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2022 Vol. 19, No. 13
Published: 2022-05-05
 
 
5 Effect of Bushen Shengxue Decoction on bone marrow cells in the early stage of chemotherapy
WU Rong1 ZHU Wei1 WANG Wenjuan1 CHI Li1 JIA Chunrong2 YUE Zhujun3
Objective To observe the effect of Bushen Shengxue Decoction on bone marrow cells in the early stage of chemotherapy. Methods Sixty-five male SPF class BALB/c mice aged six to eight weeks with body weight of (20±2) g were selected and divided into blank group, model group, positive control group, high dose Bushen Shengxue Decoction group, and low dose Bushen Shengxue Decoction group according to random number table method, with 13 mice in each group. For five days of preventive administration, the high (47.0 g/kg) and low (23.5 g/kg) dose Bushen Shengxue Decoction groups were given intragastric administration, while the other groups were given intragastric administration with equal amount of distilled water. After preventive administration, Cyclophosphamide (100 mg/kg) was intraperitoneally injected into model group, positive control group, high and low dose Bushen Shengxue Decoction groups, and the same amount of normal saline was intraperitoneally injected into blank group for consecutive three days. At the same time, the positive control group was subcutaneously injected with recombinant human granulocyte colony stimulating factor (30 μg/kg), and the other groups were given the same prophylactic administration for consecutive five days. After the intervention, bone marrow cells of each group were collected, and ultrastructure of the cells was observed. The contents of tumor necrosis factor -α (TNF-α), transforming growth factor -β (TGF-β), and interferon-γ (IFN-γ) in bone marrow were detected. The mRNA expression of JAK kinase 2 (JAK2), signal transduction and transcription activator 5 (STAT5), and the protein expression of JAK2, STAT5, and phosphorylated STAT5 (P-STAT5) in bone marrow cells were detected. Results In blank group, the distribution of nucleated cells was dense, the nuclear membrane and cell membrane were intact, and the organelle structure was clear. There were few nuclear cells in the model group and a large number of cell fragments. The number of nuclear cells in the other groups increased to varying degrees, while the cell body decreased and the organelles were good. The contents of TNF-α, TGF-β, and IFN-γ in the model group were higher than those in the blank group, the contents of TNF-α, TGF-β, and IFN-γ in the high and low dose Bushen Shengxue Decoction groups were lower than those in the model group, and the contents of TGF-β and IFN-γ in the high dose Bushen Shengxue Decoction group were lower than those in the low dose Bushen Shengxue Decoction group, the differences were all statistically significant (P ＜ 0.05 or P ＜ 0.01). Compared with blank group, the mRNA expression of JAK2 and STAT5 in model group was down-regulated. Compared with model group, STAT5 mRNA expression in the high and low dose Bushen Shengxue Decoction groups was up-regulated. Compared with the low dose Bushen Shengxue Decoction group, the expression of JAK2 mRNA in the high dose Bushen Shengxue Decoction group was down-regulated, the differences were all statistically significant (P ＜ 0.05 or P ＜ 0.01). The expression levels of JAK2, P-STAT5, and STAT5 protein in the model group were lower than those in the blank group, the expression levels of JAK2 and P-STAT5 protein in the high and low dose Bushen Shengxue Decoction groups were higher than those in the model group, the expression level of P-STAT5 protein in the high dose Bushen Shengxue Decoction group was lower than that in the low dose Bushen Shengxue Decoction group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Bushen Shengxue Decoction can alleviate bone marrow cell damage in the early stage of chemotherapy, and the mechanism is related to the reduction of hematopoietic negative regulatory factor content and positive regulation of JAK2-STAT5 pathway.
2022 Vol. 19 (13): 5-9 [Abstract] ( 31 ) HTML (1 KB)  PDF (1693 KB)  ( 168 )
10 Analysis of medication rules of national patents on Chinese medicine compounds in treating diabetic foot based on data mining
HUANG Xueyun1 CHEN Chunxiao1 ZHAO Ling2
Objective To analyze medication rules of national patents on Chinese medicine compounds in the intervention for diabetic foot (DF) based on data mining method, and to provide references for the optimization of clinical prescriptions and medications. Methods In the Chinese patent announcement interface of China National Intellectual Property Administration website, “‘diabetic foot’ and ‘traditional Chinese medicine’”, “‘diabetic foot’ and ‘Chinese herb’”, and “‘gangrene of consumptive thirst’ and ‘Chinese herb’” were used as search terms, and the search period was from the establishment of the database to August 30, 2021, in order to search the patents of Chinese herbs treating DF. Frequency statistics were performed by Excel 2019, and association rules and systematic cluster analysis were performed by using SPSS Modeler 18.0, SPSS 26.0, and Cytoscape 3.7.2 softwares, respectively, in order to mine the core Chinese herbs combinations. Results A total of 56 patents and 56 traditional Chinese medicine compound combinations were included; there were 270 kinds of Chinese herbs, and the top three with high frequency were Astragali Radix, Angelicae Sinensis Radix, and Salviae Miltiorrhizae Radix Et Rhizoma; the four nature of drugs were mainly pungent and salty, the five flavors were mainly warm and cold, the spleen and liver meridians were in the majority; the top ten supporting of Chinese medicine association rules were Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizoma, Astragali Radix-Chuanxiong Rhizoma, Astragali Radix-Carthami Flos, etc.; the top 30 Chinese herbs were divided into seven groups by systematic cluster analysis; the new prescriptions included Astragali Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Angelicae Sinensis Radix, and Paeoniae Radix Rubra. Conclusion In the treatment of DF, Astragali Radix combined with traditional Chinese medicine for promoting blood circulation and removing blood stasis is mostly used, and different core drug combinations are selected according to the different double clip syndrome.
2022 Vol. 19 (13): 10-14 [Abstract] ( 50 ) HTML (1 KB)  PDF (1766 KB)  ( 57 )
15 Research status and hotspots visualization analysis of Watson care theory at home and abroad from 2000 to 2020
WANG Zhao1 WANG Zhangyi1 WANG Yue1 PANG Xiaoli2 WANG Hongyun2 JIAO Jinjin3
Objective To analyzes the research situation of Watson care theory at home and abroad in recent 20 years, aiming to reveal the current situation, hotspots, and existing problems of application at home and abroad. Methods In CNKI, Wanfang, and VIP databases, “human care theory” or “Watson theory” or “Watson care theory” and “nursing” were used as the search terms. In Web of Science, “human caring” OR “Watson’s theory” OR “Watson’s caring” was used for retrieval. The search period was limited from January 2000 to December 2020. Bibliometrics and visualization software were used to analyze the included literatures. Results A total of 160 articles were included in Chinese and 218 articles were included in English. The amount of annual literature published was gradually increasing, but the funding was insufficient, the degree of cooperation and exchange among authors was not high, the distribution of countries, regions, and institutions were uneven, and the quality of literature needs to be improved. Foreign research hotspots mostly focus on the clinical care experience and perception of patients and nursing staff, focusing on nursing education, nursing management, home nursing, community nursing, and remote nursing. In China, the research focus was on clinical practice, such as acquired immune deficiency syndrome, cancer, schizophrenia, and other diseases of nursing. Conclusion Watson care theory research has been gradually paid attention, but there are still many deficiencies. In the future, we should stren-gthen the multi-disciplinary, multi-institutional, and trans-national cooperation and exchange, build a theoretical system of care suitable for China’s national conditions, and further improve the quality of theoretical research.
2022 Vol. 19 (13): 15-19 [Abstract] ( 67 ) HTML (1 KB)  PDF (1586 KB)  ( 68 )
20 Study of quality control method of Wenyang Fuzheng Powder based on gas chromatography fingerprint and gas chromatography-mass spectrometry identification
YANG Sicheng1 HUANG Ju1 ZHOU Zhongyu2 HUANG Wei2 CHEN Shuhe3 DUAN Xueyun3 LIU Guoxiu4 ZHAI Huaqiang4 SUN Wanjin3 HUANG Zhengde3
Objective To establish a quality control model of Wenyang Fuzheng Powder as a representative prescription containing volatile components based on the identification of gas chromatography (GC) fingerprint and gas chromatography-mass spectrometry (GC-MS) analysis technology, and to provide a basis for the standard study of powder. Methods The volatile oil in Wenyang Fuzheng Powder was extracted by the volatile oil determination method and analyzed by GC-MS technology on the basis of the establishment of GC fingerprint. An Elite-WAX ETR (max 250℃, 0.25 μm×0.25 mm×30 m) capillary column was used in this experiment. The GC conditions: the heating program was set as the initial temperature of 50℃, holding time of one minutes, heating to 180℃ at a rate of 10℃/min, holding time of three minutes, then heating to 240℃ at a rate of 10℃/min, holding time of five min. The carrier gas was high-purity nitrogen (≥ 99.999%), and the carrier gas flow rate was 1.0 ml/min, the shunt ratio was set as 20∶1, the detector was FID, the detector temperature was 280℃, and the injector temperature was 200℃. The GC-MS conditions: electron impact ion source, bombarding voltage 70 eV, positive ion mode, ion source temperature was 230℃, interface temperature was 220℃; the scanning range of MS was m/z 30-500 amu; carrier gas was high purity helium (≥99.999%). Results Through the analysis of volatile oil of ten batches of Wenyang Fuzheng Powder, 12 common peaks were obtained, the fingerprint of volatile components of Wenyang Fuzheng Powder was established and the qualitative study was carried out. The quality and quantity of the main volatile components in this formula could be repeated and stable in different batches, and this model could be used for quality control research. Conclusion In this study, a quality control model of Wenyang Fuzheng Powder is established. The method is simple, safe and reliable, and provides a basis for quality evaluation of Wenyang Fuzheng Powder.
