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| Effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil partial closure in the treatment of keloids |
| LU Huixiu CAO Haiyu LI Jianying SUN Jing LIANG Yunchuan |
| Department of Dermatology, Shijiazhuang People’s Hospital, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To observe the effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil (5-Fu) partial closure in the treatment of keloids. Methods A total of 120 patients with keloids treated in the Department of Dermatology, Shijiazhuang People’s Hospital from January 2018 to October 2019 were selected as the research subjects, and they were divided into three groups according to random number table method, with 40 patients in each group. Control group A was treated with Cynergy pulsed dye laser. Control group B was treated with Betamethasone and 5-Fu partial closure treatment. Experimental group was treated with Cynergy pulsed dye laser therapy combined with Betamethasone and 5-Fu partial closure treatment. All the three groups were treated once every four weeks for four times in total. The Vancouver scar rating scale score and changes in scar area before and after treatment, clinical efficacy, incidence of adverse reactions and recurrence rate were compared. Results After treatment, the color, vascular distribution, thickness, softness and pruritus scores in the three groups were all decreased compared with before treatment, and the experimental group was all lower than the control group A and B. After treatment, the scar area in the three groups was smaller than before treatment, and the experimental group was smaller than the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Comparison of clinical efficacy distribution between the experimental group and the control group A and between the experimental group and the control group B showed statistically significant differences (all P ＜ 0.05). There was no statistical significance in the rate of adverse reactions between the experimental group and the control group A, and between the experimental group and the control group B (all P ＞ 0.05). The recurrence rate of the experimental group was lower than that of the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Conclusion Cynergy pulsed dye laser combined with Betamethasone and 5-Fu partial closure for keloids treatment can both reduce symptoms and reduce scar area, and the combination of the two is more effective, the effect is more ideal, safe and reliable, and can reduce recurrence rate.
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