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| Effect of Buzhong Yiqi Decoction on detrusor contractility in patients with underactive bladder |
| SHEN Jianwu1 ZHANG Peng2 MOU Yanyan3 ZHENG Weijun3 YANG Xiaoqin1 MENG Jun1 DING Jiasen1 GAO Zhan1▲ |
1.Department of Urology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;
2.Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China;
3.Basic Medical College, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310053, China |
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Abstract Objective To evaluate the clinical effect of Buzhong Yiqi Decoction in the treatment of detrusor contractility in patients with underactive bladder. Methods The clinical data of 49 patients treated in Department of Urology of Xiyuan Hospital, China Academy of Chinese Medical Sciences from December 2015 to October 2019 was analyzed retrospectively. According to different treatment methods, the patients were divided into treatment group (27 cases) and control group (22 cases). After indwelling catheterization, the control group was treated with Tamsulosin Hydrochloride Sustained Release Capsules, and the treatment group was treated with Buzhong Yiqi Decoction on the basis of the control group. The treatment course was 1-6 months. The differences of volume of first desire to void (VFD), volume of normal desire to void (VND), maximum flow rate (Qmax), maximum detrusor pressure (Pdet.max), detrusor pressure at the time of maximum flow (Pdet.Qmax), residual urine volume (RV) were compared between the two groups. The adverse reactions of the two groups were recorded during the treatment. Results After treatment, the levels of Qmax, Pdet.max and Pdet.Qmax in both groups were higher than those before treatment, and the RV was lower than that before treatment, the differences were statistically significant (P ＜ 0.05). While there were no significant differences of VFD and VND in the two groups compared with those before treatment (P ＞ 0.05). After treatment, the levels of Qmax, Pdet.max and Pdet.Qmax in the treatment group were all higher than those in the control group (P ＜ 0.05), but there were no statistically significant differences of VFD, VND and RV between the two groups (P ＞ 0.05). No obvious adverse reactions occurred during the treatment in both groups. Conclusion Buzhong Yiqi Decoction in the treatment of underactive bladder has significant effects, which can effectively improve patients’ underactive detrusor.
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