2022 Vol. 19 (13): 20-24 [Abstract] ( 30 ) HTML (1 KB)  PDF (1390 KB)  ( 75 )
25 Isolation and identification of chemical constituents from she medicine Lygodium root
ZHANG Xiaoqin1 YUAN Zhouxin1 NI Jingli1 WANG Nani2
Objective To study the chemical constituents of she medicine Lygodium root. Methods The ethanol extract was isolated and purified by normal silica gel column chromatography and preparative high performance liquid chromatography, and its structure was identified by 1H nuclear magnetic resonance spectroscopy, 13C nuclear magnetic resonance and other techniques. Results Thirteen compounds were isolated and identified as： 6-hydroxy-2-isopropyl-7-methyl-1,4-naphthoquinone （1）, protocatechuic aldehyde （2）, vomifoliol （3）, （E） -3, 4-dihydroxyphenylmethylene acetone （4）, p-hydroxycinnamic acid （5）, 3-chloro-4-hydroxy-benzoic acid （6）, kaempfer-3-O-rutin glycoside （7）, p-hydroxy benzaldehyde （8）, daucosterol （9）, 4-hydroxybenzylidenacetone （10）, methyl 3, 4-dihydroxybenzoate （11）, methyl gallate （12）, 4-methoxy-6-（3’, 4’-dihydroxystyrene） -2-pyran （13）. Conclusion 2-8 and 10-13 are the first compounds isolated from the genus Lygodium japonicum （Thunb.） Sw.
2022 Vol. 19 (13): 25-28 [Abstract] ( 24 ) HTML (1 KB)  PDF (1440 KB)  ( 26 )
29 Correlation analysis of SCNN1A polymorphism and its encoding protein expression with preeclampsia#br#
SUI Shuang FENG Guohui HUANG Ying LI Xiaoying
Objective To investigate the expression and significance of SCNN1A polymorphism and its coding protein in placenta tissues of Uygur ethnic group pregnant women with preeclampsia. Methods A total of 122 Uyghur ethnic group pregnant women with preeclampsia who delivered or terminated their pregnancy in People’s Hospital of Xinjiang Uygur Autonomous Region (hereinafter referred to as “our hospital”) from January 2017 to December 2019 were selected as the case group; according to the time limit of onset, the patients were divided into early onset preeclampsia group (onset of gestational age < 34 weeks, 50 cases) and late onset preeclampsia group (onset of gestational age ≥34 weeks, 72 cases). At the same time, 125 normal pregnant women who delivered to term in our hospital during the same period were selected as the control group. By collecting placental tissue from both groups, DNA, RNA, and protein were extracted from the placenta tissues of the patients, and the longest exon 13 polymorphism of SCNN1A was detected by first-generation sequencing. Real-time PCR was used to detect α-ENaC mRNA transcription level, and Western blot was used to detect α-ENaC protein expression level. The correlation between α-ENaC protein expression level and renal function index was analyzed. Results There was only one polymorphic site—T663A, among the six mutation sites in exon 13 of SCNN1A gene in the two groups. There was no significant difference in T663A polymorphic loci gene type between two groups (P > 0.05). Genotypes and alleles of T663A polymorphic loci showed no significant difference amang all groups (P > 0.05). There was no significant difference in α-ENaC expression among different T663A polymorphic loci genotypes (P > 0.05). There were no significant differences in α-ENaC mRNA and protein among all groups (P > 0.05). The relative expression of α-ENaC protein was negatively correlated with urinary protein (r = -0.846, P < 0.05). Conclusion α-ENaC protein expression is related to renal function impairment in pregnant women.
2022 Vol. 19 (13): 29-32 [Abstract] ( 32 ) HTML (1 KB)  PDF (1375 KB)  ( 18 )
33 Evaluation the physical dependence of Xuanfei Zhisuo Mixture in rats with natural withdrawal model and mice with precinitated withdrawal model
SONG Yuehong1 CHEN Ying2▲ ZHANG Chenxi2 JIA Yanli2 DONG Futian1 HAN Gang2 DONG Yansheng2▲ SONG Minping1▲
Objective To evaluate the physical dependence potential of Xuanfei Zhisuo Mixture in rats with natural withdrawal model and mice with precinitated withdrawal model. Methods Sixty SPF SD rats aged 5 to 7 week-old, male and female, weighing 160 to 230 g, were randomly divided into solvent control group, Morphine Hydrochloride group, low, medium and high dose Xuanfei Zhixu Mixture groups according to body weight, with 12 rats in each group. The solvent control group was orally gavage with pure water, the Morphine Hydrochloride group was subcutaneously injected with Morphine Hydrochloride injection, and the dose groups of Xuanfei Zhisuo Mixture were orally gavaged 0.732、1.83、3.66 mg/（kg·d） of Xuanfei Zhisuo Mixture, respectively, and were given continuously for 30 d, three times a day. Withdrawal score within 156 h after withdrawal and body weight change at 14 d after withdrawal were observed from the second day after last administration. Sixty SPF Balb/c mice aged 3 to 6 week-old, male and female, weighing 16 to 24 g, were randomly divided into solvent control group, Morphine Hydrochloride group, low, medium and high dose Xuanfei Zhisuo Mixture groups according to their body weight, with 12 mice in each group. The solvent control group was orally gavage with pure water, the Morphine Hydrochloride group was subcutaneously injected with Morphine Hydrochloride injection, and the dose groups of Xuanfei Zhisuo Mixture were orally gavaged 1.83, 4.575, 9.15 mg/（kg·d） of Xuanfei Zhisuo Mixture, respectively, and were given continuously for five days, three times a day. Mice in each group were intraperitoneally injected with 2 mg/kg Naloxone six hours after the last administration, and the jumping times and twisting times within 30 min as well as body weight changes before and one hour after withdrawal were observed. Results Natural withdrawal test in rats showed that: Compared with the solvent control group, the withdrawal score of Morphine Hydrochloride group was increased, the withdrawal score of low dose Xuanfei Zhisuo Mixture group was significantly increased at 12 and 18 h, and the withdrawal score of medium and high dose Xuanfei Zhisuo Mixture groups was significantly increased at 12, 18, 36, 66, 84, and 108 h, with statistical significance (P < 0.05); compared with solvent control group, body weight change in Morphine Hydrochloride group was significantly decreased from day 2 to day 7 (P < 0.05), but there was no significant difference between the two groups from day 8 to day 14 (P ＞ 0.05). There was no significant difference in body weight between low, medium and high dose Xuanfei Zhisuo Mixture groups and solvent control group on the 1st to 14th day of natural withdrawal (P ＞ 0.05). Mice precinitated withdrawal experiment showed that: compared with the solvent control group, the jumping times and twisting times of mice in Morphine Hydrochloride group were increased, and the body weight change was significantly decreased, with statistical significance (P < 0.05), compared with the solvent control group, there were no significant differences in jumping and twisting times and body weight of mice in low, medium and high dose Xuanfei Zhisuo Mixture groups (P ＞ 0.05). Conclusion Natural withdrawal reaction is observed in 0.732, 1.83, and 3.66 mg/（kg·d） dose of Xuanfei Zhisuo Mixture in rats, and the lowest addictive dose is 0.732 mg/（kg·d）. In mice precinitated withdrawal, Xuanfei Zhisuo Mixture dose groups of 1.83, 4.575, and 9.15 mg/（kg·d） show no obvious withdrawal reaction.
2022 Vol. 19 (13): 33-37 [Abstract] ( 27 ) HTML (1 KB)  PDF (864 KB)  ( 78 )
38 Study on preparation and process pcale-up of Sitafloxacin Tablets  #br#
ZHANG Tianke1 HUANG Daoming2
Objective To optimize the formula process of Sitafloxacin Tablets, and determine its scale-up of process parameters through mathematical models. Methods The in vitro dissolution similarity(similarity factor f2≥50) was used as the evaluation index to screen the prescription process, and the scale-up process parameters were determined by mathematical model. Results The preparation formula was Sitafloxacin 50 mg, mannitol 50 mg, corn starch 36 mg, low-substituted hydroxypropylcellulose 18 mg, appropriate amount of 3% hydroxypropyl cellulose aqueous solution, magnesium stearate 1 mg, film coating premix (Opadry), the coating weight gain was 3%; the key processing parameters were the granulation speed of 80 r/min, the granulation time of 2 min. Conclusion The developed sitafloxacin tablets are similar in vitro dissolution curve of the original drug, and the prescription and process parameters are reasonable, which can be used to guide the commercial production of sitafloxacin tablets.
2022 Vol. 19 (13): 38-41,46 [Abstract] ( 26 ) HTML (1 KB)  PDF (991 KB)  ( 157 )
42 Research progress on the correlation between gut microbiota and stroke#br#
WANG Xue1 ZHU Luwen2 LI Hongyu3 TANG Qiang3
In recent years many evidence have shown that gut microbiota, as a new target involved in homeostasis regulation, it can increase the risk of stroke by affecting blood pressure, blood lipid, blood glucose, and participating in immune inflammatory response. There was also a specific association between gut microbiota and stroke-related nosocomial infections. Stroke, as a common cerebrovascular disease, gut microbiota and bacterial metabolites play an important role in its pathophysiological process, which is of great significance in improving prognosis. This paper reviews the related studies on gut microbiota and stroke, in order to provide a more comprehensive perspective and ideas for the prevention, treatment, and further exploration of stroke.
