疏肝健脾针刺法对肿块型肉芽肿性小叶性乳腺炎患者免疫功能的影响

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Abstract Objective To observe the effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis. Methods Eighty patients with lump type granulomatous lobular mastitis were selected from the outpatient department of traditional Chinese medicine and the outpatient department of mammary gland of Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University, the patients were divided into treatment group (40 cases) and control group (40 cases) by random number table method. The control group was given oral Prednisone Acetate Tablets, the treatment group was treated with the acupuncture method of soothing the liver and fortifying the spleen on the basis of the control group. After three months of treatment, clinical efficacy of the two groups was evaluated, the clinical symptoms and immune indexes [serum T lymphocyte population (CD3, CD4, CD8)], immunoglobulin (Ig) G, IgA, IgM, complement C3, and complement C4 were compared between the two groups. Results The total effective rate in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the size of breast lump in the two groups was smaller than that before treatment, and that in the treatment group was smaller than that in the control group (P ＜ 0.05). Visual analogue scale scores of the two groups after treatment were lower than those before treatment, and those in the treatment group was lower than those in the control group (P ＜ 0.05). After treatment, the levels of serum CD3 and CD4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Serum CD8 level in the two groups after treatment was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the levels of serum IgG, IgA, IgM, complement C3, and complement C4 in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P ＜ 0.05). Conclusion Acupuncture method of “soothing the liver and fortifying the spleen” could improve the serum immune indexes of patients with lumpy type granulomatous lobular mastitis, and balance the immune function. The clinical effect is better than oral Prednisone Acetate Tablets alone.

Key words： Acupuncture method of soothing the liver and fortifying the spleen Lump type Granulomatous lobular mastitis Immune function

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	HU Shan LIU Yulei CHEN Pengdian CHEN Yan WANG Junling NING Yan

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HU Shan LIU Yulei CHEN Pengdian CHEN Yan WANG Junling NING Yan. Effect of acupuncture method of soothing the liver and fortifying the spleen on immune function of patients with granulomatous lobular mastitis#br#[J]. 中国医药导报, 2022, 19(13): 131-135.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I13/131

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