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2018 Vol. 15, No. 36 Published: 2018-12-25

	4	Protective mechanism of retinoic acid on primary cultured alveolar type Ⅱ epithelial cells under hyperoxia
		PAN Qiqi* MA Jinshuai* LIU Xiuxiang LYU Meng
		Objective To investigate protective mechanism of retinoic acid on primary cultured alveolar type Ⅱ epithelial cells under hyperoxia. Methods Alveolar type Ⅱ epithelial cells were isolated and purified from fetal rat lung tissue at 19 days of gestation. When the cells grew to the fused state (80% bottle bottom), the cells were divided into air group, hyperoxia group and hyperoxygenation + RA group. The apoptosis of AECⅡ was detected by flow cytometry, the β-catenin protein expression of Wnt signal pathway was detected by Western blot, and the β-catenin gene expression was detected by PCR. Results Compared with the air group and the hyperoxygenation + RA group, the AECⅡ number of AnnexinV (+) PI (-) and AnnexinV (+) PI (+) markers in the hyperoxia group was significantly higher at 24 h of exposure (P < 0.01), and the cell number was significantly reduced after RA addition. Compared with the air group, the expression of β-catenin protein of the hyperoxia group was significantly decreased, the difference was statistically significant (P < 0.01), while compared with the high oxygen group, the expression of β-catenin protein of the hyperoxygenation + RA group was upregulated significantly (P < 0.01). Conclusion Hyperaerobic environment can lead to massive apoptosis and necrosis of AECⅡ, and RA can reduce apoptosis of this cell by up-regulating the expression of β-catenin protein, thus playing a protective role in hyperoxic lung injury.
		2018 Vol. 15 (36): 4-7,27 [Abstract] ( 238 ) HTML (1 KB) PDF (1338 KB) ( 182 )

	8	DNAzymes target design for Ezrin mRNA antisense technologyPAN Huilong1 ZHANG Guoru2▲ WANG Jin3 WU Xingyuan2
		PAN Huilong1 ZHANG Guoru2▲ WANG Jin3 WU Xingyuan2
		Objective To analyze the structure of distant metastasis associated protein (Ezrin mRNA) and find and verify the best target of DNAzymes. Methods RNAstructure and RNAdraw programs were used to analyze the structure of Ezrin mRNA and calculate its first or secondary structure. If RNAstructure and RNAdraw simultaneously calculate 4 or more unpaired single chain ring forming regions, the single chain ring forming region would be set as the target area of antisense technology for the design of the target of the DNAzymes. Then, according to the principle of minimum free energy, the OligoWalk program was used for screening, and the target of each antisense technology was screened by screening. The experimental method was used to verify the prediction results. Results There were 42 common single chain regions predicted by the two software, of which 21 were single matched, and 27 were coding regions. AU1655, AU1751, AU1766, AU1789 and GU2623 were located in the single chain region over 10 consecutive unpaired bases. Only AU1655, AU1751, AU1766 and AU1789 meet the requirements. The results of enzyme digestion showed that DNAzymes could cut Ezrin mRNA most ideally at AU1751 site. Conclusion Compared with the traditional experiment to find the target, the combined thermal dynamic parameters of the two stage structure of nucleic acid could deal with the design and selection of the target more accurately and quickly. The DNAzymes corresponding to the AU1751 locus is less likely to form stable self heterozygotes, which is beneficial to DNAzymes binding to RNA.
		2018 Vol. 15 (36): 8-11 [Abstract] ( 230 ) HTML (1 KB) PDF (557 KB) ( 110 )

	12	Protective effects of Tongxinluo on high glucose-induced human retinal capillary endothelial cells injury
		WEI Geng CAO Liu ZHANG Suming HOU Fengying ZHAO Yusha HE Suyan
		Objective To explore the intervention effects and related mechanism of Tongxinluo on high glucose-induced human retinal capillary endothelial cells (HRCECs) injury. Methods The cells damaged model was established with high glucose. The HRCECs were divided into normal group, model group (30 mmol/L glucose), Tongxinluo low dose group (TXL-L group, 100 μg/mL Tongxinluo), Tongxinluo middle dose group (TXL-M group, 200 μg/mL Tongxinluo) and TXL high dose group (TXL-H group, 400 μg/mL Tongxinluo) by random number table method. The cell viability, contents of endothelin (ET)-1, interleukin (IL)-6 and intercellular adhesion molecule (ICAM)-1 in supernatant, and the endothelial nitric oxide synthase (eNOS) and nuclear factor (NF)-κB protein expression in cells of each group were detected. Results Compared with normal group, the cell viability was significantly decreased, the contents of ET-1, IL-6 and ICAM-1 in supernatant were significantly increased, the protein expression of eNOS was significantly down-regulated, and the protein expression of NF-κB was significantly up-regulated in model group (P ＜ 0.01). Compared with model group, the contents of ET-1 in supernatant were significantly decreased in TXL-M group and TXL-H group (P ＜ 0.01), and the contents of IL-6 and ICAM-1 in supernatant were significantly decreased, the protein expression of eNOS was significantly up-regulated, and the protein expression of NF-κB was significantly down-regulated in TXL-L group, TXL-M group and TXL-H group (P ＜ 0.05 or P ＜ 0.01). Conclusion Tongxinluo can signifcantly improve high glucose-induced HRCECs injury, and plays a role in cell protection through reducing inflammatory injury.
		2018 Vol. 15 (36): 12-15 [Abstract] ( 203 ) HTML (1 KB) PDF (542 KB) ( 125 )

	16	Mitochondrial protective mechanism of Danqu Capsules against myocardial ischemia / reperfusion injury
		TIAN Xin1 XU Pan2 LIU Chaofeng1
		Objective To explore the mitochondrial protective mechanism of Danqu Capsules on myocardial ischemia /reperfusion injury. Methods Thirty healthy male SD rats were divided into 5 groups by random number table method (n = 6): sham operation group, model group, 300 mg/kg of Danqu Capsules group, 600 mg/kg of Danqu Capsules group, and Isosorbide Mononitrate group (10 mg/kg). The method of ligation of the left anterior descending branch of coronary artery was used to make model, and the changes of ST segment at different time points of ischemia / reperfusion were recorded. The levels of myocardial injury markers [cardiac troponin T (cTnT), creatine kinase isoenzyme (CK-MB)] were measured by enzyme-linked immunosorbent assay (ELISA) method. The ultrastructure of myocardial mitochondria was observed with transmission electron microscope, and the expression of mitochondrial fission protein p-Drp1 and fussion protein Mfn2 was measured by immunoblotting. Results 300, 600 mg/kg of Danqu Capsules groups could reduce the levels of myocardial injury markers (P ＜ 0.01), relieve the ST segment elevating of ECG (P ＜ 0.01), reduce mitochondrial fission of myocardial cells and lessen the expression of mitochondrial protein p-Drp1 (P ＜ 0.01), but there was no significant difference in the expression of mitochondrial fusion protein Mfn2 (P ＞ 0.05). Conclusion Danqu Capsules can alleviate myocardial ischemia / reperfusion injury, improve myocardial ischemia and reduce mitochondrial fission of myocardial cells, which may be related to the inhibition of the expression of mitochondrial fission protein p-Drp1.
		2018 Vol. 15 (36): 16-19 [Abstract] ( 265 ) HTML (1 KB) PDF (708 KB) ( 144 )

	20	Research progress on the health-related physical fitness status of aging population and its influencing factors in China
		XU Jun1 JIANG Lijie1 XIA Cong1 CAI Wang2 LIN Yuanqi1 WU Weixuan1 LI Wenyuan3
		Health-related physical fitness refers to the quality of health promotion and disease prevention. It is the intact state of people′s physical, psychological, social and other aspects in response to life, work and various unexpected situations. This paper uses literature analysis method to summarize and analyze the definition and research status of health-related physical fitness at home and abroad. This paper introduces the definition of health-related physical fitness at home and abroad, and discusses the current situation of health fitness at home and abroad. On the basis of this theory, the health and physical fitness status of the elderly population in China and its main influencing factors are discussed in order to provide theoretical guidance for the elderly population to carry out targeted health promotion activities.
		2018 Vol. 15 (36): 20-23 [Abstract] ( 257 ) HTML (1 KB) PDF (594 KB) ( 535 )

	24	Research progress of relationship the between immune cells and hepatocellular carcinoma
		ZHAGN Jinghao1 ZHENG Chao1 ZHOU Zhenhua2 ZHU Xiaojun1 ZHANG Xin2 SUN Xuehua1,2 GAO Yueqiu1,2
		Hepatocellular carcinoma (HCC) is the primary malignant tumor of liver, which has a high morbidity and mortality. Dysfunction of the immune system can lead to abnormal immune surveillance of HCC, and hepatocellular carcinoma cells can also act on the immune system to lead immune escape. Immune cells including dendritic cells (DCs), macrophage (MΦ), myeloid-derived suppressor cells (MDSCs), natural killer cell (NK), cytotoxic lymphocyte (CTL), CD4+T cell, regulatory cells (Treg), helper T cell 7 (Th7) and natural killer T cells (NKT), play an important role in the occurrence and development process of HCC. In this paper, advances in the interaction between immune cells and liver cancer are reviewed to provide new ideas and methods for the treatment of HCC.
		2018 Vol. 15 (36): 24-27 [Abstract] ( 271 ) HTML (1 KB) PDF (603 KB) ( 182 )