2022 Vol. 19 (13): 42-46 [Abstract] ( 92 ) HTML (1 KB)  PDF (670 KB)  ( 166 )
47 Research progress of in vitro and in vivo experiments on the treatment of oligoasthenozoospermia by kidney-tonifying and spermatogenic method
MENG Fanchao LI Haisong WANG Bin FENG Junlong DENG Sheng BAO Binghao WANG Jisheng▲
The treatment of oligoasthenozoospermia by kidney-tonifying and spermatogenic method is widely used in the field of traditional Chinese medicine. However, there are few reviews on its mechanism and significance. In this paper, animal experiment and cell experiment on oligoasthenozoospermia in recent years were reviewed to provide reference for further exploring the treatment of oligoasthenozoospermia by kidney-tonifying and spermatogenic method. Animal experimental modeling mainly by chemical means, such as the use of tripterygium glycosides and adenine, and other drugs for gavage. Relevant in vivo experimental studies show that Wuzi Yanzong Pills, the classic prescription of kidney-tonifying and spermatogenic, and the clinical test prescription have played a significant role in the treatment of oligoasthenozoospermia. It was found in vitro that the sertoli cells, testicular interstitial cells, and spermatogonial cells could be significantly improved by kidney-tonifying and spermatogenic method.
2022 Vol. 19 (13): 47-50,63 [Abstract] ( 67 ) HTML (1 KB)  PDF (696 KB)  ( 90 )
51 Research progress on acquired immune deficiency syndrome patients with depression#br#
HUANG Mingyan1 DING Xue2 MA Xiuxia2 MENG Pengfei2 GUO Jiale1 ZHONG Pengzhan1 CAI Xiaoyang1 XU Liran2
In the course of long-term highly active anti-retroviral therapy (HAART), acquired immune deficiency syndrome (AIDS) patients can easily lead to depression due to physiological and psychological reasons. Depression can also reduce the compliance of HAART, affect the HAART effect, and the quality of life. The occurrence of depression in AIDS patients is related to general factors such as gender, economic level, and education level, psychological factors, social support, and AIDS related factors. The treatment of AIDS patients with depression must be carried out simultaneously with HAART. For mild depression, comprehensive therapy such as psychotherapy and traditional Chinese medicine can be used. Moderate and above depression should be treated with antidepressants. This paper reviews the related research progress of AIDS complicated with depression, in order to provide reference for the clinical diagnosis and treatment of AIDS complicated with depression.
2022 Vol. 19 (13): 51-54 [Abstract] ( 41 ) HTML (1 KB)  PDF (546 KB)  ( 73 )
55 Progress of the application of therapeutic drug monitoring of carbapenem in patients with critical illness#br#
BAI Jing LIU Jingfeng DUAN Meili
Therapeutic drug monitoring (TDM) studies the process of drugs in vivo based on pharmacokinetics (PK). It is an important means of clinical individualized drug use to achieve optimal pharmacodynamics (PD). Due to the special pathophysiological state of patients with critical illness, there are obvious differences in drug concentration between themselves and individuals during treatment, which increases the risk of insufficient treatment dose or drug toxicity. Carbapenem antimicrobial agents are widely used in anti infection treatment of patients with critical illness. Combined with PK / PD parameters, it is necessary to use TDM to guide clinical treatment, but the clinical implementation is still not standardized at present, and the effectiveness is controversial. This paper reviews the application progress of carbapenem antimicrobial agents TDM in patients with critical illness.
2022 Vol. 19 (13): 55-58 [Abstract] ( 28 ) HTML (1 KB)  PDF (469 KB)  ( 152 )
59 Research progress on the relationship between C-reactive protein gene polymorphism and tumorigenesis and development#br#
REN Shan1* REN Minwei2* DAI Wenbin3
The baseline level of human C-reactive protein (CRP) is most significant influenced by single nucleotide polymorphism in CRP gene and has individual differences. In recent years, epidemiology and research have found that the increased CRP level caused by genetic polymorphism in CRP gene is closely related to the increased risk of cancer and the proliferation and metastasis of tumors and poor prognosis. In addition, a number of genome-wide single nucleotide polymorphisms that are involved in the regulation of CRP levels are being identified and have similar functions. But some studies have found no causal relationship between genetically elevated CRP levels and cancer. It is believed that these differences may be related to different races, regions, sample sizes, environmental factors and genetic factors. This article reviews the research progress of CRP gene polymorphism and tumorigenesis and development, in order to provide reference for the study of the pathogenesis of CRP gene polymorphism and tumor immune-related etiology pathway.
2022 Vol. 19 (13): 59-63 [Abstract] ( 42 ) HTML (1 KB)  PDF (570 KB)  ( 33 )
64 Reform status and exploration of higher medical education under the background of artificial intelligence#br#
WANG Yan CHU Hong LIANG Jingjing LU Zuneng XIAO Zheman
With the development of global science and technology, the information age has gradually developed into the age of artificial intelligence. Artificial intelligence is deriving more technologies and innovations in medicine. “artificial intelligence + medical” brings convenient medical treatment experience to both doctors and patients, which has huge market demand. However, at present, there are few artificial intelligence-related teaching staff in higher medical education, and the artificial intelligence courses carried out are not yet complete, leading to the shortage of medical artificial intelligence compound talents. Vocational innovation is the driving force of educational reform, and the reform of higher medical education is bound to embark on a journey. This article will deeply explore the current medical development model, analyze the current situation of medical education reform at home and abroad, explore the top-level design and policies of medical education, and put forward important measures to promote the development of medical education in the age of artificial intelligence, so as to help national precision medicine. In addition, in higher medical education, it is necessary to strengthen the understanding of the ethical and legal issues brought about by “artificial intelligence + medical”, and correctly and effectively use artificial intelligence for serve medicine.
2022 Vol. 19 (13): 64-67 [Abstract] ( 97 ) HTML (1 KB)  PDF (602 KB)  ( 321 )
68 Exploration and analysis of ploymerase chain reaction experimental technique in training the scientific research ability of medical graduate students#br#
PANG Lijun PEI Mingxia LIU Kai LIN Minghua CHEN Dexi
In order to enable graduate students to have a deeper understanding of polymerase chain reaction technology and master and apply it flexibly in their future scientific research projects. In this paper, the principle of experiment, teaching objectives, teaching process, derived experiments and uses, matters needing attention in experiments, problems found in teaching, and other aspects are elaborated in detail. It also summarizes the teaching work of experimental teaching for graduate students and explores and analyzes how to improve the scientific research ability of medical graduate students through experimental teaching.
2022 Vol. 19 (13): 68-70 [Abstract] ( 59 ) HTML (1 KB)  PDF (512 KB)  ( 126 )
71 Exploration on the reform of integrating the curriculum ideology and politics into the teaching of undergraduates in dental implantology#br#
LIAO Lifan1 HE Longlong2 MENG Zhaoli2 ZHAO Ningbo2 FENG Hainan2 DU Liangzhi1▲
Ideological and political education is the task of college education in the new era. It is a basic requirement for medical practitioners’ medical ethics and style, and it is also a realistic requirement for cultivating qualified builders and successors of the socialist cause. Oral implantology is a new and rapidly developing subject. While conducting professional teaching, it should actively respond to the requirements of ideological and political education in the new era, and integrate ideological and political education into the current teaching system. This article discusses the problems and solutions in the ideological and political teaching of dental implantology. The solution includes taking the syllabus of Oral Implantology as the leading, integrating curriculum ideology and politics into oral implantology classroom teaching; integrating team based learning teaching based on clinical cases into curriculum ideology and politics elements; using online and offline hybrid teaching methods incorporated into the curriculum ideological and political construction, so that students not only learn professional knowledge, but also subtly possess socialist values.
2022 Vol. 19 (13): 71-74 [Abstract] ( 55 ) HTML (1 KB)  PDF (610 KB)  ( 145 )
75 Reform and practice of classroom teaching evaluation in medical colleges from the perspective of educational evaluation reform in the new era#br#
SU Qingfang WU Chuang
The reform of education evaluation in the new era puts forward new requirements for the evaluation of classroom teaching in colleges. On the basis of sorting out the existing problems of the current classroom teaching evaluation one by one, the new requirements of the standard, in-depth research, each breakthrough. Adopt the “total” evaluation subject, “optimization” evaluation standard, “intelligence” evaluation platform, “overall” evaluation process, “feedback” evaluation results, and “retrospective” evaluation application, promote the “three linkages” of “all person participation and comprehensive evaluation” “focus on learning experience and process evaluation” “process feedback and result utilization”, we established a precision classroom teaching evaluation system. It effectively solves the problems existing in classroom evaluation, implemented the evaluation reform requirements, and promoted the improvement of education and teaching quality.
2022 Vol. 19 (13): 75-78 [Abstract] ( 31 ) HTML (1 KB)  PDF (611 KB)  ( 48 )
79 Thoughts on the “Original intention” of medical students in the spiritual cultivation of red medicine spirit#br#
WU Yonggang
“Original intention” is a concentrated reflection of a person’s inner sense of mission and values. The “original intention” of medical students is related to the development of China’s future medical and health undertakings. Based on the current situation of medical humanistic education, combining social cognition theory, the red medical spirit and the “beginner’s mind” education of medical students are combined, so as to enhance the sense of mission and responsibility of medical students. This paper discusses that red medical spirit is the basic mark and basic follow of Chinese medical practitioners, introduces the connotation and characteristics of red medical spirit, probes into the three dimensions of red medical spirit to cultivate medical students’ “original intention”, and puts forward three approaches for integrating red medical spirit into the process of medical students’ talent cultivation.
