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| Effect of self-made Qige Huayu Formula on coagulation function, pain level and quality of life in patients with esophageal cancer after stent implantation |
| XU Yapei1 YANG Zhufeng1▲ YANG Jing1 LONG Run1 LI Shiji1 GU Nuonuo2 |
1.Department of Digestive Endoscopy, Hebei Provincial Hospital of Traditional Chinese Medicine, Heibei Province, Shijiazhuang 050011, China;
2.Department of Anorectal, Shijiazhuang Hospital of Traditional Chinese Medicine, Heibei Province, Shijiazhuang 050011, China |
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Abstract Objective To observe the effect of self-made Qige Huayu Formula on coagulation function, pain level and quality of life in patients with esophageal cancer after stent implantation. Methods A total of 62 patients with esophageal cancer admitted to Hebei Provincial Hospital of Traditional Chinese Medicine from June 2018 to June 2019 were selected and divided into treatment group and control group by the random number table method, with 31 cases in each group. The patients in both groups underwent endoscopic esophageal stent implantation. On this basis, treatment group was given self-made Qige Huayu Formula, while the control group was given Kuanxiong Lige Pills. The two groups were both given medicine for one month continuously. The clinical efficacy, traditional Chinese medicine (TCM) syndrome score, coagulation function (prothrombin time [PT], thrombin time [TT], activated partial thromboplastin time [APTT], plasma fibrinogen [FIB]), numerical rating scale (NRS) score and quality of life questionnaire (QLQ) -C30 score were compared between the two groups. Results Before treatment, there were no significant differences in TCM syndrome score, coagulation function, NRS score and QLQ-C30 score between the two groups (all P ＞ 0.05). After treatment, the clinical total effective rate of the treatment group was higher than that of the control group (P ＜ 0.05). After treatment, the TCM syndrome scores of the two groups were lower than that before treatment, and treatment group were lower than those of the control group (P ＜ 0.05). After treatment, FIB level in two groups were higher than before treatment, and treatment group was higher than that of the control group (P ＜ 0.05), while PT, TT and APTT levels in two groups were lower than those before treatment, and the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the NRS score of the two groups was lower than before treatment, and treatment group was lower than the control group (P ＜ 0.05). After treatment, the scores of QLQ-C30 in the two groups were increased, and the scores in the treatment group were higher than those of the control group (P ＜ 0.05). Conclusion Self-made Qige Huayu Formula has significant clinical effect in the treatment of esophageal cancer after stent implantation, which can improve the coagulation function, alleviate pain level and improve the quality of life of patients, which is worthy of clinical research and application.
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