52 [Abstract] ( 155 ) HTML (1 KB)  PDF (527 KB)  ( 75 )
53 Research progress of RNA binding motif 25 in malignant tumors
LI Wanghong TANG Jintian SHU Yin LIU Chen WANG Ruibin WANG Boqing
RNA binding motif protein 25 (RBM25) belongs to the RNA-binding protein family. It’s expressed proteins, located in nuclear spots, are shear factors and participate in the selective shearing process of genes. In recent years, more and more scholars have paid attention to the effect of RBM25 on malignant tumors. Current studies have shown that the high and low expression level of RBM25 and abnormal shear have an impact on the occurrence, development, metastasis and prognosis of malignant tumors. This paper reviews the research progress of RBM25 in diverse malignant tumors, such as acute myeloid leukemia, prostate cancer, human papillomavirus positive head and neck malignancies, breast cancer, lung adenocarcinoma, osteosarcoma and colon cancer and so on.
2020 Vol. 17 (35): 53-56 [Abstract] ( 97 ) HTML (1 KB)  PDF (578 KB)  ( 230 )
57 Research progress of bone marrow mesenchymal stem cells in treatment of myocardial infarction
ZHAO Liping1 ZHOU Chenming2 LI Jingjing3 XU Yannan4▲
Myocardial infarction is the most common critical disease in clinic, which is a serious threat to human health. Bone marrow mesenchymal stem cells are ideal seed cells for the treatment of cardiovascular diseases due to their advantages of multidifferentiation, easy access, rapid proliferation, low immunogenicity and strong transplantability. The mechanism of bone marrow mesenchymal stem cells therapy in myocardial infarction includes anti-inflammatory and anti-fibrosis, promoting angiogenesis, and immune regulation. However, in the process of transplantation, the survival of transplanted cells is affected by the activity, migration, homing and other factors of transplanted cells. In this paper, the characteristics of bone marrow mesenchymal stem cells and the mechanism of treating myocardial infarction are summarized as follows.
2020 Vol. 17 (35): 57-60 [Abstract] ( 107 ) HTML (1 KB)  PDF (531 KB)  ( 60 )
61 Analysis of nutritional status and influencing factors of vitamin D in Shanghai shooters in winter
YAN Shimin JIANG Yunfei SHEN Juan LIU Wei XU Shiheng CHEN Fengling
Objective To investigate the current status of vitamin D levels of Shanghai shooters in winter and to compare them with local healthy young people of the same age, and to analyze its influencing factors. Methods From February to March 2018, 46 shooting athletes from the Shanghai shooting team were selected as the athlete group, and 50 healthy young people of the same age who had a physical examination at the Shanghai Ninth People’s Hospital during the same period were selected as the control group. The serum 25-hydroxyvitamin D[25(OH)D] level, and relevant information was collected. The difference in vitamin D levels between athletes and people of the same age were analyzed, as well as the possible influencing factors that lead to the difference. Results The level of 25(OH)D and serum parathyroid hormone (PTH) of the athlete group was significantly higher than that of the control group, the blood calcium level was significantly lower than that of the control group, while the sun exposure time was longer than that of the control group, and the differences were statistically significant (P ＜ 0.05). There was a statistically significant difference in the distribution of serum 25(OH)D levels between the two groups (P ＜ 0.05). The difference in exposure time of athletes with different serum 25(OH)D levels was statistically significant (P ＜ 0.05). Among them, the vitamin-deficient athletes had significantly longer exposure time than other levels (P ＜ 0.05). There was a positive correlation between serum 25(OH)D levels and sun exposure time in all subjects (r = 0.685, P ＜ 0.05). The level of serum 25(OH)D in the athlete group was correlated with the exposure time (r = 0.498, P ＜ 0.05). Sun exposure time was a protective factor that affects the serum 25(OH)D level in the athlete group (OR = 0.095，95%CI: 0.018-0.493, P ＜ 0.05). Conclusion In winter, Shanghai shooting athletes have insufficient or lack of vitamin D. Sun exposure time is the protective factor of serum 25(OH)D level in athletes. A reasonable assessment of the nutritional status of athletes’ vitamin D and the formulation of a reasonable vitamin D supplementation plan will help maintain athletes’ health and improve their competitive status.
2020 Vol. 17 (35): 61-63,71 [Abstract] ( 161 ) HTML (1 KB)  PDF (703 KB)  ( 74 )
64 Discussion on the training model of general medical students based on professional identity
FENG Gong1* LI Rong2* LIU Junlin3* HAO Shuai2 XU Meiqi2 WU Ge2 MI Man1 YAN Qinqin1▲
Objective To explore the training mode of general medical students from the perspective of professional identity. Methods A cluster sampling method was adopted to select 600 general medical students from Xi’an Medical University as the research objects, and a nested case-control study with gender as a matching factor (matching according to 1∶1) was adopted. Starting from September 2018, the first survey of occupational recognition would be conducted; the second survey would be conducted in December 2019. The students whose occupational identity had changed in the two surveys were taken as the case group (the score changes from high to low for the case-control group 1 and the score from low to high for the case-control group 2), and students whose occupational identity unchanged as the control group. The influencing factors of professional identity were analyzed. Results In the case-control group 1, there were statistically significant differences in the occupational identity scores of students of different grades, ages, and majors (P ＜ 0.05). Grade (OR = 0.589) and major (OR = 0.546) were independent factors influencing the professional identity of general medicine students (P ＜ 0.05). In the case-control 2 group, there was a statistically significant difference in the professional identity scores of students who participated in club activities and whether they had part-time experience (P ＜ 0.05). Part-time experience (OR = 0.648) was an independent factor influencing the professional identity of general medicine students (P ＜ 0.05). Conclusion Grade, major, and part-time experience are important factors that affect students’ professional identity. Based on this, a plan for optimizing the training model of general medical students can be further explored.
2020 Vol. 17 (35): 64-67 [Abstract] ( 134 ) HTML (1 KB)  PDF (437 KB)  ( 20 )
68 Correlation analysis between resourcefulness and quality of life in elderly patients with coronary heart disease
DAI Ping LIU Zhenfan CHEN Baixia HUANG Kaisen
Objective To investigate the current situation of resourcefulness in elderly patients with coronary heart disease, to analyze the influencing factors of resourcefulness, and to explore the relationship between resourcefulness and quality of life. Methods The convenience sampling method was adopted to investigate and analyzed 188 elderly patients with coronary heart disease who were admitted to People’s Hospital of Deyang City from June to October 2019 using general information questionnaire, resourcefulness scale, and quality of life scale. Results In this study, a total of 196 questionnaires were issued and 188 valid questionnaires were returned. The effective response rate was 95.9%. There was a statistically significant difference in the intelligence level of elderly patients with coronary heart disease with different ages, education levels, monthly income and disease course (P ＜ 0.05). There was no statistically significant difference between the average score of individual resourcefulness and the average score of social resourcefulness (P ＞ 0.05). The quality of life score and each dimension were negatively correlated with the resourcefulness score and each dimension (r ＜ 0, P ＜ 0.01). Conclusion Elderly patients with coronary heart disease are at an intermediate level of resourcefulness, and patients with high age, low education, low income, and short course of disease should be the focus of clinical care in the future. At the same time, improving the quality of life of elderly patients with coronary heart disease is also conducive to the improvement of resourcefulness.