2022 Vol. 19 (13): 79-82,91 [Abstract] ( 60 ) HTML (1 KB)  PDF (804 KB)  ( 131 )
83 Application effect of project teaching method in massage teaching of standardized training of residents#br#
WANG Haoyang WANG Xianbin TAN Zengde PAN Junying GAO Liquan ZHANG Mingming▲
Objective To explore the practical effect of project teaching method in clinical teaching of standardized training of residents. Methods A total of 130 standardized training of residents in the Department of Massage Division, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from May to December 2020 were selected as research subjects, and they were divided into two groups according to the random number table method, the experimental group (65 students) and the control group (65 students). The control group received conventional clinical teaching, and the experimental group received project teaching method. The two groups were compared in terms of exam scores and Mini-CEX clinical skills evaluation model. Results The total score, theory score, and skii operation score of the experimental group were higher than those of the control group (P ＜ 0.05). There were no significant differences in consultation skills, communication and expression ability, and comprehensive organizational ability between the two groups (P ＞ 0.05). The scores of physical examination skills, professional theoretical literacy, clinical discrimination ability, and overall clinical ability of the experimental group were higher than those of the control group (P ＜ 0.05). Conclusion The application of project teaching method in clinical teaching of massage department can effectively improve the quality of teaching, adapt to the current training needs of traditional Chinese medicine clinicians, improve the clinical practice ability of traditional Chinese medicine physicians, and better complete the clinical teaching task of massage discipline.
2022 Vol. 19 (13): 83-86 [Abstract] ( 59 ) HTML (1 KB)  PDF (546 KB)  ( 23 )
87 Application effect of situational simulation teaching in the hospital infection control for anesthesiology residents#br#
ZHANG Yuguan LI Xu XU Li
Objective To study the application of situational simulation teaching in sensory knowledge learning in anesthesiology department. Methods A total of 96 resident physicians in the Department of Anesthesiology, Peking Union Medical College Hospital within three years from January to March 2021 were selected for training. According to the random number table method, the students were divided into two groups, with 48 students in each group. They were trained by the traditional teaching method and the situational simulation teaching method respectively, namely the traditional teaching group and the situational simulation teaching group. Before and after the training, network questionnaire was used to assess the knowledge points related to hospital sense for all residents. The main outcome index was the scores after assessment. The secondary outcome indicators were the scores before and after training and the comparison of the correct scores of the two groups in different test sites. Results Compared with the scores before training, the test scores of the two groups increased after training, and the situation simulation group was higher than the traditional group, the differences were statistically significant (P ＜ 0.05). The meanings and choice of scene standard prevention, hospital infection common type definition, and diagnosis standard, the core of the surgical site infection prevention method, the core of catheter-related bloodstream infection prevention methods, common type of nosocomial blood-borne infections and prevention strategies, medical waste management, environment related to hospital infection, and prevention and control strategy and safe injection of a total of eight knowledge points accuracy rate in the simulation teaching group were higher than the traditional teaching group, the differences were statistically significant (P ＜ 0.05). Conclusion Situational simulation teaching can improve the learning of preventive measures of infection control.
2022 Vol. 19 (13): 87-91 [Abstract] ( 38 ) HTML (1 KB)  PDF (677 KB)  ( 37 )
92 Application effect of early enteral combined with parenteral nutrition on patients with tracheotomy after resection of intracranial hematoma#br#
MA Juxia CHEN Li WANG Ruijie TONG Lingling▲
Objective To investigate the application effect of early enteral combined with parenteral nutrition on patients with tracheotomy after resection of intracranial hematoma. Methods Seventy-eight patients with tracheotomy incision after resection of intracranial hematoma admitted to Fuyang Second People’s Hospital from June 2018 to December 2019 were divided into parenteral group, enteral group, and combined group by random number table method, with 26 cases in each group.  Enteral nutrition alone, parenteral nutrition alone, and early enteral combined and parenteral nutrition were given respectively. The nutritional status, immune level and short term prognosis were compared before and after nutrition intervention among three groups. Results The levels of total protein (TP), prealbumin (PA), albumin, transferrin (TRF) in the three groups after intervention were higher than those before intervention (P ＜ 0.05). After intervention, the levels of TP, PA, and TRF in combined group were higher than those in parenteral group, and the levels of PA and TRF in combined group were higher than those in parenteral group (P ＜ 0.05). The levels of PA and TRF in enteral group were higher than those in parenteral group (P ＜ 0.05). The levels of serum IgM, IgG, and IgA in three groups were higher than before intervention (P ＜ 0.05). After intervention, serum IgM, IgG, and IgA levels in combined group were significantly higher than those in parenteral group, and serum IgM and IgA levels in combined group were significantly higher than those in enteral group (P ＜ 0.05). The level of IgA in enteral group after intervention was higher than that in parenteral group (P ＜ 0.05). GCS scores of three groups after intervention were higher than before (P ＜ 0.05). There was no significant difference in the incidence of gastrointestinal intolerance among the three groups (P ＞ 0.05). The incidence of upper gastrointestinal bleeding in combined group was lower than that in parenteral group and enteral group (P ＜ 0.05). The total length of hospitalization in combined group was shorter than that in parenteral group and enteral group (P ＜ 0.05). Conclusions Early enteral combined with parenteral nutrition could significantly improve the immune function and nutritional status of patients with tracheotomy after resection of intracranial hematoma.
2022 Vol. 19 (13): 92-95 [Abstract] ( 42 ) HTML (1 KB)  PDF (524 KB)  ( 19 )
96 Study on the correlation between chemotactic factor CXCL11 and its receptor CXCR7 with disease activity in systemic lupus erythematosus#br#
ZU Beibei1 CHEN Yanhong2 RAO Yongmei3 LI Meirong3 LIU Lin3 MA Qianqian3▲
Objective To investigate the correlation of CXC-type chemotactic factor (CXC) ligand 11 and its receptor CXCR7 with disease activity in systemic lupus erythematosus (SLE). Methods The enrolled 40 SLE patients were the first onset patients from October 2018 to October 2020 in the Department of Rheumatology and Immunology of Xuzhou Central Hospital of Jiangsu Province (hereinafter referred to as “our hospital”). According to the SLE disease activity index, they were divided into SLE non-disease activity group (10 cases), mild disease activity group (10 cases), moderate-severe disease activity group (20 cases); a total of 20 healthy subjects in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay and flow cytometry were used to detect the expressions of CXCL11, CD3+CXCR7+ T cells, and CD19+CXCR7+ B cells in peripheral blood of SLE patient group and healthy control group, respectively, while the relationship between CXCL11, CXCR7 and SLE disease activity were analyzed. Results The expression levels of CD3+CXCR7+T cells, CD19+CXCR7+B cells, and CXCL11 in peripheral blood of the SLE group were higher than those of the healthy control group, and the differences were highly statistically significant (P ＜ 0.01). There were significant differences in the levels of CD19+CXCR7+, CD3+CXCR7+, and CXCL11 in SLE patients in different disease activity groups (P ＜ 0.05). Among them, the indicators in the inactive disease group, the mild activity group, and the moderately severe activity group were higher than those in the healthy control group, while the indicators of the mild activity group and the moderate to severe activity group were higher than those of the inactive disease group, the indexes in the moderate-severe activity group were higher than those in the mild activity group, and the differences were statistically significant (P ＜ 0.05). The expressions of CD3+CXCR7+T cells, CD19+CXCR7+B cells, and CXCL11 in SLE patients were positively correlated with systemic lupus erythematosus disease activity index score, dsDNA, erythrocyte sedimentation rate, and C-reactive protein (r ＞ 0, P ＜ 0.05); negatively correlated with complement C3 (r ＜ 0, P ＜ 0.05). Conclusion CXCL11 and CXCR7 are not only highly expressed in SLE patients, but may also be involved in the occurrence, development and disease activity of SLE. Chemokines CXCL11 and CXCR7 can be used as indicators of SLE disease activity.
2022 Vol. 19 (13): 96-98,103 [Abstract] ( 31 ) HTML (1 KB)  PDF (570 KB)  ( 63 )
100 Influencing factors of hypertension in hemodialysis patients with end-stage renal disease#br#
ZHANG Lihong WU Han▲ LIU Fang CHENG Li
Objective To analyze the influencing factors of hypertension in hemodialysis patients with end-stage renal disease. Methods A retrospective analysis method was used to collect the clinical data of 100 patients with end-stage renal disease who underwent hemodialysis in the People’s Hospital of Bozhou from January 2020 to January 2021. According to the incidence of hypertension during dialysis, the patients were divided into the occurrence group and the non-occurrence group. The clinical data of the two groups were collected, and the influencing factors of hypertension complicated by end-stage renal disease hemodialysis patients were analyzed. Results Among the 100 patients with end-stage renal disease, a total of 76 cases were complicated with hypertension during hemodialysis, accounting for 76.00%. The proportion of patients using erythropoietin (EPO) in the occurrence group was higher than that in the non-occurrence group, while the levels of serum C-reactive protein (CRP), homocysteine (Hcy), and phosphorus (P) were higher than those in the non occurrence group, and the differences were statistically significant (P ＜ 0.05). Logistic regression analysis showed that, the use of EPO and the excessive production of CRP, Hcy, and P were the risk factors of hypertension in hemodialysis patients with end-stage renal disease (OR ＞ 1, P ＜ 0.05). Conclusion Hemodialysis patients with end-stage renal disease have a higher risk of hypertension, the use of EPO, excessive production of serum CRP, Hcy, and P are the influencing factors of hypertension in hemodialysis patients with end-stage renal disease.
