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2021 Vol. 18, No. 10 Published: 2021-04-05

	4	Roles of IL-17 signaling pathway in the development of relapsing fever neuroleptospirosis
		CHENG Meihui LU Wei ZHANG Jing DING Kaiyun LIU Hongqi▲
		Objective To investigate the roles of interleukin (IL)-17 signaling pathway in the development of relapsing fever neuroborreliosis. Methods Fourteen C57BL/6 wild-type mice were divided into two groups, six mice in group S, eight mice in group E, and eight mice with IL-17-/- signaling pathway defect (IL-17-/-) were IL-17-/- group. Three groups of mice were infected by intraperitoneal injection of DAH strain of Borrelia recurrentis (B.recurrentis), and the occurrence of bacteremia in vivo, specific antibodies and the incidence of nervous system were observed. The pathological change of spinal cord was compared between group E and IL-17-/- group. Results The mice in group S were effectively replicated and amplified and bacteremia was induced, and spirochete specific IgG and IgM were produced, and the incidence of symptoms of central nervous system diseases reached 100%. The level of bacteremia in mice of group E and IL-17-/- group were basically the same, and the production of spirochete specific IgG and IgM could be induced in mice of group E and IL-17-/- group. The central nervous system disease scores of IL-17-/- group infected with B.recurrentis were lower than those of group E after 9-14 d of infection, and the differences were statistically significant (P < 0.05 or P < 0.01). The number of microglial cells in spinal cord tissue of mice in IL-17-/- group was less than that in group E. Conclusion IL-17 signaling pathway plays an important role in the development of central nervous system diseases induced by B.recurrentis infection.
		2021 Vol. 18 (10): 4-7,11 [Abstract] ( 122 ) HTML (1 KB) PDF (1505 KB) ( 77 )

	8	Analysis on the medication rule of invigorating the spleen medical school in the treatment of emotional diseases based on data mining
		LI Yunxi1 LIN Waner1 YANG Lingling2 ZHENG Liming2 LI Yan2
		Objective To explore the medication rules of invigorating the spleen medical school in the treatment of emotional diseases. Methods The database of medication for emotional diseases was established with the works of the representative doctors of invigorating the spleen as the data source, and the factor analysis and systematic cluster analysis were carried out on the included prescriptions and Chinese medicine. Results A total of 126 prescriptions were included, involving 156 Chinese herbs. The drug use frequency was 1100 times. The top 5 frequently used herbs were Ginseng Radix et Rhizoma, Angelicae Sinensis Radix, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, Glycyrrhizae Radix et Rhizoma, Bupleuri Radix. The most frequently used efficacy of included herbs was tonifying deficiency, relieving superficies, and clearing heat. The four nature of drugs mainly included warm and cold. The five flavors mainly included pungent, sweet, and bitter. The channel tropism of Chinese herbs mainly included spleen, lung, heart, and stomach. Nine common factors were extracted from the factor analysis, the cumulative variance contribution rate was 68.007%, and the high-frequency herbs were classified into 6 categories in the systematic cluster analysis. Conclusion The principle of treatment of invigorating the spleen medical school for emotional diseases is treating deficiency syndrome with strengthening primordial qi of spleen and stomach method, treating excess syndrome with purging fire method. At the same time, they pay attention to the ascending and dredging of yang qi of spleen and stomach. While syndrome of intermingled deficiency and excess should combine the three principles of treatment, which are invigorating spleen and stomach, clearing yin-fire, ascending yang qi.
		2021 Vol. 18 (10): 8-11 [Abstract] ( 102 ) HTML (1 KB) PDF (933 KB) ( 93 )

	12	Study on the material basis and related mechanism of acute stroke based on proteomics
		LIU Tao1 TANG Tao2
		Objective To observe the common and differentially expressed proteins (DEPs) in the brain tissue of rats with acute stroke by using quantitative proteomics, and to explore the common material basis and mechanism of acute stroke. Methods Forty male SD rats aged from six to seven weeks were divided into ischemic stroke (IS) sham operation (Sham1) group, IS group, intracranial hemorrhage (ICH) sham operation (Sham2) group and ICH group according to random number table method, with 10 rats in each group. IS rat model of ischemia-reperfusion and ICH model induced by collagenase were established by suture method. After 24 hours in IS group and Sham1 group, after 48 hours in ICH group and Sham2 group, brain tissues were taken for quantitative proteomics analysis after normal saline perfusion. DEPs were identified and analyzed by bioinformatics. The related DEPs were verified by Western blot. Results Three hundred and forty-five and 425 DEPs associated with IS and ICH were screened out, among which 57 were common (20 were up-regulated and 37 were down regulated). GO analysis: exosomes, cytoplasm, plasma membrane and mitochondria were accounted for a high proportion in the classification of cell composition, exosomes, myelin sheath and synapses were ranked the top three in enrichment analysis. Protein binding, same protein binding, domain protein specific binding and phosphatidylserine binding were accounted for a high proportion in molecular functional classification, protein binding, phosphatidylserine binding and myelin sheath structural components were ranked the top three in enrichment analysis. Drug response, hypoxia response and lipopolysaccharide response were accounted for a high proportion in the classification of biological processes, neurofilament assembly, acrylamide reaction and intermediate fiber assembly were ranked in the top three in enrichment analysis. KEGG analysis showed that a total of 17 signaling pathways were abundant, of which amyotrophic lateral sclerosis, pyruvate metabolism, tyrosine metabolism and pyruvate metabolism were the main signaling pathways of acute stroke. Expressions of Nefl, Gap43, Atp6v1f, Th and Atp6v1a in IS group and Sham1 group were compared, expressions of Nefl, Gap43, Atp6v1f, Th and Atp6v1a in ICH group and Sham2 group were compared, the differences were statistically significant (P < 0.05). Nefl was up regulated, while Gap43, Atp6v1f, Th and Atp6v1a were down regulated. Conclusion There are common DEPs in acute stroke, and the core mechanism may be myelin sheath injury and metabolic disorder.
		2021 Vol. 18 (10): 12-18 [Abstract] ( 151 ) HTML (1 KB) PDF (1173 KB) ( 84 )

	19	Expression and clinical significance of miR-4313 and TBX15 in clear cell renal cell carcinoma
		SU Ji WANG Gang FENG Shiwei
		Objective To study the expression and clinical significance of microRNA (miR)-4313 and T-box transcription factor 15 (TBX15) in clear cell renal cell carcinoma (ccRCC). Methods Fluorescence quantitative PCR was used to detect the mRNA expression of miR-4313 and TBX15 in the cancer tissues of 93 ccRCC patients treated in Benxi Central Hospital, Liaoning Province from March 2018 to December 2019. Immunohistochemistry was used to detect the expression of TBX15 protein in the cancer tissues. Normal tissues adjacent to the cancer were used as control. The relationship between miR-4313 and TBX15 protein expression in cancer tissues and clinicopathological parameters was analyzed. The correlation between miR-4313 and TBX15 mRNA expression were analyzed by Pearson linear correlation analysis. Results Compared with adjacent tissues, the relative expression level of miR-4313 in ccRCC cancer tissue was significantly lower, while the relative expression level of TBX15 mRNA was significantly higher, and the differences were statistically significant (all P ＜ 0.05). The positive expression rate of TBX15 protein in cancer tissues was significantly higher than that in adjacent tissues, and the difference was statistically significant (P ＜ 0.05). There was no statistical significance in the expression of miR-4313 and TBX15 protein in cancer tissues among patients with different ages, genders, pathological grades, distant metastasis and lymph node metastasis (P ＞ 0.05). The miR-4313 expression in tumor stage Ⅲ-Ⅳ ccRCC cancer tissues were significantly lower than stage Ⅰ-Ⅱ, the TBX15 protein expression in tumor stage Ⅲ-Ⅳ ccRCC cancer tissues were significantly higher than the stageⅠ-Ⅱ, the differences were statistically significant (all P ＜ 0.05). There was a significant negative correlation between miR-4313 and TBX15 mRNA expression in cancer tissues (r = -0.671, P = 0.001). Conclusion The expression of miR-4313 in ccRCC cancer tissues decreases，while the expression of TBX15 increases. Both expressions are related to tumor stage and may become new ccRCC tumor markers.
		2021 Vol. 18 (10): 19-22 [Abstract] ( 78 ) HTML (1 KB) PDF (644 KB) ( 118 )

	23	Optimization of extraction process of Astragalus and Radix Notoginseng by multi index comprehensive score method
		LAN Yang1 ZHANG Shijin1 WANG Yali1 GUO Tingdong1 TANG Zhili1 XIE Xisheng2
		Objective To optimize the extraction process of Astragalus and Radix Notoginseng by multi index comprehensive score method combined with orthogonal design. Methods The contents of isoflavone glucoside, ferulic acid, ginsenoside Rg1 in the prescription and the comprehensive score of extract yield were used as evaluation indexes. The effects of water multiple, extraction time and extraction times on the comprehensive score were investigated by orthogonal test. Results The optimal extraction process was to add ten times of water, extract four times, 30 min each time. Under these conditions, the average content of isoflavone glucoside, ferulic acid, ginsenoside Rg1 were 0.61, 1.51, 26.23 mg/g respectively, and the and extract yield was 41.02%, and the RSD was 0.94%, 1.38%, 1.20%, 0.71%, respectively (n = 3). Conclusion The optimized process is stable and feasible, which can be used as the extraction process of this preparation.
		2021 Vol. 18 (10): 23-25,30 [Abstract] ( 117 ) HTML (1 KB) PDF (824 KB) ( 132 )