	28	Research progress on the mechanism of osteopontin in promoting the invasion and metastasis of gastric cancer
		QIN Yuechao1 YUAN Xiaolin1 QU Fanjie2
		Osteopontin (OPN) is a phosphorylated glycoprotein that is highly expressed in a variety of cancers, which has the effects of inhibiting tumor cell apoptosis and promoting tumor cell invasion and metastasis. In recent years, studies have demonstrated that OPN is overexpressed in gastric cancer and it can up-regulate the expression of various angiogenic factors and protein kinases through MAPK, NF-κB, PI3K/AKT signaling pathways, autocrine pathways, and macrophage polarization. The overexpression of OPN promotes the invasion and metastasis of gastric cancer cells. Therefore, OPN may become a new target for regulating the invasion and metastasis of gastric cancer cells. This paper analyzes and summarizes the mechanism of OPN in promoting the invasion and metastasis of gastric cancer, in order to provide reference for the treatment of OPN target of gastric cancer.
		2018 Vol. 15 (36): 28-31,39 [Abstract] ( 183 ) HTML (1 KB) PDF (622 KB) ( 157 )

	32	Research progress in the treatment of diabetic foot ulcer with vacuum sealing drainage
		CHANG Yu1 HANG Rui2
		Diabetic foot is one of the serious chronic complications of diabetic mellitus. It belongs to refractory wound. Diabetic foot is characterized by high disability rate, high cost and long course of disease, which imposes a heavy burden on patients, families and society. It is also a difficult point in current clinical treatment. In recent years, the application of vacuum sealing drainage in diabetic foot treatment has become a research hotspot at home and abroad, which can regulate inflammatory response, reduce vascular permeability, improve microcirculation, reduce matrix metalloproteinase activity in wound granulation tissue, and stimulate various cell proliferation, release of related factors, increase of gene expression, enhancement of secretion of substance P from peripheral nerve terminals and expression of calcitonin-related gene peptides to promote the healing of diabetic foot wounds. This article reviews the research progress of negative pressure drainage in the treatment of diabetic foot ulcer, in order to better guide the clinical treatment of diabetic foot disease.
		2018 Vol. 15 (36): 32-35,43 [Abstract] ( 190 ) HTML (1 KB) PDF (621 KB) ( 161 )

	36	Research status of traditional Chinese medicine constitution types and quality of life in elderly patients with chronic diseases
		WU Qiong YIN Yongtian LI Yuli CHEN Lijun
		The study of constitution of traditional Chinese medicine (TCM) has an important significance in the management of elderly patients with chronic diseases and has gradually become a hot issue in elderly patients with chronic diseases. According to the constitution of TCM, this paper summarize the characteristics of the constitution of TCM in elderly patients with chronic diseases, and reviewe the predictive factors of quality of life for elderly patients with chronic diseases in terms of individual factors, family environment factors, and social psychological factors. Meanwhile, the aim of the paper is to provide a theoretical basis for the study of the relationship between the types of TCM and the influencing factors of quality of life in elderly patients with chronic diseases.
		2018 Vol. 15 (36): 36-39 [Abstract] ( 278 ) HTML (1 KB) PDF (623 KB) ( 155 )

	40	Progress in pharmacological studies on rutaecarpine
		YUAN Zhijian HE Wenjuan HU Jing▲
		Rutaecarpine is one of the main active components of Chinese medicine Evodia rutaecarpa. It has extensive physiological and pharmacological effect, including positive inotropic and cardioprotective effect, and can vasorelaxant and reduce blood pressure. It can protect gastric mucosa and has therapeutic effect on ulcerative colitis. In addition, rutaecarpine also has antidepressant, anti-obesity, anti-tumor effect, analgesic and anti-inflammatory effects, etc. With further study of rutaecarpine by domestic and foreign scholars in recent years, this article reviews the research progress of its pharmacological effect, and aims at providing preference for reasonable exploitation in future.
		2018 Vol. 15 (36): 40-43 [Abstract] ( 173 ) HTML (1 KB) PDF (606 KB) ( 162 )

	44	Analysis of fertility desire and influencing factors of second child in nurses in Third-grade class-A hospitals in Xinjiang region
		ZHANG Xiaoya1 JIA Xueyuan1 WEI Huanhuan1 LU Zhi1 WANG Meixin2
		Objective To investigate the level of nurse′s second-children′s fertility desire and it′s influencing factors in Third-grade class-A hospitals in Xinjiang region. Methods From November 2017 to March 2018, second-children′s fertility desire questionnaire and work-family conflict questionnaire (WFC) were used to investigate nurses who had given birth to one child in six Third-grade class-A hospitals in Xinjiang region (the First Affiliated Hospital of Xinjiang Medical University, People′s Hospital of Xinjiang Uygur Autonomous Region, the Hospital of Xinjiang Production and Construction Corps, Urumqi Friendship Hospital, the Second Affiliated Hospital of Xinjiang Medical University, the Fifth Affiliated Hospital of Xinjiang Medical University) about their second-children's fertility desire and it′s influencing factors. Results The rate of second-children′s fertility desire of the 639 nurses was 49.30%. The results of single factor test combined with multivariate Logistic regression analysis showed that the main factors affecting the nurse′s second-children′s fertility desire were nurses′ age, education, department, nationality, time based work-family conflict and stress based work-family conflict (P ＜ 0.05). Conclusion Nurses in Third-grade class-A hospitals in Xinjiang region have low second-children desire fertility rate, and the influence of work is more prominent. The higher the level of conflict between work and family, the weaker the second-children desire.
		2018 Vol. 15 (36): 44-47,51 [Abstract] ( 266 ) HTML (1 KB) PDF (487 KB) ( 160 )

	48	Effect of standardized treatment technology popularization on treatment measures and efficacy in cancer pain patients in county
		HUANG Yueqiu1 ZHANG Kai2 WANG Junwei3
		Objective To explore the effect of standardized treatment technology popularization on treatment measures and efficacy in cancer pain patients in county. Methods By reviewing exclusive medical records, seven hundred and seven cancer pain cases (106 recipes) with special anesthesia records in Zhejiang Province Tiantai District from January 1, 2014 to June 31, 2015 were divided into the pre-standardized treatment group, nine hundred and fifty-two cancer pain cases (857 recipes) with special anesthesia records from July 1, 2015 to December 31, 2016 in Zhejiang Province Tiantai District were divided into the post-standardized treatment group. The methods of standardized cancer pain treatment popularization included training-examination, field guidance, education for patients, close follow-up, and continuous improvement. The opioid drugs (Morphine Injection, Morphine Tablets, Oxycodone Hydrochloride Sustained-release Tablets) usage, nonstandard condition of doctors′ treatment for cancer pain and compliance of patients to treatment between the two groups were compared. Results Compared with the pre-standardized treatment group, the per capita oral dose of opioid drugs in the post-standardized treatment group was increased (P ＜ 0.01); the per capita injection dose of opioid drugs, the proportion of doctors using the injection without indication, the medication inconsistent with the score, using opioid drugs for the first time without titration, unreasonable dose adjustment, no prevention for the adverse reaction, nonstandard treatment of explosive pain, and the proportion of patients not taking the medicine in a standard time, not taking the medicine in a standard way, and not adjusting the dose according to the doctor's advice were decreased, the differences were highly statiscally significant (P ＜ 0.01). Conclusion Training, examination, filed guidance can improve the standardization of medical staff treatment in basic-level hospitals. Various forms of education and close follow-up can improve the compliance of patients and their families to standardized treatment. As a result, the pain control rate has been greatly improved and the sufferings of patients have been alleviated to a great extent. The comfort level of advanced tumor palliative care and home care, and the life quality of patients are also improved.
		2018 Vol. 15 (36): 48-51 [Abstract] ( 205 ) HTML (1 KB) PDF (451 KB) ( 111 )

	52	Application research of 3D printing technology in the manufacture of lead block for radiotherapy
		RUAN Changli SONG Qibin ZHANG Jun▲ WU Bing FU Jingguo ZHOU Dingyi ZHENG Yongfa
		Objective To study the application effect of 3D printing technology in the manufacture of lead block for radiotherapy. Methods Patients in the simulator for placement and fixed position, and orientation films, according to the doctors by target areas for research and development of 3D printing to lead block is making model of production, making good lead block in the validation on fixed, with positioning chamber of tumor target shape, check wild and keep out of the light shooting with positioning room tumor target shapes are consistent. Results 3D printing of the production of the shooting field lead block makes the shape of the irradiation field coincide with the shape of the target area, and makes the production of the lead block cheaper, more convenient and more accurate. Conclusion 3D printing technology for the production of lead block has been proved to be an effective, popularizing and cheaper method for the production of lead block in radiotherapy.
		2018 Vol. 15 (36): 52-54 [Abstract] ( 292 ) HTML (1 KB) PDF (436 KB) ( 107 )