2022 Vol. 19 (13): 100-103 [Abstract] ( 70 ) HTML (1 KB)  PDF (507 KB)  ( 25 )
104 Analysis of influencing factors of adenomatous intestinal polyps #br#
FANG Chongwen ZHANG Yanping SUN Xiaoming CHEN Gang WANG Qi
Objective To investigate the risk factors of adenomatous intestinal polyps. Methods The data of 80 patients with colorectal polyps admitted to Anqing Municipal Hospital in Anhui Province from May 2018 to May 2021 were retrospectively analyzed, including 42 cases of adenomatous intestinal polyps and 38 cases of non-adenomatous intestinal polyps. The body mass index (BMI), smoking, drinking, blood pressure, and glucose and lipid metabolism expressions were compared between the two groups, while multivariate logistic regression was used to analyze the influencing factors of adenomatous intestinal polyps. Results There were no significant differences in BMI, diastolic blood pressure, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, low-density protein cholesterol, serum alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase between the two groups (P ＞ 0.05). There were statistically significant differences in the proportion of smoking and drinking between the two groups (P ＜ 0.05). The results of logistic regression analysis showed that smoking and drinking were the risk factors for the occurrence of adenomatous intestinal polyps (OR ＞ 1, P ＜ 0.05). Conclusion Smoking and drinking are risk factors of adenomatous intestinal polyps, and clinical attention should be paid to patients with such high-risk factors.
2022 Vol. 19 (13): 104-106 [Abstract] ( 82 ) HTML (1 KB)  PDF (442 KB)  ( 44 )
107 Effect of Hydromorphone Hydrochloride combined with Ropivacaine brachial plexus block anesthesia on postoperative analgesia of upper limb fractures#br#
CHEN Yanmei QIAN Cheng▲
Objective To explore the effect of Hydromorphone Hydrochloride combined with Ropivacaine brachial plexus block anesthesia on postoperative analgesia of upper limb fractures. Methods A total of 122 patients with lower radius fractures admitted to 904th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army from October 2018 to April 2020. They were divided into study group (61 cases) and control group (61 cases) according to random number table method. The control group received Ropivacaine brachial plexus block anesthesia, and the study group used Hydromorphone Hydrochloride on the basis of the control group. The use of patient-controlled analgesia (PCA) and pain in two groups were recorded after surgery, serum pain mediators and drug safety of two groups were compared. Results The total PNA usage of both groups at 24 and 12 h after surgery was higher than that at 8 h, the total PCA usage at 12 h in both groups after surgery was higher than that at 12 h, and the differences were statistically significant (P < 0.05). The total PCA usage in study group at 8, 12, and 24 h after surgery was lower than that in control group, and the difference was statistically significant (P < 0.05). Visual analogue scale (VAS) scores of two groups at 24 and 12 h after surgery were higher than those at 4 h, VAS scores of two groups at 24 h after surgery were higher than those at 12 h, and the differences were statistically significant (P < 0.05). VAS of study group at 4, 12, and 24 h after surgery were lower than those of control group, and the differences were statistically significant (P < 0.05). At 24 h after surgery, the levels of prostaglandin E2 (PGE2), substance P (SP) and dopamine (DA) in two groups were higher than those before surgery, PGE2, SP, and DA of study group were lower than those of control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Hydromorphone Hydrochloride combined with Ropivacaine brachial plexus block anesthesia can reduce postoperative pain in patients with upper limb fractures, reduce the release of pain mediators, and have good safety.
2022 Vol. 19 (13): 107-110 [Abstract] ( 24 ) HTML (1 KB)  PDF (568 KB)  ( 27 )
111 Effect of Dexmedetomidine on heart function in elderly undergoing total hip arthroplasty complicated with coronary heart disease#br#
QIAN Lulu REN Yingmei▲
Objective To explore the effect of Dexmedetomidine on heart function in elderly undergoing total hip arthroplasty complicated with coronary heart disease. Methods Ninty elderly patients undergoing total hip arthroplasty complicated with coronary heart disease admitted to Rugao People’s Hospital, Jiangsu Province from August 2017 to August 2020 were selected, they were divided into two groups according to the random number table method. Control group was treated with combined spinal-epidural anesthesia, and observation group was treated with Dexmedetomidine combined with combined spinal-epidural anesthesia. Mean arterial pressure (MAP), heart rate (HR), serum creatine kinase isoenzyme MB (CK-MB), cardiac troponin I (cTnI), glycogen phosphorylase isoenzyme BB (GPBB), ejection fraction (EF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) between two groups before anesthesia (T0), 30 minutes after anesthesia (T1) and 120 minutes after stopping anesthesia (T2); and the incidence of adverse reactions in two groups was observed. Results There were no statistical significances in MAP and HR of observation group at different time points (P > 0.05); MAP and HR in control group at T1 were higher than those at T0, and T2 was lower than T1, and the differences were statistically significant (P < 0.05). MAP and HR at T1 in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). There were no significant differences in the levels of CK-MB, cTnI, and GPBB in observation group at different time points (P > 0.05); the levels of CK-MB, cTnI, and GPBB at T1 in control group were higher than those at T0, and T2 was lower than T1, and the differences were statistically significant (P < 0.05). CK-MB, cTnI, and GPBB at T1-T2 in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). EF, SV, CO, and CI of observation group at different time points were significantly different (P < 0.05); CI of control group at different time points were significantly different (P < 0.05). EF, SV, CO, and CI at T1-T2 of observation group were higher than those of control group, and the differences were statistically significant (P < 0.05). There were no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Dexmedetomidine can effectively reduce the impact of surgery in elderly undergoing total hip arthroplasty complicated with coronary heart disease, it can stabilize hemodynamics and protect heart function.
2022 Vol. 19 (13): 111-114,135 [Abstract] ( 149 ) HTML (1 KB)  PDF (686 KB)  ( 24 )
115 Exploration on the rule of syndrome differentiation and treatment and medication of coronary heart disease based on medical record study about Chinese medical master #br#
YU Fan1 HAN Aiqing2 ZHOU Xuezhong3 LI Ping1 WANG Haolin2
Objective To discuss the rule of syndrome differentiation and treatment and medication strategy of coronary heart disease by Chinese medical master. Methods The medical records of Chinese medical masters were collected from published literatures and monographs by literature research method. The retrieval sources of documents and monographs were China national knowledge internet, Wanfang data knowledge service platform, Chongqing VIP Chinese periodical database, National Library of China·China National Digital Library and National Library Reference Alliance. The retrieval time was from the establishment of the database to January 2021. The collected medical record information was used for statistical analysis and data mining. Results A total of 190 research articles and 38 monographs were included, and 278 medical records were collected. A total of 17 high-frequency four diagnosis information, 13 high-frequency syndrome information, 8 high-frequency treatment methods, 21 high-frequency drugs and 15 high-frequency drug pairs were obtained. Conclusion Medical records of Chinese medical masters suggest that the location of coronary heart disease is in the heart, which is closely related to liver, spleen, and kidney. Blood stasis and phlegm are the core syndrome, and a variety of syndromes coexist. The treatment takes promoting blood circulation as the core, combined with a variety of treatment methods. Drug use has an obvious concentration trend, and drug compatibility mostly comes from classical prescriptions.
2022 Vol. 19 (13): 115-118 [Abstract] ( 45 ) HTML (1 KB)  PDF (579 KB)  ( 36 )
119 Discussion on Professor Yang Chuanhua’s experience in the prevention and treatment of perimenopausal hypertension based on harmonize theory of liver and kidney#br#
HU Fangxiao1 YANG Jie1 YANG Chuanhua2
The number of patients with perimenopausal hypertension is increasing, and their diagnosis and treatment progress has received further attention. It is more and more urgent to effectively maintain the physical and mental health of women in this special age group and solve many problems caused by perimenopause and hypertension. Based on harmonize theory of liver and kidney, Professor Yang Chuanhua believes that the location of perimenopausal hypertension is liver and kidney, the pathogenesis is deficiency of kidney qi, imbalance of kidney yin and kidney yang, and stagnation of liver qi. The treatment should tonify kidney and soothe liver. Based on harmonize theory of liver and kidney, this paper summarizes the incidence, prevention and treatment of perimenopausal hypertension, provides doctors with diagnosis and treatment ideas, develops new treatment schemes, and improves the physical and mental health of patients with perimenopausal hypertension.
2022 Vol. 19 (13): 119-122,144 [Abstract] ( 97 ) HTML (1 KB)  PDF (785 KB)  ( 45 )
123 Experience analysis of Professor Feng Ling in treating hyperlipidemia from “turbidity caused by stagnation”#br#
HOU Chengzhi CHEN Xingjuan HU Mu XU Yun WAN Jiajie FENG Ling
Hyperlipidemia is a common metabolic disease. Professor Feng Ling believes that the disease is mostly caused by “stagnation”. “Stagnation” of this disease is caused by the incoordination of the viscera, qi and blood. The result is that the nutrients are not smooth, zhizhuo is stagnant in the veins, and the fat is turbid. The pathological factors include qi stagnation, phlegm obstruction, and blood stasis. Turbidity caused by qi stagnation is the core pathogenesis of this disease. The main disease is the spleen, which is closely related to the liver and lung. Therefore, Professor Feng Ling proposes to treat the disease based on the basic treatment of “unblocking qi movement, dissipating stagnation and turbidity”. On the one hand, by regulating the spleen and liver, it can unblock qi movement and relieve stagnation and turbidity. On the other hand, by using the method of steam therapy and regulating lipid, it can open the sweat holes to unblock qi movement and dissipate stagnation and turbidity. Internal and external coherence, dispersing depression and stagnation, relieving turbidity and reducing lipid, the effect of clinical treatment for hyperlipidemia is good. A case study is attached at the end of the article. It is expected to provide new thoughts and methods for clinical treatment of the disease.
