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2021 Vol. 18, No. 24 Published: 2021-08-25

	4	Study on quality evaluation in different grades of medicinal materials and medicinal pieces of Paeonia radix alba in Bozhou
		LI Fang1,2 HUANG Weifeng3 WANG Haibin1,2 ZHOU Jianli1 HUANG Yanmei1,2 WANG Desheng1,2
		Objective To explore the quality differences of different grades of Paeonia radix alba in Bozhou. Methods The physical and chemical indexes of Paeonia radix alba in Bozhou were analyzed according to part one and part four of the Pharmacopoeia of the People’s Republic of China (2020 edition); the thin layer chromatography method was used to qualitatively identify the Paeonia radix alba in Bozhou; and the content of paeoniflorin was determined by high performance liquid chromatography method. Waters XBridge C18 column(250 mm×4.6 mm, 5 μm) was used as the column, acetonitrile-0.1% phosphoric acid solution (14:86) was used as the mobile phase, flow rate was 1.0 ml/min, the detection wavelength was 230 nm, column temperature was 30℃. Results The determination indexes of all samples (moisture, total ash, water-soluble extract, sulfur dioxide residue) were all meet the requirements. All samples showed the same color spots in the same position as the reference. The content of paeoniflorin in different grades of Paeonia radix alba in Bozhou were different, and the content of the second grade was the highest. There was little difference in paeoniflorin content among different grades of Paeonia radix alba in Bozhou. Conclusion In the market, the specification grades of medicinal materials and medicinal pieces of Paeonia radix alba in Bozhou based on the central diameter and piece diameter cannot reflect the intrinsic quality, objectively.
		2021 Vol. 18 (24): 4-7 [Abstract] ( 409 ) HTML (1 KB) PDF (833 KB) ( 747 )

	8	Correlation between expression of ASH1L and its related regulatory factors in peripheral blood of patients with oral lichen planus and immune function
		WANG Fangfang1 WANG Ying2 CAI Yang3▲
		Objective To analyze the correlation between the expression of ASH1L and its related regulatory factors in the peripheral blood of patients with oral lichen planus (OLP) and the immune function, and to explore its role and significance in the pathogenesis of OLP. Methods The peripheral blood of 40 OLP patients (OLP group) and 20 healthy volunteers (control group) were collected from the Stomatological Hospital Affiliated to Guizhou Medical University from August 2018 to August 2019. Flow cytometry and scattering turbidimetry were used to detect the levels of cellular immunity and humoral immunity. The relative expression levels of ASH1L, ubiquitin editing enzyme A20, and interleukin-6 (IL-6) mRNA in peripheral blood mononuclear cells of the two groups and their correlation with OLP immune indexes were detected by quantitative real-time PCR. Results The levels of CD3+, CD3+CD4+, CD3+CD8+, total T+B+NK cells, and IgM in OLP group were lower than those in control group, and CD19+, CD4+/CD8+, complement C3, and C4 levels were lower than those in control group, with statistical significance (P ＜ 0.05). The relative expression levels of ASH1L and A20 mRNA in OLP group were lower than those in control group, and IL-6 mRNA in OLP group was higher than that in control group, with statistical significance (P ＜ 0.05). The relative expression of ASH1L mRNA in OLP group was positively correlated with the level of IgG (r ＞ 0, P ＜ 0.05). The relative expression of A20 mRNA was positively correlated with the levels of CD8+ and IgA (r ＞ 0, P ＜ 0.05), and negatively correlated with the CD4+/CD8+ (r ＜ 0, P ＜ 0.05). Conclusion The abnormal expression of ASH1L and its related regulatory factors in the peripheral blood of OLP patients is correlated with the level of immune indicators, and plays a certain role in the immune-related pathogenesis of OLP.
		2021 Vol. 18 (24): 8-10,16 [Abstract] ( 93 ) HTML (1 KB) PDF (663 KB) ( 87 )

	11	Study on improvement of quality standard of Baibo Pills
		CHENG Zhangong ZHAO Xiaowei WU Jiankun BAI Yan
		Objective To improve the quality standard of Baibo Pills and to provide scientific basis for improving its quality standard. Methods Microscopical identification method was used to identify puncturevine caltrop fruit, divaricate saposhnikovia root, suberect spatholobus stem, safflower and heidou. Thin layer chromatography (TLC) was used to identify chinese angelica, tuber fleeceflower stem and peony root. The AgilentSB-C18 octaneylsilane bonded silica gel column (250 mm×4.6 mm, 5 μm) was used with gradient elution. The column temperature was 40℃, the flow rate was 1.0 ml/min, and the mobile phase was methanol-water (55∶45). The detection wavelength was 246 nm. The content of isopsoralen and psoralen in Baibo Pills was determined. Results The microscopic characteristics of puncturevine caltrop fruit, divaricate saposhnikovia root, suberect spatholobus stem, safflower and heidou were obvious. TLC spots of chinese angelica, tuber fleeceflower stem and peony root were clear, and negative control had no interference. The linear range of psoralen was 0.0204-0.3066 μg (r = 0.9999). The average recovery was 98.08%, relative standard deviation (RSD) = 1.07%; The linear range of isopsoralen was 0.0204-0.3054 μg (r = 0.9998). The average recovery was 97.92%, RSD = 1.99%. Conclusion The method is comprehensive, accurate and reproducible, which can improve the quality control of Baiba Pills.
		2021 Vol. 18 (24): 11-16 [Abstract] ( 193 ) HTML (1 KB) PDF (1020 KB) ( 67 )

	17	Discussion on the mechanism of action of danshen root-fortune’s drynaria rhizome couplet medicines in the treatment of femoral head necrosis based on network pharmacology
		CHEN Zhong1 ZHENG Yang1 QIU Xiangzhong2 ZHANG Xincheng2 YIN Chendong1
		Objective To explore the mechanism of action of danshen root-fortune’s drynaria rhizome couplet medicines in the treatment of femoral head necrosis based on network pharmacology. Methods Through collecting the active ingredients of danshen root-fortune’s drynaria rhizome from the traditional Chinese medicine systems pharmacology database and analysis platform and screening according to ADME, the potential drug targets were obtained by using UNIPORT database. GeneCards and OMIM databases were used to obtain potential targets of femoral head necrosis, and the intersection of potential targets of drugs and diseases was obtained by R software and Venn diagram was drawn. Cytoscape 3.7.2 was used to construct a compound-target network. Proteinprotein interaction network diagrams were constructed using STRING database. GO functional annotation and KEGG pathway enrichment analysis were carried out for the intersection target of danshen root-fortune’s drynaria rhizome and femoral head necrosis. Results A total of 70 active components and 158 potential targets of danshen root-fortune’s drynaria rhizome couplet medicines were obtained, and 639 related targets of femoral head necrosis were obtained. The active ingredients include luteolin, kaempferol, tanshinone ⅡA, naringenin, β-sitosterol, etc. Eleven key targets, IL-6, AKT1, TP53, VEGFA, JUN, MAPK8, TNF, MAPK3, PTGS2, CASP3, and MAPK1 were identified after screening. GO function enrichment showed that the molecular functions of the target mainly involve inflammation, cell metabolism, nuclear chromatin, protein, enzyme, phosphatase receptor binding, etc. Enrichment analysis of KEGG pathway revealed 163 channels, which were mainly related to PI3K-Akt, MAPK, IL-17 and cancer-related pathways after further screening. Analysis of genes in KEGG pathway showed that almost every pathway involved core targets such as AKT, VEGFA, TNF and MAPK. Conclusion Danshen root-fortune’s drynaria rhizome couplet medicines may play a role in the treatment of femoral head necrosis through targets such as AKT, VEGFA, TNF, MAPK and pathways such as PI3K-Akt, MAPK, IL-17 and cancer.
		2021 Vol. 18 (24): 17-21,39 [Abstract] ( 200 ) HTML (1 KB) PDF (2053 KB) ( 139 )

	22	Discussion on the classification of glioma based on IDH mutation related metabolic genes
		WU Chenxing1 SONG Hongwang2 FU Xiaojun1 LI Shouwei1
		Objective To investigate the expression level of metabolic genes associated with isocitrate dehydrogenase (IDH) mutation and the classification of glioma. Methods The transcriptome data of 294 gliomas from the Chinese glioma genome atlas (CGGA) were analyzed by weighted correlation network analysis to screen the differentially expressed genes (DEG) associated with IDH status (IDH mutant type/IDH wild type, IDH-mut/wt). Genes related to metabolic pathways were screened from DEG with reference to KEGG, and cluster typing of IDH-wt gliomas was performed. Survival analysis was used to verify the clinical significance of the new types, and random forest analysis was used to screen the characteristic genes of the new types. Results According to the clustering results, IDH-wt gliomas were divided into C1, C2 and C3 types. The one-year and three-year survival rate analysis showed that IDH-mut and C1 glioma patients had significantly higher survival rate than C2 and C3 patients. Random forest analysis was used to screen out the top five most significant characteristic genes of C1 type, namely TK1, GPX8, RRM2, NNMT and GPX7, and their MDG values were 13.98, 13.94, 10.48, 10.37 and 9.54, respectively. The C1 type was diagnosed by five-gene model. The classification accuracy, sensitivity and specificity of the training group (2/3 of the data from CGGA database were randomly selected) were 95.12%, 93.75% and 95.60%. Conclusion The differentiation of metabolic subtypes of glioma is helpful for predicting prognosis and guiding the individualized treatment of glioma patients.
		2021 Vol. 18 (24): 22-25 [Abstract] ( 139 ) HTML (1 KB) PDF (778 KB) ( 129 )