	55	Relative factors analysis of residual stones after stageⅠpercutaneous nep-hrolithotomy
		WANG Pengxin1,2 WANG Xing3 TIAN Fei2 MA Li2 ZHANG Di4 DING Yuzhi5
		Objective To investigate the main influencing factors of residual stones after stageⅠ percutaneous nephrolithotomy (PCNL). Methods The perioperative data of 475 patients with unilateral renal calculi treated with PCNL in the urology department of Dingzhou People′s Hospital of Hebei Province from April 2013 to October 2017 were retrospectively analyzed. Patients with residual stones after operation were classified into the group of residual stones (group A), a total of 103 cases; the data of patients with no residual stones and clinically significant residual stones were classified into the control group (group B), a total of 372 cases. Univariate analysis was performed on factors that may affect the residual stones after stage Ⅰ PCNL, and statistically significant factors were analyzed by multivariate Logisitic regression. Results The incidence of residual calculi after stage Ⅰ PNCL was 21.68%. The type of renal pelvis, stone load, staghorn calculi, renal insufficiency, operative pathway and bleeding volume were independent risk factors for residual calculi after stage Ⅰ PCNL (P < 0.05). Conclusion Stone load > 1000 mm2, branched pelvis, staghorn calculi, renal insufficiency, single channel, and bleeding volume > 200 mL can increase the risk of residual calculi after stage Ⅰ PCNL. Preoperative correct assessment of the type of renal pelvis, active improvement of renal function, individualized treatment for staghorn calculi or complex renal calculi with excessive stones load, and active reduction of intraoperative bleeding can effectively reduce the risk of residual stones after stage Ⅰ PCNL.
		2018 Vol. 15 (36): 55-58 [Abstract] ( 239 ) HTML (1 KB) PDF (437 KB) ( 136 )

	59	Clinical effect of plasmakinetic resection of prostate combined with endocrine therapy on advanced prostate cancer and bladder outlet obstruction
		WANG Guoqiang YI Faxian ZHU Xiaojun▲ CHEN Ligang
		Objective To investigate the effect of plasmakinetic resection of prostate (PKRP) combined with endocrine therapy on advanced prostate cancer with bladder outlet obstruction, international prostate symptom score (IPSS) and quality of life score (QOL). Methods From January 2016 to January 2017, 60 patients with advanced prostate cancer and bladder outlet obstruction admitted to the Department of Urology, Inner Mongolia Medical University Hospital were selected as study subjects. According to the treatment, they were divided into study group and control group, with 30 cases in each group. The control group underwent simple endocrine therapy. The study group combined with PKRP treatment on the basis of the former. The clinical treatment-related indicators, IPSS score, QOL score, and survival rate were compared between the two groups. Results Maximum urinary flow rates (Qmax) and other clinical treatment-related indicators in the study group were better than those in the control group (P < 0.01). There was no significant difference in IPSS scores between the two groups before treatment (P > 0.05). IPSS scores decreased in the two groups than that before treatment (P < 0.01), and IPSS scores in the study group were lower than those in the control group after 3 months of treatment (P < 0.01). QOL scores in the study group were higher than those in the control group after 3 months of treatment (P < 0.01). Conclusion PKRP combined with endocrine therapy can effectively improve clinical symptoms and prostatic function in patients with advanced prostate cancer complicated with bladder outlet obstruction. The curative effect is definite, and it is helpful to improve the quality of life and survival rate of patients. It can be popularized and applied.
		2018 Vol. 15 (36): 59-61,70 [Abstract] ( 201 ) HTML (1 KB) PDF (720 KB) ( 138 )

	62	Study on the orthogonal design of the optimal choice on scapulohumeral periarthritis with physical therapy, manipulative therapy and acupuncture therapy
		LIU Xifang1 WANG Jin2 YANG Minyi1 SONG Yixin1 JIANG Yuan1 LIANG Dongsheng1 ZHAO Congzhe1 HAN Weihua1
		Objective To study the effect of different combinations of physical therapy, manipulation and acupuncture on patients with periarthritis of shoulder, and to explore the optimal treatment protocol by using orthogonal design. Methods A total of 80 patients with scapulohumeral periarthritis who met the inclusion criteria were selected from Outpatient and Inpatient Department in Ward Two of Department of TCM Orthopedics and Ward of Sports Injury Shoulder Elbow, Xi′an Honghui Hospital Affiliated to Xi′an Jiaotong University from January 2016 to December 2017. They were divided into eight groups according to the orthogonal design of L8(27) tables with 10 cases in each group by random block method. Three factors including A (physical therapy), B (manipulation therapy), C (acupuncture therapy) and the corresponding 2 levels ( infrared ray therapy and extracorporeal shock wave therapy, joint mobilization therapy and manipulation therapy, ordinary acupuncture therapy and warm needle penetration therapy) were used for treatment, shoulder joint pain and function were observed by intuitive analysis and variance analysis. Results Compared with before treatment, different combinations of physical therapy, manipulation therapy and acupuncture therapy all reduced the visual analogue scale (VAS) score and improved the shoulder joint function score of patients with scapulohumeral periarthritis, and the differences were statistically significant (P ＜ 0.05). Physical therapy, manipulation and acupuncture therapy were the significant factors to improve shoulder joint pain and function through visual analysis and variance analysis of shoulder pain VAS score and functional score (P ＜ 0.05). Physical therapy was the best, followed by manipulation therapy, while acupuncture therapy was the least (RA＞RB＞RC, rA＞rB＞rC). Compared with different levels of the same factors, the extracorporeal shock wave therapy was better than infrared ray therapy (K2＞K1, k2＞k1), joint mobilization therapy was better than manipulation therapy (K1＞K2, k1＞k2), and warm needle penetration therapy was better than ordinary acupuncture therapy (K2＞K1, k2＞k1). Extracorporeal shock wave therapy combined with joint mobilization therapy and warm needle penetration joint mobilization therapy was the best treatment for patients with scapulohumeral periarthritis. Conclusion The combination of extracorporeal shock wave therapy, joint mobilization therapy and warm needle penetration therapy is the best optimized protocol for the treatment of pain and dysfunction in patients with scapulohumeral periarthritis, which is worthy being popularized.
		2018 Vol. 15 (36): 62-66 [Abstract] ( 259 ) HTML (1 KB) PDF (489 KB) ( 149 )

	67	The application value of G-arm X-ray machine assisted PFNA placement in the femoral intertrochanteric fracture
		LIU Jun HAO Shenshen LIU Zhibin WANG Fei LI Changhong LIU Yanxiong
		Objective To explore the application value of G-arm X-ray machine assisted nailing in proximal femoral nail anti-rotation (PFNA) placement in the femoral intertrochanteric fracture. Methods Seventy-five cases of femoral intertrochanteric fractures in Yan'an University Affiliated Hospital treated by PFNA from February 2016 to August 2017 were retrospectively analyzed. Thirty-nine cases were received intraoperative G-arm X-ray machine assisted nailing (regarded as G-arm group), while 36 cases were received intraoperative C-arm X-ray machine assisted nailing (regarded as C-arm group). The operative time, intraoperative blood loss, intraoperative fluoroscopy times and Harris score of the hip joint function at the last follow-up were compared between the two groups. Results In the G-arm group, 35 cases were anatomically repositioned and 4 cases were functionally repositioned, while in the C-arm group, 31 cases were anatomically repositioned and 5 cases were functionally repositioned, there was no statistically significant difference between the two groups (P ＞ 0.05). The follow-up was 5-8 months in the two groups. The operative time, intraoperative blood loss, and intraoperative fluoroscopy times of the G-arm group were less than those of the C-arm group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the Harris scores between the two groups at the last follow-up (P ＞ 0.05). Conclusion The use of G-arm X-ray machine assisted nailing in PFNA of femoral intertrochanteric fracture can reduce the operation time, intraoperative blood loss and intraoperative fluoroscopy times, and obtain good clinical efficacy.
		2018 Vol. 15 (36): 67-70 [Abstract] ( 261 ) HTML (1 KB) PDF (449 KB) ( 128 )

	71	Expression level and clinical significance of ADMA and DDAH2 in earlyonset severe preeclampsia
		ZHAO Li′na Li Jiawei LIU Guocheng
		Objective To discuss the expression of ADMA and DDAH2 in plasma and placental and the correlation between the two factors in early onset severe preeclampsia (EPSP). To approach the possible role of DDAH2 and ADMA in the pathogenesis and progression of EPSP. And to seek the basis of early diagnosis and treatment of disease based on pathogenesis. Methods From January 2017 to January 2018, 45 cases with severe preeclampsia in Guangdong Maternal and Child Health Hospital ("our hospital" for short) were selected as the experimental group, of which 25 cases in early onset severe preeclampsia group, 20 cases in late onset severe preeclampsia group, and 35 healthy pregnant women delivery in our hospital during the same period were selected as the control group. The expression levels of ADMA and DDAH2 in sera and placenta tissues of two groups were detected with Enzyme-linked immunosorbent assay (ELISA). Spearman linear correlation analysis was used for correlation analysis. Results The expression level of ADMA in serum of early-onset severe preeclampsia was significantly higher than that of later onset severe preeclampsia and control group (P < 0.05). The expression level of ADMA of later onset severe preeclampsia in serum was significantly higher than that of control group (P < 0.05). The expression level of DDAH2 of in serum of early onset severe preeclampsia group was significantly lower than that of later onset severe preeclampsia group and control group (P < 0.05). The expression level of DDAH2 in serum of later onset severe preeclampsia group was significantly lower than that of control group (P < 0.05). The positive staining rate of ADMA in the placenta tissues of early onset severe preeclampsia was significantly higher than that of late onset severe preeclampsia (P < 0.05). The positive staining rate of ADMA in the placenta tissue of late onset severe preeclampsia was significantly higher than that of control group (P < 0.05). The positive staining rate of DDAH2 in the placenta tissues of early onset severe preeclampsia was significantly lower than that of late onset severe preeclampsia (P < 0.05). The positive staining rate of DDAH2 in the placenta tissues of late onset severe preeclampsia was significantly lower than that of control group (P < 0.05). The expression levels of DDAH2 and ADMA in serum and in the placenta tissues of earlyonset severe preeclampsia appeared in a obvious negative correlation (r = -0.77, P < 0.05). Conclusion The significantly higher expression level of ADMA and the significantly lower expression level of DDAH2 in serum and in the placenta tissue of early onset severe preeclampsia, they are negatively correlated. ADMA and DDAH2 are closely related to early onset severe preeclampsia. They may interact with each other in the process of trophoblast infiltration and participate pathogenesis of the early onset severe preeclampsia.
		2018 Vol. 15 (36): 71-74,82 [Abstract] ( 206 ) HTML (1 KB) PDF (654 KB) ( 56 )

