|
|
|
| Clinical study of Xuebijing combined with basic fibroblast growth factor in the treatment of Ⅱ and Ⅲ degree burn residual wounds |
| CHEN Zechun LI Jun CHEN Tao |
| Department of Burn, Ankang Central Hospital, Shaanxi Province, Ankang 725000, China |
|
|
|
Abstract Objective To study the clinical effect of Xuebijing combined with basic fibroblast growth factor in the treatment of Ⅱ and Ⅲ degree burn residual wounds. Methods From January 2015 to January 2018, in Shaanxi Ankang Certral Hospital, Ⅱ, Ⅲ degree of 81 cases of burn patients were chosen. According to random number table method, they were divided into observation group (41 cases) and control group (40 cases). Two groups were given conventional debridement and disinfection processing, the control group was given rh-bFGF treatment, on basis of which, observation group was given Xuebijing treatment, after 2 weeks of treatment, the contrast effect, pathogen clearance, cytokines, visual analogue scale (VAS) and self-evaluation of anxiety scale (SAS) score of the two groups were compared, the residual wound healing time and drug adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group, and the healing time of the residual wounds was significantly shorter than that of the control group, with statistically significant differences (P < 0.05). After treatment, the pathogen clearance rate of both groups was higher than that before treatment, and the observation group was significantly higher than that of the control group, with statistically significant differences (P < 0.05). After treatment, CRP, PCT and L-1β, IL-6, tumor TNF-α levels, VAS and SAS scores of the two groups were significantly lower than those before treatment, the indexes above in the observation group were significantly lower than the control group, the differences were statistically significant (P < 0.05). There was no statistically significant difference in adverse drug reactions between the two groups (P > 0.05). Conclusion Application of Xuebijing combined with rh-bFG in the treatment of Ⅱ, Ⅲ degree burn remnant wounds has good effect, high safety, which can increase the clearance rate of bacterium of cause of disease, lower levels of cytokines, improve the quality of life.
|
|
|
|
|
|
[1] 李建武，薛宏斌，高栋梁，等.多种细胞生长因子联合应用对烧伤创面愈合的影响[J].中国现代医药杂志，2016， 18（1）：17-20.
[2] 吴祖馨.血必净注射液对严重烧伤患者脏器功能的影响[J].中西医结合心血管病电子杂志，2016，4（7）：80-81.
[3] 覃秋海.深Ⅱ度烧伤创面处理和修复的研究进展[J].临床医学，2017，37（4）：125-126.
[4] 杨智斌，吴学军，马强，等.FGF生物蛋白海绵治疗烧伤残余肉芽创面的疗效[J].宁夏医科大学学报，2017，39（2）：183-185.
[5] 唐虹.乌司他丁、血必净联合治疗对烧伤后脓毒症凝血功能及全身炎性反应影响的临床研究[J].中国医科大学学报，2015，44（12）：1132-1136.
[6] 中国医师协会烧伤医师分会《烧伤感染诊治指南》编辑委.烧伤感染的诊断标准与治疗指南（2012版）[J].中华烧伤杂志，2012，28（6）：401-403.
[7] Sato Y，Oba T，Danjo K，et al. Effect of concomitant use of dental drug on the properties of recombinant human basic fibroblast growth factor formulation for periodontal disease [J]. Yakugaku Zasshi，2013，133（1）：125-131.
[8] 闫君，王红珍，王鹏.重组人表皮生长因子凝胶辅助用于深Ⅱ度烧伤创面修复疗效分析[J].中国伤残医学，2016， 24（11）：173-174.
[9] 李红英，刘丽华，王静，等.烧伤创面病原菌感染的相关因素分析[J].中华医院感染学杂志，2017，27（2）：345-347.
[10] 刘俊玲，白明明.血必净联合纳米银敷料对烧伤患者的疗效分析[J].西部中医药，2016，29（6）：102-103.
[11] 汪乐，林雪松，项雪燕，等.老年Ⅱ度烧伤创面应用纳米银医用抗菌敷料与血必净联合治疗疗效分析[J].浙江创伤外科，2016，21（1）：164-165.
[12] 晋国营，范友芬，陈粹，等.重组人碱性成纤维细胞生长因子对深二度烧伤创面愈合的效果观察[J].现代实用医学，2014，26（4）：480-481.
[13] 马启海.血必净注射液联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床研究[J].现代药物与临床，2017，32（12）：2469-2472.
[14] 吴素英.碱性成纤维细胞生长因子与小儿烧伤创面的愈合[J].中国组织工程研究，2012，16（33）：6215-6222.
[15] 吴燕文，寿倍明，李煜，等.重组人酸性成纤维细胞生长因子联合负压引流系统治疗烧伤残余创面的临床对照试验[J].中国实用医药，2015，10（28）：3-5.
[16] 冯建科，邢亮，魏伟，等.血必净对重度以上烧伤切痂植皮术后患者血清C反应蛋白与降钙素原的影响[J].检验医学与临床，2018，15（11）：1566-1568.
[17] 罗长生.纳米银联合血必净治疗Ⅱ度烧伤疗效及安全性分析[J].临床合理用药杂志，2015，8（8）：23-24.
[18] 马江波.负压封闭引流术联合重组牛碱性成纤维细胞生长因子对四肢电烧伤创面的疗效观察[J].中华危重症医学杂志：电子版，2014，7（2）：126-128.
[19] 徐丽红.FGF+Collagen联合百多邦治疗烧伤后残余创面对炎性因子表达及创面愈合的影响[J].河北医科大学学报，2017，38（10）：1168-1171.
[20] 黄爱萍.血必净联合抗生素治疗重度烧伤的临床效果[J].中国当代医药，2017，24（26）：129-131.
[21] 计鹏，梁敏，杨晨，等.血必净注射液治疗烧伤后脓毒症疗效及对肾脏保护作用[J].现代中西医结合杂志，2016， 25（34）：3831-3833. |
|
|
|