	26	Investigation of the molecular mechanism of Yiqi Huatan Prescription in the treatment of coronavirus disease 2019 based on network pharmacology
		CHEN Xueqing1 LIU Yanzhui2 FENG Jing3 LUO Yuanyuan4 LI Shan5
		Objective To investigate the molecular mechanism of Yiqi Huatan Prescription in the treatment of coronavirus disease 2019 (COVID-19) by network pharmacology. Methods The active ingredients and potential targets in Yiqi Huatan Prescription were searched by traditional Chinese medicine systems pharmacology database and analysis platform. The drug-ingredient-target network was established. GeneCards database was used to screen the related targets of COVID-19, and STRING database was used to analyze the protein-protein interaction of the common targets of COVID-19 and drug action. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed using DAVID database. Results A total of 145 active ingredients, 267 potential action targets were screened from Yiqi Huatan Prescription, and a total of 251 COVID-19 related targets were screened, 56 targets were obtained through the intersection between the ingredient-target and COVID-19 related targets, and ten key targets were identified after topological analysis. GO analysis showed that Yiqi Huatan Prescription was involved in 57 biological processes, 11 molecular functions and four cellular components, such as inflammation response, immune response, apoptosis process, positive and negative regulation of apoptosis process, proteins binding, enzymes binding, cytokine activity and so on. KEGG analysis obtained 25 pathways including some infectious diseases such as Chagas disease, hepatitis B, pulmonary tuberculosis and pertussis as well as some signaling pathways such as tumor necrosis factor signaling pathway, Toll-like receptor signaling pathway, and mitogen-activated protein kinase signaling pathway. Conclusion Yiqi Huatan Prescription may have potential therapeutic effect against COVID-19 through synergy of multi-functions, multi-targets and multi-pathways, provides theoretical support and scientific basis for traditional Chinese medicine matching further study and clinical application.
		2021 Vol. 18 (24): 26-31 [Abstract] ( 103 ) HTML (1 KB) PDF (2393 KB) ( 71 )

	32	Study of effects and mechanism of long non-coding RNA FAL1 on the proliferation and apoptosis of gastric cancer cells
		CAO Xiankui XIE Bin SHAO Yang LIN Jie
		Objective To explore the effect and mechanism of long non-coding RNA FAL1 on the proliferation and apoptosis of gastric cancer. Methods Normal gastric mucosal cells GES-1 and gastric cancer cells SGC-7901, BGC-823 were taken from the Central Laboratory of Liaoning Cancer Hospital & Institute, and RT-PCR was used to detect the expression of FAL1 and STAT3 in the cells; Western-blot was detected the expression of STAT3 protein; inhibition of FAL1 and overexpression of STAT3 in gastric cancer cells, double staining with CCK-8 and Annexin V-FITC PI were evaluated cell proliferation and apoptosis. Results The expression levels of FAL1 in human gastric cancer cell lines SGC-7901 and BGC-823 were higher than that in gastric mucosal cells GES-1, and the differences were statistically significant (P ＜ 0.05). The expression levels of STAT3 in SGC-7901 and BGC-823 were higher than that in GES-1, and the differences were statistically significant (P ＜ 0.05). The expression level of FAL1 in gastric cancer cells was decreased after transfection (P ＜ 0.05). The expression level of STAT3 in gastric cancer cells was also decreased (P ＜ 0.05). After the si-FAL1#2 sequence was transfected into SGC-7901 and BGC-823 cells, cell proliferation was slowed down. On this basis, over-expression of STAT3, the proliferation ability of the inhibited cells was partially restored (P ＜ 0.05); early cell apoptosis increased significantly, after overexpression of STAT3, apoptotic cells were decreased (P ＜ 0.05). Conclusion FAL1 promotes the proliferation of gastric cancer cells and inhibits apoptosis by up-regulating the expression of STAT3.
		2021 Vol. 18 (24): 32-35 [Abstract] ( 387 ) HTML (1 KB) PDF (907 KB) ( 62 )

	36	Advances in the application of exosomes in traditional Chinese medicine
		GAO Zhonglin1 BAI Chengfei1 ZHANG Xiaofeng2 SHI Liang2 CHENG Xiaohong2
		Exosomes are rich in genomic and non-genomic biomolecules that conduct cell communication activity. It is widely present in the body fluids, not only participates in the pathogenesis of systemic multi-system diseases, but also can be used as therapeutic agent and drug delivery media, so it is called “natural drug carrier”. Traditional Chinese medicine plays its therapeutic role of targeted regulation and long-distance transmission by regulating exosomes. This paper reviews the application of exosomes in cardiovascular disease, liver disease, respiratory system disease and tumor system disease in traditional Chinese medicine, providing new ideas for the research of traditional Chinese medicine.
		2021 Vol. 18 (24): 36-39 [Abstract] ( 200 ) HTML (1 KB) PDF (530 KB) ( 311 )

	40	Role of autophagy-related regulatory signaling pathways in bone remodeling and the progress of traditional Chinese medicine prevention and treatment
		MO Yafeng1 HU Minli2 TANG Yanghua1 LI Guosong1 XIN Dawei1 XIONG Zhenfei1
		Bone remodeling is a bioremediation process with many influencing factors. Bone nonunion prolongs the treatment period of the disease, which is a thorny problem in the treatment of fracture patients. At present, the factors affecting bone remodeling and the mechanism of the related drugs promoting bone remodeling have not been fully clarified. Autophagy plays an important role in the life activities of osteoblasts, osteoclasts and osteocytes, so the regulation of autophagy has important research value in bone remodeling. In this paper, the mechanism of action of autophagy related signal pathways in bone remodeling and traditional Chinese medicine prevention and treatment of bone nonunion are reviewed, to open up new ideas and methods for the treatment of bone nonunion.
		2021 Vol. 18 (24): 40-43 [Abstract] ( 151 ) HTML (1 KB) PDF (531 KB) ( 105 )

	44	Research progress of microRNAs in the diagnosis and prognosis of acute myocardial infarction
		LI Yibo ZHAO Guoan MENG Weizheng WANG Xiulong LI Dongxu LIN Fei
		Acute myocardial infarction (AMI) is one of the most common cardiovascular emergencies in the world, with high morbidity and mortality. Early and accurate diagnosis can slow down the development of AMI and reduce the mortality. MicroRNAs (miRNAs) are involved in vascular remodeling after myocardial infarction by affecting myocardial cell proliferation, apoptosis and autophagy. More and more studies have confirmed that abnormal expression of miRNAs can be used as biomarkers for diagnosis and prognosis in patients with AMI, which may have important clinical significance for the treatment of AMI patients. This article reviews the recent advances in the therapeutic role of miRNAs in AMI, and summarizes the potential use of miRNAs as biomarkers for the diagnosis and prognosis of AMI.
		2021 Vol. 18 (24): 44-47 [Abstract] ( 168 ) HTML (1 KB) PDF (536 KB) ( 36 )

	48	Research progress on the application of ternary linkage nursing model in patients with chronic diseases
		ZHOU Lijun LIU Yanli YAN Xingyu WEI Qifei ZHANG Qi WANG Ning
		With the increasing incidence of chronic diseases year by year, the quality of life of patients with chronic diseases has been seriously affected, bringing heavy pressure to the family and society. The ternary linkage nursing model of hospital-community-family has a significant effect in the treatment of chronic diseases, which can improve patients’ compliance behavior, reduce patients’ readmission rate, improve patients’ quality of life and improve social and economic benefits. By consulting the relevant literature at home and abroad, this paper summarizes the concept of hospital-community-family ternary linkage nursing model and its application effect in patients with chronic diseases. To provide a theoretical basis for effective intervention programs to improve the quality of life of patients with chronic diseases in the future.
		2021 Vol. 18 (24): 48-51 [Abstract] ( 174 ) HTML (1 KB) PDF (529 KB) ( 222 )

	52	Heart failure awareness in patients at high risk for developing heart failure and the effect of lecture on the improvement of awareness
		CHEN Shaomin CHEN Baoxia FENG Xinheng
		Objective To understand the awareness of heart failure among high-risk groups of heart failure and the effect of heart failure knowledge lectures in improving awareness. Methods From June to December 2019, the Heart Failure Prevention and Treatment Team of Peking University Third Hospital held six heart failure knowledge lectures for people at high risk of heart failure. Participants were patients with heart failure A and B, a total of 420 cases. Before the knowledge lecture and after the lecture, a questionnaire survey on the awareness of heart failure was carried out. The awareness of heart failure includes five aspects: the cause, severity, clinical manifestations, medical treatment and self-management of heart failure. Results A total of 363 questionnaires were returned, and 345 questionnaires were finally qualified, with an effective recovery rate of 82.14%. High-risk patients with heart failure had a great lack of knowledge about heart failure. 54 patients (15.7%) who could select the eight diseases listed in the questionnaire that cause heart failure were correct; and 66 patients (19.1%) had the correct clinical manifestations which couldy list the five heart failures listed in the questionnaire; only 205 patients (59.4%) indicated that they had symptoms of heart failure and would seek medical attention as soon as possible; in terms of self-management, only 128 patients (37.1%) thought it should be restricted In terms of drinking water, 98 patients (28.4%) believed that infection should be avoided. After the knowledge lecture, the score after class was higher than before class, and the difference was statistically significant (P ＜ 0.05). Conclusion It is very necessary to carry out health education of heart failure knowledge for patients at high risk of heart failure.
		2021 Vol. 18 (24): 52-55,63 [Abstract] ( 127 ) HTML (1 KB) PDF (653 KB) ( 50 )