	26	Discussion on the molecular mechanism of Qingre Kasen Keli in the treatment of renal edema based on network pharmacology and molecular docking
		DUAN Yanfen1 ZHANG Dongning1 HOU Shuaihong2 MO Guoyan1 HAN Lintao1 HUANG Fang3 YIN Qiang1,2 LI Jingjing3
		Objective To investigate the molecular mechanism of Qingre Kasen Keli in the treatment of renal edema based on network pharmacology and molecular docking. Methods The active ingredients of Cichorii Herba in Qingre Kasen Keli were screened through the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and related literatures. The targets of Qingre Kasen Keli were collected and matched with those targets related to renal edema. The “compound-targe-pathway” network was constructed by Cytoscape 3.7.0. R language was used for GO functional enrichment analysis and KEGG pathway enrichment analysis to predict its mechanism of action in the treatment of renal edema, and the effective compounds in Qingre Kasen Keli were molecule docking with the core targets. Results Thirty-five active ingredients were screened from Qingre Kasen Keli, involving 153 gene targets. It was found that they were mainly involved in PI3K-Akt, MAPK1, Ras, and Rap1 signaling pathway etc. in the treatment of renal edema through targets such as EGFR, KDR, MAPK3, IGF1R, AKT1, and GSK3B etc. The results of molecular docking showed that the selected active ingredients had strong binding ability to target. Conclusion The main active components, functional activities, mechanism of action and signal pathway of Qingre Kasen Keli in the treatment of renal edema are inferred by using network pharmacology research method, which provide theoretical support and ideas for further research in the future.
		2021 Vol. 18 (10): 26-30 [Abstract] ( 62 ) HTML (1 KB) PDF (1086 KB) ( 277 )

	31	Research progress of IgA-mediated mucosal immunity and regulation of intestinal flora in the onset of childhood asthma
		HOU Shuting1,2 LU Yuan3 ZHAO Xia1,2
		Asthma is a common chronic respiratory disease in children, which seriously affects the physical and mental health and quality of life of children. The airways and intestines of children with asthma have varying degrees of damage to the mucosal epithelial cells, and immunoglobulin A (IgA) is the main antibody secreted by mucosal immunity, which can limit the colonization of the intestinal flora and maintain the balance of the intestinal flora and protect the epithelial cell layer Integrity, thereby preventing asthma and improving its prognosis. In addition, Chinese medicine has cloud “exteiror-interior relationship between lung and large intestine”, and “lung and bowel combined treatment” is a common method of clinical treatment of asthma, IgA may be a bridge between the lung and large intestine. This paper summarized the literature from the perspective of the effect of IgA in mucosal immunity on children’s asthma, in order to provide new ideas for the mechanism research of children’s asthma, provide new targets for clinical treatment, and provide scientific theoretical support for “exteiror-interior relationship between lung and large intestine”.
		2021 Vol. 18 (10): 31-34 [Abstract] ( 171 ) HTML (1 KB) PDF (570 KB) ( 147 )

	35	Research progress on molecular mechanisms of autophagy and apoptosis in endometriosis
		CONG Huifang1 LI Yang2 YU Yang1 ZHANG Tianchan1,3
		Endometriosis is an estrogen-dependent progressive disease, the occurrence and development of the disease are mostly related to the autophagy and apoptosis mechanisms of endometrial cells. Patients with endometriosis promote the occurrence of endometriosis by inhibiting the level of apoptosis of endometriosis cells to protect cells and promote cell proliferation. However, the role of autophagy in endometriosis is still controversial. However, whether autophagy is an “enemy” or a “friend” in endometriosis is still controversial. Both low and high levels of autophagy have been observed in endometriosis lesions, and can promote the development of endometriosis via inhibiting apoptosis in different ways. Therefore, the relationship between autophagy and apoptosis in endometriosis and the expression level of autophagy still need to be explored continuously.
		2021 Vol. 18 (10): 35-38 [Abstract] ( 330 ) HTML (1 KB) PDF (564 KB) ( 220 )

	39	Research progress of mitophagy in sepsis
		ZHANG Xintong1 LIU Jingzhuo1 LI Pan1 MA Desheng1 MA Li2
		Sepsis is a common disease in intensive care unit, which is characterized by high morbidity and mortality, and is easy to cause systemic multiple organ damage and even failure. At present, the treatment of sepsis mainly focuses on etiological treatment, fluid resuscitation, anti-infection and other targets, but the treatment effect is not good due to the rapid progress of the disease. Mitophagy can clear damaged, aged and dysfunctional mitochondria through Parkin-dependent and Parkin-independent pathways, effectively avoid excessive cell damage and maintain homeostasis of intracellular environment, which plays an important role in many diseases. Mitophagy, mediated by Parkin, Fun14 domain-containing protein 1, Bcl-2 interacting protein 3, dynamin related protein 1, can inhibit the release of inflammatory factors and reactive oxygen species, reduce the occurrence of multiple organ dysfunction, and play a protective role in sepsis. This article reviews the aspects of the mechanism and treatment of mitophagy in sepsis, so as to provide a new basis for the treatment of sepsis.
		2021 Vol. 18 (10): 39-42 [Abstract] ( 173 ) HTML (1 KB) PDF (568 KB) ( 63 )

	43	The present situation and enlightenment of foreign smart home care
		HUANG Qiyuan LI Ying TANG Xianping
		Facing the severe aging trend of population in China, “how to provide for the aged” has become a challenge for the government and society. In recent years, China has promoted the combination of “internet+” and older adult care industry. Smart home care services have emerged. However, China’s smart home care is still in the infancy stage. If we want to give full play to its advantages, we must refer to foreign advanced science and management technology. This paper reviews the development status of smart elderly care in foreign countries, focusing on the application of remote medical care, smart home, artificial intelligence and other elderly care facilities in the home life of the elderly, and puts forward some suggestions on the top-level design, supply and demand matching, talent training and smart service popularization of smart elderly care in China, so as to provide some reference for the development of smart home care in China.
		2021 Vol. 18 (10): 43-46 [Abstract] ( 259 ) HTML (1 KB) PDF (566 KB) ( 1289 )

	47	Application of imaging examination techniques in the diagnosis and evaluation of knee joint diseases
		CAO Xindi1 SUN Kaixin1 GU Fei1 ZHUANG Yueqin2 LIU Kunpeng1 WANG Cheng1 ZHANG Jun1
		Knee joint is the most complex joint in human body, many factors can lead to knee joint diseases, imaging examination technology plays an important role in the diagnosis and evaluation of knee joint diseases. Now according to the literature, we summarize and discuss the different imaging techniques in the diagnosis and evaluation of knee joint diseases. X-ray is a common clinical technique; CT combined with related technology is better in personalized operation of knee replacement; MRI has specificity and higher value in displaying knee cartilage and other tissues; clinical value of ultrasound is getting more and more attention. Clinicians need to be familiar with the specificity of different examination techniques, combined with the comprehensive judgment of the patient’s condition, and carry out reasonable examination.
		2021 Vol. 18 (10): 47-50 [Abstract] ( 154 ) HTML (1 KB) PDF (565 KB) ( 197 )

	51	Application effect of blended teaching method in evidence-based medicine course for graduate students
		LIU Yingli1,2 LI Zhixia3 LIU Yang4 YU Shuqing5 LI Man1,2 SUN Feng5,6
		Objective To explore the application effect of blended teaching method in evidence-based medicine (EBM) for graduate students. Methods A total of 22 graduate students enrolled in the first semester of the academic year 2019-2020 (from September 2019 to November 2019) and signed to the course Evidence Synthesis and Application in Medicine：Advanced Meta-analysis of Peking University Health Science Center were selected as the research subjects. The blended teaching method was consisted of traditional classroom teaching, WeChat question-answering and offline consultation. Questionnaire survey was used to evaluate the teaching effect of knowledge, skills, learning attitude and application after class. Results Compared with before class, students’ understanding of EBM related concepts of “absolute risk”, “odds ratio” and “heterogeneity” was improved after class, and the differences were statistically significant (all P ＜ 0.05). Before and after class, there were no significant differences in literature retrieval ability, average monthly literature reading and retrieval cases (P ＞ 0.05). Compared with before class, after class, students showed significant improvement in three aspects: “In daily clinical work, doctors need to increase the use of medical evidence”, “You are interested in the learning and skills of applying EBM to clinical practice” and “EBM is helpful for you to make clinical decisions”, and the differences were statistically significant (all P ＜ 0.05). The result of barriers to implementing EBM practices showed that 65.22% of the students thought that they did not have enough time, and 69.57% of the students thought that their ability to strictly evaluate the literature was limited. Conclusion The blended teaching method, which combines traditional classroom teaching, WeChat question-answering and offline consultation, improves the teaching effect of EBM. It is suggested that it should be promoted and used in future teaching work.
		2021 Vol. 18 (10): 51-54,62 [Abstract] ( 64 ) HTML (1 KB) PDF (639 KB) ( 119 )

