右美托咪定对合并冠心病的老年全髋关节置换术患者心功能的影响

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Abstract Objective To explore the effect of Dexmedetomidine on heart function in elderly undergoing total hip arthroplasty complicated with coronary heart disease. Methods Ninty elderly patients undergoing total hip arthroplasty complicated with coronary heart disease admitted to Rugao People’s Hospital, Jiangsu Province from August 2017 to August 2020 were selected, they were divided into two groups according to the random number table method. Control group was treated with combined spinal-epidural anesthesia, and observation group was treated with Dexmedetomidine combined with combined spinal-epidural anesthesia. Mean arterial pressure (MAP), heart rate (HR), serum creatine kinase isoenzyme MB (CK-MB), cardiac troponin I (cTnI), glycogen phosphorylase isoenzyme BB (GPBB), ejection fraction (EF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) between two groups before anesthesia (T0), 30 minutes after anesthesia (T1) and 120 minutes after stopping anesthesia (T2); and the incidence of adverse reactions in two groups was observed. Results There were no statistical significances in MAP and HR of observation group at different time points (P > 0.05); MAP and HR in control group at T1 were higher than those at T0, and T2 was lower than T1, and the differences were statistically significant (P < 0.05). MAP and HR at T1 in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). There were no significant differences in the levels of CK-MB, cTnI, and GPBB in observation group at different time points (P > 0.05); the levels of CK-MB, cTnI, and GPBB at T1 in control group were higher than those at T0, and T2 was lower than T1, and the differences were statistically significant (P < 0.05). CK-MB, cTnI, and GPBB at T1-T2 in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). EF, SV, CO, and CI of observation group at different time points were significantly different (P < 0.05); CI of control group at different time points were significantly different (P < 0.05). EF, SV, CO, and CI at T1-T2 of observation group were higher than those of control group, and the differences were statistically significant (P < 0.05). There were no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Dexmedetomidine can effectively reduce the impact of surgery in elderly undergoing total hip arthroplasty complicated with coronary heart disease, it can stabilize hemodynamics and protect heart function.

Key words： Dexmedetomidine Coronary heart disease Elderly Total hip arthroplasty Heart function

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	QIAN Lulu REN Yingmei▲

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QIAN Lulu REN Yingmei▲. Effect of Dexmedetomidine on heart function in elderly undergoing total hip arthroplasty complicated with coronary heart disease#br#[J]. 中国医药导报, 2022, 19(13): 111-114,135.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I13/111

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