	75	Analysis of related factors of lower extremity deep venous thrombosis in pregnant women
		ZHANG Chunmei1 YANG Tao2 AN′na1 SUN Lijun1 WU Jun1
		Objective To explore the related factors and diagnosis and treatment scheme of lower extremity deep venous thrombosis in pregnant women. Methods From June to December 2016, pregnant women in Department of Obstetrics of Tangshan City Maternity and Child Care Hospital and Department of Vascular Surgery of Tangshan Gongren Hospital in Heibei Province were selected as research subjects, 73 pregnant women with deep venous thrombosis of lower extremities were enrolled in study group, and 73 pregnant women with non deep venous thrombosis were selected as control group. The incidence of deep venous thrombosis, constituent ratio of risk factors, diagnosis and treatment plan, and the prognosis of treatment were discussed. Results There were 73 cases of deep venous thrombosis occurred in 6425 pregnant women, and the incidence rate was 1.14%. Multivariate Logistic regression analysis showed that age, body mass index, puerperal bed rest time, cesarean section, postpartum hemorrhage, gestational hypertension and gestational diabetes were risk factors for the occurrence of deep vein thrombosis in maternal lower limbs (P < 0.05). The symptoms such as swelling of the lower extremities were relieved, and 8 of them developed deep vein thrombosis syndrome. After thrombolytic therapy, the thigh diameter, leg circumference and venous patency score were significantly improved in 62 patients, compared with before thrombolytic therapy (P < 0.01). During the follow-up, patients with deep venous thrombosis of the lower extremities were dissolved, 46 cases of venous lumen recovered unobstructed and 5 cases had mild filling defect, of which 5 cases had deep venous thrombosis syndrome. Conclusion The pregnant women are high risk group of deep venous thrombosis of lower extremity. The intervention on the risk factors of deep venous thrombosis of the lower limbs of pregnant and parturient is beneficial to reduce the occurrence of deep vein thrombosis of lower extremity. The reasonable treatment plan can improve the effect of treatment and ensure the safety of mother and child.
		2018 Vol. 15 (36): 75-78 [Abstract] ( 215 ) HTML (1 KB) PDF (621 KB) ( 79 )

	79	Relationship between serum vitamin D and cytokines, immunoglobulin E and acidic granulocyte cationic protein in children with asthma
		ZHANG Xiaofo WANG Manzhi WEI Songqing LI Jia WU Lei
		Objective To investigate the relationship between serum vitamin D and cytokines, IgE and ECP in children with asthmatic bronchitis. Methods Ninety children with asthmatic bronchitis (hepatitis group), 90 children with asthma (asthma group), and 90 healthy children (control group) diagnosed in the Pediatric Department of Changsha Central Hospital from March 2016 to January 2017 were selected as the study objects. The levels of serum 25-(OH)D3, IgE, IL-4, IL-12, IL-2, IFN-γ, TGF-β1, and ECP in the three groups were compared and analyzed. Results The 25-(OH)D3 level in the asthma group and asthma group were significantly lower than that in the control group (P < 0.05); the asthma group was higher than the asthma group (P < 0.05). The levels of IL-4, TGF-β1, IgE and ECP in the asthma group and asthma group were significantly higher than those in the control group (P < 0.05), and IL-12, IL-2, IFN-γ were significantly lower than those in the control group (P < 0.05). The IL-12, IgE, IL-2, IFN-γ and ECP of the asthma group were lower than those of the asthma group (P < 0.05). The IL-4 in the asthma group was higher than that in the asthma group (P < 0.05). Serum 25-(OH)D3 level in the asthma group was negatively associated with IL-4 (r = -0.419, P = 0.001), IL-12 (r = -0.488, P = 0.000), TGF-β1 (r = - 0.392, P = 0.002), IgE (r = -0.527, P = 0.000), IL-2 (r = -0.539, P = 0.000), and INF-γ (r = -0.520, P = 0.000), while had no significant correlation with serum ECP (r = -0.274, P = 0.063). Conclusion Serum 25-(OH)D3 level is decreased in children with asthmatic bronchitis, inflammatory factor, IgE and ECP levels are elevated, and that has certain relationship with serum 25-(OH)D3.
		2018 Vol. 15 (36): 79-82 [Abstract] ( 273 ) HTML (1 KB) PDF (627 KB) ( 212 )

	83	Study on distributions of MTHFR C677T gene polymorphism among pregnant women in Guiyang region
		XIONG Yonghong1 REN Lingyan2 ZHUO Zhaozhen2 WANG Shimin2 JIANG Minmin2 LI Guifang2▲ HUANG Shengwen1，2▲
		Objective To explore the distributions of 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms among pregnant women in Guiyang region, provide a theoretical basis of scientific supplementation of folic acid. Methods From January 2017 to June 2018, in Guizhou Provincial People′s Hospital, 2644 pregnant women in Guiyang region were selected, the genotype of MTHFR C677T was detected by PCR-fluorescence probing. The distribution of C677T gene polymorphisms among Han and the ethnic minority women in Guiyang were analyzed statistically, then the results were compared with data of Han women reported and other ethnic minorities women in other regions had been reported before. Results The frequencies of CC, CT and TT of MTHFR C677T genotypes were 37.8%, 48.3% and 13.9%, frequencies of C, T alleles were 61.9% and 38.1% of Han women in Guiyang region, these were compared with Miao women, the differences were statistically significant (P < 0.05), compared with women of Buyi, Dong and Tujia nationalities, the differences were statistically significant (P < 0.05), Compared with the Han women in Guiyang and the Han women in Jiangsu, Qionghai, Nanning, Huizhou, Xian, Ningxia, Yantai, Langfang, Changchun, Shangzhi, the differences were statistically significant (P < 0.05), no statistically differences between Guiyang and Chengdu, Kunming (P > 0.05). There were statistically significant differences between Miao women in Liuzhou, Dong women in Sanjiang, Li women in Sanya, Chaoxian women in Yanbian, the differences were statistically significant (P < 0.05), no statistically differences with Tujia women in Badong, Bai women in Dali, Hui women in Yinchuang(P > 0.05). Conclusion The distributions of MTHFR C677T genes polymorphisms among women of childbearing age in Guiyang are different in various minorities and areas, which have national specificity and regional specificity.
		2018 Vol. 15 (36): 83-86 [Abstract] ( 186 ) HTML (1 KB) PDF (587 KB) ( 135 )

	87	Relationship of cord blood orexin and adiponectin and growth and development of neonatal
		DONG Yan1 CHENG Sisi1▲ REN Changjun1 JIANG Xiufang1 ZHONG Xun2
		Objective To study the relationship of the cord blood orexin, adiponectin, growth and development of neonatal. Methods From October 2015 to February 2016, in the First Hospital of Hebei Medical University, 90 newborns were selected as study object, they were divided into preterm group (30 cases) and term infant group (60 cases). The levels of cord blood orexin and adiponectin were measured, and the body weight, body length and head circumference were accurate measured at the first days after birth, and the body mass index (BMI) and Ponderal index (PI) were calculated. The correlation of the levels cord blood orexin and adiponectin and newborn growth indexes were analyzed. Results The gestational age, body weight, body height, head circumference, placental weight and BMI in two groups were compared, the differences were statistically significant (P < 0.01); the gender and PI were compared, the differences were not statistically significant (P > 0.05). The level of cord blood orexin in preterm group was significantly higher than the term infants group, and the level of adiponectin in preterm group was significantly lower than the term infants group, the differences were statistically significant (P < 0.01). The level of orexin was negative correlation to gestational age, body weight, body height, head circumference, placental weight and BMI (r = -0.612, -0.562, -0.582, -0.557, -0.608, -0.521, all P < 0.05), and the level of adiponectin was positive correlation to gestational age, body weight, body height, head circumference, placental weight and BMI (r = 0.547, 0.534, 0.512, 0.524, 0.533, 0.498, all P < 0.05), but the level of orexin and adiponectin were not correlation to gender and PI (P > 0.05). Further multiple stepwise regression analysis showed that cord blood orexin and adiponectin were closely related to neonatal growth and development indicators (P < 0.05). Conclusion Orexin and adiponectin in cord blood are involved in the body weight regulation and growth process of newborns, and they are closely related to the growth and development indicators of newborns, they may reflect the growth and development of newborn.
		2018 Vol. 15 (36): 87-89,94 [Abstract] ( 213 ) HTML (1 KB) PDF (595 KB) ( 91 )