2020 Vol. 17 (35): 68-71 [Abstract] ( 150 ) HTML (1 KB)  PDF (440 KB)  ( 39 )
72 Systematic evaluation of the effect of immune induction after heart transplantation on the prevention of rejection
LI Yang HOU Zhen TONG Weiyi DENG Jingfei YANG Yuan▲
Objective To systematically evaluate the effect of immune induction on preventing rejection after heart transplantation. Methods PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database were searched, and related literature on induction therapy of heart transplantation were collected, including antithymocyte immunoglobulin (ATG), basiliximab (BAS). The time from the establishment of the database to March 2020, the main result was the one-year rejection rate, and RevMan 5.4 software was used for analysis. Results Finally, a total of 12 studies were included, with a total of 38 764 cases. The results showed that the one-year rejection rate of the BAS group was higher than that of the ATG group, and the difference was statistically significant (OR = 2.03, 95%CI：1.78-2.32, P ＜ 0.01). There was no statistically significant difference in the one-year rejection rate between the ATG group, the BAS group and the non-induction group (P ＞ 0.05). The one-year rejection rate of the Alemtuzumab group was lower than that of the no-induction group, and the difference was statistically significant (P ＜ 0.05). Conclusion After heart transplantation, the effect on preventing one-year rejection of ATG is better than that of the BAS.
2020 Vol. 17 (35): 72-75 [Abstract] ( 71 ) HTML (1 KB)  PDF (799 KB)  ( 87 )
76 Effect of vitamin A supplementation on T lymphocyte levels in peripheral blood of children with iron deficiency anemia and repeated lower respiratory infection
JIA Liyuan1 WANG Li1▲ QIAN Zengli2 WEN Li1 ZHAI Xiaoying1 QUAN Meijie1 LI Wenzi1 YANG Mingli1
Objective To explore the effect of vitamin A (VitA) supplementation on T lymphocytes levels in peripheral blood of children with iron deficiency anemia and repeated lower respiratory infection. Methods A total of 116 patients with iron deficiency anemia and repeated lower respiratory infection who admitted to Hebei Children’s Hospital from January 2017 to June 2019 were enrolled. They were divided into the observation group and the control group by random number table method, with 58 cases in each group. The control group was given routine anti-infection treatment. On this basis, the observation group was given VitA supplementation treatment. The changes in levels of anemia status indexes, T lymphocyte subsets and immunoglobulins before and after treatment were compared between the two groups. The effective rate, cough time, white blood cell count recovery normal time and hospital stay time were recorded and compared between the two groups. Results The effective rate in the observation group was higher than that in the control group (P < 0.05). After 6 months of treatment, the levels of hemoglobin, mean corpuscular volume, content of mean corpuscular hemoglobin and mean corpuscular-hemoglobin concentration in both groups were higher than those before treatment, and the observation group was higher than the control group (P < 0.05). After 6 months of treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were higher than those before treatment, while the levels of CD8+ were lower than those before treatment. The levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, while the levels of CD8+ were lower than those in the control group (P < 0.05). After 6 months of treatment, IgM, IgA and IgG levels in the two groups were higher than those before treatment  and the observation group was higher than the control group (P < 0.05). The duration of cough, the time of white blood cell count recovery normal and hospital stay time in the observation group were shorter than those in the control group (all P < 0.05). Conclusion Anti-infection treatment assisted by VitA can effectively improve anemia and low immune function in children with iron deficiency anemia and repeated lower respiratory infection, shorten treatment process and accelerate their recovery.
2020 Vol. 17 (35): 76-79 [Abstract] ( 122 ) HTML (1 KB)  PDF (370 KB)  ( 78 )
80 Effect of Ligustrazine Injection combined with Edaravone in the treatment of cerebral vasospasm after intracranial aneurysm surgery
CHEN Libo ZHU Di LIANG Xuguang
Objective To investigate the clinical effect of Ligustrazine Injection combined with Edaravone in the treatment of cerebral vasospasm after intracranial aneurysm surgery. Methods A total of 100 patients with cerebral vasospasm after intracranial aneurysm surgery were selected from Chifeng Municipal Hospital, Inner Mongolia Autonomous Region from January 2017 to December 2019. They were divided into control group and study group according to the random number table method, with 50 cases in each group. The control group was treated with Edaravone and the study group was treated with Ligustrazine Injection on the basis of the control group. The efficacy, nervous function, middle cerebral artery blood flow velocity (VMCA), serum related indexes and adverse reactions were compared between the two groups. Results After four weeks of treatment, the clinical total effective rate of the study group was higher than that of the control group (P ＜ 0.05). After four weeks of treatment, the score of  national Institutes of health stroke scale (NIHSS), the levels of interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), endothelin-1 (ET-1) in the two groups were lower than those before treatment, and the study group was lower than the control group (P ＜ 0.05). After four weeks of treatment, the levels of nitric oxide (NO) and VMCA in the two groups were higher than those before treatment (P < 0.05), and  the study group was higher than that in the control group (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Ligustrazine Injection combined with Edaravone is effective in the treatment of cerebral vasospasm after intracranial aneurysm surgery. It can promote the improvement of the body’s nervous function, restore blood flow speed, and it is safe and reliable. It may be related to the improvement of the body’s IL-6, TNF-α, ET-1 and NO levels.
2020 Vol. 17 (35): 80-83 [Abstract] ( 85 ) HTML (1 KB)  PDF (434 KB)  ( 28 )
84 Clinical effect of Donepezil combined with Idebenone in the treatment of early vascular cognitive dysfunction
JI Lili HUANG Tingting▲
Objective To investigate the clinical effect of Donepezil combined with Idebenone in the treatment of early vascular cognitive dysfunction. Methods A total of 94 patients with early vascular cognitive dysfunction admitted to Changzhou Wujin People’s Hospital, Jiangsu Province from January to December 2019 were selected as the research objects. According to the random number table method, all the enrolled patients were divided into observation group and control group, with 47 cases in each group. The control group was given Donepezil routine treatment, the observation group on the basis of the control group combined with Idebenone. The two groups were compared before and after treatment with a simple mental state examination (MMSE) score, clinical efficacy, daily living activity assessment scale (ADL) score, and adverse drug reactions. Results The total clinical effective rate in the observation group was higher than that in the control group (P ＜ 0.05). The overall analysis of MMSE score showed that the differences in intergroup comparison, time point comparison and interaction were statistically significant (all P ＜ 0.05). Intra-group comparison: MMSE scores of both groups were significantly higher than those before treatment at 30 and 60 days after treatment, and those at 60 days after treatment were higher than those at 30 days after treatment (all P ＜ 0.05). Comparison between groups: 30 and 60 days after treatment, MMES score of the observation group was higher than that of the control group (all P ＜ 0.05). The overall analysis of ADL score showed that the differences in intergroup comparison, time point comparison and interaction were statistically significant (all P ＜ 0.05). Intra-group comparison: ADL scores of the two groups were significantly higher than those before treatment at 30 and 60 days after treatment (all P ＜ 0.05). Comparison between groups: 30 and 60 days after treatment, ADL score of the observation group was higher than that of the control group (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups after treatment (P ＞ 0.05). Conclusion Donepezil combined with Idebenone is effective in the treatment of early vascular cognitive dysfunction, and can effectively improve the cognitive impairment of patients.
