趋化因子CXCL11及其受体CXCR7与系统性红斑狼疮疾病活动相关性研究

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Abstract Objective To investigate the correlation of CXC-type chemotactic factor (CXC) ligand 11 and its receptor CXCR7 with disease activity in systemic lupus erythematosus (SLE). Methods The enrolled 40 SLE patients were the first onset patients from October 2018 to October 2020 in the Department of Rheumatology and Immunology of Xuzhou Central Hospital of Jiangsu Province (hereinafter referred to as “our hospital”). According to the SLE disease activity index, they were divided into SLE non-disease activity group (10 cases), mild disease activity group (10 cases), moderate-severe disease activity group (20 cases); a total of 20 healthy subjects in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay and flow cytometry were used to detect the expressions of CXCL11, CD3+CXCR7+ T cells, and CD19+CXCR7+ B cells in peripheral blood of SLE patient group and healthy control group, respectively, while the relationship between CXCL11, CXCR7 and SLE disease activity were analyzed. Results The expression levels of CD3+CXCR7+T cells, CD19+CXCR7+B cells, and CXCL11 in peripheral blood of the SLE group were higher than those of the healthy control group, and the differences were highly statistically significant (P ＜ 0.01). There were significant differences in the levels of CD19+CXCR7+, CD3+CXCR7+, and CXCL11 in SLE patients in different disease activity groups (P ＜ 0.05). Among them, the indicators in the inactive disease group, the mild activity group, and the moderately severe activity group were higher than those in the healthy control group, while the indicators of the mild activity group and the moderate to severe activity group were higher than those of the inactive disease group, the indexes in the moderate-severe activity group were higher than those in the mild activity group, and the differences were statistically significant (P ＜ 0.05). The expressions of CD3+CXCR7+T cells, CD19+CXCR7+B cells, and CXCL11 in SLE patients were positively correlated with systemic lupus erythematosus disease activity index score, dsDNA, erythrocyte sedimentation rate, and C-reactive protein (r ＞ 0, P ＜ 0.05); negatively correlated with complement C3 (r ＜ 0, P ＜ 0.05). Conclusion CXCL11 and CXCR7 are not only highly expressed in SLE patients, but may also be involved in the occurrence, development and disease activity of SLE. Chemokines CXCL11 and CXCR7 can be used as indicators of SLE disease activity.

Key words： Systemic lupus erythematosus CXC-type chemokine receptor 7 CXC-type chemokine receptor 11 Disease activeity

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	ZU Beibei1 CHEN Yanhong2 RAO Yongmei3 LI Meirong3 LIU Lin3 MA Qianqian3▲

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ZU Beibei1 CHEN Yanhong2 RAO Yongmei3 LI Meirong3 LIU Lin3 MA Qianqian3▲. Study on the correlation between chemotactic factor CXCL11 and its receptor CXCR7 with disease activity in systemic lupus erythematosus#br#[J]. 中国医药导报, 2022, 19(13): 96-98,103.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I13/96

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