	90	Effect of Chinese medicine cycle therapy combined with metformin on normal weight polycystic ovary syndrome and its effect on sex hormone and insulin resistance
		CHEN Haiyan TANG Ling▲ XIAO Chengcong LUO Jie DAI Yong
		Objective To explore the effect of traditional Chinese medicine cycle therapy combined with metformin in the treatment of normal-weight polycystic ovary syndrome (PCOS), and analyze the effects on sex hormones and insulin resistance. Methods From April 2016 to December 2017, Dongzhimen Hospital of Beijing University of Chinese Medicine, 90 patients with normal weight PCOS were selected, they were divided into two groups by random number table method. The study group (45 cases) was treated with traditional Chinese medicine cycle therapy combined with metformin for 3 months，the control group (45 cases) was treated with metformin treatment for 3 months, the efficacy and safety of the two groups were compared, of the two groups of patients before and after treatment of sex hormones, fasting blood glucose (FPG), fasting insulin (FINS), insulin resistance (HOMA-IR), changes in ovulation rate were analyzed. Results After treatment, the clinical symptom scores of menstrual thinning, amenorrhea, backache, cold, libido, hairy, urination, and stool symptoms in the two groups decreased (P < 0.05), and the clinical symptom scores in study group were lower than the control group (P < 0.05). After treatment, E2, FSH, ovulation rate in two groups increased (P < 0.05), LH, T, LH/FSH, FPG, FINS, HOMA-IR in study group decreased (P < 0.05), LH, FPG, FINS, HOMA-IR in control group decreased (P < 0.05), T, FSH, LH/FSH in control group had no change (P > 0.05). After treatment, the LH, T, LH/FSH, FPG, FINS and HOMA-IR in study were lower than the control group (P < 0.05). The effective rate of treatment in the study group was higher than the control group (P < 0.01), and the incidence rate of adverse reaction was lower than the control group (P < 0.05). Conclusion Chinese medicine cycle therapy combined with metformin in the treatment of normal weight PCOS is more effective, safer, and can significantly reduce the level of sex hormones and insulin resistance in PCOS patients.
		2018 Vol. 15 (36): 90-94 [Abstract] ( 204 ) HTML (1 KB) PDF (631 KB) ( 155 )

	95	Clinical effect of therapeutic regimen of reduce phlegm and eliminate stasis combined with Iguratimod in treating Beh?觭et syndrome
		WANG Yong1 HU Cuiping2 CHANG Junying1 NIU Yanyun3 DAI Pu4 GU Zhanqing1
		Objective To explore the effect of therapeutic regimen of reduce phlegm and eliminate stasis combined with Iguratimod in treating Beh?觭et syndrome patients on the changes of inflammatory indices, clinical efficacy and safety. Methods From December 2015 to February 2017, 50 patients with Beh?觭et syndrome in Handan Hospital of Traditional Chinese Medicine were selected. They were divided into Chinese and Western medicine group 25 cases and Western medicine group 25 cases. Chinese and Western medicine group was given reduce phlegm and eliminate stasis decoction and Iguratimod Tablets, Western medicine group was given Iguratimod Tablets. Clinical efficacy, C reactive protein level, immunoglobulin A level, adverse reactions of medicine in the two groups were compared after 2 months′ treatment. Results After treatment, C reactive protein and immunoglobin A levels decreased than those before treatment (P < 0.01), the levels of C reactive protein and immunoglobulin A in the Chinese and Western medicine group were significantly lower than those in the western medicine group (P ＜ 0.05). The clinical efficacy of the Chinese and Western medicine group was higher than the Western medicine group (P < 0.05); and adverse reactions rate in the Chinese and Western medicine group was lower than Western medicine group (P < 0.05). Conclusion Therapeutic regimen of reduce phlegm and eliminate stasis combined with Iguratimod can reduce Behcet syndrome patients′ C reactive protein and immunoglobulin A levels, improve clinical efficacy.
		2018 Vol. 15 (36): 95-98 [Abstract] ( 254 ) HTML (1 KB) PDF (432 KB) ( 65 )

	99	Meta-analysis of efficacy and safety of Amlodipine combined with Benazepril in the treatment of hypertension in comparison with single drug therapy
		ZHAO Li'na1 HU Haochen1 JIANG Jie1,2▲ ZHANG Tiantian1▲
		Objective To evaluate the efficacy and safety of Amlodipine 2.5 mg combined with Benazepril 10 mg in patients with hypertension in comparison with single Amlodipine and Benazepril monotherapy. Methods A comprehensive search was conducted on the databases of CNKI, VIP, PubMed,Web of Science and Springer from January 1995 to February 2017 for relevant studies on the clinical drug treatment and investigation and analysis of hypertension. Two investigators screened the literature based on inclusion and exclusion criteria and extracted relevant data,using stata 14.0 for statistical analysis. Results A total of 5 randomized controlled trials were included, and a total of 964 patients were included in the study. Meta-analysis showed that Amlodipine 2.5 mg combined with Benazepril 10 mg were more effective in the treatment of hypertension than single-drug treatment group [RR = 1.49, 95%CI (1.34-1.65), P = 0.000], and it was superior to Amlodipine alone or Benazepril alone in the treatment of hypertension [RR = 1.47, 95%CI(1.17-1.86), P = 0.01; RR = 1.49, 95%CI (1.32-1.68), P = 0.000]. In terms of safety, the incidence of adverse reactions of Amlodipine 2.5 mg combined with Benazepril 10 mg in the treatment of hypertension were not significantly different from that of the single drug treatment group [RR = 1.23, 95%CI (0.94-1.62), P = 0.164]. There was no significant difference compared with Amlodipine or Benazepril in the treatment of hypertension [RR = 1.37, 95%CI (0.75-2.53), P = 0.377; RR = 1.20, 95%CI (0.88-1.63), P = 0.269]. The most common adverse reactions were headache, dizziness, cough, sinusitis, edema, and viral infection, and the incidence rate was not significantly different between the combination group and the single drug group. Conclusion Amlodipine 2.5 mg combined with Benazepril 10 mg is more effective than amlodipine and benazepril alone in the treatment of hypertension, and there is no significant difference in safety.
		2018 Vol. 15 (36): 99-104 [Abstract] ( 270 ) HTML (1 KB) PDF (1100 KB) ( 57 )

	105	Clinical study of Xuebijing combined with basic fibroblast growth factor in the treatment of Ⅱ and Ⅲ degree burn residual wounds
		CHEN Zechun LI Jun CHEN Tao
		Objective To study the clinical effect of Xuebijing combined with basic fibroblast growth factor in the treatment of Ⅱ and Ⅲ degree burn residual wounds. Methods From January 2015 to January 2018, in Shaanxi Ankang Certral Hospital, Ⅱ, Ⅲ degree of 81 cases of burn patients were chosen. According to random number table method, they were divided into observation group (41 cases) and control group (40 cases). Two groups were given conventional debridement and disinfection processing, the control group was given rh-bFGF treatment, on basis of which, observation group was given Xuebijing treatment, after 2 weeks of treatment, the contrast effect, pathogen clearance, cytokines, visual analogue scale (VAS) and self-evaluation of anxiety scale (SAS) score of the two groups were compared, the residual wound healing time and drug adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group, and the healing time of the residual wounds was significantly shorter than that of the control group, with statistically significant differences (P < 0.05). After treatment, the pathogen clearance rate of both groups was higher than that before treatment, and the observation group was significantly higher than that of the control group, with statistically significant differences (P < 0.05). After treatment, CRP, PCT and L-1β, IL-6, tumor TNF-α levels, VAS and SAS scores of the two groups were significantly lower than those before treatment, the indexes above in the observation group were significantly lower than the control group, the differences were statistically significant (P < 0.05). There was no statistically significant difference in adverse drug reactions between the two groups (P > 0.05). Conclusion Application of Xuebijing combined with rh-bFG in the treatment of Ⅱ, Ⅲ degree burn remnant wounds has good effect, high safety, which can increase the clearance rate of bacterium of cause of disease, lower levels of cytokines, improve the quality of life.
		2018 Vol. 15 (36): 105-108 [Abstract] ( 193 ) HTML (1 KB) PDF (434 KB) ( 107 )

