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| Clinical effect of Zibitai combined with low-dose Atorvastatin Calcium in the treatment of elderly patients with hyperlipidemia#br# |
| LI Jian ZHOU Xinling▲ WANG Zhixiao WANG Yi |
| Department of Cardiology, Guangxi International Zhuang Medical Hospital, Guangxi Zhuang Autonomous Region, Nanning 530201, China |
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Abstract Objective To investigate the efficacy of Zibitai combined with Atorvastatin Calcium in elderly patients with hyperlipidemia. Methods From January 2019 to January 2021, 120 elderly patients with hyperlipidemia in Guangxi International Zhuang Medical Hospital were divided into control group (60 cases, Atorvastatin Calcium 20 mg, once a day) and study group (60 cases, 240 mg, twice a day+Atorvastatin Calcium 10 mg, once a day) by random number table method, all treated for 12 weeks. The changes in blood lipid, liver and kidney function, creatine kinase (CK) and fasting plasma glucose (FPG) were deterimined, and adverse events were recorded in both groups. Results After treatment, there was no statistically significant difference in high density lipoprotein-cholesterol (HDL-C) of the two groups compared with before treatment (P ＞ 0.05), while the levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and triglyceride (TG) were lower than those before treatment, the differences were statistically significant (P ＜ 0.05). There were no significant differences in TC, LDL-C, HDL-C, and TG between the two groups after treatment (P ＞ 0.05). There were no significant differences in the levels of FPG, creatinine, CK, and ALT between the two groups after treatment compared with those before treatment and between the groups (P ＞ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The efficacy and safety of Zibitai combined with low-dose Atorvastatin Calcium in the treatment of elderly patients with hyperlipidemia are good.
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