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| Analysis of the effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and changes in ultrasound scores |
| XU Liang GU LAN |
| Department of Neonatology, Suzhou Ninth People’s Hospital, Jiangsu Province, Suzhou 215200, China |
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Abstract Objective To observe the clinical effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and the change of ultrasound scores. Methods A total of 150 neonatal pneumonia admitted to Suzhou Ninth People’s Hospital in Jiangsu Province from February 2016 to July 2019 were selected as the research subjects, they were divided into study group and control group, with 75 cases in each group. Both groups were given basic treatment + Ambroxol treatment, children in study group were treated with N-acetylcysteine for treatment. Both groups were treated for 7 days. The levels of peripheral blood white blood cell count (WBC), hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT), interleukin (IL)-2, arterial partial pressure of oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2), and ultrasound scores were compared between two groups before and after treatment. Results After 7 days of treatment, PaO2 of study group was higher than that of control group, while hs-CRP, PCT, and ultrasound scores were lower than those of control group (P ＜ 0.05). The remission time of fever, cough, dry and wet rales, and asthma in study group were shorter than those in control group (P < 0.05). The total effective rate in study group was higher than that in control group (P < 0.05). During the treatment, no serious adverse reactions occurred in two groups. Conclusion Ambroxol combined with N-acetylcysteine is safe and effective in the treatment of neonatal pneumonia, and has a positive effect on improving clinical symptoms and reducing inflammation in children.
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