	109	Clinical effect of self-made Shegan Mahuang Decoction on acute exacerbation of chronic bronchitis
		LIU Xiufang DING Hui LU Shan
		Objective To study the clinical efficacy of self-made Shegan Mahuang Decoction in treatment of acute exacerbation of chronic bronchitis. Methods A total of 93 patients with acute exacerbation of chronic bronchitis admitted in Yixing People′s Hospital from January 2016 to December 2017 were selected as subjects， and they were divided into control group and treatment group by random number table method, with 46 cases in the control group and 47 cases in the treatment group. The control group was treated with conventional treatment， the treatment group was treated with self-made Shegan Mahuang Decoction on basis of the treatment in the control group. The two groups were treated for 10 days. Hospitalization time, wheezing, cough and expectoration relieving time were compared between the two groups. Clinical efficacy, levels of blood oxygen saturation （SpO2）, arterial oxygen partial pressure （PaO2）, arterial carbondioxide partial pressure （PaCO2）, serum interleukin-8 （IL-8）, high-sensitivity c-reactive protein （hs-CRP）, tumor necrosis factor alpha （TNF-α）, interferon-gamma （IFN-γ） were compared between the two groups. Adverse reactions were recorded and compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the control group and the difference was statistically significant （P ＜ 0.05）. The hospitalization time, wheezing, cough and expectoration relieving time in the treatment group were significantly shorter than those in the control group, the difference was highly statistically significant （P ＜ 0.01）. After treatment， the levels of SpO2 and PaO2 in the two groups were significantly higher than those before treatment （P ＜ 0.05）, and the indices in the treatment group were higher than those in the control group （P ＜ 0.01）. Levels of PaCO2, serum IL-8, hs-CRP, TNF-α, IFN-γ were lower than those before treatment significantly （P ＜ 0.05）, and those in the treatment group were lower than the control group （P ＜ 0.01）. The adverse reaction rate of the treatment group was significantly lower than that of the control group （P ＜ 0.05）. Conclusion Self-made Shegan Mahuang Decoction in treatment of acute exacerbation of chronic bronchitis has good efficacy, which can shorten the treatment time obviously， reduce inflammation and improve respiratory tract ventilation function, and it has good safety.
		2018 Vol. 15 (36): 109-112 [Abstract] ( 230 ) HTML (1 KB) PDF (760 KB) ( 117 )

	113	Clinical effect on treatment of Buyang Huanwu Decoction combined with GP chemotherapy regimen in the treatment of advanced non-small cell lung cancer
		WU Yiting1 QU Jinglian2 GUO Nannan1 ZHAO Feng1 LIU Yanwen1
		Objective To investigate the effect of Buyang Huanwu Decoction combined with GP chemotherapy on hypercoagulability and quality of life in patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 113 patients with NSCLC admitted to Zhongda Hospital, Southeast University from August 2016 to March 2018 were selected. The patients were divided into control group 56 cases and study group 57 cases by random number table method. The control group was given the chemotherapy regimen of Gemcitabine combined with Cisplatin (GP), and the study group was combined with Buyang Huanwu Decoction on the basis of the control group. The clinical efficacy, coagulation state and quality of life of the two groups were compared. Adverse reactions of the two groups were observed and compared. Results The total effective rate in the study group was significantly higher than the control group (P ＜ 0.05). After treatment, PLT, FIB, PT and APTT levels of the two groups decreased than those before treatment, and those in the study group were lower than the control group (P ＜ 0.05). The KPS scores of the two groups increased after treatment (P ＜ 0.05), and that in the study group was higher than the control group (P ＜ 0.01). The total incidence of adverse reactions in the study group was lower than the control group (P ＜ 0.01). Conclusion The combination of Buyang Huanwu Decoction combined with GP chemotherapy is effective and reliable in the treatment of advanced NSCLC. It can relieve the hypercoagulability and improve the quality of life, with few adverse reactions and high safety.
		2018 Vol. 15 (36): 113-116 [Abstract] ( 236 ) HTML (1 KB) PDF (712 KB) ( 69 )

	117	Research on TCM constitution distribution and pathogenesis factors of endometriosis
		CHENG Chen ZHANG Lei ZHU Li WAN Guiping▲
		Objective To explore the distribution law of Traditional Chinese Medicine (TCM) constitution, the relationship between endometriosis and TCM constitution distribution, and the pathogenesis factors of endometriosis. Methods Based on the multi-center epidemiology, the data of the general survey and standardized collection of TCM constitution scale for patients with endometriosis and healthy women were collected. Seventy-seven cases of endometriosis patients detected by epidemiological investigations in three hospitals in Suzhou, Taizhou and Rugao in Jiangsu Province (Suzhou Yangcheng Lake Hospital, Taizhou City Integrated Traditional Chinese and Western Medicine Hospital, Rugao Chinese Medicine Hospital) from January 2016 to December 2017 were selected as study group. One hundred cases of healthy women without endometriosis were selected as control group. The database of the TCM constitution questionnaire was set up, the statistical analysis of relevant data was performed by SPSS 24.0 software. Results For the comparison analysis of different constitutions including static-blood constitution, Qi deficiency constitution, Yang deficiency constitution, Yin deficiency constitution, phlegm-dampness constitution, damp-heat constitution, Qi-stagnation constitution, moderate constitution, and special constitution, the top three constitutions in study group were Qi-stagnation constitution (39%), static-blood constitution (26%), and phlegm-dampness constitution (12%). The ratios of Qi-stagnation constitution, static-blood constitution in the study group were higher than those in the control group, the ratio of moderate constitution was lower than that in the control group, the differences were highly statistically significant (P ＜ 0.01). Combined with professional knowledge analysis, the differences in menarche age, menstrual period, menstrual blood volume, menstrual cycle, history of dysmenorrhea, abortion times, history of infertility between the two groups were highly statistically significant (P ＜ 0.01). The difference in the history of uterine surgery between the two groups was statistically significant (P ＜ 0.05). Compared with control group, the dietary factors in the study group was sweeter and greasier, the difference was statistically significant (P ＜ 0.05); the temperament factors were irritable, sentimental, and depressed, and the life factor was significant pressure increase, the differences were highly statistically significant (P ＜ 0.01). Conclusion The main disease constitution of endometriosis is Qi-stagnation constitution, the static-blood constitution and phlegm-dampness constitution are the second, while the main constitution of healthy women is moderate constitution. The formation of physical constitution is the result of multiple factors, and may be related to the menstrual period, menstrual blood volume, infertility history, dysmenorrhea history, abortion times, history of uterine surgery, eating habits and living habits.
		2018 Vol. 15 (36): 117-120 [Abstract] ( 195 ) HTML (1 KB) PDF (755 KB) ( 114 )

	121	Analysis of the rule of traditional Chinese medicine in the treatment of Helicobacter pylori infection
		WANG Di1 ZHANG Wenjiang2.3
		Objective To explore the rule of application of traditional Chinese medicine in the treatment of Helicobacter pylori infection. Methods Using the keyword search method to search the literature from January 1993 to December 2017 in CNKI, Wanfang and VIP database, and finally 80 documents in conformity with the standard. The keyword search method was used to retrieve 80 articles from January 1993 to December 2017 in CNKI, Wanfang and VIP databases. The database was established with EXCEL form. SPSS statistical software was used to analyze the frequency, four properties, five flavors, meridian tropism, drug category and treatment principle and method in medication. Results A total of 101 flavors of traditional Chinese medicine were used in the literature, and the frequency of use was 822. The top three highest frequency of use were licorice, berberine, and dandelion; the top drugs ranked according to the category of drugs were tonifying Qi and lifting yang, Qi-regulating and heat-clearing and Dampness-drying drugs. The medicinal properties were mainly warm, cold and calm, with a cumulative frequency of 94.9%; the four properties were mainly warm, cold and calm, with a cumulative frequency of 94.9%; the five flavors were mainly bitter, spicy and sweet, with a cumulative frequency of 97.2%. The main meridian attribution was to enter the spleen, heart and liver, with a cumulative frequency of 85.9%. The treatment principle and method were mainly to clear away heat and dampness, soothing liver and regulating qi, promoting blood circulation and removing blood stasis. Conclusion The treatment of Helicobacter pylori infection follows the principle of strengthening the body and eliminating pathogens, and is based on syndrome differentiation and treatment.
		2018 Vol. 15 (36): 121-124 [Abstract] ( 188 ) HTML (1 KB) PDF (721 KB) ( 143 )

	125	Clinical effect of self-made Zishen Tiaogan Decoction combined with auricular acupoint pressure in the treatment of perimenopausal syndrome
		YANG Yaqin1 WANG Lu1 XIANG Xi1 GE Man1 JIN Zhichun2
		Objective To investigate the clinical effect of self-made Zishen Tiaogan Decoction combined with auricular point sticking pressure in the treatment of perimenopausal syndrome. Methods Ninety-eight patients with perimenopausal syndrome admitted to Hubei Maternal and Child Health Care Hospital from January 2015 to December 2017 were selected and divided into control group and treatment group by random number table method, with 49 cases in each group. The control group was treated with auricular point sticking pressure, and the treatment group was treated with Zishen Tiaogan Decoction on the basis of control group. Both groups were treated with 3 courses of treatment and 4 weeks was as a course of treatment. The modified Kupperman scores of the two groups were evaluated and compared before and after treatment. The clinical effects of the two groups were compared. The levels of serum estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the two groups were detected and compared. The occurrence of adverse reactions during treatment was recorded and compared between the two groups. Results After treatment, the scores of modified Kupperman in both groups were significantly lower than those before treatment, moreover, the modified Kupperman scores in the treatment group were significantly lower than those in the control group, the differences were all statisticall significam (P ＜ 0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the serum E2 levels in both groups were higher than those before treatment, while the serum FSH and LH levels were lower than those before treatment, and the serum E2 levels in the treatment group were higher than those in the control group, while the serum FSH and LH levels were lower than those in the control group, with statistically significant differences (P ＜ 0.05). During the treatment, no obvious adverse reactions occurred in either group. Conclusion Zishen Tiaogan Decoction combined with auricular point sticking in the treatment of perimenopausal syndrome has significant clinical efficacy, which can obviously improve symptoms, effectively regulate the level of sexual hormones in the body, with a good safety.
		2018 Vol. 15 (36): 125-128 [Abstract] ( 197 ) HTML (1 KB) PDF (764 KB) ( 63 )

