宫腔灌注人粒细胞集落刺激因子对薄型子宫内膜患者冻融胚胎移植结局的影响

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Abstract Objective To observe the effect of intrauterine perfusion of human granulocyte colony stimulating factor (G-CSF) on outcome of frozen-thawed embryo transfer (FET) in patients with thin endometrium. Methods A total of 100 patients with thin endometrium infertility who underwent FET in Hebei Research Institute for Family Planning from December 2017 to December 2019 were selected as study objects. They were divided into control group (39 cases) and study group (61 cases) according to the odd and even days of the first visit day in this cycle. Both groups were treated with hormone replacement cycle. Control group was treated with 0.9% sodium chloride, and study group was intrauterine perfusion with G-CSF. Endometrial thickness, blood flow index, endometrial morphology, and blood flow typing before and after intrauterine perfusion were compared, and pregnancy outcome of two group were observed. Results After intrauterine perfusion, endometrial thickness in study group was higher than that in control group, and uterine artery pulsatility index was lower than that in control group, and the differences were statistically significant (P < 0.05). There were no significant differences in resistance index and systolic peak velocity/end-diastolic velocity value between two groups (P > 0.05). There was no significant difference in endometrial morphology between two groups before and after intrauterine perfusion (P > 0.05). After intrauterine perfusion, the subendometrial blood flow typing of two groups was compared, and the difference was statistically significant (P < 0.05). There was no significant difference in the period cancellation rate between two groups (P > 0.05). The clinical pregnancy rate and implantation rate of study group were higher than those of control group, and the differences were statistically significant (P < 0.05). Conclusion Intrauterine infusion of G-CSF can increase the thickness of thin endometrium and improve the outcome of FET in patients with thin endometrium.

Key words： Human granulocyte colony stimulating factor Frozen-thawed embryo transfer Thin endometrium Intrauterine perfusion Pregnancy rate

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	GE Li’na ZHANG Li▲ YAN Meng

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GE Li’na ZHANG Li▲ YAN Meng. Effect of intrauterine perfusion of human granulocyte colony stimulating factor on outcome of frozen-thawed embryo transfer in patients with thin endometrium[J]. 中国医药导报, 2021, 18(24): 88-91.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I24/88

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