2020 Vol. 17 (35): 84-87 [Abstract] ( 144 ) HTML (1 KB)  PDF (467 KB)  ( 23 )
88 Effect of Mifepristone in the adjuvant treatment of patients with perimenopausal dysfunctional uterine bleeding and its influence on serum nitric oxide, prostaglandin and endometrial thickness
SUN Hongxia ZHU Ting
Objective To investigate the effect of Mifepristone in the adjuvant treatment of patients with perimenopausal dysfunctional uterine bleeding and its influence on serum nitric oxide (NO), prostaglandin and endometrial thickness. Methods One hundred and twenty cases of perimenopausal dysfunctional uterine bleeding patients in Suzhou Municipal Hospital Affiliated to Nanjing Medical University from August 2016 to July 2019 were selected as research objects. They were divided into combination group and control group by using random number table method, 60 cases in each group. Combination group was given Mifepristone and levonorgestrel intrauterine contraceptive system (LNG-IUS) treatment, control group was given LNG-IUS treatment. The course of treatment was 12 weeks. The endometrial thickness, serum NO, prostaglandin E2 (PGE2), prostaglandin 2α (PGF2α), peripheral blood hemoglobin (Hb) and vaginal bleeding time were compared between two groups before and after treatment. The adverse reactions of two groups were recorded. Results Twelve weeks of treatment, the endometrial thickness of two groups was thinner than that before treatment, and that of combination group was thinner than that of control group (P < 0.05). Twelve weeks of treatment, the level of Hb in combination group was higher than that in control group, and Hb level in control group was higher than that before treatment (P < 0.05). Twelve weeks of treatment, the serum NO level of two groups was lower than that before treatment, and that of combination group was lower than that of control group (P < 0.05). Twelve weeks of treatment, the serum levels of PGE2 and PGF2α in two groups were higher than those before treatment, and those in combination group were higher than those in control group (P < 0.05). Twelve weeks of treatment, the vaginal bleeding time of two groups was shorter than that before treatment, and that of combination group was shorter than that of control group (P < 0.05). There was no significant difference in the incidence of adverse reaction between two groups (P > 0.05). Conclusion Mifepristone combined with LNG-IUS is better than LNG-IUS in the treatment of perimenopausal dysfunctional uterine bleeding, and it has a better regulating effect on serum NO and PGF2α, and more effectively reduces the thickness of endometrium.
2020 Vol. 17 (35): 88-91 [Abstract] ( 79 ) HTML (1 KB)  PDF (507 KB)  ( 15 )
92 Effects of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of chronic cough in children
LI Yanmei1 HAO Jinping1 ZHAO Yuhong2
Objective To study the effects of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of chronic cough in children. Methods Seventy-two children with chronic cough admitted to Department of Pediatrics in Heze Municipal Hospital from August 2017 to January 2019 were selected and divided into study group (Cefaclor and Bromhexine Hydrochloride for Suspension treatment) and control group (conventional treatment) according to random number table method, 36 cases in each group, with a course of 10 days. Therapeutic effects of two groups were compared. The daytime and night cough scores, sputum inflammatory factors (IL-4, hs-CRP and TNF-α), serum disease-related factors (ECP, EOS, SP and CGRP) were recorded before and after treatment. Results After ten days of treatment, there was no significant difference in the treatment effect between two groups (P > 0.05). After ten days of treatment, the daytime and night cough scores of two groups were lower than those before treatment, and study group was lower than that control group (P < 0.05). After ten days of treatment, sputum levels of IL-4, hs-CRP and TNF-α in two groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). After ten days of treatment, serum levels of ECP, EOS, SP and CGRP in two groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). Conclusion Cefaclor and Bromhexine Hydrochloride for Suspension has a significant efficacy in the treatment of chronic cough in children, and it can effectively alleviate cough symptoms and inflammatory response.
2020 Vol. 17 (35): 92-95 [Abstract] ( 143 ) HTML (1 KB)  PDF (475 KB)  ( 66 )
96 Clinical features of intestinal obstruction after laparoscopic appendectomy in children
CHEN Long LI Xianling LIU Tingting
Objective To investigate clinical features of intestinal obstruction after laparoscopic appendectomy in children. Methods Clinical data of 1571 cases of laparoscopic appendectomy in Beijing Children’s Hospital, Capital Medical University from August 2013 to February 2019 were retrospectively analyzed. The children were divided into perforated group and non perforated group according to whether the appendix was perforated or not. The incidence of postoperative intestinal obstruction was compared between two groups. According to the age, the children were divided into infant group, preschool group, school-age group and adolescent group. The incidence of intestinal obstruction in different age groups was compared. Results There was significant difference in the incidence of postoperative intestinal obstruction between perforated group and non perforated group (P < 0.05). The incidence of postoperative intestinal obstruction in different age groups was significantly different (P < 0.05). The incidence of postoperative intestinal obstruction in adolescent group was lower than that in infant group (P < 0.05). The incidences of postoperative intestinal obstruction in school-age group and adolescent group were lower than those in preschool group (P < 0.05). Conclusion Improving the early diagnosis rate of appendicitis in children, especially the diagnosis of appendicitis in pre-school age children, timely operation intervention before appendix perforation can reduce the incidence of postoperative intestinal obstruction.
2020 Vol. 17 (35): 96-98,103 [Abstract] ( 137 ) HTML (1 KB)  PDF (822 KB)  ( 70 )
99 Clinical effect of 131I-Metuximab combined with hepatic arterial transcatheter arterial chemoembolization in the treatment of primary liver cancer
WAN Chao CHEN Biao LIN Dandan HE Xiaoqin XU Ximing
Objective To evaluate the efficacy and safety of 131I-Metuximab injection (Licartine) combined with hepatic artery transcatheter arterial chemoembolization (TACE) in the treatment of advanced primary liver cancer. Methods A total of 45 patients with advanced liver cancer who admitted to the Cancer Center of Renmin Hospital of Wuhan University from January 2017 to February 2019 were selected and divided into two groups according to the treatment method, 15 cases in group A, receiving licartin combined with TACE treatment; 30 cases in group B received TACE treatment alone. After treatment, patients of the two groups were followed up to observe, and the objective response rate (ORR), disease control rate (DCR), progress free survival (PFS) time, interventional treatment-related adverse reactions, hematological toxicity (white blood cell [WBC] count, platelet [PLT] count) and liver function damage [total bilirubin (TB), alanine transaminase (ALT)] rate were compared between the two groups. Results There were no significant differences in ORR, DCR and PFS between the two groups (all P ＞ 0.05). In terms of adverse reactions related to interventional therapy, there were no significant differences in the incidence of fever, abdominal pain, nausea and vomiting between the two groups (all P ＞ 0.05). In terms of hematological toxicity, the PLT count in group A was significantly lower than that in group B at one week after operation, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in WBC counts between the two groups at one week after surgery (P ＞ 0.05). In terms of liver function, there were no statistically significant differences in TB and ALT levels between the two groups at one week after surgery (P ＞ 0.05). The above-mentioned adverse reactions were mostly grade Ⅰ-Ⅱ, and no serious adverse events related to the treatment drugs occurred. Conclusion Licartin combined with TACE for the treatment of patients with primary liver cancer is well tolerated and safe, but the efficacy needs further verification.
2020 Vol. 17 (35): 99-103 [Abstract] ( 148 ) HTML (1 KB)  PDF (591 KB)  ( 70 )
104 Efficacy and prognostic analysis of Cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer
ZHONG Liping SHEN Junjun HAN Shuwen QI Quan LIAO Haihong JIANG Yizhen PAN Yuefen
Objective To explore the efficacy and prognostic factors of Cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer (mCRC) patients. Methods A retrospective analysis of the clinicopathological data of 83 cases of KRAS wild-type mCRC patients treated with Cetuximab in Huzhou Central Hospital from June 2013 to June 2018. The COX proportional hazard model was used to conduct the univariate and multivariate analyses of the clinicopathological factors that may influence the treatment of progression free survivals (PFS) time with cetuximab to determine the prognostic factors. Results Among patients with mCRC treated with cetuximab, the objective response rate was 63.9%, and the disease control rate was 86.7%. The median follow-up for the whole group was 15.5 months, the median PFS was 8.7 months, and the PFS rates at 6, 12, and 18 months were 71.1%, 32.5% and 13.3%, respectively. Multivariate analysis showed that the primary tumor site, baseline carbohydrate antigen (CA)199 level, rash and severity and early tumor regression were independent prognostic factors(P ＜ 0.05). Conclusion Baseline CA199 level, tumor location, skin rash, and early tumor regression may be independent risk factors for PFS in patients with KRAS wild-type mCRC treated with cetuximab, and help predict the effect and prognosis of cetuximab treatment.
