固定剂量氨氯地平联合贝那普利对比单药治疗高血压有效性和安全性的Meta分析

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Abstract Objective To evaluate the efficacy and safety of Amlodipine 2.5 mg combined with Benazepril 10 mg in patients with hypertension in comparison with single Amlodipine and Benazepril monotherapy. Methods A comprehensive search was conducted on the databases of CNKI, VIP, PubMed,Web of Science and Springer from January 1995 to February 2017 for relevant studies on the clinical drug treatment and investigation and analysis of hypertension. Two investigators screened the literature based on inclusion and exclusion criteria and extracted relevant data,using stata 14.0 for statistical analysis. Results A total of 5 randomized controlled trials were included, and a total of 964 patients were included in the study. Meta-analysis showed that Amlodipine 2.5 mg combined with Benazepril 10 mg were more effective in the treatment of hypertension than single-drug treatment group [RR = 1.49, 95%CI (1.34-1.65), P = 0.000], and it was superior to Amlodipine alone or Benazepril alone in the treatment of hypertension [RR = 1.47, 95%CI(1.17-1.86), P = 0.01; RR = 1.49, 95%CI (1.32-1.68), P = 0.000]. In terms of safety, the incidence of adverse reactions of Amlodipine 2.5 mg combined with Benazepril 10 mg in the treatment of hypertension were not significantly different from that of the single drug treatment group [RR = 1.23, 95%CI (0.94-1.62), P = 0.164]. There was no significant difference compared with Amlodipine or Benazepril in the treatment of hypertension [RR = 1.37, 95%CI (0.75-2.53), P = 0.377; RR = 1.20, 95%CI (0.88-1.63), P = 0.269]. The most common adverse reactions were headache, dizziness, cough, sinusitis, edema, and viral infection, and the incidence rate was not significantly different between the combination group and the single drug group. Conclusion Amlodipine 2.5 mg combined with Benazepril 10 mg is more effective than amlodipine and benazepril alone in the treatment of hypertension, and there is no significant difference in safety.

Key words： Hypertension Benazepril Amlodipine Meta-Analysis

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	ZHAO Li'na1 HU Haochen1 JIANG Jie1
	2▲ ZHANG Tiantian1▲

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ZHAO Li'na1 HU Haochen1 JIANG Jie1,2▲ ZHANG Tiantian1▲. Meta-analysis of efficacy and safety of Amlodipine combined with Benazepril in the treatment of hypertension in comparison with single drug therapy[J]. 中国医药导报, 2018, 15(36): 99-104.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I36/99

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