	55	Application of case-based learning in clinical probation teaching of dermatology for overseas students
		GE Rui MU Xin ZHOU Yan ZHANG Jian WANG Lijuan ZHANG Zixi MOU Kuanhou
		Objective To explore the application effect of case-based learning (CBL) in clinical probation teaching of dermatology for overseas students. Methods A total of 68 overseas students from the Xi’an Jiaotong University Health Science Center in 2015 grade were selected and they were divided into the control group and the experimental group according to the internship arrangement, with 34 students in each group. In the clinical probation teaching of dermatology department of overseas students from February to March 2020, the traditional probation teaching mode was adopted in the control group, while the case-based learning mode was adopted in the experimental group. According to the results of the final theoretical assessment and questionnaire survey, the teaching effects of the two teaching modes were compared. Results The average theoretical score and excellent and good rate of the experimental group were higher than those of the control group, and the differences were statistically significant (all P ＜ 0.05). The subjective evaluation scores of the experimental group were higher than those of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion In clinical probation teaching of dermatology for overseas students, CBL teaching method can improve the clinical teaching effect to a certain extent, and is worthy of further promotion.
		2021 Vol. 18 (10): 55-58 [Abstract] ( 114 ) HTML (1 KB) PDF (615 KB) ( 128 )

	59	Design and application on mixed teaching in bilingual curriculum of introduction of Pharmacy based on Chaoxing Xuexi Tong
		LI Yanping WU Jianfeng
		Introduction to pharmacy is a professional compulsory course for lower grade pharmacy students. How to effectively carry out bilingual teaching in this course deserves people’s attention. In this paper, the Chaoxing Xuexi Tong intelligence platform is introduced into the bilingual teaching of introduction to pharmacy, which achieves remarkable teaching effects. This paper systematically introduces the design, implementation and experience of bilingual curriculum mixed teaching of introduction to pharmacy based on Chaoxing Xuexi Tong. In general, the application of Chaoxing Xuexi Tong can effectively help teachers to organize and implement bilingual teaching activities, realize mixed teaching, improve students’ learning enthusiasm and class participation, and provide a good platform for teachers and students to communicate in and out of class.
		2021 Vol. 18 (10): 59-62 [Abstract] ( 72 ) HTML (1 KB) PDF (666 KB) ( 26 )

	63	Construction of mixed on-line and off-line practical teaching system for optometry major of Xi’an Medical College based on college-hospital-enterprise cooperation
		YANG Yang1 LI Jun2 WANG Li1 LIU Wenlan1 YAN Jin1 ZHU Dan1 LI Lei3
		The speciality of optometry of Xi’an Medical College makes full use of the characteristics of the combination of medical science with engineering. Based on college-hospital-enterprise cooperation, the practical teaching operation is guaranteed through the establishment of professional practice ability, the establishment of online and offline cooperation platform, and the establishment of “double teachers and double posts” type teaching team. Then the practical teaching content is improved by optimizing the basic practice content and place, setting up the two-level comprehensive practice, and carrying out innovation and social practice. Finally, the mixed on-line and off-line practical teaching system with college-hospital-enterprise cooperation is constructed.
		2021 Vol. 18 (10): 63-66,75 [Abstract] ( 74 ) HTML (1 KB) PDF (676 KB) ( 75 )

	67	Application of immersive clinical thinking training platform in internal nursing
		WANG Shasha1 LIU Yanli1 GUO Wei1 YAN Xingyu1 LU Xia1 HUANG Zhen2
		Objective To explore the application effect of immersive clinical thinking training platform in internal nursing. Methods Two classes of Grade 2016 and Grade 2017, majoring in nursing of Shandong University of Traditional Chinese Medicine from September 2019 to January 2020, were randomly selected as the research objects. The class of Grade 2016 was the control group (50 students), and the traditional teaching method was adopted. The class of Grade 2017 was the experimental group (48 students). On the basis of the control group, the experimental group was taught by the immersive clinical thinking training platform introduced by Shandong University of Traditional Chinese Medicine, which was the combination of DxR Nursing SELECT clinical thinking training system and high-end simulators. The teaching effects of the two groups were compared through theoretical assessment, practical skill achievement, autonomous learning ability, critical thinking and satisfaction. Results The scores of theoretical assessment, practical skills, autonomous learning ability and critical thinking ability in the experimental group were all higher than those in the control group, with statistical significance (P ＜ 0.05). In addition, more than 75% of students in the experimental group approved the immersive clinical thinking training platform. Conclusion The application of immersive clinical thinking training platform in internal nursing can effectively improve students’ critical thinking ability, create an inquiry-based learning atmosphere, mobilize students’ initiative in independent learning, and is conducive to improving the teaching effect of internal nursing.
		2021 Vol. 18 (10): 67-70 [Abstract] ( 56 ) HTML (1 KB) PDF (654 KB) ( 23 )

	71	Application of formative evaluation in nursing research teaching
		ZHENG Xiaoying1 WANG Fei1 LU Yingxue1 ZHANG Renchuan2 WANG Liqin3 WANG Xuehui4
		Objective To explore the application of formative evaluation in nursing research course of nursing undergraduates in Heilongjiang University of Chinese Medicine. Methods A non-synchronous control study was conducted to select 224 nursing undergraduate students of Grade 2015 and Grade 2016 in Heilongjiang University of Chinese Medicine from September 2018 to July 2019 as the research objects. Among them, 109 nursing students of 2015 were the control group, 115 nursing students of grade 2016 were enrolled in the observation group. The observation group adopted formative assessment teaching method, while the control group adopted traditional teaching method. After teaching, the two groups were compared in terms of course examination scores, autonomous learning ability and teaching satisfaction. Results After teaching, the test scores of students in the observation group were higher than those in the control group, and the difference was statistically significant (P ＜ 0.05), the learning significance, learning control, self-efficacy, learning management, learning plan, learning help, learning summary, learning evaluation and total scores of the observation group were significantly higher than those of the control group, with statistical significance (P ＜ 0.05). The students in the observation group were more satisfied with the course, teaching method, teaching arrangement, teacher-student interaction and evaluation method were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Formative evaluation is helpful to improve the teaching level of nursing research, stimulate students’ initiative in learning, and thus enhance students’ comprehensive quality and ability.
		2021 Vol. 18 (10): 71-74 [Abstract] ( 68 ) HTML (1 KB) PDF (665 KB) ( 67 )

	76	Study on the effect of video-assisted teaching on improving the clinical competence of ICU undergraduate nursing students
		NING Yuyin1 HUANG Jie2 HUANG Yi1 JIANG Zhengyan1 YANG Xiaofeng3 LIANG Qun1 SU Yuhong3 WU Qian2
		Objective To explore the application effect of video-assisted teaching in ICU undergraduate nursing students’ clinical competence. Methods A total of 58 nursing undergraduates who worked as ICU interns in the First Affiliated Hospital of Guangxi University of Chinese Medicine (hereinafter referred to as “our hospital”) from May 2018 to June 2019 were selected as the control group. Fifty-four nursing undergraduates who practiced in the same department of our hospital from July 2019 to June 2020 were selected as the observation group. Problem-based learning (PBL) and case-based learning (CBL) methods were used in the control group, the observation group incorporated video learning on this basis. After four weeks of practice, nursing students’ clinical competence, theoretical knowledge, operational skills, students’ satisfaction with teaching, teachers’ satisfaction with students of the two groups were compared. Results The total scores of clinical competence, theoretical knowledge, operational skills, students’ satisfaction with teaching and teachers’ satisfaction with students in the observation group were all higher than those in the control group, with statistical significance (all P ＜ 0.05). Conclusion Video-assisted teaching is helpful to improve ICU nursing students’ clinical competence, theoretical and technical performance, and teachers and students are more satisfied with each other. It is worthy of popularization and application in clinical nursing teaching.
		2021 Vol. 18 (10): 76-79 [Abstract] ( 152 ) HTML (1 KB) PDF (654 KB) ( 109 )

	80	Clinical effect of Qianggan Capsules in the treatment of patients with chronic hepatitis B
		WANG Hua1 YANG Liuming1 HUANG Ling1 XIN Hongwu2 ZHAO Yanlong1 XU Junkao1 HUANG Chunrong1 FENG Guanggui1
		Objective To investigate the curative efficacy of Qianggan Capsules in the treatment of chronic hepatitis B (CHB) patients with hepatic fibrosis. Methods From July 2017 to July 2019, 100 patients with CHB admitted to Lianjiang People’s Hospital of Guangdong Province were selected as the research subjects. According to the random number table method, they were divided into control group and treatment group, with 50 cases in each group. Control group was treated with Glucurone Tablets and Compound Vitamin B Tablets, and study group was treated with Qianggan Capsules, all treated for six months. Alanine aminotransferase (ALT), total bilirubin (TBil), albumin (ALB), prothrombin time (PT), platelet derived growth factor BB (PDGF-BB), transforming growth factor β1 (TGF-β1), matrix metalloproteinase 1 (MMP-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) were compared between two groups. The change of constitution of traditional Chinese medicine in two groups were observed and the occurrence of adverse reactions was recorded. Results After treatment, ALT and TBil levels were lower than those before treatment, PT was shorter than that before treatment, and ALB level was higher than that before treatment (all P < 0.05). After treatment, there were no significant differences in ALT, TBil, ALB and PT between two groups (P ＞ 0.05). After treatment, PDGF-BB, TGF-β1, MMP-1 and TIMP-1 levels in control group were not significantly differences from those before treatment (P > 0.05). PDGF-BB, TGF-β1 and TIMP-1 levels in treatment group were lower than before treatment, and MMP-1 level was higher than that before treatment. After treatment, PDGF-BB, TGF-β1 and TIMP-1 levels in treatment group were lower than those in control group, and MMP-1 level was higher than those in control group (all P < 0.05). After treatment, there was no significant difference in the change of constitution between control group and that before treatment (P ＞ 0.05); there was statistical significance in the change of constitution in treatment group compared with that before treatment (P < 0.05). After treatment, there was statistically significant difference in the change of constitution between two groups (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Qianggan Capsules can improve hepatic fibrosis indexes and improved the constitution of traditional Chinese medicine in patients with CHB.
		2021 Vol. 18 (10): 80-83 [Abstract] ( 182 ) HTML (1 KB) PDF (635 KB) ( 30 )