2022 Vol. 19 (13): 123-126 [Abstract] ( 31 ) HTML (1 KB)  PDF (667 KB)  ( 44 )
127 Clinical exploration and analysis of Banxia Houpu Decoction in the treatment of digestive system diseases#br#
WANG Jiehong1 JIANG Pengyan2 WANG Xianning2
Banxia Houpu Decoction is the original formula in the treatment of “plum-stone qi”. The author has drawn a conclusion that Banxia Houpu Decoction’s compatibility characteristics that treating with both elimination and reinforcement, ascending and descending regulation, and regulating the mood with spleen and stomach’s physiological and pathological characteristics by analyzing its theory and clinical practice. In addition, antidepressant effect of this prescription also accords with the diagnosis and treatment ideas and means of various emotion-related gastrointestinal diseases. The author has received exact effect in treating gastrointestinal diseases by Banxia Houpu Decoction, and summarized clinical experience through typical cases.
2022 Vol. 19 (13): 127-130 [Abstract] ( 22 ) HTML (1 KB)  PDF (648 KB)  ( 184 )
131 Effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis#br#
HU Shan LIU Yulei CHEN Pengdian CHEN Yan WANG Junling NING Yan
Objective To observe the effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis. Methods Eighty patients with lump type granulomatous lobular mastitis were selected from the outpatient department of traditional Chinese medicine and the outpatient department of mammary gland of Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University, the patients were divided into treatment group (40 cases) and control group (40 cases) by random number table method. The control group was given oral Prednisone Acetate Tablets, the treatment group was treated with the acupuncture method of soothing the liver and fortifying the spleen on the basis of the control group. After three months of treatment, clinical efficacy of the two groups was evaluated, the clinical symptoms and immune indexes [serum T lymphocyte population (CD3, CD4, CD8)], immunoglobulin (Ig) G, IgA, IgM, complement C3, and complement C4 were compared between the two groups. Results The total effective rate in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the size of breast lump in the two groups was smaller than that before treatment, and that in the treatment group was smaller than that in the control group (P ＜ 0.05). Visual analogue scale scores of the two groups after treatment were lower than those before treatment, and those in the treatment group was lower than those in the control group (P ＜ 0.05). After treatment, the levels of serum CD3 and CD4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Serum CD8 level in the two groups after treatment was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the levels of serum IgG, IgA, IgM, complement C3, and complement C4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Conclusion Acupuncture method of “soothing the liver and fortifying the spleen” could improve the serum immune indexes of patients with lumpy type granulomatous lobular mastitis, and balance the immune function. The clinical effect is better than oral Prednisone Acetate Tablets alone.
2022 Vol. 19 (13): 131-135 [Abstract] ( 43 ) HTML (1 KB)  PDF (728 KB)  ( 233 )
136 Analysis of medication rule of orthopedics and traumatology in Naxi and Buyi nationalities based on data mining#br#
ZHOU Honghai1 LU Qingwang2 LI Jilin2 LI Dongyang2 HE Xinyu2 ZENG Yuming2
Objective To analyze the medication rule of orthopedics and traumatology in Naxi and Buyi nationalities based on data mining. Methods By extracting the prescriptions for orthopedics and traumatology of Naxi and Buyi nationalities in relevant national medicine monographs, the medication rule was excavated by frequency analysis, cluster analysis, and association rule analysis. Results A total of 111 orthopedics and traumatology prescriptions of Naxi nationality were collected, involving 256 drugs, 35 drugs were used more than six times; 96 orthopedics and traumatology prescriptions of Buyi nationality were collected, involving 150 drugs, 24 drugs were used more than three times. High-frequency drugs of Naxi nationality were mostly tonifying, dispelling wind and dampness, activating blood and resolving stasis drugs; high-frequency drugs of Buyi nationality were mostly dispelling wind and dampness, activating blood and resolving stasis drugs. The drug property of high-frequency drugs of the two nationalities was mainly warm (including mild warm), and the drug flavours were mainly pungent, bitter (including mild bitter), and sweet, and the main channels were liver and kidney channels. Seven kinds of clustering combinations and 33 groups of association rules were obtained for Naxi nationality. Six kinds of clustering combinations and 36 groups of association rules were obtained for Buyi nationality. Conclusion Naxi and Buyi nationalities are good use of drugs which the drug property are warm, the drug flavours are pungent, bitter and sweet, the channels are liver and kidney channels. Orthopedics and traumatology drugs of Naxi nationality are mainly used to tonify liver and kidney, followed by dispelling wind and dampness, activating blood and resolving stasis, while orthopedics and traumatology drugs of Buyi nationality are mainly used to dispel wind and dampness, activate blood and resolving stasis, followed by tonifying liver and kidney.
2022 Vol. 19 (13): 136-138,156 [Abstract] ( 33 ) HTML (1 KB)  PDF (2157 KB)  ( 45 )
140 Professor Zhang Zhenyu’s experience in the treatment of knee osteoarthritis by four in one, combining the local, and multi-factor treatment#br#
SU Hong1 ZHANG Zhenyu1 FAN Su1 WAN Youhong2 LI Meijiao2 ZHANG Xi1 HU Qian1
Knee osteoarthritis is more common in clinic, the main symptoms are knee joint pain and even deformity, and movement in all directions can be restricted. Professor Zhang Zhenyu believes that the local pain and other symptoms of knee osteoarthritis patients can be relieved by manipulation. The main goal of treatment is to eliminate knee joint pain, improve walking and squatting functions, and enhance the life quality. The crouch of knee joint movement needs the parts such as knee, hip, spine, and abdomen to participate in to complete jointly. On the contrary, knee, hip, spine, abdomen, and other prats factors can cause knee dysfunction. Therefore, in the treatment of knee osteoarthritis, it is necessary to combine the local and the whole. The four in one, multi-factor treatment, local knee adjustment, overall hip adjustment, spine adjustment, abdomen adjustment, and so on, have a good effect on knee osteoarthritis.
2022 Vol. 19 (13): 140-144 [Abstract] ( 148 ) HTML (1 KB)  PDF (886 KB)  ( 37 )
145 Clinical study of Tongmai Yangxin Pills in the treatment of female primary stable microvascular angina#br#
RUN Jingmo ZHANG Shuaiyong SU Yongjian LI Jie YAN Liqiu▲ YUAN Bomin▲
Objective To evaluate the clinical effect of Tongmai Yangxin Pills on female primary stable microvascular angina (MVA). Methods A total of 577 female patients who were first diagnosed with primary stable MVA in Cangzhou Central Hospital of Hebei Medical University from June 2015 to June 2020 were selected. They were divided into control group (288 cases) and Tongmai Yangxin Pills group (289 cases) by random number table method. The control group was given conventional drug treatment for coronary heart disease, and Tongmai Yangxin Pills group was given Tongmai Yangxin Pills on the basis of control group. All patients were followed up for six months, the significant effective rate and effective rate, rehospitalization rate, and incidence of adverse reaction between two groups were compared, grading of angina by Canadian Society of Cardiology (CCS) and positive rate of electrocardiogram exercise test before and after treatment between two groups were compared. Results The clinical effect in Tongmai Yangxin Pills group was better than that in control group (P ＜ 0.05). After treatment, the grading of angina by CCS in the two groups was lower than that before treatment, and which in Tongmai Yangxin Pills group was lower than that in the control group (P ＜ 0.05). After treatment, the positive rate of electrocardiogram exercise test in both groups was lower than that before treatment, and which in Tongmai Yangxin Pills group was lower than that in control group (P ＜ 0.05). The rehospitalization rate of Tongmai Yangxin Pills group was lower than that in control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Tongmai Yangxin Pills has a significant clinical effect on female patients with primary stable MVA.
2022 Vol. 19 (13): 145-148 [Abstract] ( 64 ) HTML (1 KB)  PDF (499 KB)  ( 49 )
149 Application of echoendoscope combined with laparoscopy in the diagnosis and treatment of gastrointestinal submucosal tumors#br#
PENG Tao1 LOU Zhan2 ZHENG Fengfan1 ZHANG Zuojun1 WANG Lu1 GAO Huibin1 LI Shuguang3 YANG Yongjiang3
Objective To evaluate the clinical value of ultrasonoscopy combined with laparoscopy in the diagnosis and treatment of gastrointestinal submucosal tumor (SMT). Methods A total of 80 patients with SMT admitted to the First Affiliated Hospital of Hebei North University from January 2018 to December 2020 were enrolled. All patients underwent echoendoscope before surgery and they were divided into study group (echoendoscope-assisted laparoscopy) and control group (laparoscopy alone) according to random number table method, with 40 patients in each group. The consistency between echoendoscope and pathological examination was compared with pathological examination as the gold standard. The differences of gastrointestinal hormone indexes between the two groups were compared before and three days after surgery. Results The results of echoendoscope were almost identical with those of pathological diagnosis in 80 patients (P ＜ 0.05). Three days after surgery, the level of gastrin (GAS) was lower than that before treatment, and the level of vasoactive intestinal peptide (VIP) was higher than that before treatment, and the level of GAS in the study group was higher than that in the control group, while the level of VIP was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Echoendoscope has a clear diagnostic effect. Intraoperative combined application with laparoscopy can make tumor levels and peripheral blood vessels clear, improve gastrointestinal hormone secretion, and has significant clinical application value.