2020 Vol. 17 (35): 104-107 [Abstract] ( 149 ) HTML (1 KB)  PDF (576 KB)  ( 112 )
108 Expression changes of miR-582-5p and Rab27a in non-small cell lung cancer tissues and their relationship with clinicopathological parameters
GUO Yi1,2 GUO Wei2 WANG Yanhong3
Objective To investigate the expression of miR-582-5p and RAS oncogene family Rab27a in non-small cell lung cancer (NSCLC) tissues and their relationship with clinicopathological parameters. Methods The expression of miR-582-5p and Rab27a levels in 120 NSCLC tissues and adjacent tissues were detected by real-time quantitative polymerase chain reaction (qRT-PCR). Rab27a protein expression level in tissues were detected by Western blot. The expressions differences of miR-582-5p and Rab27a and their relationships with clinicopathological features were analyzed statistically. Results Compared with adjacent tissues, the expression level of miR-582-5p was lower than that in NSCLC tissues, while the expression of Rab27a was higher (all P ＜ 0.05). Compared with TNM stage Ⅰ-Ⅱ cancer tissue without lymph node metastasis, the expression level of miR-582-5p in TNM stage Ⅲ-Ⅳ cancer tissue with lymph node metastasis was lower, while the expression level of Rab27a was higher (all P ＜ 0.05). There was a negative correlation between miR-582-5p and Rab27a expression levels in cancer tissues (r = -0.633，P = 0.000). Conclusion The expression level of miR-582-5p is decreased and the expression level of Rab27a is increased in NSCLC tissues, which may be new molecular markers for diagnosis and treatment of NSCLC.
2020 Vol. 17 (35): 108-111 [Abstract] ( 84 ) HTML (1 KB)  PDF (602 KB)  ( 75 )
112 Effect of molecular classification of breast cancer patients on their post-traumatic growth
ZHANG Xuemei1 WEI Tao1 JIANG Zhaobin1 CHEN Yongxia2 TIAN Wuguo3 YANG Xiumu1▲
Objective To explore the impact of molecular classification of breast cancer patients on post-traumatic growth (PTG). Methods This study adopted a cross-sectional survey and used convenience sampling to select 236 breast cancer patients admitted to the First Affiliated Hospital of Bengbu Medical College from January to December 2019 as the research objects. According to molecular classification, they were divided into four groups (Luminal A group, Luminal B group, human epidermal growth factor receptor 2 [HER2] positive group and triple negative group). The post-traumatic growth inventory (PTGI) was used to conduct questionnaire surveys on the four groups of breast cancer patients at the time of puncture diagnosis, one month after diagnosis, three months after diagnosis, and six months after diagnosis, the differences between the groups were compared. Results The average PTG score of breast cancer patients was (51.73±9.02), and there was no statistically significant difference in the total PTG score of the four groups at the time of puncture diagnosis (P ＞ 0.05). The total PTG scores of breast cancer patients in the Luminal B group and HER2 positive group at the time of six months after diagnosis were higher than the total PTG score at the time of diagnosis, and the differences were highly statistically significant (all P ＜ 0.01). At the time of six months after diagnosis, the total PTG score of the Luminal A group was lower than that of the Luminal B group, and the difference was highly statistically significant (P ＜ 0.01). At the time of six months after the diagnosis of breast cancer, the total PTG score of the HER2 positive group was higher than that of the triple negative group, and the difference was statistically significant (P ＜ 0.05). Conclusion The PTG levels of breast cancer patients are at a low-moderate level, and the PTG level of Luminal B and HER2 positive breast cancer patients have changed significantly after a short term. Clinical nursing practice should focus on the PTG of Luminal A and triple negative breast cancer patients.
2020 Vol. 17 (35): 112-115 [Abstract] ( 124 ) HTML (1 KB)  PDF (586 KB)  ( 197 )
116 Effect of self-made Qige Huayu Formula on coagulation function, pain level and quality of life in patients with esophageal cancer after stent implantation
XU Yapei1 YANG Zhufeng1▲ YANG Jing1 LONG Run1 LI Shiji1 GU Nuonuo2
Objective To observe the effect of self-made Qige Huayu Formula on coagulation function, pain level and quality of life in patients with esophageal cancer after stent implantation. Methods A total of 62 patients with esophageal cancer admitted to Hebei Provincial Hospital of Traditional Chinese Medicine from June 2018 to June 2019 were selected and divided into treatment group and control group by the random number table method, with 31 cases in each group. The patients in both groups underwent endoscopic esophageal stent implantation. On this basis, treatment group was given self-made Qige Huayu Formula, while the control group was given Kuanxiong Lige Pills. The two groups were both given medicine for one month continuously. The clinical efficacy, traditional Chinese medicine (TCM) syndrome score, coagulation function (prothrombin time [PT], thrombin time [TT], activated partial thromboplastin time [APTT], plasma fibrinogen [FIB]), numerical rating scale (NRS) score and quality of life questionnaire (QLQ) -C30 score were compared between the two groups. Results Before treatment, there were no significant differences in TCM syndrome score, coagulation function, NRS score and QLQ-C30 score between the two groups (all P ＞ 0.05). After treatment, the clinical total effective rate of the treatment group was higher than that of the control group (P ＜ 0.05). After treatment, the TCM syndrome scores of the two groups were lower than that before treatment, and treatment group were lower than those of the control group (P ＜ 0.05). After treatment, FIB level in two groups were higher than before treatment, and treatment group was higher than that of the control group (P ＜ 0.05), while PT, TT and APTT levels in two groups were lower than those before treatment, and the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the NRS score of the two groups was lower than before treatment, and treatment group was lower than the control group (P ＜ 0.05). After treatment, the scores of QLQ-C30 in the two groups were increased, and the scores in the treatment group were higher than those of the control group (P ＜ 0.05). Conclusion Self-made Qige Huayu Formula has significant clinical effect in the treatment of esophageal cancer after stent implantation, which can improve the coagulation function, alleviate pain level and improve the quality of life of patients, which is worthy of clinical research and application.