	84	Effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil partial closure in the treatment of keloids
		LU Huixiu CAO Haiyu LI Jianying SUN Jing LIANG Yunchuan
		Objective To observe the effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil (5-Fu) partial closure in the treatment of keloids. Methods A total of 120 patients with keloids treated in the Department of Dermatology, Shijiazhuang People’s Hospital from January 2018 to October 2019 were selected as the research subjects, and they were divided into three groups according to random number table method, with 40 patients in each group. Control group A was treated with Cynergy pulsed dye laser. Control group B was treated with Betamethasone and 5-Fu partial closure treatment. Experimental group was treated with Cynergy pulsed dye laser therapy combined with Betamethasone and 5-Fu partial closure treatment. All the three groups were treated once every four weeks for four times in total. The Vancouver scar rating scale score and changes in scar area before and after treatment, clinical efficacy, incidence of adverse reactions and recurrence rate were compared. Results After treatment, the color, vascular distribution, thickness, softness and pruritus scores in the three groups were all decreased compared with before treatment, and the experimental group was all lower than the control group A and B. After treatment, the scar area in the three groups was smaller than before treatment, and the experimental group was smaller than the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Comparison of clinical efficacy distribution between the experimental group and the control group A and between the experimental group and the control group B showed statistically significant differences (all P ＜ 0.05). There was no statistical significance in the rate of adverse reactions between the experimental group and the control group A, and between the experimental group and the control group B (all P ＞ 0.05). The recurrence rate of the experimental group was lower than that of the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Conclusion Cynergy pulsed dye laser combined with Betamethasone and 5-Fu partial closure for keloids treatment can both reduce symptoms and reduce scar area, and the combination of the two is more effective, the effect is more ideal, safe and reliable, and can reduce recurrence rate.
		2021 Vol. 18 (10): 84-87 [Abstract] ( 59 ) HTML (1 KB) PDF (596 KB) ( 41 )

	88	Expression and clinical significance of sEPCR in patients with sepsis
		QIAN Jun1,2 HUANG Zhongwei1,2 XU Jianru2 LU Renfei3 WANG Haiyan2
		Objective To investigate the expression and clinical significance of soluble endothelial cell protein C receptor (sEPCR) in plasma of sepsis patients. Methods A total of 100 patients with sepsis who were treated in Third People’s Hospital of Nantong City, Jiangsu Province (hereinafter referred to as “our hospital”) from October 2018 to October 2019 were selected and they were divided into two groups according to the severity of the disease, including 65 patients in the sepsis group and 35 patients in the septic shock group. Meanwhile, 50 healthy subjects in our hospital during the same period were selected as the control group. Plasma sEPCR level of each group was detected, and the differences in plasma sEPCR level among each group were compared, and the differences among patients with different prognosis were analyzed. Receiver operating characteristic (ROC) curve was used to analyze the prognostic value of plasma sEPCR level in the prognosis of patients. Results Plasma sEPCR level in the septic shock group was significantly higher than that in the sepsis group and the control group at admission, and the sepsis group was higher than the control group, and the differences were statistically significant (all P ＜ 0.05). Plasma sEPCR level of died patients in the sepsis group and the septic shock group was significantly higher than that in the surviving patients at admission and after three days of treatment, and the differences were statistically significant (all P ＜ 0.05). The changes of plasma sEPCR level of died patients in the sepsis group and the septic shock group were significantly lower than those in the surviving patients, and the differences were statistically significant (all P ＜ 0.05). The area under the ROC curve for predicting the death of patients with sEPCR at admission and three days after treatment and its changes were 0.674, 0.884 and 0.848, respectively (all P ＜ 0.05). Conclusion The increased expression of plasma SEPCR in patients with sepsis is related to the severity of the disease, and has certain clinical significance in predicting the prognosis of patients.
		2021 Vol. 18 (10): 88-91 [Abstract] ( 109 ) HTML (1 KB) PDF (630 KB) ( 89 )

	92	Effect of hemoperfusion frequency on the efficacy of severe organophosphorus pesticide poisoning
		ZHAO Yang LI Caixia▲ WANG Haimei HUANG Kun
		Objective To observe the effect of hemoperfusion frequency on the efficacy of severe organophosphorus pesticide poisoning. Methods Clinical data of 160 patients with severe organophosphorus pesticide poisoning admitted to Fuyang People’s Hospital, Anhui Province from January 2017 to February 2020 were retrospectively analyzed. Forty patients receiving conventional treatment were selected as the control group, 68 patients receiving single hemoperfusion therapy in addition to conventional treatment were selected as the single hemoperfusion group, and 52 patients receiving more than two times of hemoperfusion therapy in addition to conventional treatment were selected as the multiple hemoperfusion group. The efficacy, complications, fatality rate and cholinesterase activity of the three groups were compared. Results The mechanical ventilation time, coma time, hospital stay time and 80% recovery time of cholinesterase activity in the multiple hemoperfusion group and the single hemoperfusion group were shorter than those in the control group, and the multiple hemoperfusion group was shorter than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). The total dosage of Atropine and Pralidoxime Iodide in the multiple hemoperfusion group and the single hemoperfusion group were less than those in the control group, and the multiple hemoperfusion group was less than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). The rate of total complications and fatality in the multiple hemoperfusion group were lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). After three days of treatment, cholinesterase activity in the three groups was increased compared with before treatment, and the multiple hemoperfusion group and single hemoperfusion group were higher than the control group, and the multiple hemoperfusion group was higher than the single hemoperfusion group, the differences were statistically significant (all P ＜ 0.05). Conclusion Multiple hemoperfusion can improve the efficacy of severe organophosphorus pesticide poisoning and reduce complications.
		2021 Vol. 18 (10): 92-95 [Abstract] ( 70 ) HTML (1 KB) PDF (632 KB) ( 136 )

	96	Influencing factors of pulmonary infection in patients with stable chronic obstructive pulmonary disease
		HE Xiaojiao LI Sinong DUAN Cheng
		Objective To observe the occurrence of pulmonary infection in patients with stable chronic obstructive pulmonary disease (COPD), and to analyze its possible influencing factors. Methods From June 2018 to June 2020, 120 patients with stable COPD admitted to West China Hospital of Sichuan University were selected, the occurrence of pulmonary infection in patients was evaluated according to relevant standards; general information questionnaire was designed, the data such as gender and age of the patients were recorded in detail, included the possible influencing factors, the influencing factors of pulmonary infection in stable COPD patients were analyzed by univariate and multivariate tests. Results A total of 120 patients with stable COPD were evaluated, the results showed that 23 patients occurred pulmonary infection, the incidence rate was 19.17%; by single regression analysis, the results showed that combined with diabetes mellitus, smoking, use time of antibiotics ≥14 days, use time of glucocorticoid >seven days and low expression of serum albumin were the influencing factors of pulmonary infection (OR > 1, P < 0.05); then multiple regression model was established and multivariate analysis was conducted, the results showed that combined with diabetes mellitus, smoking, use time of antibiotics ≥14 days and low expression of serum albumin were the influencing factors of pulmonary infection (OR > 1, P < 0.05). Conclusion The occurrence of pulmonary infection in patients with stable COPD may be affected by combined with diabetes mellitus, smoking, prolonged use time of antibiotics and low expression of serum albumin, the above factors should be focused on clinically, and targeted intervention should be given.
		2021 Vol. 18 (10): 96-99,112 [Abstract] ( 95 ) HTML (1 KB) PDF (983 KB) ( 76 )

	100	Effect of low calcium dialysis combined with HFHD on maintenance hemodialysis and calcium and phosphorus metabolism
		ZHOU Qi QIAN Guangrong TANG Xiaofei
		Objective To explore the effect of low-calcium dialysis combined with high-flux dialysis (HFHD) on uremia maintenance hemodialysis and its effect on calcium and phosphorus metabolism, so as to provide a basis for patient diagnosis and treatment. Methods The diagnosis and treatment of 81 patients with uremia maintenance hemodialysis who were admitted to Department of Nephrology, Ma’anshan People’s Hospital of Anhui Province from March 2017 to January 2020 were retrospectively analyzed. According to different treatment methods, they were divided into observation group (41 cases) and control group (40 cases). The control group was treated with normal calcium dialysis combined with HFHD, and the observation group was treated with low calcium dialysis combined with HFHD. After six months of treatment, serum calcium, phosphorus, parathyroid hormone (iPTH), renal function (serum creatinine [SCR], urea nitrogen [BUN] ), β2-microglobulin (β2-MG), C-reactive protein (CRP) levels and complications were compared. Results Compared with before treatment, after treatment, blood calcium, blood phosphorus and calcium phosphorus product in the two groups were significantly decreased, and observation group was significantly lower than control group (P ＜ 0.05); compared with before treatment, after treatment, SCR, BUN, β2-MG and iPTH levels in the two groups were significantly decreased (P ＜ 0.05), but there was no statistical significance between the two groups (P ＞ 0.05). After treatment, CRP levels in both groups were significantly decreased, and observation group was lower than control group (P ＜ 0.05); there was no significant difference in complications between the two groups (P ＞ 0.05). Conclusion Low calcium dialysis combined with HFHD in uremic maintenance hemodialysis has good effect, can significantly correct the disorder of serum calcium and phosphorus metabolism, improve renal function, reduce the body inflammatory reaction, with high safety, and can be widely used in clinic.
		2021 Vol. 18 (10): 100-103 [Abstract] ( 224 ) HTML (1 KB) PDF (592 KB) ( 79 )

