<sup>131</sup>I美妥昔单抗联合肝动脉化疗栓塞术治疗原发性肝癌的临床效果

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Abstract Objective To evaluate the efficacy and safety of ¹³¹I-Metuximab injection (Licartine) combined with hepatic artery transcatheter arterial chemoembolization (TACE) in the treatment of advanced primary liver cancer. Methods A total of 45 patients with advanced liver cancer who admitted to the Cancer Center of Renmin Hospital of Wuhan University from January 2017 to February 2019 were selected and divided into two groups according to the treatment method, 15 cases in group A, receiving licartin combined with TACE treatment; 30 cases in group B received TACE treatment alone. After treatment, patients of the two groups were followed up to observe, and the objective response rate (ORR), disease control rate (DCR), progress free survival (PFS) time, interventional treatment-related adverse reactions, hematological toxicity (white blood cell [WBC] count, platelet [PLT] count) and liver function damage [total bilirubin (TB), alanine transaminase (ALT)] rate were compared between the two groups. Results There were no significant differences in ORR, DCR and PFS between the two groups (all P ＞ 0.05). In terms of adverse reactions related to interventional therapy, there were no significant differences in the incidence of fever, abdominal pain, nausea and vomiting between the two groups (all P ＞ 0.05). In terms of hematological toxicity, the PLT count in group A was significantly lower than that in group B at one week after operation, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in WBC counts between the two groups at one week after surgery (P ＞ 0.05). In terms of liver function, there were no statistically significant differences in TB and ALT levels between the two groups at one week after surgery (P ＞ 0.05). The above-mentioned adverse reactions were mostly grade Ⅰ-Ⅱ, and no serious adverse events related to the treatment drugs occurred. Conclusion Licartin combined with TACE for the treatment of patients with primary liver cancer is well tolerated and safe, but the efficacy needs further verification.

Key words： Primary hepatic carcinoma Transcatheter arterial chemoembolization ¹³¹I metuximab Short term efficacy Adverse reactions

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	WAN Chao CHEN Biao LIN Dandan HE Xiaoqin XU Ximing

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WAN Chao CHEN Biao LIN Dandan HE Xiaoqin XU Ximing. Clinical effect of ¹³¹I-Metuximab combined with hepatic arterial transcatheter arterial chemoembolization in the treatment of primary liver cancer[J]. 中国医药导报, 2020, 17(35): 99-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I35/99

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