全程营养支持对晚期肺癌患者治疗耐受性和放疗疗效的影响

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Abstract Objective To explore the effect of whole course nutritional support on the treatment tolerance and radiotherapy effect of advanced lung cancer patients. Methods A total of 108 patients with advanced lung cancer who admitted to Lianyungang Second People’s Hospital from January 2017 to December 2018 were selected as objects. They were divided into control group and treatment group according to the random number table method, with 54 cases in each group. The control group was treated with chemoradiotherapy alone, the treatment group was treated with whole course nutritional support while undergoing chemoradiotherapy. The clinical efficacy of two groups after treatment was compared. The Karnofsky performance status (KPS) scores and serum levels of prealbumin (PA) and albumin (ALB) of two groups before and after treatment were compared. The radiotherapy interruption rates, radiotherapy total days, chemotherapy completion numbers and acute radiological response rate of the two groups were compared. Results The total remission rate in treatment group was higher than that of control group (P < 0.05). The KPS scores of two groups after treatment were lower than those before treatment, and the KPS scores of treatment group after treatment were higher than those of control group (all P < 0.05). After treatment the levels of PA and ALB of control group were lower than those before treatment, the levels of treatment group were higher than those before treatment, and the levels of PA and ALB of treatment group were higher than those of control group (all P < 0.05). The radiotherapy interruption rate of treatment group was lower than that of control group, the radiotherapy total days were less than those of control group, and the number of completed chemotherapy was higher than that of control group (all P < 0.05). The incidence rate of myelosuppression, acute gastrointestinal reactions and acute radioactive proctitis in treatment group were lower than those of control group (all P < 0.05). Conclusion Whole course nutritional support can significantly improve the radiotherapy effect and treatment tolerance of patients with advanced lung cancer, improve the quality of life and nutritional status, and reduce the acute radiation response.

Key words： Advanced lung cancer Whole course nutritional support Radiotherapy Chemotherapy Tolerance Efficacy

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	SONG Chenglin LI Suzhen ZHAO Jiuhong GE Pingping▲

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SONG Chenglin LI Suzhen ZHAO Jiuhong GE Pingping▲. Effect of whole course nutritional support on the treatment tolerance and radiotherapy effect of advanced lung cancer patients[J]. 中国医药导报, 2020, 17(35): 127-130.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I35/127

[1] 周棉勇，何江，管慧，等.1999-2018年黔南州居民肺癌发病年龄变化趋势分析[J].现代预防医学，2019，46（20）：3812-3816.
[2] 刘娟，张燕茹，章剑，等.江苏省江阴市2012—2016年肺癌发病与死亡分析[J].中国肿瘤，2019，28（10）：769-773.
[3] 盛源.单纯放疗和放化疗同步治疗老年晚期非小细胞肺癌的临床价值对比[J].中外医学研究，2019，17（35）：141-142.
[4] 马运侠，柯希兰，郭薇.营养支持结合姑息护理对肿瘤患者营养状态及生存质量的影响[J].检验医学与临床，2019， 16（17）：2550-2553.
[5] 冀赛光，强勇，胡力文，等.全程营养治疗对于食管癌患者术后体质成分的影响[J].东南国防医药，2019，21（5）：482-486.
[6] 中华医学会.临床诊疗指南肿瘤分册[M].北京：人民卫生出版社，2005.
[7] 殷蔚伯，余子豪，徐国镇，等.肿瘤放射治疗学[M].北京：中国协和医科大学出版社，2008：1039.
[8] 孙燕.内科肿瘤学[M].北京：人民卫生出版社，2001：996.
[9] 何燕，岳丽梅，夏劲节，等.2016-2018年成都市恶性肿瘤发病率分析[J].预防医学情报杂志，2019，35（11）：1268-1274.
[10] 秦楠，姜桂春.卵巢癌术后化疗病人营养状况的现状调查与分析[J].肠外与肠内营养，2019，26（6）：351-355.
[11] 杨玉薇.对30例恶性肿瘤患者营养状况的分析[J].心理月刊，2019，14（19）：41-42.
[12] 石汉平.恶性肿瘤营养不良的五大特征[C].中国中西医结合学会营养学专业委员会.第十届全国中西医结合营养学术会议论文资料汇编.中国中西医结合学会营养学专业委员会：中国中西医结合学会，2019：592.
[13] 于娇，喻凤，曹席明.全程营养支持治疗对宫颈癌患者急性放射反应、耐受性和疗效影响的临床观察[J].临床肿瘤学杂志，2018，23（7）：635-639.
[14] 仲金丹，吴君美，李元君，等.全程精细化营养支持对老年食管癌同步放化疗患者营养状况及近期生命质量的影响[J].中国医学前沿杂志：电子版，2019，11（6）：68-72.
[15] 李旻骏，滕煜宪，黎晴，等.血清前白蛋白与肝细胞癌患者肝切除术预后的相关性研究[J].中华肝胆外科杂志，2020，26（1）：27-31.
[16] 修艳丽，王璐，廖蕾，等.综合护理干预对老年早期非小细胞肺癌术后患者预后的影响[J].中国医药科学，2018， 8（16）：128-130.
[17] Ni XF，Wu J，Ji M，et al. Effect of C-reactive protein/albumin ratio on prognosis in advanced non-small-cell lung cancer [J]. Asia Pac J Clin Oncol，2018，14（6）：402-409.
[18] 林宝钗，赵李昊，薛圣留，等.术前血清白蛋白对Ⅱ~Ⅲ期食管鳞癌预后的预测价值[J].中国现代医生，2018， 56（29）：9-12，封3.
[19] 李娟，黄沈珺，潘月龙，等.晚期肿瘤患者营养状况检测指标的研究[J].重庆医学，2015，44（35）：4953-4954， 4957.
[20] 曹远东，孙新臣，唐心宇，等.全程营养支持治疗对鼻咽癌急性放疗反应及治疗依从性的影响[J].临床肿瘤学杂志，2016，21（4）：349-352.
[21] Yang J，Zhang Q，Wang X. Role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer [J]. Oncol Lett，2018，16（5）：5978-5982.
[22] 李缨，钱红娟，黄芸，等.全程营养管理对肿瘤患者化疗前后营养变化的影响[J].中国医师进修杂志，2018，41（10）：901-904.
[23] 孟凡静.全程营养管理对肺癌放疗患者康复及并发症的影响[J].护理实践与研究，2017，14（17）：86-88.