	56	Influence of personality factors and parent-child attachment on the externalized sexual behavior problems of Ningxia Hui Autonomous Region eco-immigrant adolescents
		WEI Jia1 FANG Jianqun2▲ DU Yunyun2 LIU Yanqiu3 LIU Hao2
		Objective To understand the impact of personality factors and parent-child attachment on the externalized sexual behavior of Ningxia eco-immigrant adolescents. Methods Random number table method was adopted, and the self-made general survey questionnaire, Achenbach child behavior inventory (CBCL), eysenck personality questionnair (EPQ), and inventory of parent and peer attachment (IPPA) were used in Ningxia Hui Autonomous Region from April to June 2014. A questionnaire survey was conducted on 755 ecological immigrant adolescents aged 12-16 years in the district. Results There was no statistically significant difference in the ethnic composition of immigrant adolescents of different genders (P > 0.05). The total scores of eco-immigrant adolescents in violation of discipline, aggression, and externalized sexual behavior of male were higher than those of females, and the differences were statistically significant (P < 0.05). The total scores of the ecological immigrant youths for violation of discipline, aggression and externalized sexual behavior of Hui nationality were higher than those of the Han nationality, and the differences were statistically significant (P < 0.05). The total score of externalized behavior problems was positively correlated with extroversion, neuroticism, psychoticism, mother alienation, and father alienation (r ＞ 0, P ＜ 0.05); it was negatively correlated with disguise, mothers trust, mother communication, father and father communication (r ＜ 0, P ＜ 0.05). Among personality factors, psychoticism, neuroticism, mother trust, mother communication, father trust, father communication, and father alienation in the Parent-Child Attachment Scale were related factors that affect externalized sexual behavior problems (P < 0.05). Conclusion There are gender and ethnic differences in the externalized sexual behavior of eco-immigrant adolescents. Personality factors and parent-child attachment can affect the occurrence of externalized sexual behavior of eco-immigrant adolescents.
		2021 Vol. 18 (24): 56-59 [Abstract] ( 95 ) HTML (1 KB) PDF (451 KB) ( 79 )

	60	Study on tear film grading diagnosis with domestic LY-121 tear film interference imager
		CHEN Changxi ZHANG Yang ZHANG Jingshang AN Ying DENG Shijing WAN Xiuhua CAO Kai WANG Jinda▲
		Objective To investigate the reliability and repeatability of domestic LY-121 tear film interference imager for tear film grading diagnosis. Methods Twenty-two patients (43 eyes) with dry eye symptoms in the ophthalmic clinic of Beijing Tongren Hospital, Capital Medical University from March to September 2018 were collected. The domestic LY-121 tear film interference imager was used to take tear film images, and the diagnostic grades were performed according to the Japanese DR-I tear film grading standard. One ophthalmologist graded the same batch of images at different time periods, and another ophthalmologist graded the same batch of images. The weighted Kappa coefficient was used to evaluate the consistency among physicians and within physicians, as well as the consistency between domestic LY-121 tear film interference imager and foreign equipment. Results LY-121 tear film interference imager had clear tear film imaging. The number of eyes diagnosed at grade 1 to 4 by the same physician twice was 6, 17, 12, 8 and 6, 18, 14, 5, respectively. The consistent proportion between the two was 88.4%, with no statistical significance (P ＞ 0.05). Kappa value was 0.818 (95%CI: 0.707, 0.929). Comparison of grade 1 to 4 diagnosis results between the two physicians: 6, 17, 12, and 8 eyes were graded by doctor 1 and 7, 21, 10 and 5 eyes were graded by doctor 2. The consistent proportion between the two was 76.8%, with no statistical significance (P > 0.05). Kappa value was 0.781 (95%CI: 0.775, 0.787). Comparison of the two instruments: the diagnostic results of the domestic LY-121 tear film interference imager were 6, 17, 12 and 8 eyes respectively, and the diagnostic results of OCULUS eye-surface comprehensive analyzer were 6, 15, 12 and 8 eyes respectively, and there was no statistical significance between them (P > 0.05). Kappa value was 0.862 (95%CI: 0.803, 0.921). Conclusion The consistency and repeatability of domestic LY-121 tear film interference imager in the diagnosis of dry eye disease are good, and the performance is not inferior to that of imported mature equipment.
		2021 Vol. 18 (24): 60-63 [Abstract] ( 127 ) HTML (1 KB) PDF (337 KB) ( 48 )

	64	Clinical effect of the formula of five evolutive phases and six climatic factors in the treatment of patients with diabetic nephropathy
		ZHENG Xiaodong1 ZHANG Nana1 FENG Yan2
		Objective To explore and analyze the clinical effect of the formula of five evolutive phases and six climatic factors in the treatment of patients with diabetic nephropathy. Methods A total of 120 patients with diabetic nephropathy admitted to Liaocheng Traditional Chinese Medicine Hospital in Shandong Province from June 2019 to June 2020 were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with the formula of five evolutive phases and six climatic factors. Both groups were treated continuously for six months. Clinical efficacy, traditional Chinese medicine syndrome score, renal function index, and inflammatory factor levels were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of traditional Chinese medicine syndrome score, serum creatinine (SCr), urea nitrogen, 24 h urinary protein (24hUP), serum interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), and C-reactive protein (CRP) in two groups were all lower than before treatment, and the levels of traditional Chinese medicine syndrome score, SCr, urea nitrogen, 24hUP, IL-6, TNF-α, and CRP in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The clinical effect of treating diabetic nephropathy with the formula of five evolutive phases and six climatic factors is outstanding, which has prominent advantages in relieving related symptoms and signs, and at the same time can promote the improvement of renal function indicators and inflammatory state.
		2021 Vol. 18 (24): 64-67 [Abstract] ( 159 ) HTML (1 KB) PDF (430 KB) ( 83 )

	68	Changes of glucose and lipid metabolism, thyroid hormone and antibody levels in patients with T2DM and their clinical significance
		CAO Yu ZHU Wenlin CHU Wuyang
		Objective To investigate the changes of glucose and lipid metabolism, thyroid hormone and antibody levels in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. Methods A total of 76 T2DM patients admitted to Anqing First People’s Hospital of Anhui Province (hereinafter referred to as “our hospital”) from April 2020 to October were selected as the study group. They were divided into light group (6 mmol/L＜FBG≤8 mmol/L, 37 cases), medium group (8 mmol/L＜FBG≤12 mmol/L, 26 cases) and heavy group (FBG > 12 mmol/L, 13 cases) according to the level of fasting blood glucose (FBG). In addition, 76 healthy subjects in our hospital during the same period were selected as the control group. Differences in the levels of glucolipid metabolism index (including glycosylated hemoglobin [HbA1c], FBG, triacylglycerol [TAG], total cholesterol [TC], low density lipoprotein [LDL], high density lipoprotein [HDL]), thyroid hormone (including total triiodothyronine [TT3], total thyroxine [TT4], thyroid stimulating hormone [TSH]), and autoantibodies (including thyroid peroxidase autoantibody [TPOAb] and thyroglobulin antibody [TGAb]) between groups were compared. Results The levels of HbA1c, FBG, TAG, TC, LDL, TSH, TPOAb, and TGAb in the study group were higher than those in the control group, while the levels of HDL and TT3 were lower than those in the control group, with statistical significance (P ＜ 0.05). The levels of HbA1c, FBG, TAG, TC, LDL, TSH, TPOAb, and TGAb in medium and heavy groups were higher than those in light group, while the levels of HDL and TT3 were lower than those in light group, with statistical significance (P ＜ 0.05). The levels of HbA1c, FBG, TAG, TC, LDL, TSH, TPOAb, and TGAb in the heavy group were higher than those in the medium group, and the level of TT3 was lower than that in the medium group, with statistical significance (P ＜ 0.05). Conclusion Changes in glucose and lipid metabolism, thyroid hormone and antibody levels in T2DM patients can effectively reflect the severity of the disease. Clinical detection of glucose and lipid metabolism, thyroid hormone and antibody levels in T2DM patients is of great significance for diagnosis, evaluation and targeted treatment of the disease.
		2021 Vol. 18 (24): 68-71 [Abstract] ( 130 ) HTML (1 KB) PDF (433 KB) ( 56 )