	104	Changes and clinical characteristics of serum CRP, IL-6 and PCT in AECOPD patients with different LAA levels on HRCT
		ZHU Fan
		Objective To investigate the changes and clinical characteristics of serum C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT) levels in different low density attenuation regions (LAA) of high-resolution CT (HRCT) patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The 81 patients with AECOPD who were diagnosed and treated in Chizhou People’s Hospital from May 2017 to May 2020 were selected as the research objects. All patients underwent HRCT examination, according to the bronchial wall thickening and the degree of emphysema in the images, they were divided into three groups, type A group (33 cases): with or without bronchial wall thickening, three levels of total LAA score grade≤1 grade; type E group (22 cases): without bronchial wall thickening, three levels of total LAA score grade≥2 grade; type M group (26 cases): combined with bronchial wall thickening, three levels of total LAA score grade≥2 grade. The serum levels of CRP, IL-6, PCT and clinical characteristics of the three groups were compared. Results The serum levels of CRP, IL-6, and PCT in type M group were significantly higher than those in type A group and type E group, the difference were statistically significant (P ＜ 0.05); there was no statistically significant difference in serum CRP, IL-6, PCT levels between patients with type A group and type E group (P ＞ 0.05). The smoking index of type A group was significantly lower than that of type E group and type M group; the prealbumin level of type A group was significantly higher than that of type E group and type M group; the proportion of acute exacerbations≥2 times in the past one year in type A group was significantly lower than that in type E group and type M group; the partial pressure of carbon dioxide (PaCO2) in group A was significantly lower than that in type E group and type M group, the differences were statistically significant (P ＜ 0.05); there was no statistically significant difference between the clinical characteristics of patients with type E group and type M group (P ＞ 0.05). Conclusion The serum CRP, IL-6, PCT levels and clinical characteristics of AECOPD patients with different LAA grades of HRCT are different, which can be used as important indicators for patient condition prediction, formulation and implementation of personalized treatment plans.
		2021 Vol. 18 (10): 104-107 [Abstract] ( 112 ) HTML (1 KB) PDF (594 KB) ( 92 )

	108	Meta-analysis on the safety and efficacy of acupuncture combined with intraspinal analgesia in labor analgesia
		SHUI Linhui1 HE Huixin1 PENG Sai1 DENG Chaowen1 TENG Yongjie1 LEI Huajuan1 LI Zikui2
		Objective To systematically evaluate the safety and efficacy of acupuncture combined with intraspinal analgesia in labor analgesia. Methods The databases of PubMed, Embase, Cochrane Library, CNKI, Wanfang Data, CBM and VIP were searched by computer, and the randomized controlled trials of acupuncture combined with intraspinal labor analgesia were collected. The retrieval time was from the inception to August 2020. The literatures that met the criteria were screened and meta-analysis was carried out by RevMan 5.3. Results Ten literatures were included, including 872 patients. The results of meta-analysis showed that the conversion rate of vaginal delivery to cesarean section (OR = 0.45, 95%CI [0.26, 0.77], P = 0.003), postpartum hemorrhage volume (MD = -45.14, 95%CI [-85.32, -4.96], P = 0.03) and intraspinal drug dosage (MD = -4.35, 95%CI [-5.97, -2.74], P ＜ 0.000 01) in the experimental group were lower than those in the control group. However, there was no significant differences between the two groups in visual analogue scales of cervix with full open (MD = -0.19, 95%CI [-0.45, 0.07], P = 0.15) and the time of active phase of the first stage of labor (MD = -15.79, 95%CI [-32.83, 1.24], P = 0.07). Conclusion Compared with intraspinal labor analgesia, acupuncture combined with intraspinal analgesia can reduce the intraspinal drug dosage and postpartum hemorrhage volume, and reduce the rate of vaginal delivery to cesarean section. However, it still needs to be verified by large sample, multi-center and high quality studies.
		2021 Vol. 18 (10): 108-112 [Abstract] ( 170 ) HTML (1 KB) PDF (1357 KB) ( 72 )

	113	Effect of point injection combined with nerve plexus block of interscalene in the treatment of cervical spondylotic radiculopathy
		YUE Honghong GAO Yinqiu
		Objective To explore effect of point injection combined with nerve plexus block of interscalene in the treatment of cervical spondylotic radiculopathy (CSR). Methods A total of 72 patients with CSR admitted to the Department of Pain, Guang’anmen Hospital, China Academy of Chinese Medical Sciences from March 2019 to January 2020 were selected and they were divided into treatment group and control group according to random number table method, with 36 cases in each group. The treatment group was treated with injection of cervical points of jiaji, fēngchí, and jiānjǐng combined with nerve plexus block of interscalene, while the control group was only treated with nerve plexus block of interscalene. Both groups were treated once every seven days, seven days as a course of treatment, a total of four courses of treatment. The visual analogue scale (VAS) after 1, 2, 3 and 4 weeks of treatment and the excellent and good rate of clinical effect after four weeks of treatment in both groups were observed. Results After four courses of treatment, overall analysis showed that there were statistically significant differences of VAS in groups, time point comparison and interaction between the two groups (P ＜ 0.05). Further pairwise comparison was conducted, and intra-group comparison showed that there were statistically significant differences in intra-group VAS at each time point in two groups (all P ＜ 0.05). Comparison between groups showed that there was no statistically significant difference in VAS between the two groups before treatment (P ＞ 0.05), and the VAS of the treatment group was lower than that of the control group at all time points after one to four weeks of treatment, with statistically significant differences (all P ＜ 0.05). The excellent and good rate of clinical efficacy in treatment group was higher than that in control group (P ＜ 0.05). Conclusion The analgesic effect and clinical efficacy of point injection combined with nerve plexus block of interscalene in the treatment of CSR are better than those of nerve plexus block of interscalene alone.
		2021 Vol. 18 (10): 113-116 [Abstract] ( 187 ) HTML (1 KB) PDF (537 KB) ( 94 )

	117	Anesthetic effect of lumbar plexus-sciatic nerve and L1-L2 paravertebral nerve block combined with general anesthesia and its influence of cognitive function in elderly patients with operation of intertrochanteric fracture of femur
		LUO Ping CHEN Aifang XIANG Yuhua▲
		Objective To investigate the anesthetic effect of lumbar plexus-sciatic nerve and L1-L2 paravertebral nerve block combined with general anesthesia and its influence of cognitive function in elderly patients with operation of intertrochanteric fracture of femur. Methods A total of 80 elderly patients with operation of intertrochanteric fracture of femur from January 2018 to December 2019 in Quzhou Municipal Hospital of Traditional Chinese Medicine, Zhejiang Province were selected as the research subjects, and they were divided into observation group (40 cases) and control group (40 cases) according to random number table method. The observation group was given lumbar plexus-sciatic nerve and L1-L2 paravertebral nerve block combined with general anesthesia, while the control group was given laryngeal mask airway general anesthesia. The mean arterial pressure (MAP), heart rate (HR), anesthesia effect, and mini mental state examination (MMSE) score of the two groups were observed. Results The overall analysis found that there were significant differences in time, inter group and interaction between the two groups (P ＜ 0.05). Further pairwise comparisons were made. There was no significant differences in MAP and HR between T1-T4 and T0 in observation group (P ＞ 0.05). MAP of T1, T2 and T4 was significantly higher than that of T0, and HR of T1-T3 was significantly higher than that of T0 in the control group, with statistical significance (all P ＜ 0.05). Comparison between groups showed that MAP of T1-T2 and HR of T1-T3 in observation group were lower than those in control group at the same time point (all P ＜ 0.05). The excellent and good rate of anesthesia in observation group was higher than that in control group, and the difference was statistically significant (P ＜ 0.05). The MMSE scores at three days after operation in both groups were lower than those before operation, but the observation group was higher than the control group, with statistical significance (all P ＜ 0.05). Conclusion Lumbar plexus-sciatic nerve and L1-L2 paravertebral nerve block combined with general anesthesia in elderly patients with operation of intertrochanteric fracture of femur has good anesthesia effects and little impact on cognitive function.
		2021 Vol. 18 (10): 117-120 [Abstract] ( 172 ) HTML (1 KB) PDF (507 KB) ( 69 )

