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| Analysis of prognostic factors of severe lung cancer patients complicated with invasive pulmonary aspergillosis |
| DENG Lijuan1 WANG Hongzhou2 |
1.Department of Respiratory Medicine, Sichuan Mianyang 404 Hospital, Sichuan Province, Mianyang 621000, China;
2.Department of Respiratory and Critical Care Medicine, Sichuan Science City Hospital, Sichuan Province, Mianyang 621000, China |
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Abstract Objective To analyze the prognostic factors of severe lung cancer patients complicated with invasive pulmonary aspergillosis. Methods A total of 60 patients with severe lung cancer complicated with invasive pulmonary aspergillosis admitted to Sichuan Mianyang 404 Hospital from January to December 2019 were selected as the study subjects. General data of patients with severe lung cancer complicated with invasive pulmonary aspergillosis were collected, including age, gender, smoking history, organ failure, etc., to study the prognostic risk factors of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Results Univariate analysis showed that age, whether have organ failure or not, whether have hypoproteinemia or not, duration of anti-invasive pulmonary aspergillosis treatment, and whether to receive anti-invasive pulmonary aspergillosis treatment before diagnosis all affected the prognosis of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Multiple regression multivariate analysis showed that advanced age (OR = 1.342, 95%CI [1.104-3.844], P < 0.05), organ failure (OR = 1.202, 95%CI[1.088-3.122], P ＜ 0.05), hypoproteinemia (OR = 1.570, 95%CI [1.157-3.916], P < 0.05) were independent risk factors for prognosis of patients with severe lung cancer complicated with invasive pulmonary aspergillosis. Conclusion Severe lung cancer complicated with invasive pulmonary aspergillosis patients with advanced age, organ failure and hypoproteinemia have a high short-term mortality rate, so the value of early and continuous anti-invasive treatment of pulmonary aspergillosis should be emphasized
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