	129	A new interpretation of “official of the sovereign” and “official of the fairness”
		GAO Ya AN Hong XU Shijie▲
		The usual understanding of “official of the sovereign” and “official of the fairness” refers to official position. Based on the hermeneutics, in the way of explaining word meaning, comprehending further implication and concrete practice, this article reveals astronomical meaning of “official of the sovereign” and “official of the fairness”, that the position and function of the heart and the gallbladder is the astronomy reflection and the relationship between them is also related to this. Therefore, it is called “official of the sovereign” and “official of the fairness”. The deep meaning of action and inaction is further stated, and discussed in three aspects of nursing heart, soothing gallbladder and curing heart and gallbladder together.
		2018 Vol. 15 (36): 129-131,143 [Abstract] ( 200 ) HTML (1 KB) PDF (775 KB) ( 150 )

	132	The efficacy of thunder-fire moxibustion combined with Dog-days Paste in the treatment of patients with chronic diarrhea
		CHEN Yu1 GAO Hui2
		Objective To investigate the efficacy of thunder-fire moxibustion combined with Dog-days Paste in the treatment of chronic diarrhea. Methods Form July to August 2017, 68 patients with chronic diarrhea were admitted to the Outpatient Department of Yangzhou Traditional Chinese Medicine Hospital. They were randomly divided into the treatment group (35 cases) and the control group (33 cases). The treatment group was treated with thunder-fire moxibustion combined with Dog-days Paste, and the control group was treated with Bifid-triple Viable combined with Dioctahedral Smectite, and the clinical efficacy of the two groups was compared. Results After one month of treatment, 22 patients in the treatment group showed significant efficacy, 13 patients showed improvement, and the total effective rate reached 100.0%. In the control group, 5 patients had significant efficacy, 12 patients improved, 16 patients were ineffective, and the total effective rate was 51.5%. The total effective rate of the two groups was compared, and the difference was highly statistically significant (P ＜ 0.01). Conclusion The effect of thunder-fire moxibustion combined with Dog-days Paste in the treatment of chronic diarrhea is significantly better than that of Bifid-triple Viable combined with Dioctahedral Smectite.
		2018 Vol. 15 (36): 132-134 [Abstract] ( 184 ) HTML (1 KB) PDF (747 KB) ( 104 )

	135	Study on the characteristics of TCM syndrome of chronic cerebral circulatory insufficiency
		LI Nannan1 CHEN Zhigang1 MENG Fanxing1 REN Shan1 CAI Yingli1 LI Xuejun1 LIU Jialin2
		Objective To provide basis for TCM syndrome differentiation and treatment of chronic cerebral circulatory insufficiency through clinical observation of TCM syndrome distribution regularity and characteristics of patients suffering from chronic cerebral circulatory insufficiency. Methods All 76 patients with chronic cerebral circulatory insufficiency were the inpatients and outpatients of Dongfang Hospital of Beijing University of Chinese Medicine from January 2014 to January 2017. This paper clinically collected the TCM syndrome data about the patients with chronic cerebral circulatory insufficiency, developed the TCM syndrome observation scale, observed the TCM syndrome distribution regularity of 76 cases of patients with chronic cerebral circulatory insufficiency, input and analyzed the data, and explored the TCM syndrome distribution regularity of chronic cerebral circulatory insufficiency. Results ①In the 76 cases of patients with chronic cerebral circulatory insufficiency, the number of men was greater than women, and hypertensive disease accounted for the highest proportion in the concomitant underlying diseases, followed by dyslipidemia, diabetes, and coronary disease. ②Distribution of TCM syndrome factors: the common disease nature syndrome factors of the patients with chronic cerebral circulatory insufficiency included marrow deficient, phlegm turbidity, blood deficiency, qi deficiency and blood stasis; the common disease location syndrome factors included the brain, kidney and liver. In the complicated situation of all syndrome factors of patients with chronic cerebral circulatory insufficiency, there were only 4 cases (5.3%) with single symptom, and 65 cases (85.5%) with 2-4 symptoms. There were 29 cases (38.2%) with pure deficiency syndrome, only 1 case (1.3%) with pure excess syndrome, and 46 cases (60.5%) with the syndrome of intermingled deficiency and excess. ③A cluster analysis of 9 disease nature syndrome factors was made; when clustered into two categories, phlegm turbidity and marrow deficiency was classified as category Ⅰ, and other 7 symptoms were classified as category Ⅱ. ④The correlation between the disease nature syndrome factors of chronic cerebral circulatory insufficiency patients and the concomitant underlying diseases was analyzed respectively, and the results showed that the blood stasis showed a positive correlation with dyslipidemia (P ＜ 0.05); phlegm turbidity syndrome was positively correlated with hypertension (P ＜ 0.05). But, there was no significant correlation between other syndrome factors and underlying diseases (P ＞ 0.05). Conclusion Chronic cerebral circulatory insufficiency is a kind of disease intermingled deficiency and excess, with vital energy deficiency, blood deficiency, marrow deficiency and etc. as the root causes, and phlegm turbidity and blood stasis as the manifestations; the syndrome of phlegm turbidity and marrow deficiency in the patints suffering form chronic cerebral circulatory insufficiency complicated with atherosclerotic stenosis is more apparent. The pathogenesis of chronic cerebral circulatory insufficiency is complex, the main syndrome is intermingled deficiency and excess.
		2018 Vol. 15 (36): 135-139 [Abstract] ( 232 ) HTML (1 KB) PDF (808 KB) ( 100 )

	140	Study on kidney theory of Zhubing Yuanhou Lun
		YANG Wen FANG Zhaoqin LU Tao YAN Yan
		Zhubing Yuanhou Lun is considered as the first theory monograph about etiology and pathogenesis in our country. This paper takes kidney of Zhubing Yuanhou Lun as the starting point to analyze comprehensively and discuss the contents related to physiology, etiology and pathogenesis, therapeutic principle and method, and others of kidney. Moreover, it describes the pathogenesis of syndromes and symptoms of kidney in detail. The purpose of this paper is to explore the academic connotation and the origin of pathogenesis theory of viscera-state doctrine of kidney, thus it can provide a reference for document research and clinical practice of the theory of viscera-state doctrine of kidney.
		2018 Vol. 15 (36): 140-143 [Abstract] ( 198 ) HTML (1 KB) PDF (788 KB) ( 104 )

	144	Follow-up of 1 case of acromegaly with the first clinical manifestation of subacute thyroiditis and review of the literature
		LI Jia
		The clinical data of one patient of acromegaly with first clinical manifestation as subacute thyroiditis was fully analyzed, and related literatures were reviewed. The patient ignored progressive somatic enlargement and jaw overgrowth weakness for years, and visited different department before endocrinology, until subacute thyroiditis happened, through reviewing the whole story of the patient, and hormone and MRI examination, acromegaly caused by pituitary tumor releasing excess growth hormone was diagnosed. After operation, the appearance and bone were both recovered. Acromegaly is a rare chronic disease which combined with different complications in several systems，and subacute thyroiditis as the first manifestation is rare. After reviewing the literature, growth hormone may play a role in the crosstalk between immune system and neuroendocrine system, which may give new way of knowing acromegaly.
		2018 Vol. 15 (36): 144-147,151 [Abstract] ( 170 ) HTML (1 KB) PDF (1037 KB) ( 174 )

	148	Study on design of intelligent health care APP for female college students
		YAO Ziang1 WANG Jing2 SUN Chenyao3 PENG Hongye4 YIN Chunyuan5 ZHAI Xing6 WANG Ping6
		This paper aimes at designing and developing intelligent health care APP to improve the sub-health problem that widespread in the female college students. According to the user′s information, this intelligent health care APP can process intelligent analysis, first identify the user′s physical type, and then from the "medicinal tea - medicated pastry-medicated soup pot-care after lunch, living nursing advice" five aspects, the APP will feedback a set of systematic and feasible scheme of health care food to the user. Through practice, it improves that the APP could help female college students to properly regulate medicated food and diet therapy, and has the function of health care and elimination of sub-health.
		2018 Vol. 15 (36): 148-151 [Abstract] ( 219 ) HTML (1 KB) PDF (984 KB) ( 110 )

	152	Cultural connotation of traditional Chinese medicine in the ideas of Xi Jinping′s Governance of China
		ZHANG Qinglin1 ZHANG Honglei2
		The culture of traditional Chinese medicine has rooted deep in the excellent humanistic ideology and social concept of the Chinese nation in the past thousands of years, and is also the true representation of historical culture and social development. General Secretary Xi Jinping melts the core thoughts of traditional Chinese medicine, such as “preventive treatment of disease” “addressing both symptoms and diseases” “the overall concept” and “dialectical treatment”, into the process of governing the country and administration, putting forward a series of new ideas, new thought and new strategies for the new era of socialist modernization with Chinese characteristics, provide scientifically theoretical guidance and guide to action, which, in the meanwhile, helps the ancient Chinese medicine culture yield unusually brilliant results, and promotes the inheritance and development of traditional Chinese medicine culture, so that Chinese medicine will spread better throughout the world, and enhance the cultural soft power of the whole nation.
		2018 Vol. 15 (36): 152-155 [Abstract] ( 206 ) HTML (1 KB) PDF (720 KB) ( 107 )