2020 Vol. 17 (35): 116-119 [Abstract] ( 110 ) HTML (1 KB)  PDF (543 KB)  ( 90 )
120 Analysis of prognostic factors of severe lung cancer patients complicated with invasive pulmonary aspergillosis
DENG Lijuan1 WANG Hongzhou2
Objective To analyze the prognostic factors of severe lung cancer patients complicated with invasive pulmonary aspergillosis. Methods A total of 60 patients with severe lung cancer complicated with invasive pulmonary aspergillosis admitted to Sichuan Mianyang 404 Hospital from January to December 2019 were selected as the study subjects. General data of patients with severe lung cancer complicated with invasive pulmonary aspergillosis were collected, including age, gender, smoking history, organ failure, etc., to study the prognostic risk factors of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Results Univariate analysis showed that age, whether have organ failure or not, whether have hypoproteinemia or not, duration of anti-invasive pulmonary aspergillosis treatment, and whether to receive anti-invasive pulmonary aspergillosis treatment before diagnosis all affected the prognosis of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Multiple regression multivariate analysis showed that advanced age (OR = 1.342, 95%CI [1.104-3.844], P < 0.05), organ failure  (OR = 1.202, 95%CI[1.088-3.122], P ＜ 0.05), hypoproteinemia (OR = 1.570, 95%CI [1.157-3.916], P < 0.05) were independent risk factors for prognosis of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Conclusion Severe lung cancer complicated with invasive pulmonary aspergillosis patients with advanced age, organ failure and hypoproteinemia have a high short-term mortality rate, so the value of early and continuous anti-invasive treatment of pulmonary aspergillosis should be emphasized
2020 Vol. 17 (35): 120-122 [Abstract] ( 89 ) HTML (1 KB)  PDF (513 KB)  ( 13 )
123 Comparison on the effect of photodynamic therapy with different concentrations of 5-aminolevulinic acid in the treatment of CIN1/2 patients with HR-HPV infection
TU Hongqin WU Weiqing▲ ZHANG Jie SUN Wenjie SHI Kejun
Objective To analyze the efficacy of photodynamic therapy with different concentrations of 5-aminolevulinic acid (5-ALA) in the treatment of cervical intraepithelial neoplasia (CIN) 1/2 patients with high risk of human papillomavirus (HR-HPV) infection. Methods A total of 80 cases of CIN1/2 patients with HR-HPV infection who treated in Yixing People’s Hospital of Jiangsu Province from January 2017 to June 2019 were selected as the study objects. They were divided into the observation group and the control group according to random number table method, with 40 cases in each group. The control group was given low-concentration 5-ALA, and the observation group was treated with high-concentration 5-ALA. The number of patients with mild cervical abnormalities or normal cervical, HR-HPV negative conversion rate, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels and adverse reactions at 3 and 6 months after treatment were compared between the two groups. Results There were no statistically significant differences between the two groups in the number of mild cervical abnormalities or normal cervical and HR-HPV DNA conversion negative rate of CIN1 patients between the two groups at 3 and 6 months after treatment (P > 0.05); the number of mild cervical abnormalities or normal cervical and HR-HPV DNA conversion negative rate of CIN2 patients in the observation group were higher than those in the control group (P < 0.05). IL-6 level at 3 months after treatment was higher than that before treatment, and TNF-α level was lower than that before treatment; the levels of IL-6 and TNF-α in the observation group were higher than those in the control group (all P < 0.05). None of the patients had secondary infection, bleeding, cervical stenosis or scar formation. Conclusion High concentration 5-ALA photodynamic therapy for CIN1/2 patients with HR-HPV infection has a significant clinical effect, which can effectively improve the negative rate of HR-HPV, and improve the level of inflammatory factors.
2020 Vol. 17 (35): 123-126 [Abstract] ( 131 ) HTML (1 KB)  PDF (562 KB)  ( 115 )
127 Effect of whole course nutritional support on the treatment tolerance and radiotherapy effect of advanced lung cancer patients
SONG Chenglin LI Suzhen ZHAO Jiuhong GE Pingping▲
Objective To explore the effect of whole course nutritional support on the treatment tolerance and radiotherapy effect of advanced lung cancer patients. Methods A total of 108 patients with advanced lung cancer who admitted to Lianyungang Second People’s Hospital from January 2017 to December 2018 were selected as objects. They were divided into control group and treatment group according to the random number table method, with 54 cases in each group. The control group was treated with chemoradiotherapy alone, the treatment group was treated with whole course nutritional support while undergoing chemoradiotherapy. The clinical efficacy of two groups after treatment was compared. The Karnofsky performance status (KPS) scores and serum levels of prealbumin (PA) and albumin (ALB) of two groups before and after treatment were compared. The radiotherapy interruption rates, radiotherapy total days, chemotherapy completion numbers and acute radiological response rate of the two groups were compared. Results The total remission rate in treatment group was higher than that of control group (P < 0.05). The KPS scores of two groups after treatment were lower than those before treatment, and the KPS scores of treatment group after treatment were higher than those of control group (all P < 0.05). After treatment the levels of PA and ALB of control group were lower than those before treatment, the levels of treatment group were higher than those before treatment, and the levels of PA and ALB of treatment group were higher than those of control group (all P < 0.05). The radiotherapy interruption rate of treatment group was lower than that of control group, the radiotherapy total days were less than those of control group, and the number of completed chemotherapy was higher than that of control group (all P < 0.05). The incidence rate of myelosuppression, acute gastrointestinal reactions and acute radioactive proctitis in treatment group were lower than those of control group (all P < 0.05). Conclusion Whole course nutritional support can significantly improve the radiotherapy effect and treatment tolerance of patients with advanced lung cancer, improve the quality of life and nutritional status, and reduce the acute radiation response.
2020 Vol. 17 (35): 127-130 [Abstract] ( 99 ) HTML (1 KB)  PDF (552 KB)  ( 42 )
131 Relationship between TMSG-1 and CXCR4 expression in colon cancer and clinicopathological features and prognosis
ZHU Xianfei
Objective To investigate the relationship between the expression of tumor metastasis suppressor gene-1 (TMSG-1) and chemokine receptor 4 (CXCR4) in colon cancer and clinicopathological features and prognosis. Methods From September 2016 to September 2017, 58 patients with colon cancer in Yiwu Central Hospital of Zhejiang Province were selected as study objects. The cancer tissues from patients with colon cancer and the adjacent tissues more than 5 cm away from the tumor site were collected. The expression of TMSG-1 and CXCR4 was detected by immunohistochemistry. The expression of TMSG-1 and CXCR4 in different pathological features and the expression of TMSG-1 and CXCR4 in patients with different prognosis were compared. Results The positive expression rates of TMSG-1 and CXCR4 in cancer tissues were higher than those in adjacent tissues (P < 0.05). TNM stage, lymph node metastasis and distant metastasis were associated with positive expression of TMSG-1 and CXCR4 (P < 0.05). The overall survival of colon cancer patients with low TMSG-1 expression was higher than that with high TMSG-1 expression (P < 0.05). The overall survival of colon cancer patients with low CXCR4 expression was higher than that with high CXCR4 expression (P < 0.05). Conclusion The expression of TMSG-1 and CXCR4 is high in colon cancer, which is closely related to TNM stage, lymph node metastasis, distant metastasis and prognosis.
2020 Vol. 17 (35): 131-134 [Abstract] ( 85 ) HTML (1 KB)  PDF (647 KB)  ( 26 )
135 Meta-analysis of traditional Chinese medicine application of shénquē point in the treatment of ileus
TAN Yabin1,2 ZHOU Qin1,2 JIANG Lujian1,2 WANG Yitong1,2 ZUO Minghuan1,2 JIANG Miao3
Objective To systematically evaluate the curative effect of traditional Chinese medicine (TCM) application of shénquē point on ileus. Methods The data of randomized controlled trials about TCM application of shénquē point treated with TCM for ileus were retrieved from Wanfang Data, CNKI, VIP, PubMed, Cochrane and CBM. The retrieval time was from the establishment time of database to March 2020. The literatures were screened according to the inclusion criteria and exclusion criteria, and the RevMan5.3 software was used to analyze the data and quality evaluation of the included literatures. Results A total of 18 randomized controlled trials were included, with 1347 patients of ileus. The meta-analysis result showed that the effective rate in the treatment group was higher than the control group (RR = 1.29, 95%CI [1.22, 1.37], P ＜ 0.000 01). The recovery time of first exhaust (SMD = -1.43, 95%CI [-1.91, -0.95], P ＜ 0.000 01), recovery time of first defecation (SMD = -1.30, 95%CI [-1.73, -0.86], P ＜ 0.000 01), time of abdominal pain release (SMD = -1.47, 95%CI [-1.83, -1.11], P ＜ 0.000 01), time of abdominal distension release (SMD = -1.51, 95%CI [-2.06, -0.95], P ＜ 0.000 01), time of borborygmus resume normal (SMD = -1.18, 95%CI [-1.60, -0.76], P ＜ 0.000 01) in the experimental group was shorter than those in the control group. Conclusion On the basis of conventional treatment, TCM application of shénquē point on ileus can obviously increase the effective rate, improve the clinical symptoms and quality of life of patients.
