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| Clinical effect of Donepezil combined with Idebenone in the treatment of early vascular cognitive dysfunction |
| JI Lili HUANG Tingting▲ |
| Department of Neurology, Changzhou Wujin People’s Hospital, Jiangsu Province, Changzhou 213017, China |
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Abstract Objective To investigate the clinical effect of Donepezil combined with Idebenone in the treatment of early vascular cognitive dysfunction. Methods A total of 94 patients with early vascular cognitive dysfunction admitted to Changzhou Wujin People’s Hospital, Jiangsu Province from January to December 2019 were selected as the research objects. According to the random number table method, all the enrolled patients were divided into observation group and control group, with 47 cases in each group. The control group was given Donepezil routine treatment, the observation group on the basis of the control group combined with Idebenone. The two groups were compared before and after treatment with a simple mental state examination (MMSE) score, clinical efficacy, daily living activity assessment scale (ADL) score, and adverse drug reactions. Results The total clinical effective rate in the observation group was higher than that in the control group (P ＜ 0.05). The overall analysis of MMSE score showed that the differences in intergroup comparison, time point comparison and interaction were statistically significant (all P ＜ 0.05). Intra-group comparison: MMSE scores of both groups were significantly higher than those before treatment at 30 and 60 days after treatment, and those at 60 days after treatment were higher than those at 30 days after treatment (all P ＜ 0.05). Comparison between groups: 30 and 60 days after treatment, MMES score of the observation group was higher than that of the control group (all P ＜ 0.05). The overall analysis of ADL score showed that the differences in intergroup comparison, time point comparison and interaction were statistically significant (all P ＜ 0.05). Intra-group comparison: ADL scores of the two groups were significantly higher than those before treatment at 30 and 60 days after treatment (all P ＜ 0.05). Comparison between groups: 30 and 60 days after treatment, ADL score of the observation group was higher than that of the control group (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups after treatment (P ＞ 0.05). Conclusion Donepezil combined with Idebenone is effective in the treatment of early vascular cognitive dysfunction, and can effectively improve the cognitive impairment of patients.
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