国产LY-121泪膜干涉成像仪泪膜分级诊断研究

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Abstract Objective To investigate the reliability and repeatability of domestic LY-121 tear film interference imager for tear film grading diagnosis. Methods Twenty-two patients (43 eyes) with dry eye symptoms in the ophthalmic clinic of Beijing Tongren Hospital, Capital Medical University from March to September 2018 were collected. The domestic LY-121 tear film interference imager was used to take tear film images, and the diagnostic grades were performed according to the Japanese DR-I tear film grading standard. One ophthalmologist graded the same batch of images at different time periods, and another ophthalmologist graded the same batch of images. The weighted Kappa coefficient was used to evaluate the consistency among physicians and within physicians, as well as the consistency between domestic LY-121 tear film interference imager and foreign equipment. Results LY-121 tear film interference imager had clear tear film imaging. The number of eyes diagnosed at grade 1 to 4 by the same physician twice was 6, 17, 12, 8 and 6, 18, 14, 5, respectively. The consistent proportion between the two was 88.4%, with no statistical significance (P ＞ 0.05). Kappa value was 0.818 (95%CI: 0.707, 0.929). Comparison of grade 1 to 4 diagnosis results between the two physicians: 6, 17, 12, and 8 eyes were graded by doctor 1 and 7, 21, 10 and 5 eyes were graded by doctor 2. The consistent proportion between the two was 76.8%, with no statistical significance (P > 0.05). Kappa value was 0.781 (95%CI: 0.775, 0.787). Comparison of the two instruments: the diagnostic results of the domestic LY-121 tear film interference imager were 6, 17, 12 and 8 eyes respectively, and the diagnostic results of OCULUS eye-surface comprehensive analyzer were 6, 15, 12 and 8 eyes respectively, and there was no statistical significance between them (P > 0.05). Kappa value was 0.862 (95%CI: 0.803, 0.921). Conclusion The consistency and repeatability of domestic LY-121 tear film interference imager in the diagnosis of dry eye disease are good, and the performance is not inferior to that of imported mature equipment.

Key words： Dry eyes Diagnosis Tear film interference imager Consistency Repeatability

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	CHEN Changxi ZHANG Yang ZHANG Jingshang AN Ying DENG Shijing WAN Xiuhua CAO Kai WANG Jinda▲

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CHEN Changxi ZHANG Yang ZHANG Jingshang AN Ying DENG Shijing WAN Xiuhua CAO Kai WANG Jinda▲. Study on tear film grading diagnosis with domestic LY-121 tear film interference imager[J]. 中国医药导报, 2021, 18(24): 60-63.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I24/60

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