2020 Vol. 17 (35): 135-139 [Abstract] ( 126 ) HTML (1 KB)  PDF (1246 KB)  ( 27 )
140 Analysis of adverse drug reactions and medication safety of Compound Kushen Injection based on literature reports
DIAN Liping1 WEI Xiaoqing1 TANG Fan1 ZHANG Yuzhu2 ZHONG Shaowen2
Objective To explore the analysis of adverse reactions and medication safety of Compound Kushen Injection based on literature reports. Methods From January 1996 to February 2020, the published relevant literatures on adverse drug reaction (ADR) of Compound Kushen Injections were retrieved by computer from CNKI, Wanfang data and VIP. The statistical analysis mainly involved general data, medical history data, dosage regimen and ADR related situation. Results A total of 13 literatures were enrolled, including 76 cases. ADR caused by Compound Kushen Injection mostly occurred in people over 40 years old, and female (41 cases) was higher than male (35 cases). The occurrence of ADR may be related to daily administration dosage, menstruum, drug combination and other factors. The dangerous period of Compound Kushen Injection was 30 minutes after first infusion. The clinical manifestations of ADR could be involved in many systems, among which, gastrointestinal system and systemic damage were the main ones. Conclusion Clinical use of Compound Kushen Injection should be strictly in accordance with the instructions, attention should be paid to special groups. During the use of drugs, especially within 30 min of the first infusion, it is necessary to closely monitor patients to avoid the occurrence of serious ADR.
2020 Vol. 17 (35): 140-143 [Abstract] ( 155 ) HTML (1 KB)  PDF (600 KB)  ( 126 )
144 Effect of Buzhong Yiqi Decoction on detrusor contractility in patients with underactive bladder
SHEN Jianwu1 ZHANG Peng2 MOU Yanyan3 ZHENG Weijun3 YANG Xiaoqin1 MENG Jun1 DING Jiasen1 GAO Zhan1▲
Objective To evaluate the clinical effect of Buzhong Yiqi Decoction in the treatment of detrusor contractility in patients with underactive bladder. Methods The clinical data of 49 patients treated in Department of Urology of Xiyuan Hospital, China Academy of Chinese Medical Sciences from December 2015 to October 2019 was analyzed retrospectively. According to different treatment methods, the patients were divided into treatment group (27 cases) and control group (22 cases). After indwelling catheterization, the control group was treated with Tamsulosin Hydrochloride Sustained Release Capsules, and the treatment group was treated with Buzhong Yiqi Decoction on the basis of the control group. The treatment course was 1-6 months. The differences of volume of first desire to void (VFD), volume of normal desire to void (VND), maximum flow rate (Qmax), maximum detrusor pressure (Pdet.max), detrusor pressure at the time of maximum flow (Pdet.Qmax), residual urine volume (RV) were compared between the two groups. The adverse reactions of the two groups were recorded during the treatment. Results After treatment, the levels of Qmax, Pdet.max and Pdet.Qmax in both groups were higher than those before treatment, and the RV was lower than that before treatment, the differences were statistically significant (P ＜ 0.05). While there were no significant differences of VFD and VND in the two groups compared with those before treatment (P ＞ 0.05). After treatment, the levels of Qmax, Pdet.max and Pdet.Qmax in the treatment group were all higher than those in the control group (P ＜ 0.05), but there were no statistically significant differences of VFD, VND and RV between the two groups (P ＞ 0.05). No obvious adverse reactions occurred during the treatment in both groups. Conclusion Buzhong Yiqi Decoction in the treatment of underactive bladder has significant effects, which can effectively improve patients’ underactive detrusor.
2020 Vol. 17 (35): 144-147 [Abstract] ( 139 ) HTML (1 KB)  PDF (558 KB)  ( 78 )
148 Clinical effect of Danqi Soft Capsules combined with Trimetazidine in the treatment of angina pectoris of coronary artery heart disease
FEI Yan PAN Jun
Objective To observe the clinical effect of Danqi Soft Capsules combined with Trimetazidine in the treatment of angina pectoris of coronary artery heart disease. Methods One hundred and four patients with angina pectoris of coronary heart disease admitted to Northern Jiangsu People’s Hospital from March 2017 to May 2019 were selected and divided into control group and observation group by random number table method, with 52 cases in each group. The control group was treated with Trimetazidine, while the observation group was treated with Danqi Soft Capsules on the basis of control group. Both groups were treated for 4 weeks. The clinical efficacy was evaluated after treatment. The visual analogue scale (VAS) of angina pectoris, duration and attack times of angina pectoris, lactic acid dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase isoenzyme (CK-MB), nitric oxide (NO), endothelin-1 (ET-1), fibrinogen (FIB) and prothrombin time (PT) were compared between the two groups. The adverse reactions during treatment were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group (P ＜ 0.05). After treatment, VAS in the two groups was lower than that before treatment, the duration was shorter than that before treatment, and the attack times of angina pectoris were less than that before treatment. Moreover, VAS in the observation group was lower than that in the control group, the duration was shorter than that in the control group, and the attack times were less than that in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the LDH, AST, CK-MB, ET-1 and FIB levels in the two groups were lower than those before treatment (P ＜ 0.05), and the LDH, AST, CK-MB, ET-1 and FIB levels in the observation group were lower than those in the control group (P ＜ 0.05). The NO and PT levels in the two groups were significantly higher than those before treatment (P ＜ 0.05), and NO and PT levels in the observation group were higher than those in the control group (P ＜ 0.05). There was no significant difference of the incidence of adverse reactions between the two groups during the treatment (P ＞ 0.05). Conclusion Danqi Soft Capsules combined with Trimetazidine in the treatment of angina pectoris of coronary heart disease can obviously alleviate the degree of angina pectoris pain, reduce the duration and attack times, lower the LDH, AST, CK-MB, ET-1 and FIB levels, increase the NO and PT levels, with good clinical effect and no obvious adverse reactions.
2020 Vol. 17 (35): 148-151,155 [Abstract] ( 136 ) HTML (1 KB)  PDF (964 KB)  ( 17 )
152 Effect of comfeel hydrocolloid dressing combined with nursing intervention on the treatment effect of suspending traction of legs for femoral shaft fracture in children
SHEN Dongying TANG Meixiu ZHAO Min
Objective To investigate the effect of comfeel hydrocolloid dressing combined nursing intervention on the treatment of pediatric femoral shaft fractures with suspension traction. Methods From July 2015 to June 2018, 72 children with femoral shaft fractures who admitted Rugao People’s Hospital of Jiangsu Province were enrolled. The prospective study was used, according to the random number table method, the children were divided into intervention group and control group. The control group was given the treatment of suspension traction of the legs, and the intervention group was combined with comfeel hydrocolloid dressing and nursing intervention. The clinical efficacy, healing time, treatment-related indicators, and complications were compared between the two groups. Results The surative effect of children with femoral shaft fracture in the intervention group was significantly better than that in the control group (P ＜ 0.05). The healing time and hospitalization time were significantly shorter than the control group, and the hospitalization expenses were significantly less than the control group (P ＜ 0.05 or P ＜ 0.01). The incidence of pain and other complications in the intervention group were significantly lower than those in the control group. Conclusion Comfeel hydrocolloid dressing combined with nursing intervention can promote the rapid recovery of children with femoral shaft fracture and suspending traction, reduce the occurrence of pain and other complications, and improve clinical efficacy.