	72	Effect of different knee flexion time nodes on bone tunnel aperture after anterior cruciate ligament reconstruction
		ZOU Qizhao1 YANG Peng1 LIN Tianye1 XU Jingli1 XIONG Binglang1 HE Wei2 LI Ziqi2 ZHANG Qingwen2
		Objective To evaluate the effect of different knee flexion time nodes on bone tunnel aperture after anterior cruciate ligament reconstruction. Methods A total of 35 patients who underwent anterior cruciate ligament reconstruction in the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2016 to May 2018 were analyzed. According to the method of random number table, the patients were divided into two-week knee flexion group (17 cases were given knee flexion training two weeks after surgery) and four-week knee flexion group (18 cases were given knee flexion training four weeks after surgery). The pore size of bone tunnel on postoperative knee magnetic resonance imaging was measured, and Lysholm knee score (LKS), the International Knee Documentation Committee subjective knee form (IKDC) and Tenger activity scale were used to evaluate the recovery of knee function. Results The follow-up time was 28 to 56 months, with a median follow-up time of 44 months. In terms of bone tunnel aperture, the percentage of enlargement in the four measuring directions of the sagittal, coronal, horizontal and coronal internal mouth of the tibia in the the two-week knee flexion group was higher than that in four-week knee flexion group (P < 0.05). In terms of clinical scores, at the last follow-up, LKS, IKDC score and Tenger activity scores of the two groups were improved compared with those before surgery, and the differences were statistically significant (P < 0.05). At the last follow-up, there were no significant differences in LKS, IKDC score and Tenger activity score between the two groups (P > 0.05). Conclusion Different knee flexion time nodes have little effect on functional recovery after anterior cruciate ligament reconstruction, but early knee flexion exercise (two weeks) will significantly expand the bone tunnel, therefore, it is recommended to start knee flexion exercise no earlier than two weeks after anterior cruciate ligament reconstruction.
		2021 Vol. 18 (24): 72-75 [Abstract] ( 161 ) HTML (1 KB) PDF (484 KB) ( 93 )

	76	Effect of radiation extracorporeal shock wave acupoint combined with proprioception training on rehabilitation of elderly patients with knee osteoarthritis
		MAO Shigang1 ZHAO Yajun1 MA Xiaocheng2▲
		Objective To investigate the rehabilitation effect of radiation extracorporeal shock wave acupoint combined with proprioceptive training for elderly patients with knee osteoarthritis (KOA). Methods A total of 50 elderly patients with KOA admitted to Qingdao Municipal Hospital from April 2017 to April 2019 were selected as the research objects and they were divided into control group and observation group according to random number table method, with 25 cases in each group. The control group received routine rehabilitation combined with proprioceptive training, and on the basis of this, the observation group received radiation extracorboreal shock wave acupoint for continuous four weeks. Before treatment and four weeks after treatment, knee function in both groups was assessed using Lysholm knee score scale and the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index scale. Tumble index, muscle strength and gait parameters were compared between the two groups. Results After four weeks of treatment, LKSS score in both groups was higher than before treatment, WOMAC osteoarthritis index scale score was lower than before treatment, and LKSS score in observation group was higher than control group, WOMAC osteoarthritis index scale score was lower than control group, the differences were statistically significant (P < 0.05). The fall index of the two groups was lower than that before treatment, and the peaktorque (PT) value of knee flexion muscle group and knee extensor muscle group was higher than that before treatment; the fall index of the observation group was lower than that of the control group, and the PT value of knee flexion muscle group and knee extensor muscle group was higher than that of the control group, with statistical significance (P < 0.05). The step length and step speed of the two groups were higher than those before treatment, and the observation group was higher than the control group, with statistical significance (P < 0.05). Conclusion radiation extracorporeal shock wave acupoint combined with proprioceptive training is more conducive to improving knee joint function, balance ability of elderly KOA patients, and gait improvement is more obvious, which is more valuable in promoting the rehabilitation of elderly KOA patients.
		2021 Vol. 18 (24): 76-79 [Abstract] ( 100 ) HTML (1 KB) PDF (449 KB) ( 39 )

	80	Analysis of the effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and changes in ultrasound scores
		XU Liang GU LAN
		Objective To observe the clinical effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and the change of ultrasound scores. Methods A total of 150 neonatal pneumonia admitted to Suzhou Ninth People’s Hospital in Jiangsu Province from February 2016 to July 2019 were selected as the research subjects, they were divided into study group and control group, with 75 cases in each group. Both groups were given basic treatment + Ambroxol treatment, children in study group were treated with N-acetylcysteine for treatment. Both groups were treated for 7 days. The levels of peripheral blood white blood cell count (WBC), hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT), interleukin (IL)-2, arterial partial pressure of oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2), and ultrasound scores were compared between two groups before and after treatment. Results After 7 days of treatment, PaO2 of study group was higher than that of control group, while hs-CRP, PCT, and ultrasound scores were lower than those of control group (P ＜ 0.05). The remission time of fever, cough, dry and wet rales, and asthma in study group were shorter than those in control group (P < 0.05). The total effective rate in study group was higher than that in control group (P < 0.05). During the treatment, no serious adverse reactions occurred in two groups. Conclusion Ambroxol combined with N-acetylcysteine is safe and effective in the treatment of neonatal pneumonia, and has a positive effect on improving clinical symptoms and reducing inflammation in children.
		2021 Vol. 18 (24): 80-83 [Abstract] ( 111 ) HTML (1 KB) PDF (576 KB) ( 30 )

	84	Clinical effect of transcutaneous electrical nerve stimulation combined with Kangfu Xiaoyan Shuan in the treatment of female chronic pelvic pain
		WANG Yu LU Dan ZHENG Ping DUAN Aihong LIU Bing
		Objective To investigate the clinical effect of transcutaneous electrical nerve stimulation (TENS) combined with Kangfu Xiaoyan Shuan in the treatment of female chronic pelvic pain (CPP). Methods Sixty-eight patients with CPP caused by pelvic inflammatory disease (PID) who treated in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from September 2016 to March 2018 were selected as syudy objects. They were divided into TENS treatment group (20 cases), drug treatment group (26 cases), combination treatment group (22 cases) according to the wishes of patients. TENS treatment group was treated with French neuromuscular stimulation therapy instrument, drug treatment group was treated with Kangfu Xiaoyan Shuan, and combined treatment group was treated with TENS and Kangfu Xiaoyan Shuan. Symptom score (McCormack score) and SF-36 scale score were compared among three groups before and after treatment, and the occurrence of adverse reactions in three groups were observed. Results After treatment, McCormack scores in three groups were lower than those before treatment, and the differences were statistically significant (P < 0.05); McCormack scores of combined treatment group were lower than those of TENS treatment group and drug treatment group, and the differences were statistically significant (P < 0.05). After treatment, the physical health total scores and mental health total scores of three groups were higher than those before treatment, and the differences were statistically significant (P < 0.05); the physical health total scores and mental total health scores of combined treatment group were higher than those of TENS treatment group and drug treatment group, and the differences were statistically significant (P < 0.05). No obvious adverse reactions occurred in three groups. Conclusion The improvement of physical symptoms and quality of life of patients with CPP caused by PID by TENS combined with Kangfu Xiaoyan Shuan are significantly better than that of TENS and drug monotherapy.
		2021 Vol. 18 (24): 84-87 [Abstract] ( 117 ) HTML (1 KB) PDF (615 KB) ( 33 )

	88	Effect of intrauterine perfusion of human granulocyte colony stimulating factor on outcome of frozen-thawed embryo transfer in patients with thin endometrium
		GE Li’na ZHANG Li▲ YAN Meng
		Objective To observe the effect of intrauterine perfusion of human granulocyte colony stimulating factor (G-CSF) on outcome of frozen-thawed embryo transfer (FET) in patients with thin endometrium. Methods A total of 100 patients with thin endometrium infertility who underwent FET in Hebei Research Institute for Family Planning from December 2017 to December 2019 were selected as study objects. They were divided into control group (39 cases) and study group (61 cases) according to the odd and even days of the first visit day in this cycle. Both groups were treated with hormone replacement cycle. Control group was treated with 0.9% sodium chloride, and study group was intrauterine perfusion with G-CSF. Endometrial thickness, blood flow index, endometrial morphology, and blood flow typing before and after intrauterine perfusion were compared, and pregnancy outcome of two group were observed. Results After intrauterine perfusion, endometrial thickness in study group was higher than that in control group, and uterine artery pulsatility index was lower than that in control group, and the differences were statistically significant (P < 0.05). There were no significant differences in resistance index and systolic peak velocity/end-diastolic velocity value between two groups (P > 0.05). There was no significant difference in endometrial morphology between two groups before and after intrauterine perfusion (P > 0.05). After intrauterine perfusion, the subendometrial blood flow typing of two groups was compared, and the difference was statistically significant (P < 0.05). There was no significant difference in the period cancellation rate between two groups (P > 0.05). The clinical pregnancy rate and implantation rate of study group were higher than those of control group, and the differences were statistically significant (P < 0.05). Conclusion Intrauterine infusion of G-CSF can increase the thickness of thin endometrium and improve the outcome of FET in patients with thin endometrium.
		2021 Vol. 18 (24): 88-91 [Abstract] ( 96 ) HTML (1 KB) PDF (606 KB) ( 176 )

