碳青霉烯类治疗药物浓度监测在危重症患者中的应用进展

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Abstract Therapeutic drug monitoring (TDM) studies the process of drugs in vivo based on pharmacokinetics (PK). It is an important means of clinical individualized drug use to achieve optimal pharmacodynamics (PD). Due to the special pathophysiological state of patients with critical illness, there are obvious differences in drug concentration between themselves and individuals during treatment, which increases the risk of insufficient treatment dose or drug toxicity. Carbapenem antimicrobial agents are widely used in anti infection treatment of patients with critical illness. Combined with PK / PD parameters, it is necessary to use TDM to guide clinical treatment, but the clinical implementation is still not standardized at present, and the effectiveness is controversial. This paper reviews the application progress of carbapenem antimicrobial agents TDM in patients with critical illness.

Key words： Therapeutic drug monitoring Carbapenem Critical illness Efficacy Bacteria drug resistance

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	BAI Jing LIU Jingfeng DUAN Meili

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BAI Jing LIU Jingfeng DUAN Meili. Progress of the application of therapeutic drug monitoring of carbapenem in patients with critical illness#br#[J]. 中国医药导报, 2022, 19(13): 55-58.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I13/55

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