2020 Vol. 17 (35): 152-155 [Abstract] ( 77 ) HTML (1 KB)  PDF (589 KB)  ( 96 )
156 Effect of action research analysis on preventive effect of recurrent cerebral hemorrhage in hypertensive patients and its adaptation
CAO Hong ZHANG Xiangtong
Objective To explore and analyze the preventive effect of action research analysis on recurrent cerebral hemorrhage in hypertensive patients and its impact on their adaptation. Methods From January 2018 to January 2020, 80 cases of patients who had the hypertension with recurrent cerebral hemorrhage were treated in the First Affiliated Hospital of Harbin Medical University were selected. All the patients were taken a random number table method divided into control group and observation group, with 40 cases in each group. Control group was given the conventional intervention, on the basic of the control group, observation group was given the action research analysis. The behavior change, risk factor and adaptation status of recurrent cerebral hemorrhage were compared between the two groups. Results The proportion of patients who had a salty or high-fat diet, smoking, excessive drinking, lack of exercise, excessive stress in life, inability to adhere to regular medication, and unable to regularly monitor blood pressure in the two groups after intervention were lower than those before intervention, and the above indexes after the intervention in the observation group were lower than those in the control group after intervention, the differences had a statistically significant (P ＜ 0.05). The risk coefficients of diet, medication, exercise, defecation and other occurrences in the two groups after intervention were lower than those before intervention, and the above indexes after the intervention in the observation group were lower than those in the control group after intervention, the differences had a statistically significant (P ＜ 0.05). The emotional function, social function, physiological function, mental health and overall health scores in the two groups after intervention were higher than those before intervention, and the above-mentioned index scores in the observation group after intervention were higher than those in the control group after intervention, the differences had a statistically significant (P ＜ 0.05). Conclusion The application of action research analysis can effectively change the daily behavior of hypertensive patients with recurrent cerebral hemorrhage, reduce the risk of recurrent cerebral hemorrhage, and improve their adaptation.
2020 Vol. 17 (35): 156-159,180 [Abstract] ( 75 ) HTML (1 KB)  PDF (994 KB)  ( 71 )
160 Application of WeChat-led diversified health education in patients with Helicobacter pylori positive peptic ulcer
SUN Haili1 YANG Xueying2▲
Objective To explore the application effect of diversified health education based on WeChat in patients with Helicobacter pylori (Hp) positive peptic ulcer. Methods From July 2017 to June 2018, 125 patients with Hp-positive peptic ulcer admitted to the First Affiliated Hospital of Xi’an Jiaotong University were selected. According to the duration of hospitalization, they were divided into the treatment group (January 2018 to June 2018) with 64 cases and the control group (July 2017 to December 2017) with 61 cases. The control group was given regular health education, and the treatment group jointly applied diversified health education based on WeChat. Follow-up for 6 months, disease uncertainty, health literacy, healthy behavior, recurrence rate and other indicators between the two groups were compared. Results After 6 months of follow-up, the two groups’ disease ambiguity scores were significantly lower than those of the same group before education (P ＜ 0.05), and patients had obvious ambiguity, complexity, unpredictability, and disease uncertainty total scores in the treatment group were lower than that in the control group (P ＜ 0.05). The health literacy scores of the two groups were significantly higher than those before education in the same group (P ＜ 0.05). The total scores of basic knowledge and concepts, healthy lifestyles and behaviors, basic skills, and health literacy of the treatment group were significantly higher than those of the control group (P ＜ 0.05). After 6 months of follow-up, the health behavior scores of the experimental group were all better than those before education, nutrition, self-realization and general health behavior of the control group were better than those before education (P ＜ 0.05), and exercise, interpersonal support and stress response of the experimental group were better than those of the control group (P ＜ 0.05). The recurrence rate was significantly lower than the control group (P ＜ 0.05). Conclusion Diversified health education based on wechat can help alleviate the uncertainty of Hp-positive peptic ulcer patients, promote the development of health literacy and healthy behavior, and reduce the recurrence rate of peptic ulcer.
2020 Vol. 17 (35): 160-164 [Abstract] ( 138 ) HTML (1 KB)  PDF (606 KB)  ( 58 )
165 Effect of integrated psychotherapy on the psychological symptoms and healthy behaviors of HIV/AIDS patients
YANG Fang1 XIE Manxia2▲ LI Yan1
Objective To investigate the effect of integrated supportive psychotherapy on the psychological symptoms and healthy behaviors of patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). Methods From July 2017 to July 2019, 85 HIV/AIDS patients admitted to the Huai’an No 4 People’s Hospital were selected. According to the duration of hospitalization, they were divided into 43 cases in the treatment group(August 2018 to July 2019) and 42 cases in the control group (July 2017 to July 2018). The control group was given routine nursing intervention, and the treatment group was given integrated supportive psychotherapy. After 6 months of follow-up, the mental state, healthy behavior, satisfaction and other indicators of the two groups were compared. Results The psychological symptoms scores of the two groups were significantly lower than those before the intervention in the same group (P ＜ 0.05). Obsessive-compulsive symptoms, interpersonal care sensitivity, depression, anxiety, hostility, phobia, and paranoia scores of the treatment group were significantly lower than those of the control group, and the differences were statistically significant (P ＜ 0.05); the health behavior of the two groups was significantly higher than that before the intervention in the same group (P ＜ 0.05). The treatment group’s antiviral treatment compliance, regular sex partners, and frequent and every use of condoms were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05). The satisfaction of the treatment group was significantly better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Integrated supportive psychotherapy can help improve the psychological state of HIV/AIDS patients, promote the development of healthy behaviors, and improve patient satisfaction.
2020 Vol. 17 (35): 165-168 [Abstract] ( 113 ) HTML (1 KB)  PDF (620 KB)  ( 212 )
169 Influence of mobile phone WeChat-based intervention model on self-care ability and self-disclosure of patients after radical mastectomy
LU Ping LI Yiju ZHANG Yunyu LU Lihua CHEN Yunxia
Objective To explore the influence of the intervention model based on mobile phone WeChat on the self-care ability and self-disclosure of patients after radical mastectomy. Methods A total of 268 breast cancer patients treated in the Affiliated Hospital of Nantong University from October 2018 to October 2019 were selected as the research objects, and they were divided into the control group and the observation group by random number table, with 134 cases in each group. Both groups underwent radical mastectomy, the control group underwent conventional intervention after surgery, and the observation group underwent conventional intervention combined with mobile phone WeChat-based intervention after surgery. Before intervention and 3 months after intervention, the self-care ability (assessed by the self-care ability measurement scale [ESCA]) and self-disclosure status (assessed by the Jourard self-disclosure questionnaire [JSDQ]) were evaluated and compared between the two groups. Results After 3 months of intervention, the ESCA and JSDQ scale scores and total scores of the two groups were higher than those before intervention, and the observation group was higher than the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The intervention model based on mobile phone WeChat can improve the self-care ability of patients with breast cancer after surgery and improve their self-disclosure.
