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| Isolation and identification of chemical constituents from she medicine Lygodium root |
| ZHANG Xiaoqin1 YUAN Zhouxin1 NI Jingli1 WANG Nani2 |
1.Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China;
2.Zhejiang Academy of Traditional Chinese Medicine, Zhejiang Province, Hangzhou 310007, China |
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Abstract Objective To study the chemical constituents of she medicine Lygodium root. Methods The ethanol extract was isolated and purified by normal silica gel column chromatography and preparative high performance liquid chromatography, and its structure was identified by 1H nuclear magnetic resonance spectroscopy, 13C nuclear magnetic resonance and other techniques. Results Thirteen compounds were isolated and identified as： 6-hydroxy-2-isopropyl-7-methyl-1,4-naphthoquinone （1）, protocatechuic aldehyde （2）, vomifoliol （3）, （E） -3, 4-dihydroxyphenylmethylene acetone （4）, p-hydroxycinnamic acid （5）, 3-chloro-4-hydroxy-benzoic acid （6）, kaempfer-3-O-rutin glycoside （7）, p-hydroxy benzaldehyde （8）, daucosterol （9）, 4-hydroxybenzylidenacetone （10）, methyl 3, 4-dihydroxybenzoate （11）, methyl gallate （12）, 4-methoxy-6-（3’, 4’-dihydroxystyrene） -2-pyran （13）. Conclusion 2-8 and 10-13 are the first compounds isolated from the genus Lygodium japonicum （Thunb.） Sw.
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