	156	Current situation and trend analysis of China′s pharmaceutical industry from the perspective of new medical reform deep development based on the data of pharmaceutical economic operation
		XIAO Han ZHU Mintian ZHANG Siwen
		The new medical reform has been carried out for nearly 10 years. China′s medical and health undertakings have undergone a series of reforms and made great breakthroughs in some fields, but some deep-seated problems have not yet been fundamentally solved. Based on the data from 2005 to 2017 on the economic operation of Chinese medicine, the current situation and trend of the development of Chinese medicine industry were analyzed from the political, economic, social and technological aspects in this article. It was found that the policy environment of our country has changed greatly, the ability of independent innovation has been enhanced but still lagged behind, the concentration of industry has been improved, and the market share of public primary medical terminals will be steadily increased. This provides a reference for the rational distribution and development of China′s pharmaceutical industry.
		2018 Vol. 15 (36): 156-161,173 [Abstract] ( 238 ) HTML (1 KB) PDF (1703 KB) ( 306 )

	162	Evaluation of subclinical left ventricular function injury in type 2 diabetic patients whether with obesity by three-dimensional speckle tracking
		WEN Dehui1 XU Le1 ZHENG Yingjuan1 LIU Junfeng1 GU Jun2 WANG Yicheng1 SUN Chenxi1
		Objective To evaluate the left ventricular function of patients with type 2 diabetes mellitus with obesity using three-dimensional speckle tracking technology (3D-STI). Methods A total of 88 patients with type 2 diabetes diagnosed in the First Affiliated Hospital of Hebei North University from May 2017 to May 2018 were divided into the non-systemic obesity group(D1 group, BMI<25 kg/m2) and the systemic obesity group (D2 group, BMI≥25 kg/m2) according to whether they had systemic obesity, and there were 43 cases in D1 group and 45 cases in D2 group. Forty healthy people with age and gender matching were selected as the control group. The waist circumference (WC) of D2 group was measured to determine whether abdominal obesity was associated with abdominal obesity. The patients were divided into non-abdominal obesity group (D2WC1 group, male WC < 90 cm, female WC < 80 cm) and abdominal obesity group (D2WC2 group, male WC < 90 cm, female WC < 80 cm), 20 cases in D2WC1 group and 25 cases in D2WC2 group. Left ventricular systolic longitudinal strain (GLS), circumferential strain (GCS), area strain (GAS) and radial strain (GRS) were obtained by 3D-STI, and other clinical indicators were collected to analyze and compare the differences between the indicators among each group. Results Compared with the control group, GLS in D1 group was significantly lower (P < 0.05), global strain in all directions in D2 group was significantly lower (P < 0.001), all strain indices in D2 group were significantly lower than those in D1 group (P < 0.05), and all strain indices in D2WC2 group were significantly lower than those in D2WC1 group (P < 0.05). Conclusion Diabetic patients with normal left ventricular ejection fraction have impaired myocardial function. Obesity can further aggravate myocardial dysfunction. 3D-STI can detect early changes of left ventricular function in obese diabetic patients and provide reference for clinical intervention.
		2018 Vol. 15 (36): 162-165 [Abstract] ( 171 ) HTML (1 KB) PDF (727 KB) ( 141 )

	166	Safety evaluation of Iodixanol Injection in CT injection of cardiovascular system
		WANG Xiaoyan XIAO Jiwei WAN Yulei
		Objective To investigate the effect and safety of Iodixanol Injection in CT injection of cardiovascular system. Methods A total of 385 patients with cardiovascular system disease from January 2017 to March 2018 were enrolled in Wuhan NO.6 Hospital. The patients were numbered according to the order of admission and were randomly divided into the control group (n = 192) and the study group (n = 193) by random number table method. CT angiography was performed in both groups, and Iohexol Injection was used as CT contrast agent in the control group. Iodoxacin Injection was used as CT contrast agent in the study group. The angiographic effects，pre- and post-contrast renal function indicators, including serum creatinine (Scr), urinary protein excretion rate (UAER), blood urea nitrogen (BUN), and adverse reactions, adverse reactions including hypotension, shock, vomiting, nausea and facial edema were compared between the two groups. Results The excellent rate of angiography in the study group was higher than that in the control group, but the difference between the two groups was not statistically significant (P > 0.05). There was no significant difference in serum Scr, UAER and BUN levels between the two groups before angiography (P > 0.05). The levels of serum Scr, UAER and BUN in the two groups were higher than those in the control group (P < 0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P < 0.05). Conclusion Using Ioxanol Injection as contrast agent in CT injection angiography of patients with cardiovascular diseases can achieve good contrast effect, and is conducive to alleviating kidney injury. The incidence of adverse reactions is low and has high safety.
		2018 Vol. 15 (36): 166-169 [Abstract] ( 206 ) HTML (1 KB) PDF (758 KB) ( 208 )

	170	Application experience of teaching model sequential clinical practice in gastroenterologist training in different stages
		GUO Chunmei WU Jing LIU Hong
		The development and popularization of digestive endoscopy technology has brought a new level of the diagnosis and treatment for digestive system diseases. The demand for gastroenterologist is gradually increasing. Currently, the training of digestive endoscopy lacks standardized programs. The traditional training mode based on patient is no longer suitable for the rapid development of digestive endoscopy. In this paper, a training model nominated “teaching model sequential clinical practice” is presented. According to the trainees′ situation, the teaching mode is divided into three training stages: primary, intermediate and advanced stage. The primary stage teaching models are self-made model and endoscope training machine. Intermediate and advanced training model are in vitro and living animal models. The trainees can only enter the specified clinical practice after passing the examination in each practice stage, which aims at attaining quantification, refinement and individualized training for digestive endoscopy specialists.
		2018 Vol. 15 (36): 170-173 [Abstract] ( 210 ) HTML (1 KB) PDF (754 KB) ( 116 )

	174	Effect of acupotomy combined with yuandunzhen on piriformis syndrome
		ZHOU Jianbin1 ZHANG Yingying2 LI Kaiping3
		Objective To observe clinical effect of acupotomy combined with yuandunzhen on piriformis syndrome. Methods One hundred twenty patients diagnosed with piriformis syndrome in Department of Pain, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing University of Chinese Medicine from March 2015 to February 2018 were selected. This study was double-blind study. SPSS 22.0 software was used to generate random number and rank ordinal number. According to the ordinal number, all the patients were divided into acupotomy and yuandunzhen group, yuandunzhen group and acupotomy group with 40 cases in each group. Visual analog scale (VAS), Oswestry disability index (ODI) and the efficacy of TCM syndrome were evaluated respectively before treatment, at 7th day and 60th day after treatment and the results were statistically analyzed. Results Finally, 105 patients were followed up, and with 35 cases in each group. At 7th day and 60th day after treatment, VAS and ODI scorers in the acupotomy and yuandunzhen group were lower than those in the acupotomy group and the yuandunzhen group (P ＜ 0.01). TCM disease and syndrome effective rate of the acupotomy and yuandunzhen group was higher than the acupotomy group and the yuandunzhen group (P ＜ 0.05). Conclusion The clinical effect of acupotomy combined with yuandunzhen in treating piriformis syndrome is better than acupotomy or yuandunzhen alone, which is worthy of promotion in clinic.
		2018 Vol. 15 (36): 174-177 [Abstract] ( 179 ) HTML (1 KB) PDF (760 KB) ( 152 )

	178	Correlation between cognitive function and white matter hyperintensity in patients with vascular cognitive impairment
		HU Yumin
		Objective To explore the correlation between cognitive function and white matter hyperintensity in patients with vascular cognitive impairment. Methods A total of 114 patients with Subacute cerebral infarction were selected in Lishui Central Hospital of Zhejiang Province from May 2016 to February 2018. According to the age related white matter change scale (ARWMCRs) score, 114 patients were divided into two groups, including 37 cases of mild group (ARWMCRs scores was 0-3), 46 cases in moderate group (ARWMCRs scores was 4-7) and 31 cases in severe group (ARWMCRs scores was 8-24). The patients were examined by neuroimaging and neuropsychological tests. The changes of group characteristics and cognitive function of the patients of the three groups were analyzed. Results There was a significant difference in age and the proportion of diabetic patients between the three groups (P < 0.05). With the aggravation of white matter lesions, the age of the patients and the proportion of diabetic patients increased significantly. The difference of MMSE score and MoCA score in the three groups was statistically significant (P < 0.05), and the MMSE score and MoCA score in severe group were significantly lower than that in mild and moderate group (P < 0.05), while the MMSE score and MoCA score in the moderate group were significantly lower than those of the mild group (P < 0.05). There was a significant negative correlation between ARWMCRs score and MMSE score and MoCA score (r = -0.621, -0.582, all P < 0.05). Conclusion Age and diabetes mellitus have a certain impact on white matter lesions in patients with ischemic stroke, and white matter lesions can affect their cognitive function. The more serious the white matter lesions are, the more obvious the decline of cognitive function is. Neuroimaging examination of patients is helpful to early detection of cognitive impairment.
		2018 Vol. 15 (36): 178-181 [Abstract] ( 195 ) HTML (1 KB) PDF (1103 KB) ( 104 )

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