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| Research progress of bone marrow mesenchymal stem cells in treatment of myocardial infarction |
| ZHAO Liping1 ZHOU Chenming2 LI Jingjing3 XU Yannan4▲ |
1.School of Basic Medical, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China;
2.Electron microscope Laboratory Center, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China;
3.Department of Cell Biology, Hebei Medical University, Hebei Province, Shijiazhuang 050017, China;
4.Teaching Experiment Center，Hebei Medical University, Hebei Province, Shijiazhuang 050017, China |
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Abstract Myocardial infarction is the most common critical disease in clinic, which is a serious threat to human health. Bone marrow mesenchymal stem cells are ideal seed cells for the treatment of cardiovascular diseases due to their advantages of multidifferentiation, easy access, rapid proliferation, low immunogenicity and strong transplantability. The mechanism of bone marrow mesenchymal stem cells therapy in myocardial infarction includes anti-inflammatory and anti-fibrosis, promoting angiogenesis, and immune regulation. However, in the process of transplantation, the survival of transplanted cells is affected by the activity, migration, homing and other factors of transplanted cells. In this paper, the characteristics of bone marrow mesenchymal stem cells and the mechanism of treating myocardial infarction are summarized as follows.
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