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| Evaluation value of red blood cell distribution width combined with neutrophil/lymphocyte ratio in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease |
| WANG Lifang HAN Han SHI Bin |
| Department of Respiratory and Critical Medicine, Suqian People’s Hospital of Nanjing Gulou Hospital Group (Suqian Hospital Affiliated to Xuzhou Medical University), Jiangsu Province, Suqian 223800, China |
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Abstract Objective To investigate the evaluation value of red blood cell distribution width (RDW) combined with neutrophil/lymphocyte ratio (NLR) in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods One hundred and sixty patients with AECOPD admitted to Suqian Hospital Affiliated to Xuzhou Medical University from January 2017 to December 2019 were selected and divided into survival group (120 cases) and death group (40 cases) according to their prognosis and survival. The treatment methods, complications, RDW and NLR levels of two groups were compared. The effects of RDW and NLR on the prognosis of AECOPD were analyzed by multivariate logistic regression. The diagnostic value of serum RDW and NLR in the prognosis of AECOPD were evaluated by the area under ROC curve. Results The proportion of mechanical ventilation in survival group was significantly lower than that in death group (P < 0.05). There were no significant differences in the proportion of β2 receptor agonist and inhaled hormone between two groups (P > 0.05). The incidence rate of pulmonary heart disease in survival group was significantly lower than that in death group (P < 0.05). There were no significant differences in the incidence of hypertension, hyperlipidemia, diabetes and atrial fibrillation between two groups (P > 0.05). The levels of RDW and NLR in survival group were significantly lower than those in death group (P < 0.05). Multivariate logistic regression analysis showed that mechanical ventilation (OR = 23.050, 95%CI: 1.688-314.701, P < 0.05), pulmonary heart disease (OR = 15.223, 95%CI: 1.248-185.706, P < 0.05), RDW (OR = 171.288, 95%CI: 6.075-4829.307, P < 0.05) and NLR (OR = 8.410, 95%CI: 1.414-50.022, P < 0.05) were independent risk factors for the prognosis of AECOPD (P < 0.05). The area under the curve of combined detection was significantly higher than that of RDW and NLR (P < 0.05). Conclusion The elevated levels of RDW and NLR are risk factors for the prognosis of AECOPD patients, early combined detection can be used as an important biochemical marker to diagnose the prognosis of patients.
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