	92	Effect of different timing of pregnancy termination and mode of delivery on maternal and infant outcomes in patients with early onset severe preeclampsia
		ZHANG Ke1 YANG Yixin2 ZHANG Bo2
		Objective To explore the effect of different timing of pregnancy termination and mode of delivery on maternal and infant outcome in patients with early onset severe preeclampsia. Methods The clinical data of 86 patients with early onset severe preeclampsia admitted to Wuxi Eighth People’s Hospital from January 2014 to June 2020 were retrospectively analyzed. According to different timing of pregnancy termination, they were divided into group A (27 cases, timing of pregnancy termination＜32 weeks), group B (31 cases, timing of pregnancy termination was 32-34 weeks), and group C (28 cases, timing of pregnancy termination＞34 weeks); according to the mode of delivery, they were divided into vaginal delivery group (35 cases) and cesarean section group (51 cases). The complications and perinatal outcomes were compared in each groups. Results The onset of gestational age of group B and group C were greater than those of group A, and the onset of gestational age of group C was greater than that of group B, and the differences were statistically significant (P < 0.05). The duration of conservative treatment in group C was shorter than that in group B, and the duration of conservative treatment in group B was longer than that in group A, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of pregnancy complications among three groups (P > 0.05). The rate of perinatal mortality and neonatal asphyxia in group B and group C were lower than those in group A, and Apgar score was higher than that in group A, and the differences were statistically significant (P < 0.05). The birth weight of group C was higher than that of group A and group B, and the birth weight of group B was higher than that of group A, and the differences were statistically significant (P < 0.05). The rate of perinatal mortality, fetal distress and neonatal asphyxia in cesarean section group were lower than those in vaginal delivery group, and Apgar score was higher than that in vaginal delivery group, and the differences were statistically significant (P < 0.05). Conclusion Under the premise of ensuring safety, prolonging the gestational period to over 34 weeks in patients with early-onset severe preeclampsia has a better maternal and infant outcome, and improves the quality of neonatal survival. In addition, cesarean section can effectively reduce the incidence of perinatal mortality and neonatal asphyxia.
		2021 Vol. 18 (24): 92-95 [Abstract] ( 98 ) HTML (1 KB) PDF (574 KB) ( 65 )

	96	Effect of clinical pathway of accelerated rehabilitation surgery on patients undergoing laparoscopic panhysterectomy
		YE Cong XU Fengjuan▲
		Objective To study the effect of clinical pathway of accelerated rehabilitation surgery in patients undergoing laparoscopic panhysterectomy. Methods From October 2017 to October 2019, 96 patients with hysteromyoma undergoing hysterectomy in the Department of Gynecology, Taicang First People’s Hospital, Jiangsu Province were prospectively selected as research objects. By drawing the odd-even number plate, patients with odd numbers were assigned to the control group and patients with even numbers were assigned to the study group, with 48 cases in each group. The control group were treated with previous clinical common nursing path, while the study group were treated with clinical treatment path of accelerated rehabilitation surgery. Perioperative indicators (operation time, intraoperative blood loss, anal exhaust time, defecation time, hospital stay), inflammatory mediators (white blood cell count [WBC]), C-reactive protein [CRP], and interleukin-6 [IL-6]), and the incidence of complications were compared between the two groups. Results The operation time, anal exhaust time, defecation time and hospital stay in the study group were shorter than those in the control group, and the intraoperative blood loss was less than that in the control group, and the differences were statistically significant (P < 0.05). Three and five days after operation, the levels of WBC, CRP and IL-6 in the study group were lower than those in the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of complications between the two groups (P > 0.05). Conclusion Patients undergoing laparoscopic panhysterectomy receiving clinical treatment path of accelerated rehabilitation surgery has a better effect, for the improvement of patients’ clinical indicators and the reduction of the incidence of complications have a positive significance.
		2021 Vol. 18 (24): 96-98，131 [Abstract] ( 93 ) HTML (1 KB) PDF (1072 KB) ( 62 )

	99	Analysis of cervical cancer screening results in HIV-infected women
		FU Lihua1 LI Man2 YI Nuo1▲
		Objective To analyze the screening results of cervical cancer in women infected with human immunodeficiency virus (HIV), and to provide evidence for the prevention and management of cervical lesions in women infected with HIV. Methods Cervical thinprep cytologic test (TCT) and human papilloma virus (HPV) inspection data from Department of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University were selected from January 2018 to October 2020. A total of 137 HIV positive women were in study group and 2891 HIV negative women were in control group. Abnormal TCT and distribution of HPV subtypes in two groups were analyzed. Results The positive rate of high-risk HPV, low-risk HPV and multiple infection in study group were higher than those in control group. In study group, type 52, 16, 18, 53 were the most common HPV types; and in control group, type 52, 16, 58 and 18 were more common HPV types. In study group, 29 cases (21.16%) were abnormal TCT; and in control group, abnormal TCT was 220 cases (7.61%). Conclusion The cervical HPV positive detection rate of HIV positive women is higher than that of HIV negative women, and the incidence of cervical lesions is higher than that of HIV negative women. Women infected with HIV should be considered at high risk of cervical cancer and the screening time should be shortened.
		2021 Vol. 18 (24): 99-102 [Abstract] ( 166 ) HTML (1 KB) PDF (612 KB) ( 85 )

	103	SWOT analysis of global health cooperation of western key province in China under “belt and road initiative”
		WU Qiong CHENG Cai
		Sichuan Province as a key connection of “belt and road initiative”, analyzes “belt and road initiative” health cooperation. It is of great significance to accelerate the international health exchange and cooperation in western advantageous areas, and then promote the development of the overall health cause in western region. This paper summarizes “belt and road initiative” health cooperation, analyzes advantages, disadvantages, opportunities and challenges of “belt and road initiative” health cooperation according to SWOT analysis method. Sichuan Province should be strengthened to promote the development of “belt and road initiative” health cooperation, promote Chinese medicine overseas, innovate the mode of health care, and close cooperation with World Health Organization so as to create a new pattern of “belt and road initiative” health cooperation, give better play to its radiation leading role in international health cooperation in western region.
		2021 Vol. 18 (24): 103-106 [Abstract] ( 120 ) HTML (1 KB) PDF (423 KB) ( 195 )

	107	Discussion on combined action mechanism of tanshinone ⅡA in the treatment of diabetic neuropathy based on molecular docking technology
		LI Haoyue ZHONG Dayuan DENG Yihui
		Objective To study the combined action mechanism of tanshinone ⅡA in the treatment of diabetic neuropathy from the molecular level. Methods The structure, target, main biological functions and pathways of tanshinone ⅡA were collected through PubChem database, PharmMapper database and CTD database. Visualized by Pymol software. Results Seventeen target genes of tanshinone ⅡA in the treatment of diabetic neuropathy were obtained, the docking score showed that the compounds and targets were well docked. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that tanshinone ⅡA in the treatment of diabetic neuropathy mainly involved 25 biological functions, including peptide serine phosphorylation, lipopolysaccharide mediated signaling pathway, negative regulation of apoptosis process, and so on. It mainly involved 19 pathways, such as TNF signaling pathway, FoxO signaling pathway, VEGF signaling pathway, PI3K-Akt signaling pathway, and so on. Among them, PI3K-Akt signaling pathway, MAPK signaling pathway, TNF signaling pathway and FoxO signaling pathway were the most enriched targets. Conclusion The reliability of tanshinone ⅡA binding to 17 targets has verified from the perspective of molecular docking. It is revealed that the role of tanshinone ⅡA in the treatment of diabetic neuropathy may be closely related to PI3K-Akt signaling pathway, MAPK signaling pathway, TNF signaling pathway, and FoxO signaling pathway.
		2021 Vol. 18 (24): 107-110 [Abstract] ( 2333 ) HTML (1 KB) PDF (1341 KB) ( 202 )

	112	A textual research on Whitmania pigra Whitman as the origin of Hirudo
		HE Changhao CHEN Xiaoying ZHANG Xiaomeng WANG Lei HU Sumin
		Since 1963, Whitmania pigra Whitman has been regarded as one of the basic elements of Hirudo in Chinese Pharmacopoeia. With the development of animal taxonomy and zoologists’ in-depth study on the family and genus of hirudo, some researchers have questioned the use of Whitmania pigra Whitman as the origin. By consulting the monographs of materia medica and natural history, the blood sucking feeding habit is not the only standard to judge the basic source of medicinal leeches. Whitmania pigra Whitman meets the characteristics of “mazhi” among the medicinal leeches: living in a fresh water environment, with an average body length of about 10 cm, yellowish brown on the back, yellow on the belly, many dark longitudinal lines on the back, spindle shaped, slightly higher on the back and flat on the belly. Whitmania pigra Whitman should be the “maqi” in the notes to the collection of Bencao Jing Jizhu. It has been one of the basic sources of medicinal leeches since it is recorded in the northern and Southern Dynasties. Combined with modern pharmacology, medicinal and chemical research results and clinical application, Whitmania pigra Whitman family should be used as the basic source of medicinal leech and should not be eliminated.
		2021 Vol. 18 (24): 112-115 [Abstract] ( 107 ) HTML (1 KB) PDF (856 KB) ( 135 )