	121	Discussion on traditional Chinese medicine treatment of ovulatory disorder infertility from “liver is the pivot of reproduction”
		XU Di1 LI Nan2 BAI Jun2 ZHU Hongli2
		Numerous doctors believe that kidney deficiency is the main pathogenesis of ovulatory disorder infertility, which is often clinically based on tonifying the kidney. However, with the changing role of women in society, some scholars think that liver is closely related to female reproduction, and liver is the pivot of reproduction. According to traditional Chinese medicine, liver dysfunction is the core of ovulatory disorder infertility. Liver dysfunction can lead to disorder of qi activity, affect the growth of menstrual cycle, and destroy the coordination and balance of each link of female reproductive axis, resulting in ovulation disorder and infertility. The treatment should be based on dispersing stagnated liver qi for relieving qi stagnation, regulating qi movement, regulating spleen and resolving phlegm, and paying attention to tonifying kidney for consolidating semen. It is supported by a proven case.
		2021 Vol. 18 (10): 121-124 [Abstract] ( 64 ) HTML (1 KB) PDF (693 KB) ( 133 )

	125	Professor Zhang Huadong’s experience in treating psoriatic arthritis complicated with herpes zoster sequelae with Wupi Wuteng Yin
		WU Changyi1 ZHANG Huadong2
		The psoriatic arthritis complicated by herpes zoster sequelae are acute and lingering, which is refractory to modern medicine. Professor Zhang Huadong thinks that the etiology and pathogenesis of the two diseases are due to kidney deficiency, qi and blood obstruction of meridians, and re-sensation of exogenous pathogens. Wupi Wuteng Yin is a famous prescription for treating arthralgia by Professor Zhang Binghou, a famous national traditional Chinese medicine doctor. Wupi are used to dredge collaterals and remove skin, Wuteng are used to dredge meridians and activate blood, the effect of removing blood stasis and removing arthralgia by barks and rattan. Professor Zhang Huadong uses this prescription as principal drug, he starts from dredging meridians and activating collaterals to promote qi and activate blood circulation, so as to achieve the goal of unblocking bi obstruction and removing external evil. This paper introduces Professor Zhang Huadong’s commonly used couplet medicines for milkvetch root and Chinese angelica, unprocessed rehmannia root and prepared rehmannia root, draconis resin and sanqi, and a case of effective treatment.
		2021 Vol. 18 (10): 125-128 [Abstract] ( 201 ) HTML (1 KB) PDF (689 KB) ( 220 )

	129	Clinical effect of umbilical therapy combined with moxibustion in the treatment of elderly patients with gastric retention and its impact on functional status
		YANG Jie1 XIAO Li2 SHEN Yang3 ZHOU Tian2 SUN Tao2
		Objective To study the effect of umbilical therapy combined with moxibustion on the elderly patients with gastric retention and the impact of status. Methods Forty elderly patients with gastric retention from February 2019 to January 2020 in Department of Geriatrics, Dongfang Hospital, Beijing University of Chinese Medicine were divided into control group and treatment group according to random number table method, with 20 cases in each group. Both groups received gastrointestinal motility drugs, treatment group received umbilical therapy combined with moxibustion for 14 days. Clinical efficacy, Chinese medicine syndrome score and World Health Organization disability rating scale Ⅱ score were compared between two groups. Results The effective rate of treatment group was higher than that of control group (P < 0.05). After treatment, the scores of abdominal fullness, anorexia and fullness, loose stool, vomiting, belching, dizziness and fatigue in treatment group were lower than those before treatment, the scores of epigastric fullness, poor appetite and fullness, and vomiting in control group were lower than those before treatment, the scores of abdominal fullness, poor appetite, vomiting, belching, dizziness and fatigue in treatment group were lower than those in control group, the score of loose stool in treatment group was higher than that in control group, the differences were statistically significant (P < 0.05). After treatment, the scores of understanding and communication, self-care, getting along with others and social participation in two groups were lower than those before treatment, and treatment group was lower than that control group, the differences were statistically significant (P < 0.05). The life activity score of treatment group after treatment was lower than that before treatment, and the difference was statistically significant (P < 0.05). Conclusion Umbilical therapy combined with moxibustion has definite clinical effect on elderly patients with gastric retention, which can significantly improve Chinese medicine syndrome and improve the functional state to some extent, and the safety is good.
		2021 Vol. 18 (10): 129-132 [Abstract] ( 106 ) HTML (1 KB) PDF (744 KB) ( 135 )

	133	Clinical study of long needle stabbing nèiguān and slight fire needle pricking dànzhōng and other acupoints combined with Mexiletine Hydrochloride Tablets in the treatment of ventricular arrhythmias
		LIU Haiyong1 ZHANG Jin2 BU Lili3 CHEN Libao4 TIAN Hongyue3 MENG Hongmei3 ZHU Yajing5 YANG Xuejiao6
		Objective To observe the effect of long needle stabbing nèiguān and slight fire needle pricking dànzhōng and other acupoints combined with Mexiletine Hydrochloride Tablets in the treatment of ventricular arrhythmias. Methods Eighty patients with ventricular arrhythmia in Sanhe Hospital of Hebei Province from September 2019 to September 2020 were selected and divided into observation group and control group according to random number table method, 40 cases in each group. Observation group was treated with long needle stabbing nèiguān and slight fire needle pricking dànzhōng and other acupoints and Mexiletine Hydrochloride Tablets, control group was treated with oral administration of Mexiletine Hydrochloride Tablets and Wenxin Granules. P-R interval, QRS duration, serum brain natriuretic peptide (BNP), cardiac troponin I (cTnI) before and after treatment and curative effect were compared between two groups. Results After treatment, P-R interval and QRS duration of two groups were longer than those before treatment, and observation group was longer than that control group, the differences were statistically significant (P < 0.05). After treatment, serum BNP and cTnI levels of two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P < 0.05). Total effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion Long needle stabbing nèiguān and slight fire needle pricking dànzhōng and other acupoints combined with Mexiletine Hydrochloride Tablets in the treatment of ventricular arrhythmias can prove their efficacy in terms of electrocardiogram and laboratory examination, and the effect is relatively obvious.
		2021 Vol. 18 (10): 133-136,146 [Abstract] ( 174 ) HTML (1 KB) PDF (763 KB) ( 88 )

	137	Treatment thought of acupuncture for impotence
		XIAO Caihong1 CUI Jin2
		Professor Cui Jin summarizes the main pathogenesis of impotence through analyzing ancient literatures and modern medical research, which are kidney deficiency complicated with blood stasis; discorder of thoroughfare and conception channels, governor and belt channels; mental disorder. According to the etiology of impotence, Professor Cui Jin takes the treatment thought of tonifying kidney and removing blood stasis, coordinating thoroughfare and conception channels, governor and belt channels, and tranquillization method. Professor Cui Jin selects a specific group of acupoints for acupuncture treatment, so as to achieve the results of tonifying kidney and promoting blood circulation, coordinating thoroughfare and conception channels, governor and belt channels, and adjusting the emotion. The selection of this group of acupoints has scientific basis, and acupuncture on these acupoints can achieve the curative effects of strengthening tendons, recovering impotence and inspiring male sexual function. Thus, this paper enumerates 2 cases to explore the experience of acupuncture treatment for impotence, in order to be used in clinical treatment widely, and provides new treatment thought for the acupuncture treatment of impotence.
		2021 Vol. 18 (10): 137-140 [Abstract] ( 125 ) HTML (1 KB) PDF (736 KB) ( 189 )

	141	Study on the core drug combinations and mechanism of National Physician Master and Professor Lü Renhe in the treatment of diabetic nephropathy
		CHE Biao1 SHAO Fan2 WANG Shidong1 CHEN Xiaoyu1 LI Na1 LI Xiaoran1 TANG Cheng1
		Objective To mine the core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy and explore its synergistic mechanism of multi-component, multi-target and multi-pathway. Methods The medical records of patients with diabetic nephropathy treated in the Outpatient Clinic of Professor Lü Renhe of Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to April 2019 were collected and the medical record database was established. The frequency statistics and association rules algorithm were used to mine the core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy, and the network pharmacology method was used to analyze the mechanism of the core drug combinations. Results The core drug combinations of Professor Lü Renhe in the treatment of diabetic nephropathy were Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis. A total of 105 compounds were obtained, and 47 of them were the key targets of interaction with diseases. The 47 key targets were enriched and analyzed, which showed that the treatment of diabetic nephropathy with Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis may be related to proteoglycan in cancer, AGE-RAGE signal pathway in diabetic complications, cancer pathway, endocrine resistance, drug resistance of EGFR tyrosine kinase inhibitor, prostate cancer, and so on. Conclusion Professor Lü Renhe pays attention to the combination of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis in the treatment of diabetic nephropathy. This study preliminarily reveals the multi-component, multi-target and multi-pathway mechanism of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis, which provides a basis for the study of the molecular mechanism of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Cortex Moutan Radicis.
		2021 Vol. 18 (10): 141-146 [Abstract] ( 102 ) HTML (1 KB) PDF (1439 KB) ( 114 )

