|
|
Study on improvement of quality standard of Baibo Pills |
CHENG Zhangong ZHAO Xiaowei WU Jiankun BAI Yan |
Department of Pharmacy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China |
|
|
Abstract Objective To improve the quality standard of Baibo Pills and to provide scientific basis for improving its quality standard. Methods Microscopical identification method was used to identify puncturevine caltrop fruit, divaricate saposhnikovia root, suberect spatholobus stem, safflower and heidou. Thin layer chromatography (TLC) was used to identify chinese angelica, tuber fleeceflower stem and peony root. The AgilentSB-C18 octaneylsilane bonded silica gel column (250 mm×4.6 mm, 5 μm) was used with gradient elution. The column temperature was 40℃, the flow rate was 1.0 ml/min, and the mobile phase was methanol-water (55∶45). The detection wavelength was 246 nm. The content of isopsoralen and psoralen in Baibo Pills was determined. Results The microscopic characteristics of puncturevine caltrop fruit, divaricate saposhnikovia root, suberect spatholobus stem, safflower and heidou were obvious. TLC spots of chinese angelica, tuber fleeceflower stem and peony root were clear, and negative control had no interference. The linear range of psoralen was 0.0204-0.3066 μg (r = 0.9999). The average recovery was 98.08%, relative standard deviation (RSD) = 1.07%; The linear range of isopsoralen was 0.0204-0.3054 μg (r = 0.9998). The average recovery was 97.92%, RSD = 1.99%. Conclusion The method is comprehensive, accurate and reproducible, which can improve the quality control of Baiba Pills.
|
|
|
|
|
[1] 北京市食品药品监督管理局.北京市医疗机构制剂规程[S].北京:中国商业出版社,2014:3-4.
[2] 曹为.白驳丸治疗白癜风的疗效观察[J].中国中西医结合皮肤性病学杂志,2008,7(2):113.
[3] 国家药典委员会.中华人民共和国药典中药材显微鉴别彩色图鉴[S].北京:人民卫生出版社,2009.
[4] 国家药典委员会.中华人民共和国药典[S].一部.北京:中国医药科技出版社,2020.
[5] 国家药典委员会.中华人民共和国药典[S].四部.北京:中国医药科技出版社,2020:59.
[6] 黄志端,吴敏,魏茂陈.治带片中四种药物的薄层鉴别[J].智慧健康,2018,4(36):7-9.
[7] 魏秋宇,马海春.补脾治瘫丸质量标准研究[J].海峡药学,2017,29(12):83-85.
[8] 张圣洁,景霞.消化止泻口服液中主要成分的薄层鉴别研究[J].安徽医药,2018,22(10):1880-1883.
[9] 李建梅,周凡,希尔艾力·吐尔逊,等.反相高效液相色谱法在补骨脂提取物3种主要成分含量测定中的应用[J].中国医药导报,2017,14(27):12-15.
[10] 刘徐雪纯,杨碧莲.白癜风辨治法探究[J].环球中医药,2019,12(5):734-736.
[11] 石新荣.白癜风的病因病理及中医治疗研究[J].中外医疗,2011(17):133.
[12] 张学军.皮肤性病学[M].7版.北京:人民卫生出版社,2008:184.
[13] 陈艳萍,王波.从血论治白癜风[J].辽宁中医药大学学报,2012,14(3):151-152.
[14] 江连枝.白癜风病因、诊断及中医治疗[J].实用中医内科杂志,2013,27(11):91-92.
[15] 韩志强,吴振涛,齐春惠,等.白癜风的中医药学历史与现状[J].中国麻风皮肤病杂志,2017,33(11):687-689.
[16] 刘芳,李树君,窦莉莉.白癜风的中医诊疗思路[J].皮肤病与性病,2020,42(1):36-39.
[17] 罗文辉.欧阳恒教授皮肤病论治特色[J].湖南中医学院学报,2003,23(2):21-23.
[18] 刘晓玉,许爱娥.当代8位名老中医论治白癜风经验荟萃[J].中国中西医结合皮肤性病学杂志,2008,7(2):131-132.
[19] 胡彩霞,张国强,冯佳,等.补骨脂汤联合中波高能紫外线照射治疗白癜风临床研究[J].中医学报,2016,31(11):1799-1802.
[20] 黄曼萍,梁伟海,张丽军,等.应用中药色象理论探究白瘤风外用药规律[J].中国美容医学,2011,9(20):1455-1456.
[21] 朱建龙,陈力.中医辨治白癜风探析[J].河南中医,2014, 34(11):2207-2208.
[22] 欧阳恒.中医皮肤科中的直观论治法[J].湖南中医药导报,2001,7(4):143-144.
[23] 周洁,李福伦,茅伟安.中西医治疗白癜风研究进展[J].世界临床药物,2018,39(5):302-305.
[24] 莫俊熙,黄咏菁,禤国维,等.国医大师禤国维运用二至丸治疗皮肤病经验撷要[J].中国医药导报,2021,18(8):141-144.
[25] 张莹,吕惠子.补骨脂的化学成分和药理作用研究进展[J].临床医药文献电子杂志,2020,7(30):195.
[26] 王军,王剑,鲁敏,等.异补骨脂素对氧化应激介导骨质疏松大鼠模型的作用及机制[J].疑难病杂志,2019,18(9):940-944.
[27] 李建明,许志罡.浅析药物补骨脂素的进展[J].广东职业技术教育与研究,2016(5):205-206. |
|
|
|