2022 Vol. 19 (13): 149-152 [Abstract] ( 74 ) HTML (1 KB)  PDF (894 KB)  ( 46 )
153 Correlation between diffusion weighted imaging, dynamic enhanced MRI parameters and Ki67 expression in breast cancer#br#
LI Ji1 ZHANG Jiawei1 PENG Fei1 YANG Shulan2 LI Dandan3
Objective To investigate the correlation between diffusion weighted imaging (DWI), dynamic enhanced MRI (DCE-MRI) parameters and the expression level of Ki67 in breast cancer. Methods A total of 95 patients who were first diagnosed with breast cancer in Tangshan People’s Hospital of Hebei Province from January to December 2020 were collected and divided into grade Ⅰ group (38 cases), grade Ⅱ group (42 cases), and grade Ⅲ group (15 cases) according to breast cancer classification. According to the expression level of Ki67, they were divided into low expression group (40 cases), medium expression group (40 cases), and high expression group (15 cases). General data, DWI(apparent dispersion coefficient [ADC]) and DCE-MRI parameters (time to peak of contrast agent concentration [TTP], peak enhancement [SImax], early enhancement rate [EER]) were compared. Spearman correlation coefficient was used to analyze the correlation between ADC, TTP, SImax, EER, and Ki67 expression levels. Results ADC, TTP, and SImax of grade Ⅱ and Ⅲ groups were lower than those of grade Ⅰ group, and EER was higher than that of grade Ⅰ group; ADC, TTP, and SImax of grade Ⅲ group were lower than those of grade Ⅱ group, and EER was higher than that of grade Ⅱ group, the differences were statistically significant (P ＜ 0.05). ADC, TTP, and SImax in medium and high expression groups were lower than those in low expression group, and EER was higher than that in low expression group; ADC, TTP, and SImax in high expression group were lower than those in medium expression group, and EER was higher than that in medium expression group, the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that ADC, TTP, and SImax were negatively correlated with Ki67 expression (r ＜ 0, P ＜ 0.05), and EER was positively correlated with Ki67 expression (r ＞ 0, P ＜ 0.05). Conclusion DWI and DCE-MRI parameters are correlated with Ki67 expression in breast cancer, which provided certain reference for selecting reasonable treatment plan and prognosis in the future.
2022 Vol. 19 (13): 153-156 [Abstract] ( 27 ) HTML (1 KB)  PDF (534 KB)  ( 21 )
157 Application value of two-dimensional ultrasound combined with four-dimensional ultrasound spatio-temporal image correlation in the screening of congenital heart disease in the second fetus#br#
SUN Li1 WANG Xiaoyan1 DU Yukun2 XUE Hongyuan1
Objective To investigate the application value of two-dimensional ultrasonic combined with four-dimensional ultrasonic spatio-temporal image correlation (STIC) in the screening of congenital heart disease in the second fetus. Methods A total of 260 pregnant women with the second fetus and suspected fetal congenital heart disease who underwent prenatal screening in Hebei Provincial People’s Hospital and Dingzhou People’s Hospital, Hebei Province, from January 2019 to December 2020 were selected, and all of them underwent two-dimensional ultrasonic and four-dimensional ultrasonic STIC examination during prenatal screening. Autopsy or neonatal echocardiogram results were used as the gold standard, the detection rate and diagnostic efficacy of two-dimensional ultrasound, four-dimensional ultrasonic STIC, and their combination for congenital heart disease were compared. Results Congenital heart disease was detected in 63 of the 260 newborns, 45 of which were detected by two-dimensional ultrasound, 52 of which were detected by four-dimensional ultrasonic STIC, and 62 cases were detected by the combination of the two. There was a high consistency between two-dimensional ultrasound and gold standard in the diagnosis of congenital heart disease in the second fetus (P ＜ 0.05). The four-dimensional ultrasonic STIC and its combination with two-dimensional ultrasound were almost identical with the gold standard in the diagnosis of congenital heart disease in the second fetus (P ＜ 0.05). Two-dimensional ultrasound, four-dimensional ultrasonic STIC, and their combination all had certain identification ability in screening for congenital heart disease in the second fetus, the sensitivity and specificity of their combination were 98.41% and 100.00%, respectively. Conclusion The diagnostic results of two-dimensional ultrasound combined with four-dimensional ultrasonic STIC for congenital heart disease in the second fetus are almost identical with the gold standard, which can provide a basis for precise prenatal screening.
2022 Vol. 19 (13): 157-160 [Abstract] ( 35 ) HTML (1 KB)  PDF (927 KB)  ( 28 )
161 Clinical effect of Zibitai combined with low-dose Atorvastatin Calcium in the treatment of elderly patients with hyperlipidemia#br#
LI Jian ZHOU Xinling▲ WANG Zhixiao WANG Yi
Objective To investigate the efficacy of Zibitai combined with Atorvastatin Calcium in elderly patients with hyperlipidemia. Methods From January 2019 to January 2021, 120 elderly patients with hyperlipidemia in Guangxi International Zhuang Medical Hospital were divided into control group (60 cases, Atorvastatin Calcium 20 mg, once a day) and study group (60 cases, 240 mg, twice a day+Atorvastatin Calcium 10 mg, once a day) by random number table method, all treated for 12 weeks. The changes in blood lipid, liver and kidney function, creatine kinase (CK) and fasting plasma glucose (FPG) were deterimined, and adverse events were recorded in both groups. Results After treatment, there was no statistically significant difference in high density lipoprotein-cholesterol (HDL-C) of the two groups compared with before treatment (P ＞ 0.05), while the levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and triglyceride (TG) were lower than those before treatment, the differences were statistically significant (P ＜ 0.05). There were no significant differences in TC, LDL-C, HDL-C, and TG between the two groups after treatment (P ＞ 0.05). There were no significant differences in the levels of FPG, creatinine, CK, and ALT between the two groups after treatment compared with those before treatment and between the groups (P ＞ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The efficacy and safety of Zibitai combined with low-dose Atorvastatin Calcium in the treatment of  elderly patients with hyperlipidemia are good.
2022 Vol. 19 (13): 161-164 [Abstract] ( 42 ) HTML (1 KB)  PDF (505 KB)  ( 40 )
165 Detection and analysis of serum bile acid spectrum in patients with cholelithiasis#br#
JIN Suli1 WU Yan1 WANG Ran2 YANG Li1 YAN Guochao1 ZHAO Shuai1
Objective To investigate the value of serum bile acid spectrum in clinical diagnosis and early prevention of cholelithiasis by detecting the serum bile acid spectrum in patients with cholelithiasis. Methods Serum of 48 patients with gallstone (gallstone group), and 11 patients with bile duct stone (bile duct stone group) hospitalized in the First Hospital of Hebei Medical University (hereinafter referred to as “our hospital”) from September 2019 to June 2020 and 26 healthy subjects (control group) in our hospital during the same period were collected. The 15 subcomponents of bile acids (choleic acid [CA], chenodesoxycholic acid [CDCA], deoxycholic acid [DCA], lithocholic acid [LCA], glycocholic acid [GCA], glycoursodeoxycholic acid [GUDCA], glycochenodeoxycholic acid [GCDCA], glycodeoxycholic acid [GDCA], taurocholic acid [TCA], taurodeoxycholic acid [TDCA], tauroursodeoxycholic acid [TUDCA], taurochenodeoxycholic acid [TCDCA], taurolithocholic acid [TLCA], glycocholic acid [GLCA], ursodeoxycholic acid [UDCA]) were determined by high performance liquid chromatography tandem mass spectrometry and compared. Results There were statistically significant differences in six bile acid subcomponents (GCA, GUDCA, GCDCA, TCA, TUDCA, and TCDCA) among the three groups (P ＜ 0.05). GCA, GUDCA, TCA, TCDCA, and TUDCA in gallstone group and bile duct stone group were significantly higher than those in control group, and the differences were highly statistically significant (P < 0.01). However, there were no significant differences in GCA, GUDCA, TCA, TCDCA, and TUDCA between the gallstone group and the bile duct stone group (P ＞ 0.05). The GCDCA of gallstone group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). However, there was no significant difference in GCDCA between the bile duct stone group and the control group or between the gallstone group and bile duct stone group (P ＞ 0.05). Conclusion The detection of serum bile acid metabolism spectrum can be an important marker for clinical diagnosis and early prevention of cholelithiasis.
2022 Vol. 19 (13): 165-168,172 [Abstract] ( 26 ) HTML (1 KB)  PDF (639 KB)  ( 156 )
169 Practice and thinking on hospital affairs disclosure of the public hospital under modern hospital management system#br#
REN Shan SONG Linzi YANG Jing SUN Dongyue
Hospital affairs disclosure is one of the important measures to promote the democratic and scientific management of hospitals and build a harmonious doctor-patient relationship. With the introduction of the Guiding Opinions on the Establishment of Modern Hospital Management System, new requirements have been put forward for the hospital affairs disclosure. This article discusses the policy background of hospital affairs disclosure and the status quo of hospital affairs disclosure in Xuanwu Hospital Capital Medical University. And Xuanwu Hospital, in actively promoting the hospital affairs disclosure, has strengthened organization and leadership, continuously improved system construction, clarified the division of responsibilities, actively expanded disclosure methods, strictly regulated disclosure procedures, established a confidentiality review mechanism for information disclosure, and adhered to the implementation of the supervision and assessment mechanism. At the same time, based on the status quo of hospital affairs disclosure, it is recommended to include hospital affairs disclosure into the hospital charter, implement the annual work priorities of hospital affairs disclosure, enhance the initiative of hospital affairs disclosure, and continuously strengthen supervision and establish an evaluation mechanism.
