血管性认知障碍患者认知功能与脑白质高信号相关性分析

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (1103 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the correlation between cognitive function and white matter hyperintensity in patients with vascular cognitive impairment. Methods A total of 114 patients with Subacute cerebral infarction were selected in Lishui Central Hospital of Zhejiang Province from May 2016 to February 2018. According to the age related white matter change scale (ARWMCRs) score, 114 patients were divided into two groups, including 37 cases of mild group (ARWMCRs scores was 0-3), 46 cases in moderate group (ARWMCRs scores was 4-7) and 31 cases in severe group (ARWMCRs scores was 8-24). The patients were examined by neuroimaging and neuropsychological tests. The changes of group characteristics and cognitive function of the patients of the three groups were analyzed. Results There was a significant difference in age and the proportion of diabetic patients between the three groups (P < 0.05). With the aggravation of white matter lesions, the age of the patients and the proportion of diabetic patients increased significantly. The difference of MMSE score and MoCA score in the three groups was statistically significant (P < 0.05), and the MMSE score and MoCA score in severe group were significantly lower than that in mild and moderate group (P < 0.05), while the MMSE score and MoCA score in the moderate group were significantly lower than those of the mild group (P < 0.05). There was a significant negative correlation between ARWMCRs score and MMSE score and MoCA score (r = -0.621, -0.582, all P < 0.05). Conclusion Age and diabetes mellitus have a certain impact on white matter lesions in patients with ischemic stroke, and white matter lesions can affect their cognitive function. The more serious the white matter lesions are, the more obvious the decline of cognitive function is. Neuroimaging examination of patients is helpful to early detection of cognitive impairment.

Key words： Vascular cognitive impairment Cognitive function White matter hyperintensity Correlation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HU Yumin

Cite this article:

HU Yumin. Correlation between cognitive function and white matter hyperintensity in patients with vascular cognitive impairment[J]. 中国医药导报, 2018, 15(36): 178-181.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I36/178

[1] 刘雯文，刘进才.3.0T磁共振SWI在2型糖尿病脑微出血与认知功能影响的临床研究[J].中国临床医学影像杂志，2016，27（3）：161-166.
[2] 陈大捷，陆加明，张鑫，等.神经精神性狼疮认知功能改变机制及结构和功能MRI研究进展[J].磁共振成像，2017， 8（7）：536-541.
[3] 张超，周霞，王龙，等.血管狭窄对脑白质疏松者认知功能的影响[J].中华医学杂志，2015，95（1）：44-47.
[4] 方达，韦建武，蔡旭君，等.阿尔茨海默病MRI表现与非认知功能损伤的相关性研究[J].医学影像学杂志，2015，（8）：1439-1443.
[5] Altamura C，Scrascia F，Quattrocchi CC，et al. Regional MRI Diffusion，White-Matter Hyperintensities，and Cognitive Function in Alzheimer′s Disease and Vascular Dementia [J]. J Clin Neurol，2016，12（2）：201-208.
[6] 王薇薇，王新德.第六届全国脑血管病学术会议纪要[J].中华神经科杂志，2004，37（4）：346-348.
[7] 朱海英，肖淑萍，孙红玉.血管性痴呆患者丁酰胆碱酯酶活性及与脑白质病变的相关性研究[J].中国全科医学，2013，16（25）：2257-2259.
[8] Scott JA，Tosun D，Braskie MN，et al. Independent value added by diffusion MRI for prediction of cognitive function in older adults [J]. Neuroimage Clin，2017，14（3）：166-173.
[9] 李倩，赵路清，胡风云，等.脑白质疏松症患者认知功能损害的特点及其静息态功能磁共振观察[J].中华医学杂志，2017，97（45）：3529-3533.
[10] 童宣霞，王龙，周霞，等.脑萎缩对皮质下缺血性血管病患者认知功能的影响[J].中华医学杂志，2016，96（1）：14-19.
[11] Ashrafi F，Behnam B，Arab AM，et al. Correlation of MRI findings and cognitive function in multiple sclerosis patients using montreal cognitive assessment test[J]. Med J Islam Repub Iran，2016，30（1）：357-359.
[12] 倪广峰，李晓玲.脑小血管病非痴呆患者脑微出血灶和认知功能关系的MRI研究[J].中国实用神经疾病杂志，2016，19（5）：10-12.
[13] Verlinden VJ，Jn VDG，Hofman A，et al. Brain MRI-markers Associate Differentially with Cognitive Versus Functional Decline Leading to Dementia [J]. J Am Geriat Soc，2017，65（6）：1258-1266.
[14] 苏晓微.皮质下缺血性血管性痴呆的MRI研究进展[J].国际医学放射学杂志，2016，39（2）：133-137.
[15] Crane NA，Jenkins LM，Bhaumik R，et al. Multidimensional prediction of treatment response to antidepressants with cognitive control and functional MRI [J]. Brain，2017， 140（ 2）：472-486.
[16] 廖明朗，李传资，边静，等.颅脑MRI在评价OSAHS患者认知功能异常中的临床价值研究[J].中国CT和MRI杂志，2016，14（5）：9-12.
[17] 周树虎，褚旭，乔保俊，等.磁共振弥散张量成像对预测皮质下缺血性血管性痴呆患者认知功能障碍的价值[J].脑与神经疾病杂志，2017，25（8）：479-482.
[18] Rocca MA，De Meo E，Filippi M. Functional MRI in investigating cognitive impairment in multiple sclerosis [J]. Acta Neurol Scand，2016，134（200）：39-46.
[19] 李兆勇，朱刚明，覃达贤，等.维持性透析患者脑白质弥散功能成像及与认知功能的相关性研究[J].中国CT和MRI杂志，2017，15（8）：23-26，55.
[20] Vasavada MM，Martinez B，Wang J，et al. Central Olfactory Dysfunction in?魦 Alzheimer′s Disease and Mild Cognitive Impairment：A Functional MRI Study [J]. J Alzheimers Dis，2017，59（1）：359-368.