	116	Clinical efficacy of Changbai Mountain dredging meridians and regulating viscera manipulations in the treatment of mastodynia with liver depression and qi stagnation syndrome
		YANG Xuemei1 CONG Deyu2▲ BEI Jianhong3▲ WU Yuntian1 LIU Peng2 TONG Xue1 XIE Tianxi1
		Objective To explore clinical efficacy of Changbai Mountain dredging meridians and regulating viscera manipulations in the treatment of mastodynia with liver depression and qi stagnation syndrome. Methods Seventy-two patients with mastodynia diagnosed at Outpatient Department of Acupuncture & Massage, Shenzhen Hospital of Guangzhou University of Chinese Medicine and Outpatient Department of Acupuncture & Massage, Shenzhen Maternity & Child Healthcare Hospital from July 2019 to August 2020 were selected and divided into control group and treatment group by random number table method, with 36 cases in each group. Control group was treated with Chaihu Shugan Pills, and treatment group was treated with dredging meridians and regulating viscera manipulations, including meridian massage and pressing needle. Both groups were treated for two menstrual cycles. Mastodynia visual analogue scale (VAS), short form McGill pain questionnaire (SF-MPQ) and Chinese medicine syndrome scores of two groups were compared before and after treatment, and clinical effects of two groups were compared. Results After treatment, mastodynia VAS score and SF-MPQ score in two groups were lower than those before treatment, and treatment group was lower than control group, the difference was highly statistically significant (P < 0.01). After treatment, Chinese medicine syndrome score of two groups was lower than that before treatment, and treatment group was lower than control group, the difference was highly statistically significant (P < 0.01). There was no significant difference of total clinical effective rate between two groups (P > 0.05). Conclusion Dredging meridians and regulating viscera manipulations is effective in the treatment of mastodynia with liver depression and qi stagnation syndrome, which can effectively improve its clinical symptoms, the quality of life of patients, and it is better than oral Chaihu Shugan Pills.
		2021 Vol. 18 (24): 116-119 [Abstract] ( 87 ) HTML (1 KB) PDF (781 KB) ( 109 )

	120	Exploration of Professor Lu Hao’s experience in treating type two diabetes
		LIU Yuying CHEN Qingguang XU Jiahui LU Hao
		Professor Lu Hao has accumulated rich experience in the treatment of type two diabetes through many years of clinical practice. Professor Lu Hao emphasizes the pathogenesis of “deficiency, heat, phlegm and blood stasis” in type two diabetes, inherits and innovates from Liu Wansu’s “three elimination theory”, and summarizes it into three rules of “dissipate knot, moisten dry and stimulate blood”. He initiated Qinghua Prescription flexible identification and treatment, which can provide new ideas for clinical treatment of type two diabetes. This paper introduces Professor Lu Hao’s clinical experience in the treatment of type two diabetes. One proven case is presented.
		2021 Vol. 18 (24): 120-123 [Abstract] ( 125 ) HTML (1 KB) PDF (747 KB) ( 103 )

	124	Data mining on medication rules of Wu Yu in the treatment of advanced hepatocellular carcinoma
		SONG Jinjie LI Zhongyu GUO Zhongning WU Yu
		Objective To investigate the medication rules of Professor Wu Yu in the treatment of advanced hepatocellular carcinoma. Methods Chinese medicine prescriptions of patients with advanced hepatocellular carcinoma treated in Outpatient Department of Professor Wu Yu in Xiyuan Hospital, China Academy of Chinese Medical Sciences from September 2017 to December 2018 were selected as research objects. Chinese medicine inheritance auxiliary platform of China Academy of Chinese Medical Sciences (V2.5) was used to count the drug use frequency and association rules, and the complex system entropy clustering was used for cluster analysis of core drugs to mine the core combinations and new prescriptions of drugs. Results A total of 382 prescriptions were included, and 109 Chinese medicines were used. Three most commonly used medicines were Pseudostellariae Radix (364), Poria (343) and Fritillariae Thunbergii Bulbus (336). The most commonly used medicine combinations were Pseudostellariae Radix-Poria (337), Fritillariae Thunbergii Bulbus-Pseudostellariae Radix (333) and Fritillariae Thunbergii Bulbus-Poria (327). There were 48 groups of associated medicines with confidence level of one. Ten core combinations and six new prescriptions were obtained by complex system entropy cluster analysis. Conclusion The mainly treatment method of advanced hepatocellular carcinoma by Professor Wu Yu is tonifying qi and spleen and resolving phlegm, mostly supplemented by regulating qi and removing stasis, resolving hard mass and removing toxicity. The method considers both manifestation and root cause, and it is useful for clinical reference.
		2021 Vol. 18 (24): 124-127 [Abstract] ( 123 ) HTML (1 KB) PDF (789 KB) ( 74 )

	128	Study on the regularity of hand-foot-mouth disease in Xiaogan Area based on the theory of five evolutive phases and six climatic factors
		HU Gangming1 HE Chaoxiong1 SUN Qiuling1 GAO Jieyuan1 WU Zhenggang1 ZENG Jinjun1 WAN Binbin2
		Objective To explore the regularity of hand-foot-mouth disease in Xiaogan Area by using the theory of five evolutive phases and six climatic factors. Methods Based on the theory of five evolutive phases and six climatic factors in Huangdi Neijing, the monthly incidence and annual incidence of hand-foot-mouth disease of children in Xiaogan Area from January 2008 to December 2019 were statistically analyzed. The relationship between incidence rate and the main climate of five evolutive phases and six climatic factors was also reviewed. Results Hand-foot-mouth disease reached its peak from May to June, with a small peak from November to December in some years. The attribute was a hot year, hand-foot-mouth disease was high in years with hot nature. Taking six years as a cycle, the incidence coincidence rate of six climatic factors and hand-foot-mouth disease was analyzed, and the accuracy rate was 83.33%. Conclusion The incidence of hand-foot-mouth disease in Xiaogan Area is mostly in hot years and humid months. Inferring the annual climate characteristics through five evolutive phases and six climatic factors can provide a basis for the prevention and treatment of hand-foot-mouth disease.
		2021 Vol. 18 (24): 128-131 [Abstract] ( 150 ) HTML (1 KB) PDF (779 KB) ( 96 )

	132	Discussion on Professor Yang Zhimin’s experience in treating chronic insomnia with ointment
		LIU Jingwei1 XU Fuping2 YANG Zhimin2
		Chronic insomnia has a long course and is prone to recurrent. It has great advantage on herbal paste curing chronic insomnia. Professor Yang Zhimin is a famous traditional Chinese medicine in Guangdong Province and an outstanding medical leader in Guangdong Province. He is good at using ointment to treat chronic insomnia. Professor Yang Zhimin attaches importance to the idea of regulating the spleen and stomach based on the overall concept, and believes that the ointment can save the deviation and ward off the disease, and regulate both deficiency and excess, cold and heat. Clinical syndrome differentiation and treatment is often based on the method of strengthening middle jiao, harmonizing the middle earth, warming the kidney and latent yang, benefiting the essence and strengthening the kidney, regulating cold and heat, communicating the heart and kidney, nourishing blood, soothing the liver and promoting yang qi, so as to achieve the harmony of five zang organs and sleep at night. The article analyzes four proven cases in the final.
		2021 Vol. 18 (24): 132-135,144 [Abstract] ( 90 ) HTML (1 KB) PDF (1185 KB) ( 69 )

	136	Professor Li Jianmin’s experience in treating IgA nephropathy
		CHEN Huixi1,2 LI Jianmin2 XIE Chen2 ZHANG Ya’nan2 LIU Cong2
		IgA nephropathy is one of the common primary glomerular diseases, with hematuria, hypertension and proteinuria as the main clinical manifestations. Professor Li Jianmin believes that the basic pathogenesis of the disease is deficiency in origin and excess in superficislity, deficiency of spleen and kidney, qi and yin is origin, dampness, heat, toxin and blood stasis is superficislity. Emptiness of veins, loss of kidney collaterals, stagnation of kidney collaterals and blood stasis throughout the disease. Syndrome differentiation emphasizes the combination of disease stage and syndrome differentiation, and pays attention to replenishing deficiency and purging excess in treatment. Taking the common clinical syndrome types as the starting point, this paper expounds the etiology and pathogenesis, syndrome manifestations, treatment principles and methods, addition and subtraction of prescription and medication, etc. According to the core pathogenesis and the deviation of the core pathogenesis, taking “Tongluo Baoshen Compound” as the basic formula, and absorbing the time formula of Jingfang and the experience of famous experts as the component, the medication is added or subtracted. Achieve accurate syndrome differentiation, proper medication and delay the progress of the disease. Clinical curative effect is quite good, and an experimental case is attached, so as to share with competitors.
		2021 Vol. 18 (24): 136-139,158 [Abstract] ( 183 ) HTML (1 KB) PDF (1171 KB) ( 69 )

	140	Impact of omni-media health education on disease awareness and healthy lifestyles of patients with type 2 diabetes
		LIU Juanjuan1 JI Xueguang2▲
		Objective To explore the impact of omni-media health education on disease awareness and healthy lifestyle of patients with type 2 diabetes (T2D). Methods A total of 87 cases of T2D patients admitted to the Affiliated Hospital of Yan’an University from July 2018 to June 2019 were selected. According to the length of hospitalization, they were divided into 45 cases in the observation group (January to June 2019) and 42 cases in the control group (July to December 2018). Finally, 42 cases were included in the observation group and 38 cases in the control group. The control group was given T2D routine health education, while the observation group was combined with all-media health education. Follow-up for six months, the disease awareness level, healthy behavior and lifestyle, and glucose and lipid metabolism indicators of two groups were compared. Results Follow-up for six months, the awareness rate of disease awareness between the two groups were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The illness, foot care, reducing the risk of complications, and hypoglycemia awareness rate in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The healthy lifestyle scores of the two groups were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The scores of interpersonal relationship, nutrition, stress coping, exercise and exercise of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), total cholesterol, triacylglycerol (TG), and low-density lipoprotein cholesterol of the two groups were lower than those before the intervention, and the high-density lipoprotein cholesterol was significantly higher than that before the intervention, while FBG, 2hPG, HbA1c, and TG of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Onmi-media health education helps to improve the awareness level of T2D patients, promote the development of a healthy lifestyle, and control the level of glucose and lipid metabolism.
		2021 Vol. 18 (24): 140-144 [Abstract] ( 128 ) HTML (1 KB) PDF (657 KB) ( 68 )

	145	Application effect of constructing a family intervention group based on the theory of positive psychology in the rehabilitation period of stroke
		JIA Xiaoxin HAI Ying▲
		Objective To explore and analyze the application effect of constructing a family intervention group based on positive psychology theory in the rehabilitation period of stroke. Methods A total of 120 patients with stroke who were in rehabilitation from May 2018 to May 2020 in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine by random number table method, with 60 cases in each group. The control group was implemented routine in-hospital intervention. On the basis of the control group, the observation group was constructed a family intervention group based on positive psychology theory and implemented it during the hospital stay until three months after discharge. The body mass index (BMI) and short-form Fugl-Meyer motor function scale (FMA) scores, mastery of knowledge about stroke, self-management behavior and overall well-being were compared between the two groups. Results After the intervention, the BMI and FMA scores of the two groups were higher than those before the intervention, and the FMA scores of the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the proportion of inducing causes of the two groups were higher than those before the intervention; the ratio of mastery of treatment methods, rehabilitation intervention programs, prevention of complications, nutritional diet programs, and exercise methods of the observation group were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). After the intervention, proportion of inducing causes, treatment methods, rehabilitation intervention programs, prevention and treatment of complications, nutritional diet programs, and exercise methods of observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The treatment management, diet exercise management, and lifestyle management scores of the two groups were higher than those before the intervention, and the risk factor management scores of the observation group were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05); the scores of treatment management, diet and exercise management, lifestyle management and risk factor management of observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the overall well-being score of the observation group was higher than that before the intervention, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The construction of family intervention groups based on positive psychology theory and application to stroke patients can promote the improvement of motor function, promote the patients to better grasp the knowledge related to stroke, and improve their self-management behavior and overall happiness.
		2021 Vol. 18 (24): 145-149 [Abstract] ( 137 ) HTML (1 KB) PDF (655 KB) ( 65 )

	150	Influence of stratified nursing intervention based on Rockall risk score on self-management behavior and prognosis of patients with acute upper gastrointestinal bleeding
		LIU Jinjin LI Wenxiu FENG Jian YANG Pan
		Objective To explore the effect of stratified intervention based on Rockall risk score on patients with acute upper gastrointestinal hemorrhage (AUGH). Methods A total of 107 AUGH patients admitted to the People’s Hospital of Xuancheng City from February 2018 to April 2020 were selected and divided into an observation group of 54 cases and a control group of 53 cases according to the random number table method. The control group was given routine nursing intervention, while the observation group was combined with a stratified nursing intervention based on Rockall risk score. The hemostasis time and hospital stay were compared between the two groups. Followed up for six months, and the self-management behavior scores and follow-up results of the two groups were compared. Results The hemostasis time and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). Follow-up for six months, the scores of self-management behaviors of the two groups were higher than those before intervention; the total scores of life management, diet management, disease monitoring, medication management, and self-management behaviors of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The rebleeding rate and complication rate of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Stratified intervention based on Rockall score can shorten the hemostasis time and hospital stay of AUGH patients, promote the development of self-management behavior, and reduce the rate of rebleeding and complications.
		2021 Vol. 18 (24): 150-153 [Abstract] ( 79 ) HTML (1 KB) PDF (648 KB) ( 101 )

	154	Effect of pelvic floor rehabilitation on the quality of life and family function in patients with total hysterectomy
		WU Lili1 HONG Hong2
		Objective To evaluate the effect of pelvic floor rehabilitation on the quality of life and family function in patients with total hysterectomy. Methods A total of 92 patients who underwent total hysterectomy in Qinzhou Second People’s Hospital from January to December 2019 were selected, and they were divided into the observation group and the control group according to the random number table method, with 46 cases in each group. Both groups received pelvic floor rehabilitation, the control group received routine nursing care, and the observation group implemented therapeutic communication intervention on this basis. The quality of life, family function, and negative emotions were compared between the two groups. Results After nursing, the scores of material life, physical function, social function, and psychological score in the two groups were higher than those before nursing, and the observation group were higher than the control group (P ＜ 0.05), the scores of emotional response, communicate, behavior control, role, and emotional intervention in the observation group were lower than before nursing, and the observation group was lower than the control group (P ＜ 0.05), the scores of Hamilton depression scale (HAMD) in both groups were lower than before nursing, and the HAMD score in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion The application of pelvic floor rehabilitation assisted therapeutic communication intervention in total hysterectomy patients can effectively improve the quality of life and family function of patients, alleviate negative emotions, it is worth promoting.
		2021 Vol. 18 (24): 154-158 [Abstract] ( 97 ) HTML (1 KB) PDF (684 KB) ( 17 )

	159	Impact of empowerment health education on the self-management ability and quality of life of PICC patients with hematological tumors
		WANG Min YU Youhuan▲ ZHANG Yanming LIN Guoqiang
		Objective To explore the effect of empowerment health education on the self-management ability and quality of life of peripherallyinserted central catheters (PICC) patients with hematological tumors. Methods A total of 90 PICC patients with hematological tumors admitted to the Affiliated Huai’an Hospital of Xuzhou Medical University from January 2017 to December 2018 were selected as the research objects. According to the random number table method, they were divided into treatment group and control group, with 45 cases in each group. The control group was given regular health education, and the treatment group was given a joint application of empowerment health education. Follow up for six months, the PICC self-management ability, PICC-related complications, quality of life of cancer patients were compared between the two groups. Results Follow-up for 6 months, 42 cases were actually included in the treatment group and 38 cases were included in the control group. The self-management ability scores of the two groups were significantly higher than those before the intervention, the catheter maintenance compliance, handling of abnormal situations, tube exercise, information acquisition, tube daily life scores, and PICC self-management ability total scores of treatment group were higher than those of the control group, the differences were statistically significant (P ＜ 0.05); The total rate of PICC-related complications in the treatment group were lower than those in the control group, and the difference was statistically significant (P ＜ 0.05). the functional assessment of cancer therapy-general (FACT-G) score of the two groups was significantly higher than that before the intervention of the same group, the physiological status, emotional status, activity ability scores, and FACT-G total scores of treatment group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Empowerment health education can help promote the development of PICC self-management ability of PICC patients with hematological tumor, reduce the occurrence of PICC-related complications, and improve the quality of life of patients.
		2021 Vol. 18 (24): 159-162 [Abstract] ( 115 ) HTML (1 KB) PDF (677 KB) ( 111 )

	163	Effect of early nutrition intervention combined with comfort nursing on stress response and gastrointestinal function of patients after abdominal surgery
		GAO Di LI Min ZHANG Jin WU Dan WU Yating WANG Wei▲
		Objective To explore the effect of early nutrition intervention combined with comfort nursing in patients after abdominal surgery. Methods A total of 125 cases of abdominal surgery patients admitted to the First Affiliated Hospital of Air Force Medical University from March 2017 to October 2018 were selected. According to the random number table method, they were divided into 64 cases in the treatment group and 61 cases in the control group. The control group was given routine nursing intervention, and the treatment group was given early nutrition intervention combined with comfort nursing. The stress response, nutritional status, gastrointestinal function, and adverse reactions of the two groups were compared. Results After 24 h, the heart rate (HR), diastolic blood pressure (DBP), and systolic blood pressure (SBP) of the two groups were higher than those of the same group at admission (P ＜ 0.05). HR, DBP, and SBP of the treatment group were significantly lower than those of the control group (P ＜ 0.05); one week after operation, the levels of serum albumin (ALB), prealbumin (PAB), and transferrin (TF) in the two groups were lower than those in the same group at admission (P ＜ 0.05). The contents of ALB, PAB and TF in the treatment group were significantly higher than those in the control group (P ＜ 0.05); the recovery time of bowel sounds, the time of first exhaust, and the time of first defecation in the treatment group were significantly shorter than those in the control group (P ＜ 0.05); the total rate of adverse reactions of the treatment group were significantly lower than those of the control group (P ＜ 0.05). Conclusion Early nutrition intervention combined with comfort care can help relieve the stress response of abdominal surgery patients, improve nutritional status, promote the recovery of gastrointestinal function, and reduce the occurrence of complications.
		2021 Vol. 18 (24): 163-166 [Abstract] ( 112 ) HTML (1 KB) PDF (646 KB) ( 49 )

	167	Application effect of cluster intervention in patients with acute coronary syndrome
		ZHANG Min MA Yujiao▲ TAO Jing WANG Yuting ZHANG Yu DU Yao
		Objective To explore the application effect of cluster intervention in patients with acute coronary syndrome. Methods A total of 80 patients with acute coronary syndrome admitted to Jiangsu Provincial People’s Hospital from January to December 2019 were selected. They were divided into control group and observation group by random number table method, with 40 cases in each group. Routine nursing intervention was used in the control group, while the observation group was treated with cluster intervention on the basis of the control group. Left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness in diastole (LVPWd), cardiac function indexes and quality of life scores, and nursing intervention satisfaction were compared between the two groups. Results After intervention, LVEF in both groups was higher than before intervention, and LVEF in the observation group was higher than the control group; LVEDD and LVPWd in both groups were lower than before intervention, and the observation group was lower than the control group (P ＜ 0.05). The scores of physical function, physiological function, psychological function, and social function in both groups were higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05). The satisfaction of nursing intervention in the observation group was higher than that in the control group (P ＜ 0.05). Conclusion The application of cluster intervention in patients with acute coronary syndrome can improve the cardiac function of patients, improve the quality of life and nursing intervention satisfaction.
		2021 Vol. 18 (24): 167-170 [Abstract] ( 74 ) HTML (1 KB) PDF (644 KB) ( 44 )

	171	Effect of team empowerment education model combined with empathic care in patients with missed miscarriage
		GU Xiaoling YU Xiaoping GU Huifang ZHAO Hongxuan▲
		Objective To explore the effect of team empowerment education model combined with empathic care in patients with missed miscarriage. Methods A prospective study was conducted on the medical records of 120 cases of missed miscarriage hospitalized in the Department of Family Planning ward of Wuxi Maternal and Child Health Hospital from October 2019 to October 2020. Randomly divided into control group and intervention group, with 60 cases in each group, the control group followed the routine care of the abortion care, the intervention group adopted the combination of routine nursing and team authorization education model and empathic care. Self-rating anxiety scale (SAS), visual analogue scale (VAS), health education feedback and in-hospital satisfaction were compared between the two groups. Results At discharge, the SAS score of the two groups was lower than that at admission, and the SAS score of the intervention group was lower than that of the control group, with statistical significance (P ＜ 0.05). VAS score of intervention group was lower than that of control group (P ＜ 0.05). Health education feedback and in-hospital satisfaction were higher than those in control group (P ＜ 0.05). Conclusion Team empowerment education model combined with empathic care can reduce the anxiety of patients with missed miscarriage, effectively reduce the pain index of patients with miscarry, and improve the understanding of health education content of patients and satisfaction in the hospital, so it is worth promoting.
		2021 Vol. 18 (24): 171-174 [Abstract] ( 201 ) HTML (1 KB) PDF (674 KB) ( 72 )

	175	One case report on the treatment of atrial fibrillation-mediated cardiomyopathy using the combination of atrioventricular nodal ablation and distal his bundle pacing
		YANG Minghui ZHANG Rongfeng▲
		Atrial fibrillation-mediated cardiomyopathy is a type of heart failure revealed internationally only in recent years. At present, the pathogenesis still requires further exploration, and there is also a lack of experience in the treatment of these patients. Atrioventricular node ablation can be used to control the ventricular rate in patients with atrial fibrillation and heart failure, His bundle pacing (HBP) is recognized as a pacing mode bearing the strongest physiological characteristics, especially distal HBP can obtain more ideal pacing parameters. This paper reports and analyzes the literature on a case using the combination of atrioventricular node ablation and distal HBP in treating a patient with atrial fibrillation-mediated cardiomyopathy, who could not undergo catheter ablation, in order to provides some references for similar clinical diagnosis and treatment in the future.
		2021 Vol. 18 (24): 175-178 [Abstract] ( 118 ) HTML (1 KB) PDF (695 KB) ( 57 )

	179	A case of breast cancer lymph node metastasis misdiagnosed as cellulitis
		DU Wenxia1* MI Lingyu2* HU Junli3 MENG Qingbing3 BAI Wenwen4 GAO Hengbo3
		In recent years, cellulitis has a higher incidence of disease and it is a common disease in the emergency department. This report in the patients with facial edema repeatedly as the main performance, the preliminary diagnosis of maxillofacial cellulitis, after the onset of the anti-infection treatment for a long time, the illness repeatedly, after multidisciplinary consultation, imaging examination and biopsy, eventually diagnosed with breast cancer lymph node metastasis, he was transferred to a local hospital for treatment. The early diagnosis of this patient was not timely, and related case reports were rare, so the experience should be fully learned, and the causes of facial edema should be recognized. For patients with axillary lymph node swelling, the possibility of breast cancer lymphatic metastasis should be considered, and early diagnosis should be made by puncture. For patients with delayed recovery, detailed medical history and comprehensive physical examination were conducted after admission to find abnormalities and broaden the diagnosis and treatment ideas. This article summarizes the relevant diagnosis and treatment experience, and reviews the references for clinicians’ reference.
		2021 Vol. 18 (24): 179-182,196 [Abstract] ( 96 ) HTML (1 KB) PDF (1167 KB) ( 88 )

	183	Correlation analysis of inter-provincial air pollution and health economic loss in China
		LIU Yujie1 GU Huaiying2 CHEN Yu1,3
		Objective To explore the relationship between the main air pollutants and the health economic loss of urban residents. Methods The data of environment, economy, population, and medical treatment in 30 provinces were collected, and the entropy weight method was used to reduce the dimension of the main pollutant index of exhaust emission in 30 provinces. The disease cost method and revised human capital method were used to estimate the economic loss of population health. The factors affecting health economy were explored by using multiple linear regression. Results There was a high positive correlation between the regional air pollution degree and the economic loss of health. In addition, the per capita gross national product, the number of urban population and the mortality rate all lead to the increase of the economic loss of health caused by air pollution. Conclusion Residents in areas with different levels of economic development, air pollution and population density have different spending on health economy. Relevant departments should strengthen pollution control in various aspects, effectively reduce the economic burden on people’s health and effectively improve the health level of people.
		2021 Vol. 18 (24): 183-187 [Abstract] ( 89 ) HTML (1 KB) PDF (573 KB) ( 120 )

	188	Thoughts on the path-based management of military mental rehabilitation
		ZHAO Chunhai LI Wenjuan ZHENG Jie SU Xiaoguang
		Through the implementation of systematic mental rehabilitation in hospitals, communities, and families, it can promote the recovery of patients’ social functions and the improvement of mental disability, improve the quality of life, and reduce the recurrence of mental symptoms. The mental rehabilitation of military personnel is different from ordinary mental rehabilitation. There are differences in personnel distribution, institutional settings, discipline management, organizational training, and rehabilitation needs. Through the implementation of path-based management of the military’s mental rehabilitation, the needs of the military’s mental rehabilitation are combined with the hospital’s rehabilitation management, and efforts are made to apply the achievements of modern mental rehabilitation to the practice of military mental rehabilitation. In terms of the form of rehabilitation, the content of rehabilitation, and the standards of rehabilitation, it meets the actual needs of military personnel, so as to achieve systematic rehabilitation from the hospital to the family and the army.
		2021 Vol. 18 (24): 188-191 [Abstract] ( 79 ) HTML (1 KB) PDF (715 KB) ( 27 )

	192	Exploration on the construction of an integrated platform based on “1+4” smartinternet for medical care and maintenance
		DING Xiufang1,2 HUANG Kui3 SONG Qingyang4 SUN Jia5 CAO Hongjing6 TIAN Zhijun7 WANG Yuanli7 LU Yanli7
		The increasing proportion of “empty-nest” elderly people has led to a sharp increase in the demand for health protection services for the elderly, and the proportion of disabled and partially disabled elderly people has also increased rapidly, leading to an increasingly significant demand for medical services and daily care for the elderly. However, the current medical, health and elderly care service resources are limited and cannot effectively meet the needs of the elderly. Therefore, it is extremely urgent to actively provide the elderly with services that combine medical, health and elderly care. Based on this, as the first specialized hospital for geriatrics in Dongcheng District, Beijing, after more than 20 years of exploration, it proposes the construction of an integrated platform based on the intelligent interconnection “1+4”, that is, “one platform supports, four major services are implemented.” Taking Dongcheng District, Beijing as a model, provide closed-loop services for the regional elderly with integrated medical care, and gradually promote the intelligent interconnected “1+4” medical care integrated platform to form a replicable and extendable model across the country.
		2021 Vol. 18 (24): 192-196 [Abstract] ( 76 ) HTML (1 KB) PDF (1160 KB) ( 79 )

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