自噬相关调控信号通路在骨重塑中的作用及中医药防治进展

Abstract
Figure/Table
References (30)
Related Citation (15)

Download: PDF (531 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Bone remodeling is a bioremediation process with many influencing factors. Bone nonunion prolongs the treatment period of the disease, which is a thorny problem in the treatment of fracture patients. At present, the factors affecting bone remodeling and the mechanism of the related drugs promoting bone remodeling have not been fully clarified. Autophagy plays an important role in the life activities of osteoblasts, osteoclasts and osteocytes, so the regulation of autophagy has important research value in bone remodeling. In this paper, the mechanism of action of autophagy related signal pathways in bone remodeling and traditional Chinese medicine prevention and treatment of bone nonunion are reviewed, to open up new ideas and methods for the treatment of bone nonunion.

Key words： Bone remodeling Autophagy Signal pathway Bone nonunion Traditional Chinese medicine

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MO Yafeng1 HU Minli2 TANG Yanghua1 LI Guosong1 XIN Dawei1 XIONG Zhenfei1

Cite this article:

MO Yafeng1 HU Minli2 TANG Yanghua1 LI Guosong1 XIN Dawei1 XIONG Zhenfei1. Role of autophagy-related regulatory signaling pathways in bone remodeling and the progress of traditional Chinese medicine prevention and treatment[J]. 中国医药导报, 2021, 18(24): 40-43.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I24/40

[1] Mills LA，Aitken SA，Simpson A. The risk of non-union per fracture：current myths and revised figures from a population of over 4 million adults [J]. Acta Orthop，2017，88（4）：434-439.
[2] Rupp M，Biehl C，Budak M，et al. Diaphyseal long bone nonunions-types，aetiology，economics，and treatment recommendations [J]. Int Orthop，2018，42（2）：247-258.
[3] Dailey HL，Wu KA，Wu PS，et al. Tibial Fracture Nonunion and Time to Healing After Reamed Intramedullary Nailing：Risk Factors Based on a Single-Center Review of 1003 Patients [J]. Orthop Trauma，2018，32（7）：e263-e269.
[4] 万永鲜，徐丽丽，卓乃强，等.自噬对骨质疏松症骨代谢的影响研究[J].中国骨质疏松杂志，2018，24（4）：552-556.
[5] Xiao L，Xiao Y. The Autophagy in Osteoimmonology：Self-Eating，Maintenance，and Beyond [J]. Front Endocrinol （Lausanne），2019，10：490.
[6] Cinque L，Forrester A，Bartolomeo R，et al. FGF signalling regulates bone growth through autophagy [J]. Nature. 2015，528（7581）：272-275.
[7] Corradetti MN，Inoki K，Bardeesy N，et al. Corrigendum：Regulation of the TSC pathway by LKB1：evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome [J]. Genes Dev. 2019，33（7/8）：477.
[8] 朱俊瑾，周佳琦，伍颖颖.哺乳动物雷帕霉素靶蛋白复合物1介导的自噬对骨代谢的调控[J].国际口腔医学杂志，2020，47（1）：84-89.
[9] 殷照阳，霍永峰，刘新晖，等.雷帕霉素调节自噬抑制凋亡促进骨折愈合的机制研究[J].中华老年骨科与康复电子杂志，2019，5（1）：25-32.
[10] 姜涛，邵敏，陈庆真，等.ERα-AMPK-Sirt1信号通路在骨质疏松症中的作用[J].中国骨质疏松杂志，2019，25（8）：1166-1171.
[11] 李翊，孙文超，邓洲铭，等.骨折愈合和骨不连发生过程中腺苷酸活化蛋白激酶及自噬活性的研究[J].中华实验外科杂志，2017，34（1）：90-93.
[12] 孙娜，张丽妍，徐钢，等.中药活性成分靶向激活AMPK防治骨质疏松症的研究进展[J].中国骨质疏松杂志，2020， 26（11）：1704-1707，1712.
[13] Choi MC，Jo J，Park J，et al. NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction [J]. Cells，2019，8（7）：734.
[14] 赵宝辉，刘晓峰.硫辛酸通过抑制NF-κB信号通路介导对老年大鼠骨量和骨密度保护作用[J].中国骨质疏松杂志，2020，26（10）：1436-1440.
[15] Chang KH，Sengupta A，Nayak RC，et al. p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche [J]. Cell Rep，2014，9（6）：2084-2097.
[16] Ikebuchi Y，Aoki S，Honma M，et al. Coupling of bone resorption and formation by RANKL reverse signalling [J]. Nature，2018，561（7722）：195-200.
[17] Fu D，Qin K，Yang S，et al. Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system [J]. BMC Musculoskelet Disord，2020，21（1）：281.
[18] Zhao H，Sun Z，Ma Y，et al. Antiosteoclastic bone resorption activity of osteoprotegerin via enhanced AKT/mTOR/ULK1-mediated autophagic pathway [J]. J Cell Physiol，2020，235（3）：3002-3012.
[19] 王凯，宋敏，文皓楠，等.从OPG/RANK/RANKL信号转导系统探讨老年性骨质疏松的发病机制[J].中国骨质疏松杂志，2020，26（6）：910-914.
[20] 吴克亮，林晓生，吴小绸，等.基于中医“阴阳自和”理论探讨自噬在骨质疏松症中的作用[J].中国骨质疏松杂志，2020，26（6）：915-918.
[21] 邵向阳，张志明，雍文兴，等.补肾中药干预BMSCs增殖分化与“肾藏象理论”的相关性探讨[J].时珍国医国药，2020，31（4）：913-914.
[22] 曹盼举，张晓刚，于海洋，等.基于OPG/RANK/RANKL信号轴探讨中医“瘀证”与骨质疏松症之间的关系[J].中国骨质疏松杂志，2020，26（1）：114-117.
[23] Liu F，Gao S，Yang Y，et al. Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway [J]. Oncol Rep，2018，39（3）：1523-1531.
[24] Yeh CC，Su YH，Lin YJ，et al. Evaluation of the protective effects of curcuminoid（curcumin and bisdemethoxycurcumin）-loaded liposomes against bone turnover in a cell-based model of osteoarthritis [J]. Drug Des Devel Ther，2015，9：2285-2300.
[25] Wang J，Wang X，Cao Y，et al. Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes [J]. Int J Mol Med，2018，42（5）：2604-2614.
[26] Zhou J，Jiang YY，Chen H，et al. Tanshinone I attenuate the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway [J]. Cell Prolif，2020，53（2）：e12739.
[27] 李慧，杨会，白云绮，等.基于PPAR-γ激动剂的四妙勇安汤活性部位筛选及其化学成分分析[J].中国医药导报，2020，17（16）：28-33.
[28] Brun J，Berthou F，Trajkovski M，et al. Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression [J]. Diabetes，2017， 66（10）：2541-2554.
[29] 田涛，傅强，朱健奎，等.二至丸治疗斑马鱼骨质疏松模型效益观察及破骨细胞自噬机制[J].南京中医药大学学报，2020，36（3）：352-357.
[30] 刘锌，杜斌，高丽丽，等.右归饮干预激素性股骨头坏死大鼠骨髓间充质干细胞的自噬及命运[J].中国组织工程研究，2021，25（1）：20-25.