	147	Clinical observation of endoscopic ultrasound minimally invasive treatment for upper gastrointestinal submucosal tumors
		ZHENG Fengfan PENG Tao
		Objective To explore the effect of endoscopic ultrasound minimally invasive treatment for upper gastrointestinal submucosal tumors. Methods A total of 174 cases with upper gastrointestinal submucosal tumors in the First Affiliated Hospital of Hebei North University from September 2017 to September 2019 were selected as research objects. All patients underwent endoscopic mucosal dissection. The nature, origin and distribution of upper gastrointestinal submucosal tumors were observed. The diagnostic coincidence rate of digestive endoscopy was observed, pathological diagnosis as the “gold standard”. The levels of serum tumor markers including carbohydrate antigen (CA)15-3, carcinoembryonic antigen (CEA), CA19-9 and tumour-specific growth factor were compared before and after treatment. The incidence of complications was recorded. Results Esophageal leiomyoma is the most common esophageal lesion, mainly distributed in the lower thoracic segment and upper thoracic segment, mostly originated from the muscular mucosa, and the echo characteristic is hypoecho. The diagnostic coincidence rate of endoscopic ultrasound was 99.42%. The levels of CA15-3, CEA, CA19-9 and tumor-specific growth factor after treatment were lower than those before treatment, with statistical significance (all P < 0.05). After minimally invasive treatment, nine patients developed obvious epigastric pain or retrosternal pain 24 h after surgery, three patients developed perforation, and seven patients developed significant postoperative bleeding. All patients were improved after targeted treatment. Conclusion Endoscopic ultrasound minimally invasive treatment for upper gastrointestinal submucosal tumors can not only help the clinical diagnosis of patients, but also provide corresponding treatment, with few complications and high safety, which is worthy of application and promotion.
		2021 Vol. 18 (10): 147-150 [Abstract] ( 104 ) HTML (1 KB) PDF (515 KB) ( 76 )

	151	Dynamic manifestations of lung ultrasound with different types of corona virus disease 2019
		LAN Changli
		Corona virus disease 2019 (COVID-19) is an acute infectious pneumonia. The pathogen is the newly discovered β coronavirus. It is rapid onset, rapid progress, many complications and high mortality and the population is generally susceptible. Its outbreak has become a public health event that seriously affects China and the world. Therefore, timely and accurate diagnosis of pulmonary edema progression is very important for clinicians to adopt correct and effective treatment plan. However, it is inconvenient for critically ill and highly infectious patients to go out for CT examinations, but the bedside lung ultrasound has the advantages of simple, fast, effective and mobile and so on, which has a strong substitute. This paper describe characteristics and signs of lung ultrasound (lungs ultrasound was performed at different stages of the disease progression by the author) of three patients with different symptoms (once case of critical illness, severe and ordinary) which positive by viral nucleic acid test in isolation wards of COVID-19 fixed-point hospital (the Fourth People’s Hospital of Ningxia Hui Autonomous Region) from February 10 to March 16, 2020, in order to provide valuable data for coping with the increasingly serious epidemic situation and the urgent need of clinicians’ monitoring means.
		2021 Vol. 18 (10): 151-154,158 [Abstract] ( 79 ) HTML (1 KB) PDF (1026 KB) ( 130 )

	155	Observation on group A rotavirus and routine stool testing for diarrhea children
		WU Xian JI Xianli LIN Zhigang
		Objective To investigate the result of group A rotavirus and routine stool testing for diarrhea children. Methods A total of 134 cases with diarrhea children in Yongkang First People’s Hospital of Zhejiang Province from June 2016 to June 2020 were selected as study objects. The results of group A rotavirus antigen detection in children with diarrhea of different ages, onset time and gender were observed, the consistency between group A rotavirus antigen detection and routine fecal detection was compared. Results The positive rate of group A rotavirus were 31 cases (23.1%)，the antigen positive rate of group A rotavirus in January and December were high, the positive rate of group A rotavirus infection in male and female diarrhea children were similar. Kappa consistency test showed that the positive rate of group A rotavirus antigen detection was not consistent with the positive rate of white blood cells, red blood cells and occulted blood, but the positive rate of group A rotavirus antigen detection was consistent with the positive rate of fat globules. Conclusion >six months-two years old are susceptible groups of group A rotavirus, January and December are the peak period of group A rotavirus infection. There may be have correlation between detection rate of fat globules in routine fecal detection and detection rate of group A rotavirus.
		2021 Vol. 18 (10): 155-158 [Abstract] ( 95 ) HTML (1 KB) PDF (394 KB) ( 116 )

	159	Application of project management-oriented multidisciplinary practice activities in preventing fall down / fall in bed in inpatients
		ZHANG Pengjia1 ZHAO Sijia1 JIANG Jinxia1▲ ZHAO Gang2 LU Yunxia1 TAO Yinxia1
		Objective To discuss the application effect of project management-oriented multidisciplinary practice activities in preventing fall down / fall in bed in hospitalized patients. Methods All hospitalized patients (76 690 cases) from January 2018 to December 2019 were selected as the research objects. The inpatients (39 411 cases) from January to December 2019 were used as the experimental group to set up a “tumbler” project management team, list ten major improvement project practice activities, and implement project management; the inpatients (37 279 cases) from January to December 2018 were used as the control group, and routine fall prevention management was adopted to compare the clinical process indicators of fall down/fall in bed and the occurrence of falls between the two groups. Results The implementation rate of nurses’ publicity and education measures, the passing rate of fall warning signs, the implementation rate of patients’ self-prevention measures, the passing rate of nurse risk assessment, and the rate of meeting safety standards of environmental facilities in the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of falls in hospitalized patients, the incidence of injuries of grade two and above caused by falls in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Project management-oriented multi-disciplinary practical activities applied to inpatients to prevent falls / falls have shown good results.
		2021 Vol. 18 (10): 159-162,171 [Abstract] ( 73 ) HTML (1 KB) PDF (823 KB) ( 99 )

	163	Application effect of intervention program based on Neuman theory in patients after total hysterectomy
		XU Jia'na1 YAN Ruyu1 YANG Juan1▲ ZHAO Min2
		Objective To explore the effect of nursing intervention based on Neuman theory in the psychological and emotional status of patients after hysterectomy. Methods A total of 58 patients who underwent hysterectomy from January to June 2018 in Wuxi Maternal and Child Health Hospital of Jiangsu Province (“our hospital” for short) were selected as the control group, while a total of 58 patients who underwent hysterectomy from July to December 2018 in our hospital were selected as the observation group. The control group used routine nursing care, and the observation group used Neuman theory-based nursing intervention to compare the changes in anxiety and depression mood of the two groups. Results The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the two groups after nursing were significantly lower than those before nursing, and the SAS and SDS scores of the observation group after nursing were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The paranoia, hostility, horror, somatization, anxiety, obsessive-compulsive symptoms and interpersonal relationship after nursing in the two groups were significantly lower than those before nursing, the depression and psychosis of the observation group were lower than those before nursing; the observation group after nursing was horrified, somatized, anxiety, depression, psychosis, interpersonal, the relationship scores were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The nursing satisfaction rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Nursing intervention based on Neuman’s theory is effective when applied to patients after total hysterectomy, which can effectively alleviate patients’ negative emotions, improve mental status, and increase satisfaction.
		2021 Vol. 18 (10): 163-166 [Abstract] ( 78 ) HTML (1 KB) PDF (642 KB) ( 158 )

	167	Effects of non-pharmaceutical interventions on cancer pain control and sleep quality in patients with advanced tumors
		WU Mengyuan1 WANG Xiaoyan2▲ XIE Ruhui1
		Objective To explore the application effect of non-pharmaceutical interventions in the control of cancer pain in patients with advanced cancer. Methods From July 2017 to June 2019, a total of 92 patients with advanced tumors admitted to Huai’an First Hospital Affiliated to Nanjing Medical University were selected and divided into 48 cases in the experimental group and 44 cases in the control group by random number table method. The control group was given analgesic care based on the principle of three steps of cancer pain relief, and the experimental group was combined with non-drug interventions on the basis of the control group. Followed up for three months, the visual analogue scale (VAS), pittsburgh sleep quality index (PSQI), and the general quality of life scale for cancer patients (FACT-G) were used to assess the degree of pain, sleep quality, and quality of life. Results After three months of follow-up, the VAS scores of the two groups were decreased significantly, and the differences were statistically significant (P ＜ 0.05). The VAS score of the experimental group was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The incidence of moderate and severe pain in the two groups were decreased significantly, and the differences were statistically significant (P ＜ 0.05). The incidence of moderate and severe pain in the experimental group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The PSQI scores and total scores of the two groups were significantly lower than those before the intervention, and the differences were statistically significant (P ＜ 0.05); the sleep quality, time to fall asleep, sleep time, sleep efficiency, sleep disturbance, daytime function and PSQI total scores of the experimental group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the hypnotic drug scores between the two groups (P ＞ 0.05). The FACT-G scores and total scores of the two groups were significantly higher than those before the intervention, and the differences were highly statistically significant (P ＜ 0.01). The physiological status, functional status, emotional status, social and family status and FACT-G total score of the experimental group were higher than those of the control group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion Non-pharmaceutical intervention can help relieve cancer pain in patients with advanced tumors, and improve sleep quality and quality of life.
		2021 Vol. 18 (10): 167-171 [Abstract] ( 184 ) HTML (1 KB) PDF (690 KB) ( 116 )