2020 Vol. 17 (35): 169-172 [Abstract] ( 96 ) HTML (1 KB)  PDF (620 KB)  ( 76 )
173 Application of video combined with mind map health education in patients undergoing endoscopic retrograde cholangio-pancreatography
ZHANG Yahui LI Hui
Objective To explore the application effect of video combined with mind map health education in patients with endoscopic retrograde cholangio-pancreatography (ERCP). Methods From April 2017 to August 2019, 93 patients who underwent ERCP in the Affiliated Huai’an First People’s Hospital of Nanjing Medical University were selected. According to the random number table method, they were divided into 47 cases in the treatment group and 46 cases in the control group. The control group was given regular education, and the treatment group was given health education with video combined with mind map. ERCP knowledge awareness, negative emotions and complications were compared between the two groups. Results After education, the awareness rate of health related knowledge in the two groups increased significantly (P ＜ 0.05); the awareness rate of disease knowledge, ERCP knowledge, medication management, psychological management, and healthy life in the treatment group was higher than that in the control group (P ＜ 0.05). The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in both groups were significantly reduced (P ＜ 0.01); SAS and SDS scores of the observation group were significantly higher than those of the control group (P ＜ 0.01). The incidence of complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion Video and mind map health education can help improve the health-related knowledge level of ERCP patients, relieve anxiety and depression, and reduce the occurrence of ERCP complications.
2020 Vol. 17 (35): 173-176 [Abstract] ( 92 ) HTML (1 KB)  PDF (653 KB)  ( 99 )
177 Influence of scientific research on medical organic chemistry experiment teaching quality in medical colleges
WANG Haibo QIN Xiangyang XIN Chunyan JI Nan HE Wei▲
This paper analyzes the problems existing in the integration of scientific research and undergraduate teaching in our country and proposes some measures to promote the medical organic chemistry experiment teaching quality through applying scientific research achievements. Practice has proved that the integration of scientific research into teaching can fully improve students’ experimental operation ability, increase their interest in chemical experiment course and their understanding of theoretical knowledge points, and further improve students’ innovative consciousness and ability, which has a significant role in improving the experimental teaching quality of medical organic chemistry.
2020 Vol. 17 (35): 177-180 [Abstract] ( 102 ) HTML (1 KB)  PDF (641 KB)  ( 32 )
181 Research on key index system of quality service evaluation
TIAN Tian1 PAN Limin2 WANG Chenyu1 HUANG Xiantao3
Objective To explore the key index system for quality service evaluation. Methods From June to December 2019, the First Affiliated Hospital of Hebei North University established a research group on key index system of quality service evaluation, and designed key index of quality service evaluation by indexing domestic and foreign literature. Two rounds of expert consultation were conducted by using Delphi method with 126 health management related personnel as consulting experts, and questionnaire survey was conducted to construct key indicators of quality service evaluation. Results In the first round, 123 questionnaires were recovered and 119 were valid; In the second round, 118 questionnaires were recovered and 114 were valid. The positive coefficients of both rounds were >70%. Kendall’s W coordination coefficient ranged 0-1, and the coefficient of variation was < 0.2 for both rounds. The authority of experts in the first round was 0.901, and that in the second round was 0.951. After two rounds of consultation, six indicators, tangibility, reliability, responsiveness, security, thoughtfulness and consistency, were determined as the first-level indexes. There were 23 second-level indexes. Conclusion The design of key index system of quality service evaluation based on patient experience is of great significance in clinical practice，which can effectively improve the experience of patients on medical quality and promote the evaluation of medical quality.
2020 Vol. 17 (35): 181-184 [Abstract] ( 81 ) HTML (1 KB)  PDF (628 KB)  ( 61 )
185 Application of integrated doctor-patient extended medical service on sport management of ankylosing spondylitis patients
CHEN Lixin LAN Xiaochun WEI Wei RUAN Sulian
Objective To study the effect of integrated doctor-patient extended medical service on sport management of ankylosing spondylitis patients. Methods A total of 94 ankylosing spondylitis patients who treated in Wuming Hospital of Guangxi Medical University from July 2019 to February 2020 were selected as objects. According to the random number table method, they were divided into the control group and the observation group, with 47 cases in each group. The control group was treated with routine management; the observation group was treated with the integrated doctor-patient extended medical service. Spinal function of the two groups were investigated. Results Before intervention, there were no statistically significant differences between the two groups in scores of socks wearing, bending, sitting, lying, touching height, turning, staging and physical ability (P > 0.05). After intervention, the scores of socks wearing, bending, sitting, lying, touching height, turning, staging and physical ability in the observation group were all lower than those in the control group, and the differences were statistically significant (all P < 0.05). Before intervention, there were no significant differences in scores of body fatigue, joint pain, joint stiffness and joint morning stiffness time between the two groups (P > 0.05). After intervention, the scores of body fatigue, joint pain and joint stiffness were lower than those of the control group, and joint morning stiffness time was shorter than that of the control group, and the differences were statistically significant (all P < 0.05). Conclusion The integrated doctor-patient extended medical service has better improvement effects on ankylosing spondylitis patient’s sport management and spinal function recovery. It is worthy of clinical application and promotion.
2020 Vol. 17 (35): 185-188 [Abstract] ( 113 ) HTML (1 KB)  PDF (590 KB)  ( 86 )
189 Effect of peer support education on disease uncertainty and self-management efficacy in postoperative patients with prostate cancer
HUA Jianhong ZHU Lixia YAO Huiqin WANG Yong ZHOU Liqin▲
Objective To investigate the effect of peer support on disease uncertainty and self-management efficacy in postoperative patients with prostate cancer. Methods A total of 116 patients with prostate cancer underwent surgery in Wuxi People’s Hospital Affiliated to Nanjing Medical University from January 2017 to December 2019 were enrolled. They were divided into intervention group and control group by random number table method, with 58 cases in each group. There was two cases and six cases falling off in intervention group and control group respectively, 56 cases in intervention group and 52 cases in control group. Control group was given routine nursing intervention after prostate cancer surgery, and intervention group was combined with peer support education on the basis of control group. After six months of follow-up, the indicators of disease uncertainty, self-management efficacy and quality of life were compared between two groups. Results After six months of follow-up, the scores of uncertainty, inconsistency, complexity and unpredictability in two groups were lower than those before intervention, and the scores of uncertainty, inconsistency and unpredictability in intervention group were lower than those in control group (P < 0.05). After six months of follow-up, the scores of self-decision-making, positive attitude and self decompression in two groups were higher than those before intervention, and the scores of self-decision-making, positive attitude and self decompression in intervention group were higher than those in control group (P < 0.05). After six months of follow-up, the scores of physical function, emotional function, role function, cognitive function and social function in two groups were higher than those before intervention, and the scores of emotional function, cognitive function and social function in intervention group were higher than those in control group (P < 0.05). Conclusion Peer support education can help alleviate the disease uncertainty in patients with postoperative prostate cancer, promote the development of self-management efficacy, and improve the quality of life of patients.
2020 Vol. 17 (35): 189-192,196 [Abstract] ( 90 ) HTML (1 KB)  PDF (620 KB)  ( 69 )
193 Thoughts on the predicament of the implementation of advance care planning under the background of traditional Chinese culture
SUO Tingting1 ZHAO Baojuan2 SHEN Yongqing1
Advance care planning (CAP), an effective measure to improve the quality of life of patients with end-stage diseases, can save limited medical resources while increasing the satisfaction of patients and their families. Based on the Chinese cultural background, this article summarizes the influencing factors that affect the implement of domestic ACP from three perspectives: patients, family members, and medical staff. And on this basis, it is proposed to increase publicity, train professional medical staff, build a family-oriented communication mode, timely understand the demands of patients and their families and actively explore other proposals, in order to speed up legislation, which can be considered as effective measures to cope the difficulties when implementing ACP in patients with Chinese culture background, so as to provide reference for the implementation of the ACP in China.
2020 Vol. 17 (35): 193-196 [Abstract] ( 85 ) HTML (1 KB)  PDF (631 KB)  ( 99 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech