中药周期疗法联合二甲双胍治疗体重正常型多囊卵巢综合征的效果及对性激素、胰岛素抵抗的影响

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Abstract Objective To explore the effect of traditional Chinese medicine cycle therapy combined with metformin in the treatment of normal-weight polycystic ovary syndrome (PCOS), and analyze the effects on sex hormones and insulin resistance. Methods From April 2016 to December 2017, Dongzhimen Hospital of Beijing University of Chinese Medicine, 90 patients with normal weight PCOS were selected, they were divided into two groups by random number table method. The study group (45 cases) was treated with traditional Chinese medicine cycle therapy combined with metformin for 3 months，the control group (45 cases) was treated with metformin treatment for 3 months, the efficacy and safety of the two groups were compared, of the two groups of patients before and after treatment of sex hormones, fasting blood glucose (FPG), fasting insulin (FINS), insulin resistance (HOMA-IR), changes in ovulation rate were analyzed. Results After treatment, the clinical symptom scores of menstrual thinning, amenorrhea, backache, cold, libido, hairy, urination, and stool symptoms in the two groups decreased (P < 0.05), and the clinical symptom scores in study group were lower than the control group (P < 0.05). After treatment, E2, FSH, ovulation rate in two groups increased (P < 0.05), LH, T, LH/FSH, FPG, FINS, HOMA-IR in study group decreased (P < 0.05), LH, FPG, FINS, HOMA-IR in control group decreased (P < 0.05), T, FSH, LH/FSH in control group had no change (P > 0.05). After treatment, the LH, T, LH/FSH, FPG, FINS and HOMA-IR in study were lower than the control group (P < 0.05). The effective rate of treatment in the study group was higher than the control group (P < 0.01), and the incidence rate of adverse reaction was lower than the control group (P < 0.05). Conclusion Chinese medicine cycle therapy combined with metformin in the treatment of normal weight PCOS is more effective, safer, and can significantly reduce the level of sex hormones and insulin resistance in PCOS patients.

Key words： Chinese medicine cycle therapy Metformin Body weight Polycystic ovary syndrome Insulin resistance Sex hormone

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	CHEN Haiyan TANG Ling▲ XIAO Chengcong LUO Jie DAI Yong

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CHEN Haiyan TANG Ling▲ XIAO Chengcong LUO Jie DAI Yong. Effect of Chinese medicine cycle therapy combined with metformin on normal weight polycystic ovary syndrome and its effect on sex hormone and insulin resistance[J]. 中国医药导报, 2018, 15(36): 90-94.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I36/90

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