胆石症患者血清胆汁酸谱的检测与分析

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Abstract Objective To investigate the value of serum bile acid spectrum in clinical diagnosis and early prevention of cholelithiasis by detecting the serum bile acid spectrum in patients with cholelithiasis. Methods Serum of 48 patients with gallstone (gallstone group), and 11 patients with bile duct stone (bile duct stone group) hospitalized in the First Hospital of Hebei Medical University (hereinafter referred to as “our hospital”) from September 2019 to June 2020 and 26 healthy subjects (control group) in our hospital during the same period were collected. The 15 subcomponents of bile acids (choleic acid [CA], chenodesoxycholic acid [CDCA], deoxycholic acid [DCA], lithocholic acid [LCA], glycocholic acid [GCA], glycoursodeoxycholic acid [GUDCA], glycochenodeoxycholic acid [GCDCA], glycodeoxycholic acid [GDCA], taurocholic acid [TCA], taurodeoxycholic acid [TDCA], tauroursodeoxycholic acid [TUDCA], taurochenodeoxycholic acid [TCDCA], taurolithocholic acid [TLCA], glycocholic acid [GLCA], ursodeoxycholic acid [UDCA]) were determined by high performance liquid chromatography tandem mass spectrometry and compared. Results There were statistically significant differences in six bile acid subcomponents (GCA, GUDCA, GCDCA, TCA, TUDCA, and TCDCA) among the three groups (P ＜ 0.05). GCA, GUDCA, TCA, TCDCA, and TUDCA in gallstone group and bile duct stone group were significantly higher than those in control group, and the differences were highly statistically significant (P < 0.01). However, there were no significant differences in GCA, GUDCA, TCA, TCDCA, and TUDCA between the gallstone group and the bile duct stone group (P ＞ 0.05). The GCDCA of gallstone group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). However, there was no significant difference in GCDCA between the bile duct stone group and the control group or between the gallstone group and bile duct stone group (P ＞ 0.05). Conclusion The detection of serum bile acid metabolism spectrum can be an important marker for clinical diagnosis and early prevention of cholelithiasis.

Key words： Cholelithiasis Gallstone Bile acid spectrum High performance liquid chromatography tandem mass spectrometry

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	JIN Suli1 WU Yan1 WANG Ran2 YANG Li1 YAN Guochao1 ZHAO Shuai1

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JIN Suli1 WU Yan1 WANG Ran2 YANG Li1 YAN Guochao1 ZHAO Shuai1. Detection and analysis of serum bile acid spectrum in patients with cholelithiasis#br#[J]. 中国医药导报, 2022, 19(13): 165-168,172.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I13/165

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