2022 Vol. 19 (13): 169-172 [Abstract] ( 42 ) HTML (1 KB)  PDF (563 KB)  ( 48 )
173 Application effect of integrated multidisciplinary diagnosis and treatment nursing in elderly patients with cerebrovascular disease#br#
GUAN Rui1 SUN Jinlong2▲ SONG Zhanchun3
Objective To explore the application effect of integrated multidisciplinary diagnosis and treatment nursing in elderly patients with cerebrovascular disease. Methods From October 2017 to October 2019, a total of 96 elderly patients with cerebrovascular disease in Fushun Central Hospital of Liaoning Province were studied and divided into control group and observation group according to the rolling dice method, with 48 cases in each group. The control group received routine nursing care, while the observation group received integrated multidisciplinary diagnosis and treatment nursing on the basis of the control group. The psychological state, neurological function, limb function, and quality of life were compared between the two groups. Results After the intervention, the scores of anxiety and depression in the two groups were lower than those before the intervention, while the scores of anxiety and depression in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the neurological function scores of the two groups were lower than those before the intervention, while the observation group was lower than the control group; the limb function scores were higher than those before the intervention, while those of the observation group were higher than those of the control group, with statistical significant differences (P ＜ 0.05). After the intervention, the indicators of quality of life and the total score of quality of life in the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, with statistical significant differences (P ＜ 0.05). Conclusion The integrated multidisciplinary diagnosis and treatment nuring has a significant effect on alleviating negative emotions, can improve nerve function and limb function, and help improve the quality of life.
2022 Vol. 19 (13): 173-176,189 [Abstract] ( 118 ) HTML (1 KB)  PDF (694 KB)  ( 66 )
177 Application effect of sensitive indicators of nursing quality in safety management of elderly inpatients#br#
ZHANG Min1 YIN Fang2 HUI Fengju3 WU Qian4 LIU Hongling5 LIU Yan6 LI Fengyun7
Objective To explore the application effect of sensitive indicators of nursing quality in the safety management of elderly inpatients. Methods A total of 53 elderly inpatients who received treatment in Cangzhou People’s Hospital (“our hospital” for short) before the application of sensitive indicators of nursing quality from January to May 2020 were selected as the control group. At the same time, a total of 53 elder patients who received treatment in our hospital from June 2020 to March 2021 after applying the sensitive indicators of nursing quality were selected as the research group. The control group was given the routine nursing quality management mode, while the research group was given the nursing quality-sensitive index management mode. Sensitive indicators of nursing quality, quality of life scores, self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS) scores, and incidence of adverse events were compared between the two groups. Results The accuracy rate of specialist assessment, individualized rehabilitation training rate, nursing specialist diagnosis rate, risk assessment accuracy rate, and health education awareness rate in the study group were higher than those in the control group, with statistically significant differences (P ＜ 0.05). After the intervention, the scores of physiological function, physiological function, physical pain, mental health and overall health of the two groups were higher than those before treatment, while those of the research group were higher than those of the control group, with statistical significant differences (P ＜ 0.05). After the intervention, the SAS and SDS scores of the two groups were lower than those before the intervention, while those of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of adverse events in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of nursing quality-sensitive indicators during the safety management of elderly hospitalized patients can reduce the possibility of adverse events, effectively relieve the patients’ various negative emotions, and promote the further improvement of nursing quality, which can be widely used.
2022 Vol. 19 (13): 177-180 [Abstract] ( 30 ) HTML (1 KB)  PDF (556 KB)  ( 90 )
181 Application effect of early oral exercise training combined with neonatal touch in nursing of late preterm infants#br#
YAN Jie CHENG Gongmei▲
Objective To explore the application effect of early oral exercise training combined with neonatal touch in the nursing of late preterm infants. Methods A total of 204 late preterm infants admitted to Xijing Hospital from February 2020 to February 2021 were selected and divided into control group and observation group by random number table method, with 102 cases in each group. On the basis of routine nursing, the control group received neonatal stroking intervention, while the observation group received early oral exercise training combined with neonatal stroking intervention. Both groups were intervened until late preterm infants could be fed completely by mouth. The feeding situation and body weight changes of the two groups were compared; the intelligence development scores before and at the end of the intervention were compared between the two groups (assessed by the mental development index [MDI] and the psychomotor development index [PDI]). Results The time of oral feeding and complete oral feeding in the observation group was shorter than that in the control group, while the feeding process was earlier than that in the control group, and the differences were statistically significant (P ＜ 0.05). The body weight at the beginning of oral feeding and complete oral feeding, while the body weight at 37 weeks corrected gestational age in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). At the end of the intervention, the MDI and PDI scores of the two groups were higher than those before the intervention, while the MDI and PDI scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Early oral exercise training combined with neonatal touch can improve the feeding situation of late preterm infants, increase the weight of late preterm infants, and promote the intellectual development of late preterm infants.
2022 Vol. 19 (13): 181-184 [Abstract] ( 64 ) HTML (1 KB)  PDF (566 KB)  ( 97 )
185 Effects of integrated medical and nursing care combined with nutritional nursing intervention on the nutritional status, quality of life of inpatients with hematological tumors#br#
GONG Shuwen
Objective To observe the effects of integrated medical and nursing care combined with nutritional nursing intervention on the nutritional status, quality of life of inpatients with hematological tumors. Methods A total of 120 hematological tumor inpatients who were treated in the Department of Hematology, Yantai Affiliated Hospital of Binzhou Medical University from February 2019 to February 2021 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 60 cases in each with. The control group was given routine nursing, the observation group was given routine nursing and medical care integration nursing combined with nutritional nursing intervention, nutritional status, negative emotion, and quality of life were compared between the two groups. Results After intervention, the levels of serum albumin (ALB), prealbumin (PA) and red blood cell (RBC) in the observation group were higher than those before intervention, the levels of serum PA and Alb in the control group were higher than those before intervention, and the levels of serum ALB, PA, and RBC in the observation group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05); after intervention, the Hamilton anxiety scale score in the control group was lower than before intervention, the scores of Hamilton anxiety scale and Hamilton depression scale in the obsorvation groups were lower than before intervention, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); after intervention, scores of various quality of life in the observation group were higher than those before intervention, scores of psychological fields, independence fields, social relations fields, environment fields, and spiritual support fields in the control group were higher than those before intervention, and scores of various quality of life in the observation group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Integrated medical and nursing combined with nutritional nursing intervention can obviously improve the nutritional status and life quality of hospitalized patients with hematologic tumor.
2022 Vol. 19 (13): 185-189 [Abstract] ( 82 ) HTML (1 KB)  PDF (644 KB)  ( 55 )
190 Effect of systemic rehabilitation intervention program on muscle strength and negative emotion of patients with cerebral infarction#br#
ZHANG Lu SHEN Xiaoming
Objective To explore the application of systematic rehabilitation intervention program in patients with cerebral infarction and its effect on muscle strength and negative emotion. Methods A total of 120 patients with cerebral infarction admitted to Bozhou Hospital of Traditional Chinese Medicine in Anhui Province from February 2020 to April 2021 were selected. The patients were divided into routine group and intervention group by random number table method, 60 patients in routine group received routine nursing intervention, and 60 patients in intervention group received systematic rehabilitation intervention on the basis of routine nursing. The changes of patients’ physical strength, negative emotion, and cognitive function were observed before and one week after intervention. Results After intervention, the improvement of body muscle strength in the intervention group was better than that in the conventional group, the differences were statistically significant (P ＜ 0.05); the self-rating depression scale and self-rating anxiety scale scores of the two groups were lower than those before intervention, and the intervention group were lower than the conventional group, the differences were statistically significant (P ＜ 0.05); the scores of Montreal cognitive assessment scale and daily living scale in the two groups were higher than those before the intervention, and the intervention group were higher than the routine group, the differences were statistically significant (P ＜ 0.05). Conclusion Strengthening systematic rehabilitation intervention in cerebral infarction nursing can effectively improve patients’ physical strength, mental state, cognitive ability, and life ability.
2022 Vol. 19 (13): 190-193 [Abstract] ( 64 ) HTML (1 KB)  PDF (603 KB)  ( 109 )
194 Application effect of integrated nursing intervention in urethroplasty for congenital hypospadias in children#br#
ZHU Shengmei CHEN Yi▲
Objective To explore the application effects of integrated nursing intervention in urethroplasty for congenital hypospadias in children. Methods A total of 128 children with congenital hypospadias who received urethroplasty were selected as the study subjects from February 2020 to June 2021 in Department of Pediatric Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. According to random number table method, they were divided into control group (64 cases) and observation group (64 cases), the control group received routine nursing, and the observation group received routine nursing + integrated nursing intervention, the success rate of operation, improvement of negative emotion, postoperative complications, and nursing satisfaction were compared between the two groups. Results The success rate of operation in observation group was higher than that in control group, and the difference was statistically significant (P ＜ 0.05); the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the two groups were lower than those before nursing, and the scores of SAS and SDS in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05); the incidence of postoperative complications in the observation group were lower than that in the control group, and nursing satisfaction in the observation group was higher than that in the control group, and the difference were statistically significant (P ＜ 0.05). Conclusion In the perioperative period of urethroplasty for children with congenital hypospadias, the adoption of integrated nursing intervention can improve the success rate of surgery, improve the negative emotions of children, reduce the risk of postoperative complications, and also improve clinical nursing satisfaction.
2022 Vol. 19 (13): 194-封三 [Abstract] ( 30 ) HTML (1 KB)  PDF (591 KB)  ( 20 )
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