	172	Impact of WeChat-led health education on the level of knowledge, attitudes and behaviors of nosocomial infection prevention and control of medical staff in operating rooms
		BAI Lihuan CHEN Chuchu
		Objective To discuss the impact of WeChat-led health education on the level of knowledge, attitudes and behaviors of nosocomial infection prevention and control of medical staff in operating rooms and the effectiveness of prevention and control. Methods From July 2017 to June 2018, all 78 medical personnel who volunteered to participate in the study were selected from the Operating Room of Nanjing Integrated Traditional Chinese and Western Medicine Hospital. According to the random number table method, they were divided into an experimental group of 39 people and a control group of 39 people. At the same time, 364 surgical patients were selected as the experimental group and 345 surgical patients were selected as the control group according to the random number table method. The control group was given regular education for medical staff in the operating room, and the experimental group jointly applied health education based on WeChat. After six months of education, the medical staff of two groups were compared with their knowledge, beliefs, and behavior levels of nosocomial infection prevention and control, the incidence of nosocomial infections in surgical patients, and the satisfaction of medical staff with health education. Results After six months of education, the scores of medical staff of the two groups in operating room on nosocomial infection prevention and knowledge, attitude and behavior were higher than those before the same group (P ＜ 0.05). The scores of nosocomial infection prevention and control knowledge, prevention and control attitude, prevention and control behavior, prevention and control knowledge and behavior of medical staff in the operating room of the experimental group were higher than those of the control group (P ＜ 0.05). The incidence of nosocomial infection in the experimental group was lower than that in the control group, and the difference was highly statistically significant (P ＜ 0.01). The satisfaction of nosocomial infection education of medical staff in the experimental group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Health education based on WeChat is helpful to promote the development of the level of knowledge and practice of nosocomial infection prevention and control of medical staff in operating rooms, reduce the incidence of nosocomial infections of patients, and improve the satisfaction of nosocomial infection education of medical staff.
		2021 Vol. 18 (10): 172-175 [Abstract] ( 152 ) HTML (1 KB) PDF (643 KB) ( 78 )

	176	Effect of “family tree” educational mode on compliance of family members with type 2 diabetes mellitus patients in Guizhou Province
		YU Jie1 YANG Ping2▲ XIE Wenya3 JIANG Chengyan3 LI Jindie3 WENG Yue3
		Objective To establish a new diabetes education model with diabetic families as the whole, and to explore its impact on the treatment compliance of type 2 diabetic patients. Methods A total of 160 patients with type 2 diabetes who were admitted to the First People’s Hospital of Zunyi from January 2017 to October 2018 were selected as the research objects. They were divided into control group and experimental group according to the random number table method, with 80 cases in each group. The control group adopts regular health education, and the experimental group adopts the “family tree” education model on the basis of the control group. The differences in compliance, biochemical indicators, family diabetes prevalence, hypoglycemia incidence, and rehospitalization rates between the two groups after intervention were observed. Results After the intervention, the compliance of patients of the two groups improved, while the compliance of the experimental group after intervention was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) after intervention in the two groups were all lower than before intervention, and the differences were statistically significant (all P ＜ 0.05); in the experimental group, the levels of FBG, 2hPBG and HbA1c were all lower than the control group, and the differences were statistically significant (all P ＜ 0.05). The family prevalence, hypoglycemia incidence, and rehospitalization rate of patients in the experimental group after intervention were lower than those in the control group, and the differences were all statistically significant (all P ＜ 0.05). The awareness rate of family health education knowledge, family members’ health behavior supervision rate, and effective early warning rate of family members’ complications in the experimental group were higher than those in the control group, and the differences were all statistically significant (all P ＜ 0.05). Conclusion “Family tree” education model can improve the self-management behavior of patients with type 2 diabetes and improve patient compliance with treatment.
		2021 Vol. 18 (10): 176-179,188 [Abstract] ( 143 ) HTML (1 KB) PDF (701 KB) ( 74 )

	180	Application of “three fixed” emergency care of rupture and bleeding in patients with ectopic pregnancy
		LYU Yuanwei DONG Miao
		Objective To explore the application of “three fixed” emergency care of rupture and bleeding in patients with ectopic pregnancy. Methods From January 2018 to January 2020, 60 EP patients with rupture and bleeding treated in Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected. According to the random number table method, they were divided into control group and observation group, with 30 cases in each group. The observation group was received “three fixed” emergency care, and the control group was received routine emergency care. The rescue success rate and first aid time were compared between the two groups. The shock index of the two groups was compared after intervention. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were compared before and after intervention. Results There was no significant difference in the rescue success rate between the two groups (P ＞ 0.05); the total emergency rescue time and rescue time of observation group were shorter than those of control group (all P ＜ 0.05), the shock index after intervention was better than that of the control group (P ＜ 0.05), APTT and PT were shorter than those before intervention, and the observation group was shorter than the control group (all P ＜ 0.05). Conclusion “Three fixed” emergency care can improve the rescue success rate of EP patients with rupture and bleeding to a certain extent, shorten the emergency time, prevent shock and improve the coagulation function of patients.
		2021 Vol. 18 (10): 180-183 [Abstract] ( 127 ) HTML (1 KB) PDF (680 KB) ( 134 )

	184	Effect of self-efficacy nursing intervention on the psychological resilience and coping style of patients after pituitary adenoma surgery
		ZHU Lili1 NIE Wei2▲ LI Fengwei2
		Objective To observe the effect of self-efficacy (SE) nursing intervention on psychological resilience and coping style of patients with pituitary tumor after surgery. Methods A total of 101 patients with pituitary adenoma who underwent surgical treatment in Hu’nan Brain Hospital from June 2017 to June 2020 were retrospectively analyzed, 51 patients from June 2017 to December 2018 were included as the control group, and the observation group included 50 cases from January 2019 to June 2020. The control group received routine nursing, and the observation group received combined SE nursing on the basis of routine nursing, before intervention and one day before discharge, connor davidson resilience scale (CD-RISC), medical coping modes questionnaire (MCMQ) and self-care ability (self-made questionnaire) were evaluated in the two groups; the incidence of postoperative complications and length of hospital stay were compared between the two groups. Results One day before discharge, CD-RISC score and self-care ability score in both groups were higher than those before intervention, and the observation group was higher than the control group (all P ＜ 0.05); the face dimension score of the two groups were higher than those before intervention, and the observation group was higher than the control group (P ＜ 0.05); the scores of avoidance and yield in the two groups were lower than those before intervention, and the observation group was lower than the control group (P ＜ 0.05). One day before discharge, there was no significant difference in the total incidence between the two groups (P ＞ 0.05), the average length of hospital stay in the observation group was shorter than that in the control group (P ＜ 0.05). Conclusion After pituitary tumor surgery, patients on the basis of conventional nursing combined with SE nursing intervention, compared with traditional nursing alone, is more beneficial to improve patients’ psychological resilience and self-care ability, can improve patients’ coping style to a certain extent, with high application value.
		2021 Vol. 18 (10): 184-188 [Abstract] ( 70 ) HTML (1 KB) PDF (689 KB) ( 124 )

	189	Effect of comfort nursing combined with traditional Chinese medicine emotional nursing in perioperative period of senile femoral neck fracture
		LUO Dan
		Objective To observe the effect of comfort nursing combined with traditional Chinese medicine emotional nursing in perioperative period of senile femoral neck fracture. Methods A total of 74 senile with femoral neck fracture in the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from July 2017 to November 2018 were selected as the research subjects, 37 cases were divided into observation group (comfort nursing combined with traditional Chinese medicine emotional nursing) and control group (routine nursing) by using random number table method. Pain, joint function, psychological state, nursing satisfaction effect of two groups were observed. Results After the intervention the visual analogue score of pain in the observation group was lower than before, and the observation group was lower than the control group, the difference was statistically significant (P ＜ 0.05). The hip function score in the observation group was higher than before, and the observation group was higher than the control group, the difference was statistically significant (P ＜ 0.05). The comfort score between the two groups were compared, the difference was statistically significant (P ＜ 0.05). The scores of self-rating anxiety scale and self-rating depression scale in the observation group were lower than before, and the observation group was lower than the control group, with statistical significance (P ＜ 0.05). The nursing satisfaction score of inpatients in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion In the perioperative period of senile femoral neck fracture to give patients comfort nursing combined with traditional Chinese medicine emotional nursing, can reduce the pain of patients, promote the recovery of joint function, increase comfort level, improve bad psychological state, and enhance patient satisfaction.
		2021 Vol. 18 (10): 189-192 [Abstract] ( 169 ) HTML (1 KB) PDF (677 KB) ( 131 )

	193	Effect of predictive nursing on the satisfaction of infection department，hospital infection rate and nursing satisfaction
		HAN Hua WANG Jieping WEI Bin
		Objective To study the influence of predictive nursing on the satisfaction of the management of the accompany in the infection department, the rate of hospital infection and the satisfaction of nursing. Methods A total of 160 patients who were hospitalized from January to October 2019 in the Department of Infectious of Fuxing Hospital, Capital Medical University were selected as study objects. Using the random number table method, they were divided into 80 cases in the observation group and 80 cases in the control group. Patients in the observation group were given predictive nursing, and patients in the control group were given routine nursing. The satisfaction of the two groups of patients with the management of the infection department, hospital infection rate and nursing effect were compared and analyzed. Results The satisfaction of nursing management in observation group was significantly higher than that in control group (P ＜ 0.05). The rate of nosocomial infection in observation group was significantly lower than that in control group (P ＜ 0.05). The nursing satisfaction of observation group was higher than that of control group (P ＜ 0.05). Conclusion The application of predictive nursing in the department of infectious diseases can reduce the incidence of nosocomial infections, improve the treatment effect of patients，and strengthen the quality of nursing，which has certain clinical application value.
		2021 Vol. 18 (10): 193-196 [Abstract] ( 115 ) HTML (1 KB) PDF (636 KB) ( 66 )

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